LOCUS       NM_002188               1283 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens interleukin 13 (IL13), transcript variant 1, mRNA.
ACCESSION   NM_002188
VERSION     NM_002188.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1283)
  AUTHORS   Farhad Bilal,E., Jawdah Bilal,S. and Hasan Azeez,S.
  TITLE     Seasonal distribution and correlation between IL-10 and IL-13 gene
            polymorphism and their expression in scabies-infected patients
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (9), 59-67 (2024)
   PUBMED   39380276
  REMARK    GeneRIF: Seasonal distribution and correlation between IL-10 and
            IL-13 gene polymorphism and their expression in scabies-infected
            patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1283)
  AUTHORS   Aydin,S., Darko,K., Detchou,D. and Barrie,U.
  TITLE     A call for clinical trials in glioblastoma multiforme for
            interleukin 4, interleukin 6, interleukin 13 and CD40
  JOURNAL   Neurosurg Rev 47 (1), 571 (2024)
   PUBMED   39242402
  REMARK    GeneRIF: A call for clinical trials in glioblastoma multiforme for
            interleukin 4, interleukin 6, interleukin 13 and CD40.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1283)
  AUTHORS   Liu,Z., Zheng,Y., Yuan,M., Zhang,G. and Yang,G.
  TITLE     Association of CTACK, IL-2, and IL-13 with increased risk of lung
            cancer: A Mendelian randomization study
  JOURNAL   Cytokine 181, 156680 (2024)
   PUBMED   38885591
  REMARK    GeneRIF: Association of CTACK, IL-2, and IL-13 with increased risk
            of lung cancer: A Mendelian randomization study.
REFERENCE   4  (bases 1 to 1283)
  AUTHORS   Chen,R., Bao,Q. and Ma,X.
  TITLE     Association of IL13 polymorphisms with susceptibility to myocardial
            infarction: A case-control study in Chinese population
  JOURNAL   PLoS One 19 (8), e0308081 (2024)
   PUBMED   39088580
  REMARK    GeneRIF: Association of IL13 polymorphisms with susceptibility to
            myocardial infarction: A case-control study in Chinese population.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1283)
  AUTHORS   Hassan,A.R.M., Abdallah,A.G.M., Ismail,N.A. and Fahmy,Y.A.
  TITLE     Association of IL-13 rs20541, FOXP3 rs3761548 genes polymorphisms
            and serum level of IL-13 with allergic asthma in Egyptian patients
  JOURNAL   Egypt J Immunol 31 (3), 15-27 (2024)
   PUBMED   38985531
  REMARK    GeneRIF: Association of IL-13 rs20541, FOXP3 rs3761548 genes
            polymorphisms and serum level of IL-13 with allergic asthma in
            Egyptian patients.
REFERENCE   6  (bases 1 to 1283)
  AUTHORS   Smirnov,D.V., Smirnova,M.G., Korobko,V.G. and Frolova,E.I.
  TITLE     Tandem arrangement of human genes for interleukin-4 and
            interleukin-13: resemblance in their organization
  JOURNAL   Gene 155 (2), 277-281 (1995)
   PUBMED   7721105
REFERENCE   7  (bases 1 to 1283)
  AUTHORS   Sironi,M., Sciacca,F.L., Matteucci,C., Conni,M., Vecchi,A.,
            Bernasconi,S., Minty,A., Caput,D., Ferrara,P., Colotta,F. et al.
  TITLE     Regulation of endothelial and mesothelial cell function by
            interleukin-13: selective induction of vascular cell adhesion
            molecule-1 and amplification of interleukin-6 production
  JOURNAL   Blood 84 (6), 1913-1921 (1994)
   PUBMED   7521694
REFERENCE   8  (bases 1 to 1283)
  AUTHORS   Bamborough,P., Duncan,D. and Richards,W.G.
  TITLE     Predictive modelling of the 3-D structure of interleukin-13
  JOURNAL   Protein Eng 7 (9), 1077-1082 (1994)
   PUBMED   7530359
REFERENCE   9  (bases 1 to 1283)
  AUTHORS   Minty,A., Chalon,P., Derocq,J.M., Dumont,X., Guillemot,J.C.,
            Kaghad,M., Labit,C., Leplatois,P., Liauzun,P., Miloux,B. et al.
  TITLE     Interleukin-13 is a new human lymphokine regulating inflammatory
            and immune responses
  JOURNAL   Nature 362 (6417), 248-250 (1993)
   PUBMED   8096327
REFERENCE   10 (bases 1 to 1283)
  AUTHORS   Morgan,J.G., Dolganov,G.M., Robbins,S.E., Hinton,L.M. and Lovett,M.
  TITLE     The selective isolation of novel cDNAs encoded by the regions
            surrounding the human interleukin 4 and 5 genes
  JOURNAL   Nucleic Acids Res 20 (19), 5173-5179 (1992)
   PUBMED   1408833
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004039.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 25, 2018 this sequence version replaced NM_002188.2.
