LOCUS       NM_001558               3653 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens interleukin 10 receptor subunit alpha (IL10RA),
            transcript variant 1, mRNA.
ACCESSION   NM_001558
VERSION     NM_001558.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3653)
  AUTHORS   Grk,M., Miskovic,R., Jeremic,I., Basaric,M., Dusanovic Pjevic,M.,
            Jekic,B., Miljanovic,D., Lazarevic,I., Despotovic,A., Cirkovic,A.
            and Banko,A.
  TITLE     Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes
            with Susceptibility to and Clinical Manifestations of SLE
  JOURNAL   Int J Mol Sci 24 (14), 11292 (2023)
   PUBMED   37511050
  REMARK    GeneRIF: Association of IL10RA, IL10RB, and IL22RA
            Polymorphisms/Haplotypes with Susceptibility to and Clinical
            Manifestations of SLE.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3653)
  AUTHORS   Hanna,B.S., Llao-Cid,L., Iskar,M., Roessner,P.M., Klett,L.C.,
            Wong,J.K.L., Paul,Y., Ioannou,N., Ozturk,S., Mack,N., Kalter,V.,
            Colomer,D., Campo,E., Bloehdorn,J., Stilgenbauer,S., Dietrich,S.,
            Schmidt,M., Gabriel,R., Rippe,K., Feuerer,M., Ramsay,A.G.,
            Lichter,P., Zapatka,M. and Seiffert,M.
  TITLE     Interleukin-10 receptor signaling promotes the maintenance of a
            PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor
            immunity
  JOURNAL   Immunity 54 (12), 2825-2841 (2021)
   PUBMED   34879221
  REMARK    GeneRIF: Interleukin-10 receptor signaling promotes the maintenance
            of a PD-1(int) TCF-1(+) CD8(+) T cell population that sustains
            anti-tumor immunity.
REFERENCE   3  (bases 1 to 3653)
  AUTHORS   Nedelkopoulou,N., Taparkou,A., Agakidis,C., Mavroudi,A., Xinias,I.
            and Farmaki,E.
  TITLE     IL-10 receptor expression on lymphocytes and monocytes in children
            with food allergy
  JOURNAL   Pediatr Allergy Immunol 32 (5), 1108-1111 (2021)
   PUBMED   33595140
  REMARK    GeneRIF: IL-10 receptor expression on lymphocytes and monocytes in
            children with food allergy.
REFERENCE   4  (bases 1 to 3653)
  AUTHORS   Tang,Z., Zhang,P., Ji,M., Yin,C., Zhao,R., Huang,Z. and Huang,Y.
  TITLE     Characterization of novel and large fragment deletions in exon 1 of
            the IL10RA gene in Chinese children with very early onset
            inflammatory bowel diseases
  JOURNAL   BMC Gastroenterol 21 (1), 167 (2021)
   PUBMED   33849446
  REMARK    GeneRIF: Characterization of novel and large fragment deletions in
            exon 1 of the IL10RA gene in Chinese children with very early onset
            inflammatory bowel diseases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3653)
  AUTHORS   Tu,C.C., O'Connor,C.M. and Spencer,J.V.
  TITLE     Identification of a novel signaling complex containing host
            chemokine receptor CXCR4, Interleukin-10 receptor, and human
            cytomegalovirus US27
  JOURNAL   Virology 548, 49-58 (2020)
   PUBMED   32838946
  REMARK    GeneRIF: Identification of a novel signaling complex containing
            host chemokine receptor CXCR4, Interleukin-10 receptor, and human
            cytomegalovirus US27.
REFERENCE   6  (bases 1 to 3653)
  AUTHORS   Carson,W.E., Lindemann,M.J., Baiocchi,R., Linett,M., Tan,J.C.,
            Chou,C.C., Narula,S. and Caligiuri,M.A.
  TITLE     The functional characterization of interleukin-10 receptor
            expression on human natural killer cells
  JOURNAL   Blood 85 (12), 3577-3585 (1995)
   PUBMED   7540068
REFERENCE   7  (bases 1 to 3653)
  AUTHORS   Tan,J.C., Braun,S., Rong,H., DiGiacomo,R., Dolphin,E., Baldwin,S.,
            Narula,S.K., Zavodny,P.J. and Chou,C.C.
