LOCUS       NM_001374259            5443 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens interleukin 12 receptor subunit beta 2 (IL12RB2),
            transcript variant 8, mRNA.
ACCESSION   NM_001374259 XM_005270825
VERSION     NM_001374259.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5443)
  AUTHORS   Zare,M., Hesampour,F., Poordast,T., Valibeigi,M., Enayatmehri,M.,
            Ahmadi,S., Nasri,F. and Gharesi-Fard,B.
  TITLE     Association between gene polymorphisms of IL-12, IL-12 receptor and
            IL-27 and organ involvement in Iranian endometriosis patients
  JOURNAL   Int J Immunogenet 50 (1), 24-33 (2023)
   PUBMED   36328955
  REMARK    GeneRIF: Association between gene polymorphisms of IL-12, IL-12
            receptor and IL-27 and organ involvement in Iranian endometriosis
            patients.
REFERENCE   2  (bases 1 to 5443)
  AUTHORS   Fu,Y., Liu,L. and Wu,H.
  TITLE     Role of Genetic Polymorphisms in IL12Rbeta2 in Chronic Obstructive
            Pulmonary Disease
  JOURNAL   Int J Chron Obstruct Pulmon Dis 17, 1671-1683 (2022)
   PUBMED   35923356
  REMARK    GeneRIF: Role of Genetic Polymorphisms in IL12Rbeta2 in Chronic
            Obstructive Pulmonary Disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5443)
  AUTHORS   Wang,X., Zhou,S., Fan,M., Wang,P., Fang,H., Bian,F., Huang,T. and
            Du,X.
  TITLE     Expressions of IL-12 and its receptors in patients with lumbar disc
            herniation and their relationship with clinical efficacy
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 66 (7), 5-11 (2020)
   PUBMED   33287915
  REMARK    GeneRIF: Expressions of IL-12 and its receptors in patients with
            lumbar disc herniation and their relationship with clinical
            efficacy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5443)
  AUTHORS   Fayez,E.A., Koohini,Z., Koohini,Z., Zamanzadeh,H., de Boer,M.,
            Roos,D. and Teimourian,S.
  TITLE     Characterization of two novel mutations in IL-12R signaling in MSMD
            patients
  JOURNAL   Pathog Dis 77 (3) (2019)
   PUBMED   31158284
  REMARK    GeneRIF: Mutation analysis showed three previously reported
            mutations, two novel mutations in IL-12 R (beta1/beta2), and one
            previously reported mutation in IL-12 Mendelian Susceptibility to
            Mycobacterial Disease patients.
REFERENCE   5  (bases 1 to 5443)
  AUTHORS   Liu,Z., Yang,W., Yang,S. and Cai,K.
  TITLE     The close association between IL-12Rbeta2 and p38MAPK, and higher
            expression in the early stages of NSCLC, indicates a good prognosis
            for survival
  JOURNAL   Mol Med Rep 18 (2), 2307-2313 (2018)
   PUBMED   29956791
  REMARK    GeneRIF: The Cox proportional hazard models revealed that IL12Rb2
            and p38MAPK predicted a long OS. To the best of our knowledge, the
            present study is the first to reveal a close association between
            IL12Rb2 and p38MAPK, and their possible function in nonsmall cell
            lung cancer progression
REFERENCE   6  (bases 1 to 5443)
  AUTHORS   Presky,D.H., Minetti,L.J., Gillessen,S., Wilkinson,V.L., Wu,C.Y.,
            Gubler,U., Chizzonite,R. and Gately,M.K.
  TITLE     Analysis of the multiple interactions between IL-12 and the high
            affinity IL-12 receptor complex
  JOURNAL   J Immunol 160 (5), 2174-2179 (1998)
   PUBMED   9498755
REFERENCE   7  (bases 1 to 5443)
  AUTHORS   Rogge,L., Barberis-Maino,L., Biffi,M., Passini,N., Presky,D.H.,
            Gubler,U. and Sinigaglia,F.
