LOCUS       NM_001142784            1722 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens interleukin 11 receptor subunit alpha (IL11RA),
            transcript variant 3, mRNA.
ACCESSION   NM_001142784
VERSION     NM_001142784.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1722)
  AUTHORS   Yang,M., Tian,S., Han,X., Xu,L., You,J., Wu,M., Cao,Y., Jiang,Y.,
            Zheng,Z., Liu,J., Meng,F., Li,C. and Wang,X.
  TITLE     Interleukin-11Ralpha2 in the hypothalamic arcuate nucleus affects
            depression-related behaviors and the AKT-BDNF pathway
  JOURNAL   Gene 933, 148966 (2025)
   PUBMED   39341516
  REMARK    GeneRIF: Interleukin-11Ralpha2 in the hypothalamic arcuate nucleus
            affects depression-related behaviors and the AKT-BDNF pathway.
REFERENCE   2  (bases 1 to 1722)
  AUTHORS   Mori,C., Nagatoishi,S., Matsunaga,R., Kuroda,D., Nakakido,M. and
            Tsumoto,K.
  TITLE     Biophysical insight into protein-protein interactions in the
            Interleukin-11/Interleukin-11Ralpha/glycoprotein 130 signaling
            complex
  JOURNAL   Biochem Biophys Res Commun 682, 174-179 (2023)
   PUBMED   37820452
  REMARK    GeneRIF: Biophysical insight into protein-protein interactions in
            the Interleukin-11/Interleukin-11Ralpha/glycoprotein 130 signaling
            complex.
REFERENCE   3  (bases 1 to 1722)
  AUTHORS   Milara,J., Roger,I., Montero,P., Artigues,E., Escriva,J. and
            Cortijo,J.
  TITLE     IL-11 system participates in pulmonary artery remodeling and
            hypertension in pulmonary fibrosis
  JOURNAL   Respir Res 23 (1), 313 (2022)
   PUBMED   36376885
  REMARK    GeneRIF: IL-11 system participates in pulmonary artery remodeling
            and hypertension in pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1722)
  AUTHORS   Topa,A., Rohlin,A., Andersson,M.K., Fehr,A., Lovmar,L., Stenman,G.
            and Kolby,L.
  TITLE     The outcome of targeted NGS screening in patients with syndromic
            forms of sagittal and pansynostosis - IL11RA is an emerging
            core-gene for pansynostosis
  JOURNAL   Eur J Med Genet 65 (5), 104476 (2022)
   PUBMED   35331937
  REMARK    GeneRIF: The outcome of targeted NGS screening in patients with
            syndromic forms of sagittal and pansynostosis - IL11RA is an
            emerging core-gene for pansynostosis.
REFERENCE   5  (bases 1 to 1722)
  AUTHORS   Baars,I., Lokau,J., Sauerland,I., Muller,A.J. and Garbers,C.
  TITLE     Interleukin-11 receptor expression on monocytes is dispensable for
            their recruitment and pathogen uptake during Leishmania major
            infection
  JOURNAL   Cytokine 148, 155699 (2021)
   PUBMED   34530329
  REMARK    GeneRIF: Interleukin-11 receptor expression on monocytes is
            dispensable for their recruitment and pathogen uptake during
            Leishmania major infection.
REFERENCE   6  (bases 1 to 1722)
  AUTHORS   Magrangeas,F., Pitiot,G., Dubois,S., Bragado-Nilsson,E., Cherel,M.,
            Jobert,S., Lebeau,B., Boisteau,O., Lethe,B., Mallet,J., Jacques,Y.
            and Minvielle,S.
  TITLE     Cotranscription and intergenic splicing of human
            galactose-1-phosphate uridylyltransferase and interleukin-11
            receptor alpha-chain genes generate a fusion mRNA in normal cells.
            Implication for the production of multidomain proteins during
            evolution
  JOURNAL   J Biol Chem 273 (26), 16005-16010 (1998)
   PUBMED   9632650
REFERENCE   7  (bases 1 to 1722)
  AUTHORS   Cherel,M., Sorel,M., Apiou,F., Lebeau,B., Dubois,S., Jacques,Y. and
            Minvielle,S.
