LOCUS       NM_001258215            3782 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens interleukin 12 receptor subunit beta 2 (IL12RB2),
            transcript variant 3, mRNA.
ACCESSION   NM_001258215
VERSION     NM_001258215.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3782)
  AUTHORS   Zare,M., Hesampour,F., Poordast,T., Valibeigi,M., Enayatmehri,M.,
            Ahmadi,S., Nasri,F. and Gharesi-Fard,B.
  TITLE     Association between gene polymorphisms of IL-12, IL-12 receptor and
            IL-27 and organ involvement in Iranian endometriosis patients
  JOURNAL   Int J Immunogenet 50 (1), 24-33 (2023)
   PUBMED   36328955
  REMARK    GeneRIF: Association between gene polymorphisms of IL-12, IL-12
            receptor and IL-27 and organ involvement in Iranian endometriosis
            patients.
REFERENCE   2  (bases 1 to 3782)
  AUTHORS   Fu,Y., Liu,L. and Wu,H.
  TITLE     Role of Genetic Polymorphisms in IL12Rbeta2 in Chronic Obstructive
            Pulmonary Disease
  JOURNAL   Int J Chron Obstruct Pulmon Dis 17, 1671-1683 (2022)
   PUBMED   35923356
  REMARK    GeneRIF: Role of Genetic Polymorphisms in IL12Rbeta2 in Chronic
            Obstructive Pulmonary Disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3782)
  AUTHORS   Wang,X., Zhou,S., Fan,M., Wang,P., Fang,H., Bian,F., Huang,T. and
            Du,X.
  TITLE     Expressions of IL-12 and its receptors in patients with lumbar disc
            herniation and their relationship with clinical efficacy
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 66 (7), 5-11 (2020)
   PUBMED   33287915
  REMARK    GeneRIF: Expressions of IL-12 and its receptors in patients with
            lumbar disc herniation and their relationship with clinical
            efficacy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3782)
  AUTHORS   Fayez,E.A., Koohini,Z., Koohini,Z., Zamanzadeh,H., de Boer,M.,
            Roos,D. and Teimourian,S.
  TITLE     Characterization of two novel mutations in IL-12R signaling in MSMD
            patients
  JOURNAL   Pathog Dis 77 (3) (2019)
   PUBMED   31158284
  REMARK    GeneRIF: Mutation analysis showed three previously reported
            mutations, two novel mutations in IL-12 R (beta1/beta2), and one
            previously reported mutation in IL-12 Mendelian Susceptibility to
            Mycobacterial Disease patients.
REFERENCE   5  (bases 1 to 3782)
  AUTHORS   Liu,Z., Yang,W., Yang,S. and Cai,K.
  TITLE     The close association between IL-12Rbeta2 and p38MAPK, and higher
            expression in the early stages of NSCLC, indicates a good prognosis
            for survival
  JOURNAL   Mol Med Rep 18 (2), 2307-2313 (2018)
   PUBMED   29956791
  REMARK    GeneRIF: The Cox proportional hazard models revealed that IL12Rb2
            and p38MAPK predicted a long OS. To the best of our knowledge, the
            present study is the first to reveal a close association between
            IL12Rb2 and p38MAPK, and their possible function in nonsmall cell
            lung cancer progression
REFERENCE   6  (bases 1 to 3782)
  AUTHORS   Presky,D.H., Minetti,L.J., Gillessen,S., Wilkinson,V.L., Wu,C.Y.,
            Gubler,U., Chizzonite,R. and Gately,M.K.
  TITLE     Analysis of the multiple interactions between IL-12 and the high
            affinity IL-12 receptor complex
  JOURNAL   J Immunol 160 (5), 2174-2179 (1998)
   PUBMED   9498755
REFERENCE   7  (bases 1 to 3782)
  AUTHORS   Rogge,L., Barberis-Maino,L., Biffi,M., Passini,N., Presky,D.H.,
            Gubler,U. and Sinigaglia,F.