  TITLE     Selective expression of an interleukin-12 receptor component by
            human T helper 1 cells
  JOURNAL   J Exp Med 185 (5), 825-831 (1997)
   PUBMED   9120388
REFERENCE   8  (bases 1 to 5443)
  AUTHORS   Yamamoto,K., Kobayashi,H., Miura,O., Hirosawa,S. and Miyasaka,N.
  TITLE     Assignment of IL12RB1 and IL12RB2, interleukin-12 receptor beta 1
            and beta 2 chains, to human chromosome 19 band p13.1 and chromosome
            1 band p31.2, respectively, by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 77 (3-4), 257-258 (1997)
   PUBMED   9284929
REFERENCE   9  (bases 1 to 5443)
  AUTHORS   Presky,D.H., Yang,H., Minetti,L.J., Chua,A.O., Nabavi,N., Wu,C.Y.,
            Gately,M.K. and Gubler,U.
  TITLE     A functional interleukin 12 receptor complex is composed of two
            beta-type cytokine receptor subunits
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 14002-14007 (1996)
   PUBMED   8943050
REFERENCE   10 (bases 1 to 5443)
  AUTHORS   Chua,A.O., Chizzonite,R., Desai,B.B., Truitt,T.P., Nunes,P.,
            Minetti,L.J., Warrier,R.R., Presky,D.H., Levine,J.F., Gately,M.K.
            et al.
  TITLE     Expression cloning of a human IL-12 receptor component. A new
            member of the cytokine receptor superfamily with strong homology to
            gp130
  JOURNAL   J Immunol 153 (1), 128-136 (1994)
   PUBMED   7911493
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL389925.10 and AL358512.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 3, 2019 this sequence version replaced NM_001374259.1.
            
            Summary: The protein encoded by this gene is a type I transmembrane
            protein identified as a subunit of the interleukin 12 receptor
            complex. The coexpression of this and IL12RB1 proteins was shown to
            lead to the formation of high-affinity IL12 binding sites and
            reconstitution of IL12 dependent signaling. The expression of this
            gene is up-regulated by interferon gamma in Th1 cells, and plays a
            role in Th1 cell differentiation. The up-regulation of this gene is
            found to be associated with a number of infectious diseases, such
            as Crohn's disease and leprosy, which is thought to contribute to
            the inflammatory response and host defense. Several transcript
            variants encoding different isoforms and non-protein coding
            transcripts have been found for this gene. [provided by RefSeq, Apr
            2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3202244.1,
                                           SRR18074967.1832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000674203.2/ ENSP00000501329.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AL389925.10        60883-60977
            96-183              AL389925.10        66923-67010
            184-295             AL389925.10        73343-73454
            296-583             AL389925.10        74612-74899
            584-698             AL389925.10        79745-79859
            699-883             AL389925.10        81210-81394
            884-1026            AL389925.10        82597-82739
            1027-1177           AL389925.10        83670-83820
            1178-1257           AL389925.10        91634-91713
            1258-1477           AL389925.10        103880-104099
            1478-1678           AL389925.10        120835-121035
            1679-1777           AL358512.9         5157-5255
            1778-1936           AL358512.9         5346-5504
