LOCUS       NM_001560               3996 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens interleukin 13 receptor subunit alpha 1 (IL13RA1),
            mRNA.
ACCESSION   NM_001560
VERSION     NM_001560.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3996)
  AUTHORS   Zhang,Y., Lin,W., Yang,Y., Zhu,S., Chen,Y., Wang,H. and Teng,L.
  TITLE     MEF2D facilitates liver metastasis of gastric cancer cells through
            directly inducing H1X under IL-13 stimulation
  JOURNAL   Cancer Lett 591, 216878 (2024)
   PUBMED   38609001
  REMARK    GeneRIF: MEF2D facilitates liver metastasis of gastric cancer cells
            through directly inducing H1X under IL-13 stimulation.
REFERENCE   2  (bases 1 to 3996)
  AUTHORS   Shi,J., Shen,X., Kang,Q., Yang,X., Denzinger,M., Kornmann,M. and
            Traub,B.
  TITLE     Loss of Interleukin-13-Receptor-Alpha-1 Induces Apoptosis and
            Promotes EMT in Pancreatic Cancer
  JOURNAL   Int J Mol Sci 23 (7), 3659 (2022)
   PUBMED   35409019
  REMARK    GeneRIF: Loss of Interleukin-13-Receptor-Alpha-1 Induces Apoptosis
            and Promotes EMT in Pancreatic Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3996)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3996)
  AUTHORS   Hussein,M.S., El-Barbary,A.M., Nada,D.W., Gaber,R.A., Elkolaly,R.M.
            and Aboelhawa,M.A.
  TITLE     Identification of serum interleukin-13 and interleukin-13 receptor
            subunit expressions: Rheumatoid arthritis-associated interstitial
            lung disease
  JOURNAL   Int J Rheum Dis 24 (4), 591-598 (2021)
   PUBMED   33638296
  REMARK    GeneRIF: Identification of serum interleukin-13 and interleukin-13
            receptor subunit expressions: Rheumatoid arthritis-associated
            interstitial lung disease.
REFERENCE   5  (bases 1 to 3996)
  AUTHORS   Zhang,Y., Li,C., Zhang,M. and Li,Z.
  TITLE     IL-13 and IL-13Ralpha1 are overexpressed in extranodal natural
            killer/T cell lymphoma and mediate tumor cell proliferation
  JOURNAL   Biochem Biophys Res Commun 503 (4), 2715-2720 (2018)
   PUBMED   30107911
  REMARK    GeneRIF: IL-13 and IL-13Ralpha1 are overexpressed in extranodal
            natural killer/T cell lymphoma and mediate tumor cell
            proliferation.
REFERENCE   6  (bases 1 to 3996)
  AUTHORS   Orchansky,P.L., Kwan,R., Lee,F. and Schrader,J.W.
  TITLE     Characterization of the cytoplasmic domain of interleukin-13
            receptor-alpha
  JOURNAL   J Biol Chem 274 (30), 20818-20825 (1999)
   PUBMED   10409622
REFERENCE   7  (bases 1 to 3996)
  AUTHORS   Zhang,J.G., Hilton,D.J., Willson,T.A., McFarlane,C., Roberts,B.A.,
            Moritz,R.L., Simpson,R.J., Alexander,W.S., Metcalf,D. and
            Nicola,N.A.
  TITLE     Identification, purification, and characterization of a soluble
            interleukin (IL)-13-binding protein. Evidence that it is distinct
            from the cloned Il-13 receptor and Il-4 receptor alpha-chains
  JOURNAL   J Biol Chem 272 (14), 9474-9480 (1997)
   PUBMED   9083087
REFERENCE   8  (bases 1 to 3996)
  AUTHORS   Miloux,B., Laurent,P., Bonnin,O., Lupker,J., Caput,D., Vita,N. and
            Ferrara,P.
  TITLE     Cloning of the human IL-13R alpha1 chain and reconstitution with
            the IL4R alpha of a functional IL-4/IL-13 receptor complex
  JOURNAL   FEBS Lett 401 (2-3), 163-166 (1997)
   PUBMED   9013879
REFERENCE   9  (bases 1 to 3996)
  AUTHORS   Aman,M.J., Tayebi,N., Obiri,N.I., Puri,R.K., Modi,W.S. and
            Leonard,W.J.
