LOCUS       NM_000640               1338 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens interleukin 13 receptor subunit alpha 2 (IL13RA2),
            mRNA.
ACCESSION   NM_000640
VERSION     NM_000640.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1338)
  AUTHORS   Chao,H., Zheng,L., Hsu,P., He,J., Wu,R., Xu,S., Zeng,R., Zhou,Y.,
            Ma,H., Liu,H. and Tang,Q.
  TITLE     IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via
            JAK/STAT6 activation
  JOURNAL   JCI Insight 8 (6), e157091 (2023)
   PUBMED   36757802
  REMARK    GeneRIF: IL-13RA2 downregulation in fibroblasts promotes keloid
            fibrosis via JAK/STAT6 activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1338)
  AUTHORS   Nagai,T., Terada,N., Fujii,M., Nagata,Y., Nakahara,K., Mukai,S.,
            Okasho,K., Kamiyama,Y., Akamatsu,S., Kobayashi,T., Iida,K.,
            Denawa,M., Hagiwara,M., Inoue,T., Ogawa,O. and Kamoto,T.
  TITLE     Identification of the alpha2 chain of interleukin-13 receptor as a
            potential biomarker for predicting castration resistance of
            prostate cancer using patient-derived xenograft models
  JOURNAL   Cancer Rep (Hoboken) 6 (2), e1701 (2023)
   PUBMED   36806727
  REMARK    GeneRIF: Identification of the alpha2 chain of interleukin-13
            receptor as a potential biomarker for predicting castration
            resistance of prostate cancer using patient-derived xenograft
            models.
REFERENCE   3  (bases 1 to 1338)
  AUTHORS   Marquez-Ortiz,R.A., Contreras-Zarate,M.J., Tesic,V.,
            Alvarez-Eraso,K.L.F., Kwak,G., Littrell,Z., Costello,J.C.,
            Sreekanth,V., Ormond,D.R., Karam,S.D., Kabos,P. and Cittelly,D.M.
  TITLE     IL13Ralpha2 Promotes Proliferation and Outgrowth of Breast Cancer
            Brain Metastases
  JOURNAL   Clin Cancer Res 27 (22), 6209-6221 (2021)
   PUBMED   34544797
  REMARK    GeneRIF: IL13Ralpha2 Promotes Proliferation and Outgrowth of Breast
            Cancer Brain Metastases.
REFERENCE   4  (bases 1 to 1338)
  AUTHORS   Karakas,N., Stuckey,D., Revai-Lechtich,E. and Shah,K.
  TITLE     IL13Ralpha2- and EGFR-targeted pseudomonas exotoxin potentiates the
            TRAIL-mediated death of GBM cells
  JOURNAL   Int J Mol Med 48 (1) (2021)
   PUBMED   34080646
  REMARK    GeneRIF: IL13Ralpha2 and EGFRtargeted pseudomonas exotoxin
            potentiates the TRAILmediated death of GBM cells.
REFERENCE   5  (bases 1 to 1338)
  AUTHORS   Li,L., Wei,K., Ding,Y., Ahati,P., Xu,H., Fang,H. and Wang,H.
  TITLE     M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix
            Metabolic Imbalances via Activation of IL-13Ralpha2/MAPK Pathway in
            Rat Intervertebral Disc Degeneration
  JOURNAL   Front Immunol 12, 666361 (2021)
   PUBMED   34168643
  REMARK    GeneRIF: M2a Macrophage-Secreted CHI3L1 Promotes Extracellular
            Matrix Metabolic Imbalances via Activation of IL-13Ralpha2/MAPK
            Pathway in Rat Intervertebral Disc Degeneration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1338)
  AUTHORS   Donaldson,D.D., Whitters,M.J., Fitz,L.J., Neben,T.Y., Finnerty,H.,
            Henderson,S.L., O'Hara,R.M. Jr., Beier,D.R., Turner,K.J., Wood,C.R.
            and Collins,M.
  TITLE     The murine IL-13 receptor alpha 2: molecular cloning,
            characterization, and comparison with murine IL-13 receptor alpha 1
  JOURNAL   J Immunol 161 (5), 2317-2324 (1998)
   PUBMED   9725226
REFERENCE   7  (bases 1 to 1338)
  AUTHORS   Guo,J., Apiou,F., Mellerin,M.P., Lebeau,B., Jacques,Y. and
            Minvielle,S.
