LOCUS       NM_000641               2378 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens interleukin 11 (IL11), transcript variant 1, mRNA.
ACCESSION   NM_000641
VERSION     NM_000641.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2378)
  AUTHORS   Ng,B., Huang,K.Y., Pua,C.J., Viswanathan,S., Lim,W.W.,
            Kuthubudeen,F.F., Liu,Y.N., Hii,A.A., George,B.L., Widjaja,A.A.,
            Petretto,E. and Cook,S.A.
  TITLE     Interleukin-11 causes alveolar type 2 cell dysfunction and prevents
            alveolar regeneration
  JOURNAL   Nat Commun 15 (1), 8530 (2024)
   PUBMED   39358385
  REMARK    GeneRIF: Interleukin-11 causes alveolar type 2 cell dysfunction and
            prevents alveolar regeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2378)
  AUTHORS   Liang,P., Ness,J., Rapp,J., Boneva,S., Schwammle,M., Jung,M.,
            Schlunck,G., Agostini,H. and Bucher,F.
  TITLE     Characterization of the angiomodulatory effects of Interleukin 11
            cis- and trans-signaling in the retina
  JOURNAL   J Neuroinflammation 21 (1), 230 (2024)
   PUBMED   39294742
  REMARK    GeneRIF: Characterization of the angiomodulatory effects of
            Interleukin 11 cis- and trans-signaling in the retina.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2378)
  AUTHORS   Widjaja,A.A., Lim,W.W., Viswanathan,S., Chothani,S., Corden,B.,
            Dasan,C.M., Goh,J.W.T., Lim,R., Singh,B.K., Tan,J., Pua,C.J.,
            Lim,S.Y., Adami,E., Schafer,S., George,B.L., Sweeney,M., Xie,C.,
            Tripathi,M., Sims,N.A., Hubner,N., Petretto,E., Withers,D.J.,
            Ho,L., Gil,J., Carling,D. and Cook,S.A.
  TITLE     Inhibition of IL-11 signalling extends mammalian healthspan and
            lifespan
  JOURNAL   Nature 632 (8023), 157-165 (2024)
   PUBMED   39020175
  REMARK    GeneRIF: Inhibition of IL-11 signalling extends mammalian
            healthspan and lifespan.
REFERENCE   4  (bases 1 to 2378)
  AUTHORS   Milara,J., Roger,I., Montero,P., Artigues,E., Escriva,J., Del
            Rio,R. and Cortijo,J.
  TITLE     Targeting IL-11 to reduce fibrocyte circulation and lung
            accumulation in animal models of pulmonary hypertension-associated
            lung fibrosis
  JOURNAL   Br J Pharmacol 181 (16), 2991-3009 (2024)
   PUBMED   38679415
  REMARK    GeneRIF: Targeting IL-11 to reduce fibrocyte circulation and lung
            accumulation in animal models of pulmonary hypertension-associated
            lung fibrosis.
REFERENCE   5  (bases 1 to 2378)
  AUTHORS   Guo,X., Zhu,X., Zhou,S. and Dong,X.
  TITLE     Serum levels of IL-9 and IL-11 serve as predictors for the
            occurrence of early neurologic deterioration in patients with
            cerebral infarction
  JOURNAL   Clin Chim Acta 558, 119683 (2024)
   PUBMED   38643817
  REMARK    GeneRIF: Serum levels of IL-9 and IL-11 serve as predictors for the
            occurrence of early neurologic deterioration in patients with
            cerebral infarction.
REFERENCE   6  (bases 1 to 2378)
  AUTHORS   Wang,X.Y., Fuhrer,D.K., Marshall,M.S. and Yang,Y.C.
  TITLE     Interleukin-11 induces complex formation of Grb2, Fyn, and JAK2 in
            3T3L1 cells
  JOURNAL   J Biol Chem 270 (47), 27999-28002 (1995)
   PUBMED   7499280
REFERENCE   7  (bases 1 to 2378)
  AUTHORS   Yang,Y.C. and Yin,T.
  TITLE     Interleukin-11 and its receptor
  JOURNAL   Biofactors 4 (1), 15-21 (1992)
   PUBMED   1292471
  REMARK    Review article
REFERENCE   8  (bases 1 to 2378)
  AUTHORS   McKinley,D., Wu,Q., Yang-Feng,T. and Yang,Y.C.
