LOCUS       NM_000572               1630 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens interleukin 10 (IL10), transcript variant 1, mRNA.
ACCESSION   NM_000572
VERSION     NM_000572.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1630)
  AUTHORS   He,K., Xiao,H., MacDonald,W.A., Mehta,I., Kishore,A., Vincent,A.,
            Xu,Z., Ray,A., Chen,W., Weaver,C.T., Lambrecht,B.N., Das,J. and
            Poholek,A.C.
  TITLE     Spatial microniches of IL-2 combine with IL-10 to drive lung
            migratory TH2 cells in response to inhaled allergen
  JOURNAL   Nat Immunol 25 (11), 2124-2139 (2024)
   PUBMED   39394532
  REMARK    GeneRIF: Spatial microniches of IL-2 combine with IL-10 to drive
            lung migratory TH2 cells in response to inhaled allergen.
REFERENCE   2  (bases 1 to 1630)
  AUTHORS   Farhad Bilal,E., Jawdah Bilal,S. and Hasan Azeez,S.
  TITLE     Seasonal distribution and correlation between IL-10 and IL-13 gene
            polymorphism and their expression in scabies-infected patients
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (9), 59-67 (2024)
   PUBMED   39380276
  REMARK    GeneRIF: Seasonal distribution and correlation between IL-10 and
            IL-13 gene polymorphism and their expression in scabies-infected
            patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1630)
  AUTHORS   Pashova-Tasseva,Z., Dosseva-Panova,V., Mlachkova,A., Savov,A. and
            Tosheva,E.
  TITLE     IL-10 A-Allele as a Biomarker for Periodontitis Severity in
            Bulgarian Patients
  JOURNAL   Genes (Basel) 15 (9), 1221 (2024)
   PUBMED   39336814
  REMARK    GeneRIF: IL-10 A-Allele as a Biomarker for Periodontitis Severity
            in Bulgarian Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1630)
  AUTHORS   Vukolova,Y., Gubareva,I., Galati,G. and Germanova,O.
  TITLE     Diagnostic utility of sortilin & other biomarkers in the diagnosis
            of carotid & coronary atherosclerosis in individuals with arterial
            hypertension
  JOURNAL   Indian J Med Res 159 (5), 511-518 (2024)
   PUBMED   39382416
  REMARK    GeneRIF: Diagnostic utility of sortilin & other biomarkers in the
            diagnosis of carotid & coronary atherosclerosis in individuals with
            arterial hypertension.
REFERENCE   5  (bases 1 to 1630)
  AUTHORS   Gesser,B., Leffers,H., Jinquan,T., Vestergaard,C., Kirstein,N.,
            Sindet-Pedersen,S., Jensen,S.L., Thestrup-Pedersen,K. and
            Larsen,C.G.
  TITLE     Identification of functional domains on human interleukin 10
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14620-14625 (1997)
   PUBMED   9405662
REFERENCE   6  (bases 1 to 1630)
  AUTHORS   Eskdale,J., Kube,D., Tesch,H. and Gallagher,G.
  TITLE     Mapping of the human IL10 gene and further characterization of the
            5' flanking sequence
  JOURNAL   Immunogenetics 46 (2), 120-128 (1997)
   PUBMED   9162098
REFERENCE   7  (bases 1 to 1630)
  AUTHORS   Kim,J.M., Brannan,C.I., Copeland,N.G., Jenkins,N.A., Khan,T.A. and
            Moore,K.W.
  TITLE     Structure of the mouse IL-10 gene and chromosomal localization of
            the mouse and human genes
  JOURNAL   J Immunol 148 (11), 3618-3623 (1992)
   PUBMED   1350294
REFERENCE   8  (bases 1 to 1630)
  AUTHORS   Rousset,F., Garcia,E., Defrance,T., Peronne,C., Vezzio,N.,
            Hsu,D.H., Kastelein,R., Moore,K.W. and Banchereau,J.
  TITLE     Interleukin 10 is a potent growth and differentiation factor for
            activated human B lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 89 (5), 1890-1893 (1992)
   PUBMED   1371884
REFERENCE   9  (bases 1 to 1630)
  AUTHORS   Vieira,P., de Waal-Malefyt,R., Dang,M.N., Johnson,K.E.,
            Kastelein,R., Fiorentino,D.F., deVries,J.E., Roncarolo,M.G.,
            Mosmann,T.R. and Moore,K.W.
  TITLE     Isolation and expression of human cytokine synthesis inhibitory
            factor cDNA clones: homology to Epstein-Barr virus open reading
            frame BCRFI
  JOURNAL   Proc Natl Acad Sci U S A 88 (4), 1172-1176 (1991)
   PUBMED   1847510
REFERENCE   10 (bases 1 to 1630)
  AUTHORS   Ghosh,S., Conrad,J.R. and Klass,D.L.
  TITLE     Anaerobic acidogenesis of wastewater sludge
  JOURNAL   J Water Pollut Control Fed 47 (1), 30-45 (1975)
   PUBMED   1121048
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC022315.1, M57627.1 and
            CD369014.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 31, 2018 this sequence version replaced NM_000572.2.
            
            Summary: The protein encoded by this gene is a cytokine produced
            primarily by monocytes and to a lesser extent by lymphocytes. This
            cytokine has pleiotropic effects in immunoregulation and
            inflammation. It down-regulates the expression of Th1 cytokines,
            MHC class II Ags, and costimulatory molecules on macrophages. It
            also enhances B cell survival, proliferation, and antibody
            production. This cytokine can block NF-kappa B activity, and is
            involved in the regulation of the JAK-STAT signaling pathway.