  TITLE     Chromosome mapping and expression of the human interleukin-13
            receptor
  JOURNAL   Genomics 42 (1), 141-145 (1997)
   PUBMED   9177784
REFERENCE   8  (bases 1 to 1338)
  AUTHORS   Zhang,J.G., Hilton,D.J., Willson,T.A., McFarlane,C., Roberts,B.A.,
            Moritz,R.L., Simpson,R.J., Alexander,W.S., Metcalf,D. and
            Nicola,N.A.
  TITLE     Identification, purification, and characterization of a soluble
            interleukin (IL)-13-binding protein. Evidence that it is distinct
            from the cloned Il-13 receptor and Il-4 receptor alpha-chains
  JOURNAL   J Biol Chem 272 (14), 9474-9480 (1997)
   PUBMED   9083087
REFERENCE   9  (bases 1 to 1338)
  AUTHORS   Gauchat,J.F., Schlagenhauf,E., Feng,N.P., Moser,R., Yamage,M.,
            Jeannin,P., Alouani,S., Elson,G., Notarangelo,L.D., Wells,T.,
            Eugster,H.P. and Bonnefoy,J.Y.
  TITLE     A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human
            B, T, and endothelial cells encoding an alternate type-II
            interleukin-4/interleukin-13 receptor
  JOURNAL   Eur J Immunol 27 (4), 971-978 (1997)
   PUBMED   9130652
REFERENCE   10 (bases 1 to 1338)
  AUTHORS   Caput,D., Laurent,P., Kaghad,M., Lelias,J.M., Lefort,S., Vita,N.
            and Ferrara,P.
  TITLE     Cloning and characterization of a specific interleukin (IL)-13
            binding protein structurally related to the IL-5 receptor alpha
            chain
  JOURNAL   J Biol Chem 271 (28), 16921-16926 (1996)
   PUBMED   8663118
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Y08768.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000640.2.
            
            Summary: The protein encoded by this gene is closely related to
            Il13RA1, a subuint of the interleukin 13 receptor complex. This
            protein binds IL13 with high affinity, but lacks cytoplasmic
            domain, and does not appear to function as a signal mediator. It is
            reported to play a role in the internalization of IL13. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291957.1, Y08768.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243213.2/ ENSP00000243213.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1338              Y08768.1           29-1366
FEATURES             Location/Qualifiers
     source          1..1338
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..1338
                     /gene="IL13RA2"
                     /gene_synonym="CD213A2; CT19; IL-13R; IL13BP"
                     /note="interleukin 13 receptor subunit alpha 2"
                     /db_xref="GeneID:3598"
                     /db_xref="HGNC:HGNC:5975"
                     /db_xref="MIM:300130"
     exon            1..64
                     /gene="IL13RA2"
                     /gene_synonym="CD213A2; CT19; IL-13R; IL13BP"
                     /inference="alignment:Splign:2.1.0"
     exon            65..191
                     /gene="IL13RA2"
                     /gene_synonym="CD213A2; CT19; IL-13R; IL13BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1240
                     /gene="IL13RA2"
                     /gene_synonym="CD213A2; CT19; IL-13R; IL13BP"
                     /note="cancer/testis antigen 19; interleukin 13 binding
                     protein; interleukin 13 receptor alpha 2 chain; IL-13RA2;
                     IL-13R-alpha-2; IL-13R subunit alpha-2; IL-13 receptor
                     subunit alpha-2; interleukin 13 receptor, alpha 2"
                     /codon_start=1
                     /product="interleukin-13 receptor subunit alpha-2
                     precursor"
                     /protein_id="NP_000631.1"
                     /db_xref="CCDS:CCDS14565.1"
                     /db_xref="GeneID:3598"
                     /db_xref="HGNC:HGNC:5975"
                     /db_xref="MIM:300130"
                     /translation="MAFVCLAIGCLYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPG
                     YLGYLYLQWQPPLSLDHFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIE
                     AKIHTLLPWQCTNGSEVQSSWAETTYWISPQGIPETKVQDMDCVYYNWQYLLCSWKPG
                     IGVLLDTNYNLFYWYEGLDHALQCVDYIKADGQNIGCRFPYLEASDYKDFYICVNGSS
                     ENKPIRSSYFTFQLQNIVKPLPPVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEI
                     REDDTTLVTATVENETYTLKTTNETRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGE
                     DLSKKTLLRFWLPFGFILILVIFVTGLLLRKPNTYPKMIPEFFCDT"
     exon            192..343
                     /gene="IL13RA2"
                     /gene_synonym="CD213A2; CT19; IL-13R; IL13BP"
                     /inference="alignment:Splign:2.1.0"
     exon            344..497
                     /gene="IL13RA2"
                     /gene_synonym="CD213A2; CT19; IL-13R; IL13BP"
                     /inference="alignment:Splign:2.1.0"
     exon            498..618
                     /gene="IL13RA2"
                     /gene_synonym="CD213A2; CT19; IL-13R; IL13BP"
                     /inference="alignment:Splign:2.1.0"
     exon            619..803
                     /gene="IL13RA2"
                     /gene_synonym="CD213A2; CT19; IL-13R; IL13BP"
                     /inference="alignment:Splign:2.1.0"
     exon            804..949
                     /gene="IL13RA2"
                     /gene_synonym="CD213A2; CT19; IL-13R; IL13BP"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1094
                     /gene="IL13RA2"
                     /gene_synonym="CD213A2; CT19; IL-13R; IL13BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1213
                     /gene="IL13RA2"
                     /gene_synonym="CD213A2; CT19; IL-13R; IL13BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1338
                     /gene="IL13RA2"
                     /gene_synonym="CD213A2; CT19; IL-13R; IL13BP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1315..1320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL13RA2"
                     /gene_synonym="CD213A2; CT19; IL-13R; IL13BP"
                     /note="hexamer: AATAAA"
     polyA_site      1338
                     /gene="IL13RA2"
                     /gene_synonym="CD213A2; CT19; IL-13R; IL13BP"
                     /note="major polyA site"
ORIGIN      
        1 cttccggatg aaggctattt gaagtcgcca taacctggtc agaagtgtgc ctgtcggcgg
       61 ggagagaggc aatatcaagg ttttaaatct cggagaaatg gctttcgttt gcttggctat
      121 cggatgctta tatacctttc tgataagcac aacatttggc tgtacttcat cttcagacac
      181 cgagataaaa gttaaccctc ctcaggattt tgagatagtg gatcccggat acttaggtta
      241 tctctatttg caatggcaac ccccactgtc tctggatcat tttaaggaat gcacagtgga
      301 atatgaacta aaataccgaa acattggtag tgaaacatgg aagaccatca ttactaagaa
      361 tctacattac aaagatgggt ttgatcttaa caagggcatt gaagcgaaga tacacacgct
      421 tttaccatgg caatgcacaa atggatcaga agttcaaagt tcctgggcag aaactactta
      481 ttggatatca ccacaaggaa ttccagaaac taaagttcag gatatggatt gcgtatatta
      541 caattggcaa tatttactct gttcttggaa acctggcata ggtgtacttc ttgataccaa
      601 ttacaacttg ttttactggt atgagggctt ggatcatgca ttacagtgtg ttgattacat
      661 caaggctgat ggacaaaata taggatgcag atttccctat ttggaggcat cagactataa
      721 agatttctat atttgtgtta atggatcatc agagaacaag cctatcagat ccagttattt
      781 cacttttcag cttcaaaata tagttaaacc tttgccgcca gtctatctta cttttactcg
      841 ggagagttca tgtgaaatta agctgaaatg gagcatacct ttgggaccta ttccagcaag
      901 gtgttttgat tatgaaattg agatcagaga agatgatact accttggtga ctgctacagt
      961 tgaaaatgaa acatacacct tgaaaacaac aaatgaaacc cgacaattat gctttgtagt
     1021 aagaagcaaa gtgaatattt attgctcaga tgacggaatt tggagtgagt ggagtgataa
     1081 acaatgctgg gaaggtgaag acctatcgaa gaaaactttg ctacgtttct ggctaccatt
     1141 tggtttcatc ttaatattag ttatatttgt aaccggtctg cttttgcgta agccaaacac
     1201 ctacccaaaa atgattccag aatttttctg tgatacatga agactttcca tatcaagaga
     1261 catggtattg actcaacagt ttccagtcat ggccaaatgt tcaatatgag tctcaataaa
     1321 ctgaattttt cttgcgaa
//