  TITLE     Selective expression of an interleukin-12 receptor component by
            human T helper 1 cells
  JOURNAL   J Exp Med 185 (5), 825-831 (1997)
   PUBMED   9120388
REFERENCE   8  (bases 1 to 3782)
  AUTHORS   Yamamoto,K., Kobayashi,H., Miura,O., Hirosawa,S. and Miyasaka,N.
  TITLE     Assignment of IL12RB1 and IL12RB2, interleukin-12 receptor beta 1
            and beta 2 chains, to human chromosome 19 band p13.1 and chromosome
            1 band p31.2, respectively, by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 77 (3-4), 257-258 (1997)
   PUBMED   9284929
REFERENCE   9  (bases 1 to 3782)
  AUTHORS   Presky,D.H., Yang,H., Minetti,L.J., Chua,A.O., Nabavi,N., Wu,C.Y.,
            Gately,M.K. and Gubler,U.
  TITLE     A functional interleukin 12 receptor complex is composed of two
            beta-type cytokine receptor subunits
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 14002-14007 (1996)
   PUBMED   8943050
REFERENCE   10 (bases 1 to 3782)
  AUTHORS   Chua,A.O., Chizzonite,R., Desai,B.B., Truitt,T.P., Nunes,P.,
            Minetti,L.J., Warrier,R.R., Presky,D.H., Levine,J.F., Gately,M.K.
            et al.
  TITLE     Expression cloning of a human IL-12 receptor component. A new
            member of the cytokine receptor superfamily with strong homology to
            gp130
  JOURNAL   J Immunol 153 (1), 128-136 (1994)
   PUBMED   7911493
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB126833.1, U64198.1,
            AL389925.10, BC143249.1 and AL358512.9.
            
            Summary: The protein encoded by this gene is a type I transmembrane
            protein identified as a subunit of the interleukin 12 receptor
            complex. The coexpression of this and IL12RB1 proteins was shown to
            lead to the formation of high-affinity IL12 binding sites and
            reconstitution of IL12 dependent signaling. The expression of this
            gene is up-regulated by interferon gamma in Th1 cells, and plays a
            role in Th1 cell differentiation. The up-regulation of this gene is
            found to be associated with a number of infectious diseases, such
            as Crohn's disease and leprosy, which is thought to contribute to
            the inflammatory response and host defense. Several transcript
            variants encoding different isoforms and non-protein coding
            transcripts have been found for this gene. [provided by RefSeq, Apr
            2012].
            
            Transcript Variant: This variant (3) lacks two alternate in-frame
            exons compared to variant 1. The resulting isoform (c) has the same
            N- and C-termini but is shorter compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC143249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162568 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               DB126833.1         14-216
            204-1353            U64198.1           204-1353
            1354-1354           AL389925.10        82646-82646
            1355-1918           U64198.1           1355-1918
            1919-2718           BC143249.1         1329-2128
            2719-3782           AL358512.9         28558-29621
FEATURES             Location/Qualifiers
     source          1..3782
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..3782
                     /gene="IL12RB2"
                     /note="interleukin 12 receptor subunit beta 2"
                     /db_xref="GeneID:3595"
                     /db_xref="HGNC:HGNC:5972"
                     /db_xref="MIM:601642"
     exon            1..604
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..716
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             641..2971
                     /gene="IL12RB2"
                     /note="isoform c precursor is encoded by transcript
                     variant 3; interleukin-12 receptor beta-2 chain; IL-12R