  TITLE     The human interleukin-11 receptor alpha gene (IL11RA): genomic
            organization and chromosome mapping
  JOURNAL   Genomics 32 (1), 49-53 (1996)
   PUBMED   8786120
REFERENCE   8  (bases 1 to 1722)
  AUTHORS   Nandurkar,H.H., Hilton,D.J., Nathan,P., Willson,T., Nicola,N. and
            Begley,C.G.
  TITLE     The human IL-11 receptor requires gp130 for signalling:
            demonstration by molecular cloning of the receptor
  JOURNAL   Oncogene 12 (3), 585-593 (1996)
   PUBMED   8637716
REFERENCE   9  (bases 1 to 1722)
  AUTHORS   Van Leuven,F., Stas,L., Hilliker,C., Miyake,Y., Bilinski,P. and
            Gossler,A.
  TITLE     Molecular cloning and characterization of the human interleukin-11
            receptor alpha-chain gene, IL11RA, located on chromosome 9p13
  JOURNAL   Genomics 31 (1), 65-70 (1996)
   PUBMED   8808281
REFERENCE   10 (bases 1 to 1722)
  AUTHORS   Cherel,M., Sorel,M., Lebeau,B., Dubois,S., Moreau,J.F.,
            Bataille,R., Minvielle,S. and Jacques,Y.
  TITLE     Molecular cloning of two isoforms of a receptor for the human
            hematopoietic cytokine interleukin-11
  JOURNAL   Blood 86 (7), 2534-2540 (1995)
   PUBMED   7670098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA917660.1, BC003110.1 and
            Z38102.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 30, 2019 this sequence version replaced NM_001142784.2.
            
            Summary: Interleukin 11 is a stromal cell-derived cytokine that
            belongs to a family of pleiotropic and redundant cytokines that use
            the gp130 transducing subunit in their high affinity receptors.
            This gene encodes the IL-11 receptor, which is a member of the
            hematopoietic cytokine receptor family. This particular receptor is
            very similar to ciliary neurotrophic factor, since both contain an
            extracellular region with a 2-domain structure composed of an
            immunoglobulin-like domain and a cytokine receptor-like domain.
            Multiple alternatively spliced transcript variants have been found
            for this gene. [provided by RefSeq, Jun 2012].
            
            Transcript Variant: This variant (3) encodes a functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2243612.1,
                                           SRR14038196.2442008.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000441545.7/ ENSP00000394391.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-562               DA917660.1         1-562
            563-1707            BC003110.1         579-1723
            1708-1722           Z38102.1           1662-1676
FEATURES             Location/Qualifiers
     source          1..1722
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..1722
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /note="interleukin 11 receptor subunit alpha"
                     /db_xref="GeneID:3590"
                     /db_xref="HGNC:HGNC:5967"
                     /db_xref="MIM:600939"
     exon            1..49
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1318
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /note="interleukin-11 receptor alpha chain; IL-11R subunit
                     alpha; IL-11 receptor subunit alpha; interleukin 11
                     receptor, alpha"
                     /codon_start=1
                     /product="interleukin-11 receptor subunit alpha precursor"
                     /protein_id="NP_001136256.1"
                     /db_xref="CCDS:CCDS6567.1"
                     /db_xref="GeneID:3590"
                     /db_xref="HGNC:HGNC:5967"
                     /db_xref="MIM:600939"
                     /translation="MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSV
                     KLCCPGVTAGDPVSWFRDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGALG
                     GTVTLQLGYPPARPVVSCQAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQR
                     RSPSTGPWPCPQDPLGAARCVVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRP
                     DPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGL
                     EEVITDAVAGLPHAVRVSARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQP
                     EVEPQVDSPAPPRPSLQPHPRLLDHRDSVEQVAVLASLGILSFLGLVAGALALGLWLR
                     LRRGGKDGSPKPGFLASVIPVDRRPGAPNL"
     exon            50..149
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /inference="alignment:Splign:2.1.0"
     exon            150..210
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /inference="alignment:Splign:2.1.0"
     exon            211..380
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /inference="alignment:Splign:2.1.0"
     exon            381..495
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /inference="alignment:Splign:2.1.0"
     exon            496..528
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /inference="alignment:Splign:2.1.0"
     exon            529..695
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /inference="alignment:Splign:2.1.0"
     exon            696..859
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1001
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1121
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1218
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1301
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1722
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1681..1686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /note="hexamer: AATAAA"
     regulatory      1690..1695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /note="hexamer: AATAAG"
     polyA_site      1707
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /note="major polyA site"
     polyA_site      1722
                     /gene="IL11RA"
                     /gene_synonym="CRSDA"
                     /note="major polyA site"
ORIGIN      
        1 agagggcgag ggcgagggca gagggcgctg gcggcagcgg ccgcggaaga tgagcagcag
       61 ctgctcaggg ctgagcaggg tcctggtggc cgtggctaca gccctggtgt ctgcctcctc
      121 cccctgcccc caggcctggg gccccccagg ggtccagtat gggcagccag gcaggtccgt
      181 gaagctgtgt tgtcctggag tgactgccgg ggacccagtg tcctggtttc gggatgggga
      241 gccaaagctg ctccagggac ctgactctgg gctagggcat gaactggtcc tggcccaggc
      301 agacagcact gatgagggca cctacatctg ccagaccctg gatggtgcac ttgggggcac
      361 agtgaccctg cagctgggct accctccagc ccgccctgtt gtctcctgcc aagcagccga
      421 ctatgagaac ttctcttgca cttggagtcc cagccagatc agcggtttac ccacccgcta
      481 cctcacctcc tacaggaaga agacagtcct aggagctgat agccagagga ggagtccatc
      541 cacagggccc tggccatgcc cacaggatcc cctaggggct gcccgctgtg ttgtccacgg
      601 ggctgagttc tggagccagt accggattaa tgtgactgag gtgaacccac tgggtgccag
      661 cacacgcctg ctggatgtga gcttgcagag catcttgcgc cctgacccac cccagggcct
      721 gcgggtagag tcagtaccag gttacccccg acgcctgcga gccagctgga cataccctgc
      781 ctcctggccg tgccagcccc acttcctgct caagttccgt ttgcagtacc gtccggcgca
      841 gcatccagcc tggtccacgg tggagccagc tggactggag gaggtgatca cagatgctgt
      901 ggctgggctg ccccatgctg tacgagtcag tgcccgggac tttctagatg ctggcacctg
      961 gagcacctgg agcccggagg cctggggaac tccgagcact gggaccatac caaaggagat
     1021 accagcatgg ggccagctac acacgcagcc agaggtggag cctcaggtgg acagccctgc
     1081 tcctccaagg ccctccctcc aaccacaccc tcggctactt gatcacaggg actctgtgga
     1141 gcaggtagct gtgctggcgt ctttgggaat cctttctttc ctgggactgg tggctggggc
     1201 cctggcactg gggctctggc tgaggctgag acggggtggg aaggatggat ccccaaagcc
     1261 tgggttcttg gcctcagtga ttccagtgga caggcgtcca ggagctccaa acctgtagag
     1321 gacccaggag ggcttcggca gattccacct ataattctgt cttgctggtg tggatagaaa
     1381 ccaggcagga cagtagatcc ctatggttgg atctcagctg gaagttctgt ttggagccca
     1441 tttctgtgag accctgtatt tcaaatttgc agctgaaagg tgcttgtacc tctgatttca
     1501 ccccagagtt ggagttctgc tcaaggaacg tgtgtaatgt gtacatctgt gtccatgtgt
     1561 gaccatgtgt ctgtgaggca gggaacatgt attctctgca tgcatgtatg taggtgcctg
     1621 gggagtgtgt gtgggtcctt ggctcttggc ctttcccctt gcaggggttg tgcaggtgtg
     1681 aataaagaga ataaggaagt tcttggagat tatactcaga aa
//