  TITLE     Characterization of recombinant extracellular domain of human
            interleukin-10 receptor
  JOURNAL   J Biol Chem 270 (21), 12906-12911 (1995)
   PUBMED   7759550
REFERENCE   8  (bases 1 to 3653)
  AUTHORS   Taniyama,T., Takai,S., Miyazaki,E., Fukumura,R., Sato,J.,
            Kobayashi,Y., Hirakawa,T., Moore,K.W. and Yamada,K.
  TITLE     The human interleukin-10 receptor gene maps to chromosome 11q23.3
  JOURNAL   Hum Genet 95 (1), 99-101 (1995)
   PUBMED   7814035
REFERENCE   9  (bases 1 to 3653)
  AUTHORS   Liu,Y., Wei,S.H., Ho,A.S., de Waal Malefyt,R. and Moore,K.W.
  TITLE     Expression cloning and characterization of a human IL-10 receptor
  JOURNAL   J Immunol 152 (4), 1821-1829 (1994)
   PUBMED   8120391
REFERENCE   10 (bases 1 to 3653)
  AUTHORS   Ho,A.S., Liu,Y., Khan,T.A., Hsu,D.H., Bazan,J.F. and Moore,K.W.
  TITLE     A receptor for interleukin 10 is related to interferon receptors
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 11267-11271 (1993)
   PUBMED   8248239
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291645.1, BC028082.1,
            AP002962.2 and CA307153.1.
            
            On Nov 22, 2019 this sequence version replaced NM_001558.3.
            
            Summary: The protein encoded by this gene is a receptor for
            interleukin 10. This protein is structurally related to interferon
            receptors. It has been shown to mediate the immunosuppressive
            signal of interleukin 10, and thus inhibits the synthesis of
            proinflammatory cytokines. This receptor is reported to promote
            survival of progenitor myeloid cells through the insulin receptor
            substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor
            leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two
            transcript variants, one protein-coding and the other not
            protein-coding, have been found for this gene. [provided by RefSeq,
            Jan 2009].
            
            Transcript Variant: This variant (1) is the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1446740.1, BC028082.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000227752.8/ ENSP00000227752.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-532               AK291645.1         4-535
            533-1124            BC028082.1         513-1104
            1125-1125           AP002962.2         113952-113952
            1126-3649           BC028082.1         1106-3629
            3650-3653           CA307153.1         17-20               c
FEATURES             Location/Qualifiers
     source          1..3653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..3653
                     /gene="IL10RA"
                     /gene_synonym="CD210; CD210a; CDW210A; HIL-10R; IL-10R1;
                     IL10R"
                     /note="interleukin 10 receptor subunit alpha"
                     /db_xref="GeneID:3587"
                     /db_xref="HGNC:HGNC:5964"
                     /db_xref="MIM:146933"
     exon            1..141
                     /gene="IL10RA"
                     /gene_synonym="CD210; CD210a; CDW210A; HIL-10R; IL-10R1;
                     IL10R"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1811
                     /gene="IL10RA"
                     /gene_synonym="CD210; CD210a; CDW210A; HIL-10R; IL-10R1;
                     IL10R"
                     /note="interleukin-10 receptor alpha chain; IL-10RA;
                     IL-10R subunit 1; IL-10R subunit alpha; IL-10 receptor
                     subunit alpha; interleukin-10 receptor subunit 1;
                     interleukin 10 receptor, alpha"
                     /codon_start=1
                     /product="interleukin-10 receptor subunit alpha precursor"