            1937-2074           AL358512.9         12707-12844
            2075-2165           AL358512.9         19300-19390
            2166-2265           AL358512.9         22750-22849
            2266-5443           AL358512.9         28268-31445
FEATURES             Location/Qualifiers
     source          1..5443
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..5443
                     /gene="IL12RB2"
                     /note="interleukin 12 receptor subunit beta 2"
                     /db_xref="GeneID:3595"
                     /db_xref="HGNC:HGNC:5972"
                     /db_xref="MIM:601642"
     exon            1..95
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            96..183
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            184..295
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..2808
                     /gene="IL12RB2"
                     /note="isoform a precursor is encoded by transcript
                     variant 8; interleukin-12 receptor beta-2 chain; IL-12R
                     subunit beta-2; IL-12 receptor subunit beta-2; interleukin
                     12 receptor, beta 2"
                     /codon_start=1
                     /product="interleukin-12 receptor subunit beta-2 isoform a
                     precursor"
                     /protein_id="NP_001361188.1"
                     /db_xref="CCDS:CCDS638.1"
                     /db_xref="GeneID:3595"
                     /db_xref="HGNC:HGNC:5972"
                     /db_xref="MIM:601642"
                     /translation="MAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLG
                     STVNITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCK
                     LACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQ
                     LSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTF
                     LDIVRPLPPWDIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAK
                     GRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHI
                     DYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGN
                     WAVAVSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSA
                     VQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIRVYALSGDQGG
                     CSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSN
                     SQPQLCEIPYRVSQNSHPINSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWM
                     AFVAPSICIAIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTCAKKYPIAE
                     EKTQLPLDRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASE
                     KDMMHSASSPPPPRALQAESRQLVDLYKVLESRGSDPKPENPACPWTVLPAGDLPTHD
                     GYLPSNIDDLPSHEAPLADSLEELEPQHISLSVFPSSSLHPLTFSCGDKLTLDQLKMR
                     CDSLML"
     exon            296..583
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..698
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            699..883
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1026
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1177
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1257
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1477
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1678
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1777
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1936
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2074
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2165
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2265
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..5443