  TITLE     cDNA cloning and characterization of the human interleukin 13
            receptor alpha chain
  JOURNAL   J Biol Chem 271 (46), 29265-29270 (1996)
   PUBMED   8910586
REFERENCE   10 (bases 1 to 3996)
  AUTHORS   Kornau,H.C., Schenker,L.T., Kennedy,M.B. and Seeburg,P.H.
  TITLE     Domain interaction between NMDA receptor subunits and the
            postsynaptic density protein PSD-95
  JOURNAL   Science 269 (5231), 1737-1740 (1995)
   PUBMED   7569905
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391280.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 26, 2018 this sequence version replaced NM_001560.2.
            
            Summary: The protein encoded by this gene is a subunit of the
            interleukin 13 receptor. This subunit forms a receptor complex with
            IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors.
            This subunit serves as a primary IL13-binding subunit of the IL13
            receptor, and may also be a component of IL4 receptors. This
            protein has been shown to bind tyrosine kinase TYK2, and thus may
            mediate the signaling processes that lead to the activation of
            JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y10659.1, Y09328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371666.8/ ENSP00000360730.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AL391280.15        82032-82152
            122-261             AL391280.15        95443-95582
            262-400             AL391280.15        101380-101518
            401-521             AL391280.15        104084-104204
            522-709             AL391280.15        112481-112668
            710-861             AL391280.15        115564-115715
            862-909             AL391280.15        120956-121003
            910-1042            AL391280.15        121270-121402
            1043-1139           AL391280.15        128305-128401
            1140-1224           AL391280.15        130853-130937
            1225-3996           AL391280.15        146188-148959
FEATURES             Location/Qualifiers
     source          1..3996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..3996
                     /gene="IL13RA1"
                     /gene_synonym="CD213A1; CT19; IL-13Ra; NR4"
                     /note="interleukin 13 receptor subunit alpha 1"
                     /db_xref="GeneID:3597"
                     /db_xref="HGNC:HGNC:5974"
                     /db_xref="MIM:300119"
     exon            1..121
                     /gene="IL13RA1"
                     /gene_synonym="CD213A1; CT19; IL-13Ra; NR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1317
                     /gene="IL13RA1"
                     /gene_synonym="CD213A1; CT19; IL-13Ra; NR4"
                     /note="IL13 receptor alpha-1 chain; CD213a1 antigen;
                     IL-13R subunit alpha-1; cancer/testis antigen 19; IL-13
                     receptor subunit alpha-1; interleukin 13 receptor, alpha
                     1"
                     /codon_start=1
                     /product="interleukin-13 receptor subunit alpha-1
                     precursor"
                     /protein_id="NP_001551.1"
                     /db_xref="CCDS:CCDS14573.1"
                     /db_xref="GeneID:3597"
                     /db_xref="HGNC:HGNC:5974"
                     /db_xref="MIM:300119"
                     /translation="MEWPARLCGLWALLLCAGGGGGGGGAAPTETQPPVTNLSVSVEN
                     LCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQC
                     STNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTL
                     YYWHRSLEKIHQCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFN
                     IVPLTSRVKPDPPHIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFY
                     VQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEM
                     SIGKKRNSTLYITMLLIVPVIVAGAIIVLLLYLKRLKIIIFPPIPDPGKIFKEMFGDQ
                     NDDTLHWKKYDIYEKQTKEETDSVVLIENLKKASQ"
     exon            122..261
                     /gene="IL13RA1"
                     /gene_synonym="CD213A1; CT19; IL-13Ra; NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            262..400
                     /gene="IL13RA1"
                     /gene_synonym="CD213A1; CT19; IL-13Ra; NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            401..521
                     /gene="IL13RA1"
                     /gene_synonym="CD213A1; CT19; IL-13Ra; NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            522..709
                     /gene="IL13RA1"
                     /gene_synonym="CD213A1; CT19; IL-13Ra; NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            710..861
                     /gene="IL13RA1"
                     /gene_synonym="CD213A1; CT19; IL-13Ra; NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            862..909
                     /gene="IL13RA1"
                     /gene_synonym="CD213A1; CT19; IL-13Ra; NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1042
                     /gene="IL13RA1"
                     /gene_synonym="CD213A1; CT19; IL-13Ra; NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1139
                     /gene="IL13RA1"
                     /gene_synonym="CD213A1; CT19; IL-13Ra; NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1224
                     /gene="IL13RA1"
                     /gene_synonym="CD213A1; CT19; IL-13Ra; NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..3996
                     /gene="IL13RA1"
                     /gene_synonym="CD213A1; CT19; IL-13Ra; NR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1804..1809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL13RA1"
                     /gene_synonym="CD213A1; CT19; IL-13Ra; NR4"
                     /note="hexamer: ATTAAA"
     polyA_site      1824
                     /gene="IL13RA1"
                     /gene_synonym="CD213A1; CT19; IL-13Ra; NR4"
     regulatory      3971..3976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL13RA1"
                     /gene_synonym="CD213A1; CT19; IL-13Ra; NR4"
                     /note="hexamer: AATAAA"
     polyA_site      3996
                     /gene="IL13RA1"
                     /gene_synonym="CD213A1; CT19; IL-13Ra; NR4"
                     /note="major polyA site"
ORIGIN      
        1 ccagcccggc cgggctccga ggcgagaggc tgcatggagt ggccggcgcg gctctgcggg
       61 ctgtgggcgc tgctgctctg cgccggcggc gggggcgggg gcgggggcgc cgcgcctacg
      121 gaaactcagc cacctgtgac aaatttgagt gtctctgttg aaaacctctg cacagtaata
      181 tggacatgga atccacccga gggagccagc tcaaattgta gtctatggta ttttagtcat
      241 tttggcgaca aacaagataa gaaaatagct ccggaaactc gtcgttcaat agaagtaccc
      301 ctgaatgaga ggatttgtct gcaagtgggg tcccagtgta gcaccaatga gagtgagaag
      361 cctagcattt tggttgaaaa atgcatctca cccccagaag gtgatcctga gtctgctgtg
      421 actgagcttc aatgcatttg gcacaacctg agctacatga agtgttcttg gctccctgga
      481 aggaatacca gtcccgacac taactatact ctctactatt ggcacagaag cctggaaaaa
      541 attcatcaat gtgaaaacat ctttagagaa ggccaatact ttggttgttc ctttgatctg
      601 accaaagtga aggattccag ttttgaacaa cacagtgtcc aaataatggt caaggataat
      661 gcaggaaaaa ttaaaccatc cttcaatata gtgcctttaa cttcccgtgt gaaacctgat
      721 cctccacata ttaaaaacct ctccttccac aatgatgacc tatatgtgca atgggagaat
      781 ccacagaatt ttattagcag atgcctattt tatgaagtag aagtcaataa cagccaaact
      841 gagacacata atgttttcta cgtccaagag gctaaatgtg agaatccaga atttgagaga
      901 aatgtggaga atacatcttg tttcatggtc cctggtgttc ttcctgatac tttgaacaca
