LOCUS       NM_022465               5313 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens IKAROS family zinc finger 4 (IKZF4), transcript
            variant 1, mRNA.
ACCESSION   NM_022465
VERSION     NM_022465.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5313)
  AUTHORS   Miao,Y., Qi,S., Hu,R., Sheng,Y. and Yang,Q.
  TITLE     Association analysis of the IKZF4 gene with Alopecia Areata in the
            Chinese Han population
  JOURNAL   Altern Ther Health Med 30 (10), 314-317 (2024)
   PUBMED   38330583
  REMARK    GeneRIF: Association analysis of the IKZF4 gene with Alopecia
            Areata in the Chinese Han population.
REFERENCE   2  (bases 1 to 5313)
  AUTHORS   Weng,N., Zhou,C., Zhou,Y., Zhong,Y., Jia,Z., Rao,X., Qiu,H.,
            Zeng,G., Jin,X., Zhang,J., Zhuang,Z., Liang,Z., Deng,Y., Li,Q.,
            Yang,S., Luo,H., Wang,H. and Wu,X.
  TITLE     IKZF4/NONO-RAB11FIP3 axis promotes immune evasion in gastric cancer
            via facilitating PD-L1 endosome recycling
  JOURNAL   Cancer Lett 584, 216618 (2024)
   PUBMED   38211652
  REMARK    GeneRIF: IKZF4/NONO-RAB11FIP3 axis promotes immune evasion in
            gastric cancer via facilitating PD-L1 endosome recycling.
REFERENCE   3  (bases 1 to 5313)
  AUTHORS   Wang,Y., Zhao,H., He,Y., Zhang,P., Zeng,C., Du,T., Shen,Q., Chen,Y.
            and Zhao,S.
  TITLE     IKZF4 acts as a novel tumor suppressor in non-small cell lung
            cancer by suppressing Notch signaling pathway
  JOURNAL   Cell Signal 107, 110679 (2023)
   PUBMED   37044192
  REMARK    GeneRIF: IKZF4 acts as a novel tumor suppressor in non-small cell
            lung cancer by suppressing Notch signaling pathway.
REFERENCE   4  (bases 1 to 5313)
  AUTHORS   Vandewalle,J., Van der Auwera,B.J., Amin,H., Quartier,E.,
            Desouter,A.K., Tenoutasse,S., Gillard,P., De Block,C.,
            Keymeulen,B., Gorus,F.K. and Van de Casteele,M.
  CONSRTM   Belgian Diabetes Registry
  TITLE     Genetic variation at ERBB3/IKZF4 and sexual dimorphism in epitope
            spreading in single autoantibody-positive relatives
  JOURNAL   Diabetologia 64 (11), 2511-2516 (2021)
   PUBMED   34448034
  REMARK    GeneRIF: Genetic variation at ERBB3/IKZF4 and sexual dimorphism in
            epitope spreading in single autoantibody-positive relatives.
REFERENCE   5  (bases 1 to 5313)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 5313)
  AUTHORS   Westman,B.J., Perdomo,J., Matthews,J.M., Crossley,M. and
            Mackay,J.P.
  TITLE     Structural studies on a protein-binding zinc-finger domain of Eos
            reveal both similarities and differences to classical zinc fingers
  JOURNAL   Biochemistry 43 (42), 13318-13327 (2004)
   PUBMED   15491138
REFERENCE   7  (bases 1 to 5313)
  AUTHORS   Perdomo,J. and Crossley,M.
  TITLE     The Ikaros family protein Eos associates with C-terminal-binding
            protein corepressors
  JOURNAL   Eur J Biochem 269 (23), 5885-5892 (2002)
   PUBMED   12444977
REFERENCE   8  (bases 1 to 5313)
  AUTHORS   Koipally,J. and Georgopoulos,K.
  TITLE     A molecular dissection of the repression circuitry of Ikaros
  JOURNAL   J Biol Chem 277 (31), 27697-27705 (2002)
   PUBMED   12015313
REFERENCE   9  (bases 1 to 5313)
  AUTHORS   Perdomo,J., Holmes,M., Chong,B. and Crossley,M.
