LOCUS       NM_001372123            4532 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens IKAROS family zinc finger 5 (IKZF5), transcript
            variant 2, mRNA.
ACCESSION   NM_001372123 NR_073475
VERSION     NM_001372123.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4532)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4532)
  AUTHORS   Leinoe,E., Kjaersgaard,M., Zetterberg,E., Ostrowski,S.,
            Greinacher,A. and Rossing,M.
  TITLE     Highly impaired platelet ultrastructure in two families with novel
            IKZF5 variants
  JOURNAL   Platelets 32 (4), 492-497 (2021)
   PUBMED   32419556
  REMARK    GeneRIF: Highly impaired platelet ultrastructure in two families
            with novel IKZF5 variants.
REFERENCE   3  (bases 1 to 4532)
  AUTHORS   Lentaigne,C., Greene,D., Sivapalaratnam,S., Favier,R., Seyres,D.,
            Thys,C., Grassi,L., Mangles,S., Sibson,K., Stubbs,M., Burden,F.,
            Bordet,J.C., Armari-Alla,C., Erber,W., Farrow,S., Gleadall,N.,
            Gomez,K., Megy,K., Papadia,S., Penkett,C.J., Sims,M.C.,
            Stefanucci,L., Stephens,J.C., Read,R.J., Stirrups,K.E.,
            Ouwehand,W.H., Laffan,M.A., Frontini,M., Freson,K. and Turro,E.
  CONSRTM   NIHR BioResource
  TITLE     Germline mutations in the transcription factor IKZF5 cause
            thrombocytopenia
  JOURNAL   Blood 134 (23), 2070-2081 (2019)
   PUBMED   31217188
  REMARK    GeneRIF: IKZF5 is a novel transcriptional regulator of
            megakaryopoiesis and the eighth transcription factor associated
            with dominant thrombocytopenia in humans.
REFERENCE   4  (bases 1 to 4532)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 4532)
  AUTHORS   Westman,B.J., Perdomo,J., Matthews,J.M., Crossley,M. and
            Mackay,J.P.
  TITLE     Structural studies on a protein-binding zinc-finger domain of Eos
            reveal both similarities and differences to classical zinc fingers
  JOURNAL   Biochemistry 43 (42), 13318-13327 (2004)
   PUBMED   15491138
REFERENCE   6  (bases 1 to 4532)
  AUTHORS   Perdomo,J., Holmes,M., Chong,B. and Crossley,M.
  TITLE     Eos and pegasus, two members of the Ikaros family of proteins with
            distinct DNA binding activities
  JOURNAL   J Biol Chem 275 (49), 38347-38354 (2000)
   PUBMED   10978333
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073585.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 16, 2019 this sequence version replaced NR_073475.2.
            
            Summary: Members of the Ikaros (ZNFN1A1; MIM 603023) family of
            transcription factors, which includes Pegasus, are expressed in
            lymphocytes and are implicated in the control of lymphoid
            development.[supplied by OMIM, Jul 2002].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026626.1, SRR1803613.106153.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368886.10/ ENSP00000357881.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC073585.8         29591-29692
            103-253             AC073585.8         31210-31360
            254-432             AC073585.8         39715-39893
            433-615             AC073585.8         42210-42392
            616-4532            AC073585.8         43663-47579
FEATURES             Location/Qualifiers
     source          1..4532
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..4532
                     /gene="IKZF5"
                     /gene_synonym="PEGASUS; THC7; ZNFN1A5"
                     /note="IKAROS family zinc finger 5"
                     /db_xref="GeneID:64376"
                     /db_xref="HGNC:HGNC:14283"
                     /db_xref="MIM:606238"
     exon            1..102
                     /gene="IKZF5"
                     /gene_synonym="PEGASUS; THC7; ZNFN1A5"
                     /inference="alignment:Splign:2.1.0"
     exon            103..253
                     /gene="IKZF5"
                     /gene_synonym="PEGASUS; THC7; ZNFN1A5"
                     /inference="alignment:Splign:2.1.0"
     exon            254..432
                     /gene="IKZF5"