  TITLE     Genomic sequence and chromosomal location of human interleukin-11
            gene (IL11)
  JOURNAL   Genomics 13 (3), 814-819 (1992)
   PUBMED   1386338
REFERENCE   9  (bases 1 to 2378)
  AUTHORS   Kawashima,I., Ohsumi,J., Mita-Honjo,K., Shimoda-Takano,K.,
            Ishikawa,H., Sakakibara,S., Miyadai,K. and Takiguchi,Y.
  TITLE     Molecular cloning of cDNA encoding adipogenesis inhibitory factor
            and identity with interleukin-11
  JOURNAL   FEBS Lett 283 (2), 199-202 (1991)
   PUBMED   1828438
REFERENCE   10 (bases 1 to 2378)
  AUTHORS   Paul,S.R., Bennett,F., Calvetti,J.A., Kelleher,K., Wood,C.R.,
            O'Hara,R.M. Jr., Leary,A.C., Sibley,B., Clark,S.C., Williams,D.A.
            et al.
  TITLE     Molecular cloning of a cDNA encoding interleukin 11, a stromal
            cell-derived lymphopoietic and hematopoietic cytokine
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7512-7516 (1990)
   PUBMED   2145578
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK315294.1, AC020922.9 and
            BF055151.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000641.3.
            
            Summary: The protein encoded by this gene is a member of the gp130
            family of cytokines. These cytokines drive the assembly of
            multisubunit receptor complexes, all of which contain at least one
            molecule of the transmembrane signaling receptor IL6ST (gp130).
            This cytokine is shown to stimulate the T-cell-dependent
            development of immunoglobulin-producing B cells. It is also found
            to support the proliferation of hematopoietic stem cells and
            megakaryocyte progenitor cells. Alternatively spliced transcript
            variants encoding distinct isoforms have been found for this gene.
            [provided by RefSeq, Jun 2012].
            
            Transcript Variant: This variant (1) is the longer transcript and
            encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290572.1, X58377.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264563.7/ ENSP00000264563.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-753               AK315294.1         1-753
            754-2054            AC020922.9         72989-74289         c
            2055-2378           BF055151.1         4-327               c
FEATURES             Location/Qualifiers
     source          1..2378
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..2378
                     /gene="IL11"
                     /gene_synonym="AGIF; IL-11"
                     /note="interleukin 11"
                     /db_xref="GeneID:3589"
                     /db_xref="HGNC:HGNC:5966"
                     /db_xref="MIM:147681"
     exon            1..160
                     /gene="IL11"
                     /gene_synonym="AGIF; IL-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..753
                     /gene="IL11"
                     /gene_synonym="AGIF; IL-11"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; adipogenesis inhibitory factor; oprelvekin"
                     /codon_start=1
                     /product="interleukin-11 isoform 1 precursor"
                     /protein_id="NP_000632.1"
                     /db_xref="CCDS:CCDS12923.1"
                     /db_xref="GeneID:3589"
                     /db_xref="HGNC:HGNC:5966"
                     /db_xref="MIM:147681"
                     /translation="MNCVCRLVLVVLSLWPDTAVAPGPPPGPPRVSPDPRAELDSTVL
                     LTRSLLADTRQLAAQLRDKFPADGDHNLDSLPTLAMSAGALGALQLPGVLTRLRADLL
                     SYLRHVQWLRRAGGSSLKTLEPELGTLQARLDRLLRRLQLLMSRLALPQPPPDPPAPP
                     LAPPSSAWGGIRAAHAILGGLHLTLDWAVRGLLLLKTRL"
     exon            161..333
                     /gene="IL11"
                     /gene_synonym="AGIF; IL-11"
                     /inference="alignment:Splign:2.1.0"
     exon            334..420
                     /gene="IL11"
                     /gene_synonym="AGIF; IL-11"