                     subunit beta-2; IL-12 receptor subunit beta-2; interleukin
                     12 receptor, beta 2"
                     /codon_start=1
                     /product="interleukin-12 receptor subunit beta-2 isoform c
                     precursor"
                     /protein_id="NP_001245144.1"
                     /db_xref="CCDS:CCDS58007.1"
                     /db_xref="GeneID:3595"
                     /db_xref="HGNC:HGNC:5972"
                     /db_xref="MIM:601642"
                     /translation="MAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLG
                     STVNITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCK
                     LACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQ
                     LSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTF
                     LDIVRPLPPWDIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAK
                     GRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHI
                     DYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGN
                     WAVAVSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSA
                     VQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISEIPYRVSQNSHPINSLQPRVTY
                     VLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICIAIIMVGIFSTHYFQQKVFV
                     LLAALRPQWCSREIPDPANSTCAKKYPIAEEKTQLPLDRLLIDWPTPEDPEPLVISEV
                     LHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPRALQAESRQLVDLYK
                     VLESRGSDPKPENPACPWTVLPAGDLPTHDGYLPSNIDDLPSHEAPLADSLEELEPQH
                     ISLSVFPSSSLHPLTFSCGDKLTLDQLKMRCDSLML"
     exon            717..1004
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1119
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1304
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1447
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1598
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1678
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1898
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2099
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2237
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2328
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2428
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..3782
                     /gene="IL12RB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3185..3190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL12RB2"
                     /note="hexamer: ATTACA"
     polyA_site      3220
                     /gene="IL12RB2"
     regulatory      3509..3514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL12RB2"
                     /note="hexamer: ATTAAA"
     polyA_site      3539
                     /gene="IL12RB2"
                     /note="major polyA site"
     regulatory      3640..3645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL12RB2"
                     /note="hexamer: CATAAA"
     polyA_site      3664
                     /gene="IL12RB2"
ORIGIN      
        1 tgcagagcac agagaaagga catctgcgag gaaagttccc tgatggctgt caacaaagtg
       61 ccacgtctct atggctgtga acgctgagca cacgatttta tcgcgcctat catatcttgg
      121 tgcataaacg cacctcacct cggtcaaccc ttgctccgtc ttatgagaca ggctttatta
      181 tccgcatttt atatgagggg aaactgacgg tggagagaga attatcttgc tcaaggcgac
      241 acagcagagc ccacaggtgg cagaatccca cccgagcccg cttcgacccg cggggtggaa
      301 accacgggcg cccgcccggc tgcgcttcca gagctgaact gagaagcgag tcctctccgc
      361 cctgcggcca ccgcccagcc ccgacccccg ccccggcccg atcctcactc gccgccagct
      421 ccccgcgccc accccggagt tggtggcgca gaggcgggag gcggaggcgg gagggcgggc
      481 gctggcaccg ggaacgcccg agcgccggca gagagcgcgg agagcgcgac acgtgcggcc
      541 cagagcaccg gggccacccg gtccccgcag gcccgggacc gcgcccgctg gcaggcgaca
      601 cgtggaagaa tacggagttc tataccagag ttgattgttg atggcacata cttttagagg