                     /gene_synonym="PEGASUS; THC7; ZNFN1A5"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..1559
                     /gene="IKZF5"
                     /gene_synonym="PEGASUS; THC7; ZNFN1A5"
                     /note="isoform 1 is encoded by transcript variant 2; zinc
                     finger transcription factor Pegasus; zinc finger protein,
                     subfamily 1A, 5 (Pegasus); zinc finger protein Pegasus"
                     /codon_start=1
                     /product="zinc finger protein Pegasus isoform 1"
                     /protein_id="NP_001359052.1"
                     /db_xref="CCDS:CCDS41574.1"
                     /db_xref="GeneID:64376"
                     /db_xref="HGNC:HGNC:14283"
                     /db_xref="MIM:606238"
                     /translation="MGEKKPEPLDFVKDFQEYLTQQTHHVNMISGSVSGDKEAEALQG
                     AGTDGDQNGLDHPSVEVSLDENSGMLVDGFERTFDGKLKCRYCNYASKGTARLIEHIR
                     IHTGEKPHRCHLCPFASAYERHLEAHMRSHTGEKPYKCELCSFRCSDRSNLSHHRRRK
                     HKMVPIKGTRSSLSSKKMWGVLQKKTSNLGYSRRALINLSPPSMVVQKPDYLNDFTHE
                     IPNIQTDSYESMAKTTPTGGLPRDPQELMVDNPLNQLSTLAGQLSSLPPENQNPASPD
                     VVPCPDEKPFMIQQPSTQAVVSAVSASIPQSSSPTSPEPRPSHSQRNYSPVAGPSSEP
                     SAHTSTPSIGNSQPSTPAPALPVQDPQLLHHCQHCDMYFADNILYTIHMGCHGYENPF
                     QCNICGCKCKNKYDFACHFARGQHNQH"
     exon            433..615
                     /gene="IKZF5"
                     /gene_synonym="PEGASUS; THC7; ZNFN1A5"
                     /inference="alignment:Splign:2.1.0"
     exon            616..4532
                     /gene="IKZF5"
                     /gene_synonym="PEGASUS; THC7; ZNFN1A5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2873..2878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IKZF5"
                     /gene_synonym="PEGASUS; THC7; ZNFN1A5"
                     /note="hexamer: AATAAA"
     polyA_site      2893
                     /gene="IKZF5"
                     /gene_synonym="PEGASUS; THC7; ZNFN1A5"
                     /note="major polyA site"
     regulatory      4511..4516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IKZF5"
                     /gene_synonym="PEGASUS; THC7; ZNFN1A5"
                     /note="hexamer: AATAAA"
     polyA_site      4532
                     /gene="IKZF5"
                     /gene_synonym="PEGASUS; THC7; ZNFN1A5"
                     /note="major polyA site"
ORIGIN      
        1 acaacaaaga tggcggcggc gactgtgacg gtgacgaaga cggcggcggc ggcgacggca
       61 tttaacaagg cggtgtggtt tactccatgc agttgtcagg agacctctgt atggcttttc
      121 aattttagtt gaaattctct ctccatggcc ttttggagtc ccttgctgta tctccgaagt
      181 aaatttcaat tactctacat ttcatcaatg ttggagtggc aagaaaaagg aggaacagat
      241 ttggggtgaa aagttttgtt ttctaggtct aacaaactgt aaatgttaaa aaagcaaaga
      301 tgggtgaaaa aaaaccagag cctttggact tcgtgaaaga ttttcaggaa tacctgactc
      361 agcagaccca tcacgtgaac atgatttctg gatcagttag tggggacaaa gaagcagagg
      421 ctcttcaggg agctggaaca gatggtgatc aaaatggact tgatcaccca tctgttgaag
      481 tttccttgga tgaaaactca ggaatgttag tagacgggtt tgaaaggacc tttgatggga
      541 agcttaagtg tcggtactgc aactatgcca gcaaaggaac agcccggctt attgaacaca
      601 tcagaatcca cacaggtgaa aaacctcatc gatgtcatct ttgtccattt gcatctgctt
      661 atgagcgtca tctggaagcc catatgcgtt ctcatactgg agaaaaacca tacaaatgtg
      721 aattatgttc cttccgctgc agtgatcgaa gtaacttgtc ccatcatcga aggcgcaagc
      781 ataaaatggt accaattaaa ggtactaggt cttccttaag cagcaagaaa atgtgggggg
      841 ttttacagaa gaaaacaagc aatctgggct atagcagaag agcactaatc aacttaagtc
      901 caccttccat ggtggttcag aaaccagact accttaacga ttttacccac gaaatcccaa
      961 atatccagac tgactcctat gaaagtatgg caaaaaccac accaactggt ggccttccaa
     1021 gggaccccca agaactcatg gttgataacc ctttgaatca gctctcgact ctagcagggc
     1081 agttgtccag tctgccaccc gaaaaccaaa accctgcatc ccctgatgta gttccctgcc
     1141 ctgatgaaaa gcctttcatg attcagcagc cctctaccca agcagtagtt tctgccgtat
     1201 cagcaagtat tcctcagagc tcctctccca caagcccaga acctcggcca tcccatagtc
     1261 aaaggaacta tagtccagtg gcaggtccaa gcagtgagcc aagtgcccac acgagcactc