                     /inference="alignment:Splign:2.1.0"
     exon            421..582
                     /gene="IL11"
                     /gene_synonym="AGIF; IL-11"
                     /inference="alignment:Splign:2.1.0"
     exon            583..2378
                     /gene="IL11"
                     /gene_synonym="AGIF; IL-11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1181..1186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL11"
                     /gene_synonym="AGIF; IL-11"
                     /note="hexamer: ATTAAA"
     polyA_site      1203
                     /gene="IL11"
                     /gene_synonym="AGIF; IL-11"
                     /note="major polyA site"
     regulatory      2351..2356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL11"
                     /gene_synonym="AGIF; IL-11"
                     /note="hexamer: AATAAA"
     polyA_site      2378
                     /gene="IL11"
                     /gene_synonym="AGIF; IL-11"
ORIGIN      
        1 actgccgcgg ccctgctgct cagggcacat gcctcccctc cccaggccgc ggcccagctg
       61 accctcgggg ctcccccggc agcggacagg gaagggttaa aggcccccgg ctccctgccc
      121 cctgccctgg ggaacccctg gccctgtggg gacatgaact gtgtttgccg cctggtcctg
      181 gtcgtgctga gcctgtggcc agatacagct gtcgcccctg ggccaccacc tggcccccct
      241 cgagtttccc cagaccctcg ggccgagctg gacagcaccg tgctcctgac ccgctctctc
      301 ctggcggaca cgcggcagct ggctgcacag ctgagggaca aattcccagc tgacggggac
      361 cacaacctgg attccctgcc caccctggcc atgagtgcgg gggcactggg agctctacag
      421 ctcccaggtg tgctgacaag gctgcgagcg gacctactgt cctacctgcg gcacgtgcag
      481 tggctgcgcc gggcaggtgg ctcttccctg aagaccctgg agcccgagct gggcaccctg
      541 caggcccgac tggaccggct gctgcgccgg ctgcagctcc tgatgtcccg cctggccctg
      601 ccccagccac ccccggaccc gccggcgccc ccgctggcgc ccccctcctc agcctggggg
      661 ggcatcaggg ccgcccacgc catcctgggg gggctgcacc tgacacttga ctgggccgtg
      721 aggggactgc tgctgctgaa gactcggctg tgacccgggg cccaaagcca ccaccgtcct
      781 tccaaagcca gatcttattt atttatttat ttcagtactg ggggcgaaac agccaggtga
      841 tccccccgcc attatctccc cctagttaga gacagtcctt ccgtgaggcc tggggggcat
      901 ctgtgcctta tttatactta tttatttcag gagcaggggt gggaggcagg tggactcctg
      961 ggtccccgag gaggagggga ctggggtccc ggattcttgg gtctccaaga agtctgtcca
     1021 cagacttctg ccctggctct tccccatcta ggcctgggca ggaacatata ttatttattt
     1081 aagcaattac ttttcatgtt ggggtgggga cggaggggaa agggaagcct gggtttttgt
     1141 acaaaaatgt gagaaacctt tgtgagacag agaacaggga attaaatgtg tcatacatat
     1201 ccacttgagg gcgatttgtc tgagagctgg ggctggatgc ttgggtaact ggggcagggc
     1261 aggtggaggg gagacctcca ttcaggtgga ggtcccgagt gggcggggca gcgactggga
     1321 gatgggtcgg tcacccagac agctctgtgg aggcagggtc tgagccttgc ctggggcccc
     1381 gcactgcata gggccttttg tttgtttttt gagatggagt ctcgctctgt tgcctaggct
     1441 ggagtgcagt gaggcaatct gaggtcactg caacctccac ctcccgggtt caagcaattc
     1501 tcctgcctca gcctcccgat tagctgggat cacaggtgtg caccaccatg cccagctaat
     1561 tatttatttc ttttgtattt ttagtagaga cagggtttca ccatgttggc caggctggtt
     1621 tcgaactcct gacctcaggt gatcctcctg cctcggcctc ccaaagtgct gggattacag
     1681 gtgtgagcca ccacacctga cccataggtc ttcaataaat atttaatgga aggttccaca
     1741 agtcaccctg tgatcaacag tacccgtatg ggacaaagct gcaaggtcaa gatggttcat
     1801 tatggctgtg ttcaccatag caaactggaa acaatctaga tatccaacag tgagggttaa
     1861 gcaacatggt gcatctgtgg atagaacgcc acccagccgc ccggagcagg gactgtcatt
     1921 cagggaggct aaggagagag gcttgcttgg gatatagaaa gatatcctga cattggccag
     1981 gcatggtggc tcacgcctgt aatcctggca ctttgggagg acgaagcgag tggatcactg
     2041 aagtccaaga gttcgagacc ggcctgcgag acatggcaaa accctgtctc aaaaaagaaa
     2101 gaatgatgtc ctgacatgaa acagcaggct acaaaaccac tgcatgctgt gatcccaatt
     2161 ttgtgttttt ctttctatat atggattaaa acaaaaatcc taaagggaaa tacgccaaaa
     2221 tgttgacaat gactgtctcc aggtcaaagg agagaggtgg gattgtgggt gacttttaat
     2281 gtgtatgatt gtctgtattt tacagaattt ctgccatgac tgtgtatttt gcatgacaca
     2341 ttttaaaaat aataaacact atttttagaa taacagaa
//