                     /protein_id="NP_001549.2"
                     /db_xref="CCDS:CCDS8388.1"
                     /db_xref="GeneID:3587"
                     /db_xref="HGNC:HGNC:5964"
                     /db_xref="MIM:146933"
                     /translation="MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILH
                     WTPIPNQSESTCYEVALLRYGIESWNSISNCSQTLSYDLTAVTLDLYHSNGYRARVRA
                     VDGSRHSNWTVTNTRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESI
                     FSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMW
                     SKEECISLTRQYFTVTNVIIFFAFVLLLSGALAYCLALQLYVRRRKKLPSVLLFKKPS
                     PFIFISQRPSPETQDTIHPLDEEAFLKVSPELKNLDLHGSTDSGFGSTKPSLQTEEPQ
                     FLLPDPHPQADRTLGNREPPVLGDSCSSGSSNSTDSGICLQEPSLSPSTGPTWEQQVG
                     SNSRGQDDSGIDLVQNSEGRAGDTQGGSALGHHSPPEPEVPGEEDPAAVAFQGYLRQT
                     RCAEEKATKTGCLEEESPLTDGLGPKFGRCLVDEAGLHPPALAKGYLKQDPLEMTLAS
                     SGAPTGQWNQPTEEWSLLALSSCSDLGISDWSFAHDLAPLGCVAAPGGLLGSFNSDLV
                     TLPLISSLQSSE"
     exon            142..262
                     /gene="IL10RA"
                     /gene_synonym="CD210; CD210a; CDW210A; HIL-10R; IL-10R1;
                     IL10R"
                     /inference="alignment:Splign:2.1.0"
     exon            263..441
                     /gene="IL10RA"
                     /gene_synonym="CD210; CD210a; CDW210A; HIL-10R; IL-10R1;
                     IL10R"
                     /inference="alignment:Splign:2.1.0"
     exon            442..611
                     /gene="IL10RA"
                     /gene_synonym="CD210; CD210a; CDW210A; HIL-10R; IL-10R1;
                     IL10R"
                     /inference="alignment:Splign:2.1.0"
     exon            612..762
                     /gene="IL10RA"
                     /gene_synonym="CD210; CD210a; CDW210A; HIL-10R; IL-10R1;
                     IL10R"
                     /inference="alignment:Splign:2.1.0"
     exon            763..884
                     /gene="IL10RA"
                     /gene_synonym="CD210; CD210a; CDW210A; HIL-10R; IL-10R1;
                     IL10R"
                     /inference="alignment:Splign:2.1.0"
     exon            885..3653
                     /gene="IL10RA"
                     /gene_synonym="CD210; CD210a; CDW210A; HIL-10R; IL-10R1;
                     IL10R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3630..3635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL10RA"
                     /gene_synonym="CD210; CD210a; CDW210A; HIL-10R; IL-10R1;
                     IL10R"
                     /note="hexamer: AATAAA"
     polyA_site      3649
                     /gene="IL10RA"
                     /gene_synonym="CD210; CD210a; CDW210A; HIL-10R; IL-10R1;
                     IL10R"
                     /note="major polyA site"
ORIGIN      
        1 agtcccagcc caagggtagc tggaggcgcg caggccggct ccgctccggc cccggacgat
       61 gcggcgcgcc caggatgctg ccgtgcctcg tagtgctgct ggcggcgctc ctcagcctcc
      121 gtcttggctc agacgctcat gggacagagc tgcccagccc tccgtctgtg tggtttgaag
      181 cagaattttt ccaccacatc ctccactgga cacccatccc aaatcagtct gaaagtacct
      241 gctatgaagt ggcgctcctg aggtatggaa tagagtcctg gaactccatc tccaactgta
      301 gccagaccct gtcctatgac cttaccgcag tgaccttgga cctgtaccac agcaatggct
      361 accgggccag agtgcgggct gtggacggca gccggcactc caactggacc gtcaccaaca
      421 cccgcttctc tgtggatgaa gtgactctga cagttggcag tgtgaaccta gagatccaca
      481 atggcttcat cctcgggaag attcagctac ccaggcccaa gatggccccc gcaaatgaca
      541 catatgaaag catcttcagt cacttccgag agtatgagat tgccattcgc aaggtgccgg
      601 gaaacttcac gttcacacac aagaaagtaa aacatgaaaa cttcagcctc ctaacctctg