            
            Summary: This gene encodes an immunoregulatory cytokine produced
            primarily by activated Th2 cells. This cytokine is involved in
            several stages of B-cell maturation and differentiation. It
            up-regulates CD23 and MHC class II expression, and promotes IgE
            isotype switching of B cells. This cytokine down-regulates
            macrophage activity, thereby inhibits the production of
            pro-inflammatory cytokines and chemokines. This cytokine is found
            to be critical to the pathogenesis of allergen-induced asthma but
            operates through mechanisms independent of IgE and eosinophils.
            This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on
            chromosome 5q, with this gene particularly close to IL4. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X69079.1, L06801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304506.7/ ENSP00000304915.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AC004039.1         48369-48556         c
            189-242             AC004039.1         47258-47311         c
            243-347             AC004039.1         46901-47005         c
            348-1283            AC004039.1         45619-46554         c
FEATURES             Location/Qualifiers
     source          1..1283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..1283
                     /gene="IL13"
                     /gene_synonym="IL-13; P600"
                     /note="interleukin 13"
                     /db_xref="GeneID:3596"
                     /db_xref="HGNC:HGNC:5973"
                     /db_xref="MIM:147683"
     exon            1..188
                     /gene="IL13"
                     /gene_synonym="IL-13; P600"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..455
                     /gene="IL13"
                     /gene_synonym="IL-13; P600"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="interleukin-13 isoform 1 precursor"
                     /protein_id="NP_002179.2"
                     /db_xref="CCDS:CCDS4157.1"
                     /db_xref="GeneID:3596"
                     /db_xref="HGNC:HGNC:5973"
                     /db_xref="MIM:147683"
                     /translation="MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALR
                     ELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSG
                     FCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGQFN"
     exon            189..242
                     /gene="IL13"
                     /gene_synonym="IL-13; P600"
                     /inference="alignment:Splign:2.1.0"
     exon            243..347
                     /gene="IL13"
                     /gene_synonym="IL-13; P600"
                     /inference="alignment:Splign:2.1.0"
     exon            348..1283
                     /gene="IL13"
                     /gene_synonym="IL-13; P600"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1264..1269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL13"
                     /gene_synonym="IL-13; P600"
                     /note="hexamer: AATAAA"
     polyA_site      1283
                     /gene="IL13"
                     /gene_synonym="IL-13; P600"
                     /note="major polyA site"
ORIGIN      
        1 aagccaccca gcctatgcat ccgctcctca atcctctcct gttggcactg ggcctcatgg
       61 cgcttttgtt gaccacggtc attgctctca cttgccttgg cggctttgcc tccccaggcc
      121 ctgtgcctcc ctctacagcc ctcagggagc tcattgagga gctggtcaac atcacccaga
      181 accagaaggc tccgctctgc aatggcagca tggtatggag catcaacctg acagctggca
      241 tgtactgtgc agccctggaa tccctgatca acgtgtcagg ctgcagtgcc atcgagaaga
      301 cccagaggat gctgagcgga ttctgcccgc acaaggtctc agctgggcag ttttccagct
      361 tgcatgtccg agacaccaaa atcgaggtgg cccagtttgt aaaggacctg ctcttacatt
      421 taaagaaact ttttcgcgag ggacagttca actgaaactt cgaaagcatc attatttgca
      481 gagacaggac ctgactattg aagttgcaga ttcatttttc tttctgatgt caaaaatgtc
      541 ttgggtaggc gggaaggagg gttagggagg ggtaaaattc cttagcttag acctcagcct
      601 gtgctgcccg tcttcagcct agccgacctc agccttcccc ttgcccaggg ctcagcctgg
      661 tgggcctcct ctgtccaggg ccctgagctc ggtggaccca gggatgacat gtccctacac
      721 ccctcccctg ccctagagca cactgtagca ttacagtggg tgcccccctt gccagacatg
      781 tggtgggaca gggacccact tcacacacag gcaactgagg cagacagcag ctcaggcaca
      841 cttcttcttg gtcttattta ttattgtgtg ttatttaaat gagtgtgttt gtcaccgttg
      901 gggattgggg aagactgtgg ctgctagcac ttggagccaa gggttcagag actcagggcc
      961 ccagcactaa agcagtggac accaggagtc cctggtaata agtactgtgt acagaattct
     1021 gctacctcac tggggtcctg gggcctcgga gcctcatccg aggcagggtc aggagagggg
     1081 cagaacagcc gctcctgtct gccagccagc agccagctct cagccaacga gtaatttatt
     1141 gtttttcctt gtatttaaat attaaatatg ttagcaaaga gttaatatat agaagggtac
     1201 cttgaacact gggggagggg acattgaaca agttgtttca ttgactatca aactgaagcc
     1261 agaaataaag ttggtgacag ata
//