     1321 ccagcatagg aaacagccag ccaagcaccc cagccccagc cctgccggtc caggaccctc
     1381 agcttctgca ccactgccag cactgtgata tgtactttgc agacaacatc ctttacacta
     1441 ttcatatggg atgtcatggg tatgaaaatc cttttcagtg taatatatgt ggatgcaaat
     1501 gtaaaaacaa gtatgatttt gcctgtcatt ttgcaagagg gcaacataac caacattgat
     1561 tgaaaatagt catattttac ttagttttgc tgtttttgtg gtttggtttt ttttgttttt
     1621 tgttttggtc atccctaata aagtgtctgc taattcaagg cttatacatt atatttatag
     1681 aatataaatt tgtcagtgga ataaaatttc cccttttttt cataaaaatc tggtcagggt
     1741 catttatata ttagaacagt tagacacatt ggtgtctctt ttttcctttc ctttcgacat
     1801 tggagaattg gagtgcagtc ataatcttac aagatgttca tttgaatttc tcacatttat
     1861 ggtccataaa aacttcaagg cttatccata cttttgatgt ttcaatatgc attgaactgg
     1921 atgttatttc tgccatattt caaaatggta gaataaatta cagaatttat tactactcat
     1981 ttcagtgttt agtacagaaa ttgccttaaa aattgctatt aattgaaata tcatttagtt
     2041 cacattcctt aagttgaatc ggtagtttca tttcaactga taatagtaaa gctatttcag
     2101 tttagtaaaa attttctttt ttccacaaga ggaaatgtaa aacagttaag acttgaaatt
     2161 gaaaattctt ttaatattta aaataacttg tttattcaat gtctaaacac atgtcagttt
     2221 tccactggat ttttattttc acaggtaaat acactagagt gctagatgcc tttttcccct
     2281 gtcagtttga ctttcattta aatccttcat tctgatatca ttactgttag gtgaggtgga
     2341 taactataat gagaatctct tattcttcct attcctttga tgaccaaaga gataaagtga
     2401 agtcatcctt attattaaaa tgcagcctcc aaacaaattt ctcaagattc cttttccttc
     2461 cttctatcca ttttctgccc ataatttcca agaaaaggtg ggtatggaaa cacatgagag
     2521 aatgtgatag tgaagtcata tttacaaaac tgagaacatg tccaaaatgg attcttgtct
     2581 cctcttcaga attagccatt taaaatattt tctgtgactt caaattgtaa ttcttatttg
     2641 cagttttacc agtcttcatg tacagtgacg aaactgtgta gaaactaaat catcgcttta
     2701 gtaagaaagg ataaaaaggt gtggaagtga atataaaatg catctaaaca tgacatttaa
     2761 tttgtttata aaaataagac ttactaaata tagagtaatt cattttgaat aggaggctat
     2821 tgtttttata ttgtgtaata actcacgtac tctgaagaga gcttggtcaa acaataaaat
     2881 acattgttac taacttggtt tcttttctgt gtactttgca aaaattctat ttttaatttt
     2941 gttcatatgt tgaatgtgcc cctaattggc atcttaaaga gaatagtaag catctattaa
     3001 ccaaaaaaga actctaatag taaaggaaag ggaaatattg gtggtatgta cccacaaaac
     3061 ccccaagtgc caagttaatg gaatctctgc tttccctttc agatgctaga aagccactgt
     3121 aatgagttct tgcagtttag catccagtct aagctactgc attgtttaaa gagcagcatc
     3181 aaggacactt tctccaaact ggaactctct tctttgtcaa atcttgtact ttaaaattct
     3241 acaattctgt tacattgttg tttaaatcac agactgctca gatccatttt actgcagtag
     3301 tttccaagtg tgtaacttgg ctttagtatt tatcagttgc cagaaagaaa caggttgtca
     3361 tttggaagtt tttgtggtta ttttttccca tttttattct tcagataaaa gcagtacccc
     3421 aaaatagaaa atgaaaattt tcatgaaaca aagagaactc ccttgttaaa accagcttat
     3481 taactctgta ttctgtcaaa tgcatttttt tctaacaact gaccatggat gttgtgaagg
     3541 tgcattttaa tttaaacatg gaaaagattt ttttcataat tacatactag aatgtaaaat
     3601 tataattttg ccatgactta aagagcacag ttgatatccc aaaggttttg atgctaagaa
     3661 gctacagtta ttctaaatgc actaaaatgt ttgaggcaaa tctaccttag aggctttttt
     3721 ggtatggtat tttttaaaat atttagattt tatttaaatt tcctgtgagt tattctgtat
     3781 ttgaaaagat gttcgtgtct tcccctctgt attgaatgtt tcactcattt tatttttaat
     3841 caaatatttt atagaaatga gttgttggga agagtttaac atgcactatt tatagtactt
     3901 tgccgttaac aggcaatgtt ctgaaactaa atttattttt gttcagtgaa cataagttta
     3961 gatttttaaa gttggtagat aatttatctc cactaatatt tttttaagaa actgtgaaga
     4021 gattaactgg gaataatttt atttcagatt ttactaatgt agtatgtagc tacaacttct
     4081 tgaacttcaa gttaaggcta gacatttact ttgaaaaaat tccactgggt gtttccaggg
     4141 ctatttcatt ttagaaataa gtgtttgcca ttcttctgca aaaactggac aaggggaata
     4201 ctacaaaaaa tactcagaga taaaatcctc atttcaagtt ctacaaaata tttatcaaat
     4261 gaatgttaat ttttttttaa ttccctgcta aagacgtttt cattagtctt agagggtata
     4321 tgctttctag aacttgtttt tgttaacatg tgctttgatg taaagaacat attttgtatg
     4381 caaaacataa cttgcattat ggttgtacaa tacactatat tgtttaggga ttccggaaag
     4441 cagtttaatg cagaaataac tatatctagt atgcagttca tattgtgaat gaagctttgc
     4501 ttttgtaata aataaataag actttctaat ga
//