            Knockout studies in mice suggested the function of this cytokine as
            an essential immunoregulator in the intestinal tract. Mutations in
            this gene are associated with an increased susceptibility to HIV-1
            infection and rheumatoid arthritis. [provided by RefSeq, May 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.113941.1,
                                           SRR1163655.71990.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in cytokine storm inflammatory
                                      response
            MANE Ensembl match     :: ENST00000423557.1/ ENSP00000412237.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BC022315.1         2-30
            30-1490             M57627.1           1-1461
            1491-1630           CD369014.1         18-157              c
FEATURES             Location/Qualifiers
     source          1..1630
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..1630
                     /gene="IL10"
                     /gene_synonym="CSIF; GVHDS; IL-10; IL10A; TGIF"
                     /note="interleukin 10"
                     /db_xref="GeneID:3586"
                     /db_xref="HGNC:HGNC:5962"
                     /db_xref="MIM:124092"
     exon            1..224
                     /gene="IL10"
                     /gene_synonym="CSIF; GVHDS; IL-10; IL10A; TGIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..596
                     /gene="IL10"
                     /gene_synonym="CSIF; GVHDS; IL-10; IL10A; TGIF"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; T-cell growth inhibitory factor; cytokine
                     synthesis inhibitory factor"
                     /codon_start=1
                     /product="interleukin-10 isoform 1 precursor"
                     /protein_id="NP_000563.1"
                     /db_xref="CCDS:CCDS1467.1"
                     /db_xref="GeneID:3586"
                     /db_xref="HGNC:HGNC:5962"
                     /db_xref="MIM:124092"
                     /translation="MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDL
                     RDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQD
                     PDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSE
                     FDIFINYIEAYMTMKIRN"
     exon            225..284
                     /gene="IL10"
                     /gene_synonym="CSIF; GVHDS; IL-10; IL10A; TGIF"
                     /inference="alignment:Splign:2.1.0"
     exon            285..437
                     /gene="IL10"
                     /gene_synonym="CSIF; GVHDS; IL-10; IL10A; TGIF"
                     /inference="alignment:Splign:2.1.0"
     exon            438..503
                     /gene="IL10"
                     /gene_synonym="CSIF; GVHDS; IL-10; IL10A; TGIF"
                     /inference="alignment:Splign:2.1.0"
     exon            504..1630
                     /gene="IL10"
                     /gene_synonym="CSIF; GVHDS; IL-10; IL10A; TGIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1607..1612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IL10"
                     /gene_synonym="CSIF; GVHDS; IL-10; IL10A; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      1630
                     /gene="IL10"
                     /gene_synonym="CSIF; GVHDS; IL-10; IL10A; TGIF"
                     /note="major polyA site"
ORIGIN      
        1 acacatcagg ggcttgctct tgcaaaacca aaccacaaga cagacttgca aaagaaggca
       61 tgcacagctc agcactgctc tgttgcctgg tcctcctgac tggggtgagg gccagcccag
      121 gccagggcac ccagtctgag aacagctgca cccacttccc aggcaacctg cctaacatgc
      181 ttcgagatct ccgagatgcc ttcagcagag tgaagacttt ctttcaaatg aaggatcagc
      241 tggacaactt gttgttaaag gagtccttgc tggaggactt taagggttac ctgggttgcc
      301 aagccttgtc tgagatgatc cagttttacc tggaggaggt gatgccccaa gctgagaacc
      361 aagacccaga catcaaggcg catgtgaact ccctggggga gaacctgaag accctcaggc
      421 tgaggctacg gcgctgtcat cgatttcttc cctgtgaaaa caagagcaag gccgtggagc
      481 aggtgaagaa tgcctttaat aagctccaag agaaaggcat ctacaaagcc atgagtgagt
      541 ttgacatctt catcaactac atagaagcct acatgacaat gaagatacga aactgagaca
      601 tcagggtggc gactctatag actctaggac ataaattaga ggtctccaaa atcggatctg
      661 gggctctggg atagctgacc cagccccttg agaaacctta ttgtacctct cttatagaat
      721 atttattacc tctgatacct caacccccat ttctatttat ttactgagct tctctgtgaa
      781 cgatttagaa agaagcccaa tattataatt tttttcaata tttattattt tcacctgttt
      841 ttaagctgtt tccatagggt gacacactat ggtatttgag tgttttaaga taaattataa
      901 gttacataag ggaggaaaaa aaatgttctt tggggagcca acagaagctt ccattccaag
      961 cctgaccacg ctttctagct gttgagctgt tttccctgac ctccctctaa tttatcttgt
     1021 ctctgggctt ggggcttcct aactgctaca aatactctta ggaagagaaa ccagggagcc
     1081 cctttgatga ttaattcacc ttccagtgtc tcggagggat tcccctaacc tcattcccca
     1141 accacttcat tcttgaaagc tgtggccagc ttgttattta taacaaccta aatttggttc
     1201 taggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggct gaggcgggtg
     1261 gatcacttga ggtcaggagt tcctaaccag cctggtcaac atggtgaaac cccgtctcta
     1321 ctaaaaatac aaaaattagc cgggcatggt ggcgcgcacc tgtaatccca gctacttggg
     1381 aggctgaggc aagagaattg cttgaaccca ggagatggaa gttgcagtga gctgatatca
     1441 tgcccctgta ctccagcctg ggtgacagag caagactctg tctcaaaaaa taaaaataaa
     1501 aataaatttg gttctaatag aactcagttt taactagaat ttattcaatt cctctgggaa
     1561 tgttacattg tttgtctgtc ttcatagcag attttaattt tgaataaata aatgtatctt
     1621 attcacatca
//