  TITLE     Eos and pegasus, two members of the Ikaros family of proteins with
            distinct DNA binding activities
  JOURNAL   J Biol Chem 275 (49), 38347-38354 (2000)
   PUBMED   10978333
REFERENCE   10 (bases 1 to 5313)
  AUTHORS   Honma,Y., Kiyosawa,H., Mori,T., Oguri,A., Nikaido,T., Kanazawa,K.,
            Tojo,M., Takeda,J., Tanno,Y., Yokoya,S., Kawabata,I., Ikeda,H. and
            Wanaka,A.
  TITLE     Eos: a novel member of the Ikaros gene family expressed
            predominantly in the developing nervous system
  JOURNAL   FEBS Lett 447 (1), 76-80 (1999)
   PUBMED   10218586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC034102.32, DA797441.1 and BX647761.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022465.3.
            
            Summary: Members of the Ikaros (ZNFN1A1; MIM 603023) family of
            transcription factors, which includes Eos, are expressed in
            lymphocytes and are implicated in the control of lymphoid
            development.[supplied by OMIM, Jul 2002].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BX647761.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1966682, SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000547167.6/ ENSP00000448419.1
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               AC034102.32        139959-140256       c
            299-837             DA797441.1         1-539
            838-5313            BX647761.1         546-5021
FEATURES             Location/Qualifiers
     source          1..5313
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..5313
                     /gene="IKZF4"
                     /gene_synonym="EOS; ZNFN1A4"
                     /note="IKAROS family zinc finger 4"
                     /db_xref="GeneID:64375"
                     /db_xref="HGNC:HGNC:13179"
                     /db_xref="MIM:606239"
     exon            1..538
                     /gene="IKZF4"
                     /gene_synonym="EOS; ZNFN1A4"
                     /inference="alignment:Splign:2.1.0"
     CDS             452..2209
                     /gene="IKZF4"
                     /gene_synonym="EOS; ZNFN1A4"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger transcription factor Eos; zinc finger protein,
                     subfamily 1A, 4 (Eos); zinc finger protein Eos; ikaros
                     family zinc finger protein 4"
                     /codon_start=1
                     /product="zinc finger protein Eos isoform a"
                     /protein_id="NP_071910.3"
                     /db_xref="CCDS:CCDS44917.1"
                     /db_xref="GeneID:64375"
                     /db_xref="HGNC:HGNC:13179"
                     /db_xref="MIM:606239"
                     /translation="MHTPPALPRRFQGGGRVRTPGSHRQGKDNLERDPSGGCVPDFLP
                     QAQDSNHFIMESLFCESSGDSSLEKEFLGAPVGPSVSTPNSQHSSPSRSLSANSIKVE
                     MYSDEESSRLLGPDERLLEKDDSVIVEDSLSEPLGYCDGSGPEPHSPGGIRLPNGKLK
                     CDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCP
                     FCNYACRRRDALTGHLRTHSVSSPTVGKPYKCNYCGRSYKQQSTLEEHKERCHNYLQS
                     LSTEAQALAGQPGDEIRDLEMVPDSMLHSSSERPTFIDRLANSLTKRKRSTPQKFVGE
                     KQMRFSLSDLPYDVNSGGYEKDVELVAHHSLEPGFGSSLAFVGAEHLRPLRLPPTNCI
                     SELTPVISSVYTQMQPLPGRLELPGSREAGEGPEDLADGGPLLYRPRGPLTDPGASPS
                     NGCQDSTDTESNHEDRVAGVVSLPQGPPPQPPPTIVVGRHSPAYAKEDPKPQEGLLRG
                     TPGPSKEVLRVVGESGEPVKAFKCEHCRILFLDHVMFTIHMGCHGFRDPFECNICGYH
                     SQDRYEFSSHIVRGEHKVG"
     exon            539..632
                     /gene="IKZF4"
                     /gene_synonym="EOS; ZNFN1A4"
                     /inference="alignment:Splign:2.1.0"
     exon            633..737
                     /gene="IKZF4"