      661 atgctcattg gcatttatgt ttataatcac gtggctgttg attaaagcaa aaatagatgc
      721 gtgcaagaga ggcgatgtga ctgtgaagcc ttcccatgta attttacttg gatccactgt
      781 caatattaca tgctctttga agcccagaca aggctgcttt cactattcca gacgtaacaa
      841 gttaatcctg tacaagtttg acagaagaat caattttcac catggccact ccctcaattc
      901 tcaagtcaca ggtcttcccc ttggtacaac cttgtttgtc tgcaaactgg cctgtatcaa
      961 tagtgatgaa attcaaatat gtggagcaga gatcttcgtt ggtgttgctc cagaacagcc
     1021 tcaaaattta tcctgcatac agaagggaga acaggggact gtggcctgca cctgggaaag
     1081 aggacgagac acccacttat acactgagta tactctacag ctaagtggac caaaaaattt
     1141 aacctggcag aagcaatgta aagacattta ttgtgactat ttggactttg gaatcaacct
     1201 cacccctgaa tcacctgaat ccaatttcac agccaaggtt actgctgtca atagtcttgg
     1261 aagctcctct tcacttccat ccacattcac attcttggac atagtgaggc ctcttcctcc
     1321 gtgggacatt agaatcaaat ttcaaaaggc ttctgtgagc agatgtaccc tttattggag
     1381 agatgaggga ctggtactgc ttaatcgact cagatatcgg cccagtaaca gcaggctctg
     1441 gaatatggtt aatgttacaa aggccaaagg aagacatgat ttgctggatc tgaaaccatt
     1501 tacagaatat gaatttcaga tttcctctaa gctacatctt tataagggaa gttggagtga
     1561 ttggagtgaa tcattgagag cacaaacacc agaagaagag cctactggga tgttagatgt
     1621 ctggtacatg aaacggcaca ttgactacag tagacaacag atttctcttt tctggaagaa
     1681 tctgagtgtc tcagaggcaa gaggaaaaat tctccactat caggtgacct tgcaggagct
     1741 gacaggaggg aaagccatga cacagaacat cacaggacac acctcctgga ccacagtcat
     1801 tcctagaacc ggaaattggg ctgtggctgt gtctgcagca aattcaaaag gcagttctct
     1861 gcccactcgt attaacataa tgaacctgtg tgaggcaggg ttgctggctc ctcgccaggt
     1921 ctctgcaaac tcagagggca tggacaacat tctggtgact tggcagcctc ccaggaaaga
     1981 tccctctgct gttcaggagt acgtggtgga atggagagag ctccatccag ggggtgacac
     2041 acaggtccct ctaaactggc tacggagtcg accctacaat gtgtctgctc tgatttcaga
     2101 aattccctac agagtctccc aaaattcaca tccaataaac agcctgcagc cccgagtgac
     2161 atatgtcctg tggatgacag ctctgacagc tgctggtgaa agttcccacg gaaatgagag
     2221 ggaattttgt ctgcaaggta aagccaattg gatggcgttt gtggcaccaa gcatttgcat
     2281 tgctatcatc atggtgggca ttttctcaac gcattacttc cagcaaaagg tgtttgttct
     2341 cctagcagcc ctcagacctc agtggtgtag cagagaaatt ccagatccag caaatagcac
     2401 ttgcgctaag aaatatccca ttgcagagga gaagacacag ctgcccttgg acaggctcct
     2461 gatagactgg cccacgcctg aagatcctga accgctggtc atcagtgaag tccttcatca
     2521 agtgacccca gttttcagac atcccccctg ctccaactgg ccacaaaggg aaaaaggaat
     2581 ccaaggtcat caggcctctg agaaagacat gatgcacagt gcctcaagcc caccacctcc
     2641 aagagctctc caagctgaga gcagacaact ggtggatctg tacaaggtgc tggagagcag
     2701 gggctccgac ccaaagcccg aaaacccagc ctgtccctgg acggtgctcc cagcaggtga
     2761 ccttcccacc catgatggct acttaccctc caacatagat gacctcccct cacatgaggc
     2821 acctctcgct gactctctgg aagaactgga gcctcagcac atctcccttt ctgttttccc
     2881 ctcaagttct cttcacccac tcaccttctc ctgtggtgat aagctgactc tggatcagtt
     2941 aaagatgagg tgtgactccc tcatgctctg agtggtgagg cttcaagcct taaagtcagt
     3001 gtgccctcaa ccagcacagc ctgccccaat tcccccagcc cctgctccag cagctgtcat
     3061 ctctgggtgc caccatcggt ctggctgcag ctagaggaca ggcaagccag ctctggggga
     3121 gtcttaggaa ctgggagttg gtcttcactc agatgcctca tcttgccttt cccagggcct
     3181 taaaattaca tccttcactg tgtggaccta gagactccaa cttgaattcc tagtaacttt
     3241 cttggtatgc tggccagaaa gggaaatgag gaggagagta gaaaccacag ctcttagtag
     3301 taatggcata cagtctagag gaccattcat gcaatgacta tttctaaagc acctgctaca
     3361 cagcaggctg tacacagcag atcagtactg ttcaacagaa cttcctgaga tgatggaaat
     3421 gttctacctc tgcactcact gtccagtaca ttagacacta ggcacattgg ctgttaatca
     3481 cttggaatgt gtttagcttg actgaggaat taaattttga ttgtaaattt aaatcgccac
     3541 acatggctag tggctactgt attggagtgc acagctctag atggctccta gattattgag
     3601 agccttcaaa acaaatcaac ctagttctat agatgaagac ataaaagaca ctggtaaaca
     3661 ccaaggtaaa agggccccca aggtggtcat gactggtctc atttgcagaa gtctaagaat
     3721 gtaccttttt ctggccgggc gtggtagctc atgcctgtaa tcccagcact ttgggaggct
     3781 ga
//