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5414..5419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL12RB2"
                     /note="hexamer: AATAAA"
     polyA_site      5443
                     /gene="IL12RB2"
                     /note="major polyA site"
ORIGIN      
        1 agagagcgcg gagagcgcga cacgtgcggc ccagagcacc ggggccaccc ggtccccgca
       61 ggcccgggac cgcgcccgct ggcaggcgac acgtggtcac ggtgatccat ttgtaaagtc
      121 gggaataaat gacctctgaa gtgttgtctg tatattgatc tgctaccagt aaaacatatc
      181 tctgaagaat acggagttct ataccagagt tgattgttga tggcacatac ttttagagga
      241 tgctcattgg catttatgtt tataatcacg tggctgttga ttaaagcaaa aatagatgcg
      301 tgcaagagag gcgatgtgac tgtgaagcct tcccatgtaa ttttacttgg atccactgtc
      361 aatattacat gctctttgaa gcccagacaa ggctgctttc actattccag acgtaacaag
      421 ttaatcctgt acaagtttga cagaagaatc aattttcacc atggccactc cctcaattct
      481 caagtcacag gtcttcccct tggtacaacc ttgtttgtct gcaaactggc ctgtatcaat
      541 agtgatgaaa ttcaaatatg tggagcagag atcttcgttg gtgttgctcc agaacagcct
      601 caaaatttat cctgcataca gaagggagaa caggggactg tggcctgcac ctgggaaaga
      661 ggacgagaca cccacttata cactgagtat actctacagc taagtggacc aaaaaattta
      721 acctggcaga agcaatgtaa agacatttat tgtgactatt tggactttgg aatcaacctc
      781 acccctgaat cacctgaatc caatttcaca gccaaggtta ctgctgtcaa tagtcttgga
      841 agctcctctt cacttccatc cacattcaca ttcttggaca tagtgaggcc tcttcctccg
      901 tgggacatta gaatcaaatt tcaaaaggct tctgtgagca gatgtaccct ttattggaga
      961 gatgagggac tggtactgct taatcgactc agatatcggc ccagtaacag caggctctgg
     1021 aatatggtta atgttacaaa ggccaaagga agacatgatt tgctggatct gaaaccattt
     1081 acagaatatg aatttcagat ttcctctaag ctacatcttt ataagggaag ttggagtgat
     1141 tggagtgaat cattgagagc acaaacacca gaagaagagc ctactgggat gttagatgtc
     1201 tggtacatga aacggcacat tgactacagt agacaacaga tttctctttt ctggaagaat
     1261 ctgagtgtct cagaggcaag aggaaaaatt ctccactatc aggtgacctt gcaggagctg
     1321 acaggaggga aagccatgac acagaacatc acaggacaca cctcctggac cacagtcatt
     1381 cctagaaccg gaaattgggc tgtggctgtg tctgcagcaa attcaaaagg cagttctctg
     1441 cccactcgta ttaacataat gaacctgtgt gaggcagggt tgctggctcc tcgccaggtc
     1501 tctgcaaact cagagggcat ggacaacatt ctggtgactt ggcagcctcc caggaaagat
     1561 ccctctgctg ttcaggagta cgtggtggaa tggagagagc tccatccagg gggtgacaca
     1621 caggtccctc taaactggct acggagtcga ccctacaatg tgtctgctct gatttcagag
     1681 aacataaaat cctacatctg ttatgaaatc cgtgtgtatg cactctcagg ggatcaagga
     1741 ggatgcagct ccatcctggg taactctaag cacaaagcac cactgagtgg cccccacatt
     1801 aatgccatca cagaggaaaa ggggagcatt ttaatttcat ggaacagcat tccagtccag
     1861 gagcaaatgg gctgcctcct ccattatagg atatactgga aggaacggga ctccaactcc
     1921 cagcctcagc tctgtgaaat tccctacaga gtctcccaaa attcacatcc aataaacagc
     1981 ctgcagcccc gagtgacata tgtcctgtgg atgacagctc tgacagctgc tggtgaaagt
     2041 tcccacggaa atgagaggga attttgtctg caaggtaaag ccaattggat ggcgtttgtg
     2101 gcaccaagca tttgcattgc tatcatcatg gtgggcattt tctcaacgca ttacttccag
     2161 caaaaggtgt ttgttctcct agcagccctc agacctcagt ggtgtagcag agaaattcca
     2221 gatccagcaa atagcacttg cgctaagaaa tatcccattg cagaggagaa gacacagctg
     2281 cccttggaca ggctcctgat agactggccc acgcctgaag atcctgaacc gctggtcatc
     2341 agtgaagtcc ttcatcaagt gaccccagtt ttcagacatc ccccctgctc caactggcca
     2401 caaagggaaa aaggaatcca aggtcatcag gcctctgaga aagacatgat gcacagtgcc
     2461 tcaagcccac cacctccaag agctctccaa gctgagagca gacaactggt ggatctgtac
     2521 aaggtgctgg agagcagggg ctccgaccca aagcccgaaa acccagcctg tccctggacg
