LOCUS       NM_000628               1941 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens interleukin 10 receptor subunit beta (IL10RB),
            transcript variant 1, mRNA.
ACCESSION   NM_000628
VERSION     NM_000628.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1941)
  AUTHORS   Mao,Z., Betti,M.J., Cedeno,M.A., Pedroza,L.A., Basaria,S., Liu,Q.,
            Choi,J.M. and Markle,J.G.
  TITLE     Clinical and cellular phenotypes resulting from a founder mutation
            in IL10RB
  JOURNAL   Clin Exp Immunol 216 (2), 113-119 (2024)
   PUBMED   37503744
  REMARK    GeneRIF: Clinical and cellular phenotypes resulting from a founder
            mutation in IL10RB.
REFERENCE   2  (bases 1 to 1941)
  AUTHORS   Grk,M., Miskovic,R., Jeremic,I., Basaric,M., Dusanovic Pjevic,M.,
            Jekic,B., Miljanovic,D., Lazarevic,I., Despotovic,A., Cirkovic,A.
            and Banko,A.
  TITLE     Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes
            with Susceptibility to and Clinical Manifestations of SLE
  JOURNAL   Int J Mol Sci 24 (14), 11292 (2023)
   PUBMED   37511050
  REMARK    GeneRIF: Association of IL10RA, IL10RB, and IL22RA
            Polymorphisms/Haplotypes with Susceptibility to and Clinical
            Manifestations of SLE.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1941)
  AUTHORS   Kousathanas,A., Pairo-Castineira,E., Rawlik,K., Stuckey,A.,
            Odhams,C.A., Walker,S., Russell,C.D., Malinauskas,T., Wu,Y.,
            Millar,J., Shen,X., Elliott,K.S., Griffiths,F., Oosthuyzen,W.,
            Morrice,K., Keating,S., Wang,B., Rhodes,D., Klaric,L., Zechner,M.,
            Parkinson,N., Siddiq,A., Goddard,P., Donovan,S., Maslove,D.,
            Nichol,A., Semple,M.G., Zainy,T., Maleady-Crowe,F., Todd,L.,
            Salehi,S., Knight,J., Elgar,G., Chan,G., Arumugam,P., Patch,C.,
            Rendon,A., Bentley,D., Kingsley,C., Kosmicki,J.A., Horowitz,J.E.,
            Baras,A., Abecasis,G.R., Ferreira,M.A.R., Justice,A., Mirshahi,T.,
            Oetjens,M., Rader,D.J., Ritchie,M.D., Verma,A., Fowler,T.A.,
            Shankar-Hari,M., Summers,C., Hinds,C., Horby,P., Ling,L.,
            McAuley,D., Montgomery,H., Openshaw,P.J.M., Elliott,P., Walsh,T.,
            Tenesa,A., Fawkes,A., Murphy,L., Rowan,K., Ponting,C.P., Vitart,V.,
            Wilson,J.F., Yang,J., Bretherick,A.D., Scott,R.H., Hendry,S.C.,
            Moutsianas,L., Law,A., Caulfield,M.J. and Baillie,J.K.
  CONSRTM   GenOMICC investigators; 23andMe investigators; COVID-19 Human
            Genetics Initiative
  TITLE     Whole-genome sequencing reveals host factors underlying critical
            COVID-19
  JOURNAL   Nature 607 (7917), 97-103 (2022)
   PUBMED   35255492
REFERENCE   4  (bases 1 to 1941)
  AUTHORS   Maculewicz,E., Dzitkowska-Zabielska,M., Antkowiak,B., Antkowiak,O.,
            Mastalerz,A., Garbacz,A., Massidda,M., Bojarczuk,A., Dziuda,L. and
            Cieszczyk,P.
  TITLE     Association of Interleukin Genes IL10 and IL10RB with Parameters of
            Overweight in Military Students
  JOURNAL   Genes (Basel) 13 (2), 291 (2022)
   PUBMED   35205336
  REMARK    GeneRIF: Association of Interleukin Genes IL10 and IL10RB with
            Parameters of Overweight in Military Students.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1941)
  AUTHORS   Luo,S., Dong,X., Guo,S., Wang,Q., Dai,X., Jiang,Y., Zhu,W., Zhou,W.
            and Song,W.
  TITLE     Regulation of the Human IL-10RB Gene Expression by Sp8 and Sp9
  JOURNAL   J Alzheimers Dis 88 (4), 1469-1485 (2022)
   PUBMED   35811529
  REMARK    GeneRIF: Regulation of the Human IL-10RB Gene Expression by Sp8 and
            Sp9.
REFERENCE   6  (bases 1 to 1941)
  AUTHORS   Spencer,S.D., Di Marco,F., Hooley,J., Pitts-Meek,S., Bauer,M.,
            Ryan,A.M., Sordat,B., Gibbs,V.C. and Aguet,M.
  TITLE     The orphan receptor CRF2-4 is an essential subunit of the
            interleukin 10 receptor
  JOURNAL   J Exp Med 187 (4), 571-578 (1998)
   PUBMED   9463407
REFERENCE   7  (bases 1 to 1941)
  AUTHORS   Kotenko,S.V., Krause,C.D., Izotova,L.S., Pollack,B.P., Wu,W. and
            Pestka,S.