      961 gtcagaataa gagtcaaaac aaataagtta tgctatgagg atgacaaact ctggagtaat
     1021 tggagccaag aaatgagtat aggtaagaag cgcaattcca cactctacat aaccatgtta
     1081 ctcattgttc cagtcatcgt cgcaggtgca atcatagtac tcctgcttta cctaaaaagg
     1141 ctcaagatta ttatattccc tccaattcct gatcctggca agatttttaa agaaatgttt
     1201 ggagaccaga atgatgatac tctgcactgg aagaagtacg acatctatga gaagcaaacc
     1261 aaggaggaaa ccgactctgt agtgctgata gaaaacctga agaaagcctc tcagtgatgg
     1321 agataattta tttttacctt cactgtgacc ttgagaagat tcttcccatt ctccatttgt
     1381 tatctgggaa cttattaaat ggaaactgaa actactgcac catttaaaaa caggcagctc
     1441 ataagagcca caggtcttta tgttgagtcg cgcaccgaaa aactaaaaat aatgggcgct
     1501 ttggagaaga gtgtggagtc attctcattg aattataaaa gccagcaggc ttcaaactag
     1561 gggacaaagc aaaaagtgat gatagtggtg gagttaatct tatcaagagt tgtgacaact
     1621 tcctgaggga tctatacttg ctttgtgttc tttgtgtcaa catgaacaaa ttttatttgt
     1681 aggggaactc atttggggtg caaatgctaa tgtcaaactt gagtcacaaa gaacatgtag
     1741 aaaacaaaat ggataaaatc tgatatgtat tgtttgggat cctattgaac catgtttgtg
     1801 gctattaaaa ctcttttaac agtctgggct gggtccggtg gctcacgcct gtaatcccag
     1861 caatttggga gtccgaggcg ggcggatcac tcgaggtcag gagttccaga ccagcctgac
     1921 caaaatggtg aaacctcctc tctactaaaa ctacaaaaat taactgggtg tggtggcgcg
     1981 tgcctgtaat cccagctact cgggaagctg aggcaggtga attgtttgaa cctgggaggt
     2041 ggaggttgca gtgagcagag atcacaccac tgcactctag cctgggtgac agagcaagac
     2101 tctgtctaaa aaacaaaaca aaacaaaaca aaacaaaaaa acctcttaat attctggagt
     2161 catcattccc ttcgacagca ttttcctctg ctttgaaagc cccagaaatc agtgttggcc
     2221 atgatgacaa ctacagaaaa accagaggca gcttctttgc caagaccttt caaagccatt
     2281 ttaggctgtt aggggcagtg gaggtagaat gactccttgg gtattagagt ttcaaccatg
     2341 aagtctctaa caatgtattt tcttcacctc tgctactcaa gtagcattta ctgtgtcttt
     2401 ggtttgtgct aggcccccgg gtgtgaagca cagacccctt ccaggggttt acagtctatt
     2461 tgagactcct cagttcttgc cacttttttt tttaatctcc accagtcatt tttcagacct
     2521 tttaactcct caattccaac actgatttcc ccttttgcat tctccctcct tcccttcctt
     2581 gtagcctttt gactttcatt ggaaattagg atgtaaatct gctcaggaga cctggaggag
     2641 cagaggataa ttagcatctc aggttaagtg tgagtaatct gagaaacaat gactaattct
     2701 tgcatatttt gtaacttcca tgtgagggtt ttcagcattg atatttgtgc attttctaaa
     2761 cagagatgag gtggtatctt cacgtagaac attggtattc gcttgagaaa aaaagaatag
     2821 ttgaacctat ttctctttct ttacaagatg ggtccaggat tcctcttttc tctgccataa
     2881 atgattaatt aaatagcttt tgtgtcttac attggtagcc agccagccaa ggctctgttt
     2941 atgcttttgg ggggcatata ttgggttcca ttctcaccta tccacacaac atatccgtat
     3001 atatcccctc tactcttact tcccccaaat ttaaagaagt atgggaaatg agaggcattt
     3061 cccccacccc atttctctcc tcacacacag actcatatta ctggtaggaa cttgagaact
     3121 ttatttccaa gttgttcaaa catttaccaa tcatattaat acaatgatgc tatttgcaat
     3181 tcctgctcct aggggagggg agataagaaa ccctcactct ctacaggttt gggtacaagt
     3241 ggcaacctgc ttccatggcc gtgtagaagc atggtgccct ggcttctctg aggaagctgg
     3301 ggttcatgac aatggcagat gtaaagttat tcttgaagtc agattgaggc tgggagacag
     3361 ccgtagtaga tgttctactt tgttctgctg ttctctagaa agaatatttg gttttcctgt
     3421 ataggaatga gattaattcc tttccaggta ttttataatt ctgggaagca aaacccatgc
     3481 ctccccctag ccatttttac tgttatccta tttagatggc catgaagagg atgctgtgaa
     3541 attcccaaca aacattgatg ctgacagtca tgcagtctgg gagtggggaa gtgatctttt
     3601 gttcccatcc tcttctttta gcagtaaaat agctgaggga aaagggaggg aaaaggaagt
     3661 tatgggaata cctgtggtgg ttgtgatccc taggtcttgg gagctcttgg aggtgtctgt
     3721 atcagtggat ttcccatccc ctgtgggaaa ttagtaggct catttactgt tttaggtcta
     3781 gcctatgtgg attttttcct aacataccta agcaaaccca gtgtcaggat ggtaattctt
     3841 attctttcgt tcagttaagt ttttcccttc atctgggcac tgaagggata tgtgaaacaa
     3901 tgttaacatt tttggtagtc ttcaaccagg gattgtttct gtttaacttc ttataggaaa
     3961 gcttgagtaa aataaatatt gtctttttgt atgtca
//