     2581 gtgctcccag caggtgacct tcccacccat gatggctact taccctccaa catagatgac
     2641 ctcccctcac atgaggcacc tctcgctgac tctctggaag aactggagcc tcagcacatc
     2701 tccctttctg ttttcccctc aagttctctt cacccactca ccttctcctg tggtgataag
     2761 ctgactctgg atcagttaaa gatgaggtgt gactccctca tgctctgagt ggtgaggctt
     2821 caagccttaa agtcagtgtg ccctcaacca gcacagcctg ccccaattcc cccagcccct
     2881 gctccagcag ctgtcatctc tgggtgccac catcggtctg gctgcagcta gaggacaggc
     2941 aagccagctc tgggggagtc ttaggaactg ggagttggtc ttcactcaga tgcctcatct
     3001 tgcctttccc agggccttaa aattacatcc ttcactgtgt ggacctagag actccaactt
     3061 gaattcctag taactttctt ggtatgctgg ccagaaaggg aaatgaggag gagagtagaa
     3121 accacagctc ttagtagtaa tggcatacag tctagaggac cattcatgca atgactattt
     3181 ctaaagcacc tgctacacag caggctgtac acagcagatc agtactgttc aacagaactt
     3241 cctgagatga tggaaatgtt ctacctctgc actcactgtc cagtacatta gacactaggc
     3301 acattggctg ttaatcactt ggaatgtgtt tagcttgact gaggaattaa attttgattg
     3361 taaatttaaa tcgccacaca tggctagtgg ctactgtatt ggagtgcaca gctctagatg
     3421 gctcctagat tattgagagc cttcaaaaca aatcaaccta gttctataga tgaagacata
     3481 aaagacactg gtaaacacca aggtaaaagg gcccccaagg tggtcatgac tggtctcatt
     3541 tgcagaagtc taagaatgta cctttttctg gccgggcgtg gtagctcatg cctgtaatcc
     3601 cagcactttg ggaggctgag gcaggcggat catgaggtca ggagatcgag accattctgg
     3661 ctaacatggt gaaaccccat ctctactaaa aatattttta aaaaaaatta actgggcgtg
     3721 atggcgggcg cctgtagtcc cagctactcg ggaggctgag ggaggagaat gacatgaacc
     3781 tgggaggtgg ggcttgcagt gagccactgc actccagcct gggcaacaga gcaagactct
     3841 gtctcaaaaa agaaaaaaaa aaaaaagaat gtaccttttt cctagatttg ctggtttatt
     3901 gttttatttt ggcttcatcc tctttcagca aatcaagggc agctggatgg tgaagaccta
     3961 tattgtaaac tcaccatagt accatagtac cttgggcaac ccagcctccc actctgaatc
     4021 tcgggtgtct tgtaaagggc tggaccaaag gctccctgac cccttgtttc ctctcctttt
     4081 tgctgcagca ggccctgcct tcaggaccag ggctgtctca gggtctaaga ccccaacctc
     4141 tgaggttgtc ctcagaagtg gtctgtcccc tgttcccaaa ggcacagctt tcattcccgg
     4201 agaagatatt gagctggtcc tctgccagct caagttgagc ctggaagata actctctttt
     4261 ccacaacatg gacttggaac atgatccatg ttttgctctt taaagctgtg gcccctggct
     4321 tgccaccctc cctagcccat tgctgcctct gtctcttcac cataggcact tctgccaaac
     4381 tagtggagaa gtcttggtct aaactgctaa taatgctctt ccctaaagaa caggataaaa
     4441 gatccaaaat actttttctt aaattcctgt caagcctggg gtccaccccg taccccttcc
     4501 cacatgaacg ctggaactga gatggcttcc ccatcatcgt ctggattttc atttaacaaa
     4561 gtacttgttg taaatgtgta cttcttgcct aacgtgagga actaaaaact tgtccatgca
     4621 taccccagtc ctgtagaaat aactgttctc gggctttagg ttttccagat ttccctcaga
     4681 gctctagaaa ctgagcgatg gacagttgct ctgcttcttc aggttggaac tcttgataca
     4741 tccttgtttc ctgaaattcc aaacttaaca cctatagttc tctcaggctt tttttgaaaa
     4801 gttccttcgt ttctatttct attccactct atttagctat tattgtgcgg cacccccaat
     4861 ggttcctttc ctctcagcat cgctgtagct tgcctgtacc caggacatgc ccttgactgg
     4921 cacaaaccgt gacagacatg cccttgactg gcacaaacca tgacagacaa ggccacctcc
     4981 tcagaagcgg aacaacctat tatcttttgg caatgggagc taacttcact gttttcttac
     5041 aatacctggt ttttcctatc tttggtttcc ttttgattat ctctcatcca tctcagccac
     5101 tattctcctc ccctcccttg tgtctacaac accccatttt accaagtctc ccatttaacc
     5161 tccccatcct tttctttccc ttaaagtctc atatgatact gcagtcctca tttgtcttcc
     5221 caaaaaaaaa aaagaatttt ttttttttta aggaatcctt ccttgactcc taaagactcc
     5281 taaggatgct gaggcctcct cagcatgatt tccatatact tactttctct gttggactgc
     5341 agacaacttg aaagcaggaa ctttggcagt gtttccccag caccagcatc atgcctggtc
     5401 catagtagct accaataaaa aagtaagcat catgaaccca aaa
//