  TITLE     Identification and functional characterization of a second chain of
            the interleukin-10 receptor complex
  JOURNAL   EMBO J 16 (19), 5894-5903 (1997)
   PUBMED   9312047
REFERENCE   8  (bases 1 to 1941)
  AUTHORS   Gibbs,V.C. and Pennica,D.
  TITLE     CRF2-4: isolation of cDNA clones encoding the human and mouse
            proteins
  JOURNAL   Gene 186 (1), 97-101 (1997)
   PUBMED   9047351
REFERENCE   9  (bases 1 to 1941)
  AUTHORS   Lutfalla,G., McInnis,M.G., Antonarakis,S.E. and Uze,G.
  TITLE     Structure of the human CRFB4 gene: comparison with its IFNAR
            neighbor
  JOURNAL   J Mol Evol 41 (3), 338-344 (1995)
   PUBMED   7563119
REFERENCE   10 (bases 1 to 1941)
  AUTHORS   Lutfalla,G., Gardiner,K. and Uze,G.
  TITLE     A new member of the cytokine receptor gene family maps on
            chromosome 21 at less than 35 kb from IFNAR
  JOURNAL   Genomics 16 (2), 366-373 (1993)
   PUBMED   8314576
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU133530.2, BC001903.1,
            Z17227.1 and AI025402.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000628.4.
            
            Summary: The protein encoded by this gene belongs to the cytokine
            receptor family. It is an accessory chain essential for the active
            interleukin 10 receptor complex. Coexpression of this and IL10RA
            proteins has been shown to be required for IL10-induced signal
            transduction. This gene and three other interferon receptor genes,
            IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene
            cluster located in a small region on chromosome 21. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.681251.1,
                                           SRR5189667.251949.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000290200.7/ ENSP00000290200.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AU133530.2         8-21
            15-1693             BC001903.1         1-1679
            1694-1935           Z17227.1           1634-1875
            1936-1941           AI025402.1         19-24               c
FEATURES             Location/Qualifiers
     source          1..1941
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..1941
                     /gene="IL10RB"
                     /gene_synonym="CDW210B; CRF2-4; CRFB4; D21S58; D21S66;
                     IBD25; IL-10R2; IL-10RB"
                     /note="interleukin 10 receptor subunit beta"
                     /db_xref="GeneID:3588"
                     /db_xref="HGNC:HGNC:5965"
                     /db_xref="MIM:123889"
     exon            1..148
                     /gene="IL10RB"
                     /gene_synonym="CDW210B; CRF2-4; CRFB4; D21S58; D21S66;
                     IBD25; IL-10R2; IL-10RB"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1077
                     /gene="IL10RB"
                     /gene_synonym="CDW210B; CRF2-4; CRFB4; D21S58; D21S66;
                     IBD25; IL-10R2; IL-10RB"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cytokine receptor class-II CRF2-4; cytokine
                     receptor family II, member 4; IL-10R subunit 2; IL-10R
                     subunit beta; IL-10 receptor subunit beta; interleukin 10
                     receptor, beta; interleukin-10 receptor subunit 2;
                     cytokine receptor class-II member 4; cytokine receptor
                     family 2 member 4"
                     /codon_start=1
                     /product="interleukin-10 receptor subunit beta isoform 1
                     precursor"
                     /protein_id="NP_000619.3"
                     /db_xref="CCDS:CCDS13623.1"
                     /db_xref="GeneID:3588"
                     /db_xref="HGNC:HGNC:5965"
                     /db_xref="MIM:123889"
                     /translation="MAWSLGSWLGGCLLVSALGMVPPPENVRMNSVNFKNILQWESPA
                     FAKGNLTFTAQYLSYRIFQDKCMNTTLTECDFSSLSKYGDHTLRVRAEFADEHSDWVN
                     ITFCPVDDTIIGPPGMQVEVLADSLHMRFLAPKIENEYETWTMKNVYNSWTYNVQYWK
                     NGTDEKFQITPQYDFEVLRNLEPWTTYCVQVRGFLPDRNKAGEWSEPVCEQTTHDETV
                     PSWMVAVILMASVFMVCLALLGCFALLWCVYKKTKYAFSPRNSLPQHLKEFLGHPHHN
                     TLLFFSFPLSDENDVFDKLSVIAEDSESGKQNPGDSCSLGTPPGQGPQS"
     exon            149..272