      661 gagaagtggg agagttctgt gtccaggtga aaccatctgt cgcttcccga agtaacaagg
      721 ggatgtggtc taaagaggag tgcatctccc tcaccaggca gtatttcacc gtgaccaacg
      781 tcatcatctt ctttgccttt gtcctgctgc tctccggagc cctcgcctac tgcctggccc
      841 tccagctgta tgtgcggcgc cgaaagaagc tacccagtgt cctgctcttc aagaagccca
      901 gccccttcat cttcatcagc cagcgtccct ccccagagac ccaagacacc atccacccgc
      961 ttgatgagga ggcctttttg aaggtgtccc cagagctgaa gaacttggac ctgcacggca
     1021 gcacagacag tggctttggc agcaccaagc catccctgca gactgaagag ccccagttcc
     1081 tcctccctga ccctcacccc caggctgaca gaacgctggg aaacagggag ccccctgtgc
     1141 tgggggacag ctgcagtagt ggcagcagca atagcacaga cagcgggatc tgcctgcagg
     1201 agcccagcct gagccccagc acagggccca cctgggagca acaggtgggg agcaacagca
     1261 ggggccagga tgacagtggc attgacttag ttcaaaactc tgagggccgg gctggggaca
     1321 cacagggtgg ctcggccttg ggccaccaca gtcccccgga gcctgaggtg cctggggaag
     1381 aagacccagc tgctgtggca ttccagggtt acctgaggca gaccagatgt gctgaagaga
     1441 aggcaaccaa gacaggctgc ctggaggaag aatcgccctt gacagatggc cttggcccca
     1501 aattcgggag atgcctggtt gatgaggcag gcttgcatcc accagccctg gccaagggct
     1561 atttgaaaca ggatcctcta gaaatgactc tggcttcctc aggggcccca acgggacagt
     1621 ggaaccagcc cactgaggaa tggtcactcc tggccttgag cagctgcagt gacctgggaa
     1681 tatctgactg gagctttgcc catgaccttg cccctctagg ctgtgtggca gccccaggtg
     1741 gtctcctggg cagctttaac tcagacctgg tcaccctgcc cctcatctct agcctgcagt
     1801 caagtgagtg actcgggctg agaggctgct tttgatttta gccatgcctg ctcctctgcc
     1861 tggaccagga ggagggcccc tggggcagaa gttaggcacg aggcagtctg ggcacttttc
     1921 tgcaagtcca ctggggctgg ccccagccag gccctgcagg gctggtcagg gtgtctgggg
     1981 caggaggagg ccaactcact gaactagtgc agggtatgtg ggtggcactg acctgttctg
     2041 ttgactgggg ccctgcagac tctggcagag ctgagaaggg cagggacctt ctccctccta
     2101 ggaactcttt cctgtatcat aaaggattat ttgctcaggg gaaccatggg gctttctgga
     2161 gttgtggtga ggccaccagg ctgaagtcag ctcagaccca gacctccctg cttaggccac
     2221 tcgagcatca gagcttccag caggaggaag ggctgtagga atggaagctt cagggccttg
     2281 ctgctggggt catttttagg ggaaaaagga ggatatgatg gtcacatggg gaacctcccc
     2341 tcatcgggcc tctggggcag gaagcttgtc actggaagat cttaaggtat atattttctg
     2401 gacactcaaa cacatcataa tggattcact gaggggagac aaagggagcc gagaccctgg
     2461 atggggcttc cagctcagaa cccatccctc tggtgggtac ctctggcacc catctgcaaa
     2521 tatctccctc tctccaacaa atggagtagc atccccctgg ggcacttgct gaggccaagc
     2581 cactcacatc ctcactttgc tgccccacca tcttgctgac aacttccaga gaagccatgg
     2641 ttttttgtat tggtcataac tcagcccttt gggcggcctc tgggcttggg caccagctca
     2701 tgccagcccc agagggtcag ggttggaggc ctgtgcttgt gtttgctgct aatgtccagc
     2761 tacagaccca gaggataagc cactgggcac tgggctgggg tccctgcctt gttggtgttc
     2821 agctgtgtga ttttggacta gccacttgtc agagggcctc aatctcccat ctgtgaaata
     2881 aggactccac ctttagggga ccctccatgt ttgctgggta ttagccaagc tggtcctggg
     2941 agaatgcaga tactgtccgt ggactaccaa gctggcttgt ttcttatgcc agaggctaac
     3001 agatccaatg ggagtccatg gtgtcatgcc aagacagtat cagacacagc cccagaaggg
     3061 ggcattatgg gccctgcctc cccataggcc atttggactc tgccttcaaa caaaggcagt
     3121 tcagtccaca ggcatggaag ctgtgagggg acaggcctgt gcgtgccatc cagagtcatc
     3181 tcagccctgc ctttctctgg agcattctga aaacagatat tctggcccag ggaatccagc
     3241 catgaccccc acccctctgc caaagtactc ttaggtgcca gtctggtaac tgaactccct
     3301 ctggaggcag gcttgaggga ggattcctca gggttccctt gaaagcttta tttatttatt
     3361 ttgttcattt atttattgga gaggcagcat tgcacagtga aagaattctg gatatctcag
     3421 gagccccgaa attctagctc tgactttgct gtttccagtg gtatgacctt ggagaagtca
     3481 cttatcctct tggagcctca gtttcctcat ctgcagaata atgactgact tgtctaattc
     3541 gtagggatgt gaggttctgc tgaggaaatg ggtatgaatg tgccttgaac acaaagctct
     3601 gtcaataagt gatacatgtt ttttattcca ataaattgtc aagaccacag gaa
//