                     /gene="IL10RB"
                     /gene_synonym="CDW210B; CRF2-4; CRFB4; D21S58; D21S66;
                     IBD25; IL-10R2; IL-10RB"
                     /inference="alignment:Splign:2.1.0"
     exon            273..430
                     /gene="IL10RB"
                     /gene_synonym="CDW210B; CRF2-4; CRFB4; D21S58; D21S66;
                     IBD25; IL-10R2; IL-10RB"
                     /inference="alignment:Splign:2.1.0"
     exon            431..597
                     /gene="IL10RB"
                     /gene_synonym="CDW210B; CRF2-4; CRFB4; D21S58; D21S66;
                     IBD25; IL-10R2; IL-10RB"
                     /inference="alignment:Splign:2.1.0"
     exon            598..745
                     /gene="IL10RB"
                     /gene_synonym="CDW210B; CRF2-4; CRFB4; D21S58; D21S66;
                     IBD25; IL-10R2; IL-10RB"
                     /inference="alignment:Splign:2.1.0"
     exon            746..903
                     /gene="IL10RB"
                     /gene_synonym="CDW210B; CRF2-4; CRFB4; D21S58; D21S66;
                     IBD25; IL-10R2; IL-10RB"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1941
                     /gene="IL10RB"
                     /gene_synonym="CDW210B; CRF2-4; CRFB4; D21S58; D21S66;
                     IBD25; IL-10R2; IL-10RB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1913..1918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL10RB"
                     /gene_synonym="CDW210B; CRF2-4; CRFB4; D21S58; D21S66;
                     IBD25; IL-10R2; IL-10RB"
                     /note="hexamer: ATTAAA"
     polyA_site      1941
                     /gene="IL10RB"
                     /gene_synonym="CDW210B; CRF2-4; CRFB4; D21S58; D21S66;
                     IBD25; IL-10R2; IL-10RB"
                     /note="major polyA site"
ORIGIN      
        1 atctccgctg gttcccggaa gccgccgcgg acaagctctc ccgggcgcgg gcgggggtcg
       61 tgtgcttgga ggaagccgcg gaacccccag cgtccgtcca tggcgtggag ccttgggagc
      121 tggctgggtg gctgcctgct ggtgtcagca ttgggaatgg taccacctcc cgaaaatgtc
      181 agaatgaatt ctgttaattt caagaacatt ctacagtggg agtcacctgc ttttgccaaa
      241 gggaacctga ctttcacagc tcagtaccta agttatagga tattccaaga taaatgcatg
      301 aatactacct tgacggaatg tgatttctca agtctttcca agtatggtga ccacaccttg
      361 agagtcaggg ctgaatttgc agatgagcat tcagactggg taaacatcac cttctgtcct
      421 gtggatgaca ccattattgg accccctgga atgcaagtag aagtacttgc tgattcttta
      481 catatgcgtt tcttagcccc taaaattgag aatgaatacg aaacttggac tatgaagaat
      541 gtgtataact catggactta taatgtgcaa tactggaaaa acggtactga tgaaaagttt
      601 caaattactc cccagtatga ctttgaggtc ctcagaaacc tggagccatg gacaacttat
      661 tgtgttcaag ttcgagggtt tcttcctgat cggaacaaag ctggggaatg gagtgagcct
      721 gtctgtgagc aaacaaccca tgacgaaacg gtcccctcct ggatggtggc cgtcatcctc
      781 atggcctcgg tcttcatggt ctgcctggca ctcctcggct gcttcgcctt gctgtggtgc
      841 gtttacaaga agacaaagta cgccttctcc cctaggaatt ctcttccaca gcacctgaaa
      901 gagtttttgg gccatcctca tcataacaca cttctgtttt tctcctttcc attgtcggat
      961 gagaatgatg tttttgacaa gctaagtgtc attgcagaag actctgagag cggcaagcag
     1021 aatcctggtg acagctgcag cctcgggacc ccgcctgggc aggggcccca aagctaggct
     1081 ctgagaagga aacacactcg gctgggcaca gtgacgtact ccatctcaca tctgcctcag
     1141 tgagggatca gggcagcaaa caagggccaa gaccatctga gccagcccca catctagaac
     1201 tcccagaccc tggacttagc caccagagag ctacatttta aaggctgtct tggcaaaaat
     1261 actccatttg ggaactcact gccttataaa ggctttcatg atgttttcag aagttggcca
     1321 ctgagagtgt aattttcagc cttttatatc actaaaataa gatcatgttt taattgtgag
     1381 aaacagggcc gagcacagtg gctcacgcct gtaataccag caccttagag gtcgaggcag
     1441 gcggatcact tgaggtcagg agttcaagac cagcctggcc aatatggtga aacccagtct
     1501 ctactaaaaa tacaaaaatt agctaggcat gatggcgcat gcctataatc ccagctactc
     1561 gagtgcctga ggcaggagaa ttgcatgaac ccgggaggag gaggaggagg ttgcagtgag
     1621 ccgagatagc ggcactgcac tccagcctgg gtgacaaagt gagactccat ctcaaaaaaa
     1681 aaaaaaaaaa aaattgtgag aaacagaaat acttaaaatg aggaataaga atggagatgt
     1741 tacatctggt agatgtaaca ttctaccaga ttatggatgg actgatctga aaatcgacct
     1801 caactcaagg gtggtcagct caatgctaca cagagcacgg acttttggat tctttgcagt
     1861 actttgaatt tatttttcta cctatatatg ttttatatgc tgctggtgct ccattaaagt
     1921 tttactctgt gttgcactat a
//