                     /gene_synonym="EOS; ZNFN1A4"
                     /inference="alignment:Splign:2.1.0"
     exon            738..998
                     /gene="IKZF4"
                     /gene_synonym="EOS; ZNFN1A4"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1166
                     /gene="IKZF4"
                     /gene_synonym="EOS; ZNFN1A4"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1316
                     /gene="IKZF4"
                     /gene_synonym="EOS; ZNFN1A4"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1448
                     /gene="IKZF4"
                     /gene_synonym="EOS; ZNFN1A4"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..5313
                     /gene="IKZF4"
                     /gene_synonym="EOS; ZNFN1A4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5290..5295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IKZF4"
                     /gene_synonym="EOS; ZNFN1A4"
                     /note="hexamer: AATAAA"
     polyA_site      5313
                     /gene="IKZF4"
                     /gene_synonym="EOS; ZNFN1A4"
                     /note="major polyA site"
ORIGIN      
        1 acactcttgc ctctctcagg catttgttgt gcagttcctc tttgtctgct gggcacgagg
       61 ggcaacagca tctgcctttc cctccctgtg cacacaccca ccacccaccc ccttcactgt
      121 cttggaaaag ggatgctgta gcctagcatc tcccccacta tatacacata tacattctct
      181 ccagccccct ccccaagcac atccaagcgt gctctcccct ctccttctct ccctctctct
      241 ctctctctct ctcacacaca cacacacaca cacactcaac acacatacac cctgggctga
      301 gctgctcttg ctggctgcag ccgtgggcct ctgctcaccg tgccgctgct gctgcctgcg
      361 aaatgacggc ggttcccctc acttccagga atccacgctt cctggaaggt gagtggctgg
      421 gctcacccct gcctgccact gagacgcaga catgcataca ccacccgcac tccctcgccg
      481 tttccaaggc ggcggccgcg ttcgcacccc agggtctcac cggcaaggga aggataatct
      541 ggagagggat ccctcaggag ggtgtgttcc ggatttcttg cctcaggccc aagactccaa
      601 ccattttata atggaatctt tattttgtga aagtagcggg gactcatctc tggagaagga
      661 gttcctcggg gccccagtgg ggccctcggt gagcaccccc aacagccagc actcttctcc
      721 tagccgctca ctcagtgcca actccatcaa ggtggagatg tacagcgatg aggagtcaag
      781 cagactgctg gggccagatg agcggctcct ggaaaaggac gacagcgtga ttgtggaaga
      841 ttcattgtct gagcccctgg gctactgtga tgggagtggg ccagagcctc actcccctgg
      901 gggcatccgg ctgcccaatg gcaagctcaa gtgtgacgtc tgcggcatgg tctgtattgg
      961 acccaacgtg ctcatggtgc acaagcgcag tcacactggt gaaaggccct tccattgcaa
     1021 ccagtgtggt gcctccttca cccagaaggg gaacctgctg cgccacatca agctgcactc
     1081 tggggagaag ccctttaaat gtcccttctg caactatgcc tgccgccggc gtgatgcact
     1141 cactggtcac ctccgcacac actcagtctc ctctcccaca gtgggcaagc cctacaagtg
     1201 taactactgt ggccggagct acaaacagca gagtaccctg gaggagcaca aggagcggtg
     1261 ccataactac ctacagagtc tcagcactga agcccaagct ttggctggcc aaccaggtga
     1321 cgaaatacgt gacctggaga tggtgccaga ctccatgctg cactcatcct ctgagcggcc
     1381 aactttcatc gatcgtctgg ccaatagcct caccaaacgc aagcgttcca caccccagaa
     1441 gtttgtaggc gaaaagcaga tgcgcttcag cctctcagac ctcccctatg atgtgaactc
     1501 gggtggctat gaaaaggatg tggagttggt ggcacaccac agcctagagc ctggctttgg
     1561 aagttccctg gcctttgtgg gtgcagagca tctgcgtccc ctccgccttc cacccaccaa
     1621 ttgcatctca gaactcacgc ctgtcatcag ctctgtctac acccagatgc agcccctccc
     1681 tggtcgactg gagcttccag gatcccgaga agcaggtgag ggacctgagg acctggctga
     1741 tggaggtccc ctcctctacc ggccccgagg ccccctgact gaccctgggg catcccccag
     1801 caatggctgc caggactcca cagacacaga aagcaaccac gaagatcggg ttgcgggggt
     1861 ggtatccctc cctcagggtc ccccacccca gccacctccc accattgtgg tgggccggca
     1921 cagtcctgcc tacgccaaag aggaccccaa gccacaggag gggttattgc ggggcacccc
     1981 aggcccctcc aaggaagtgc ttcgggtggt gggcgagagt ggtgagcctg tgaaggcctt
     2041 caagtgtgag cactgccgta tcctcttcct ggaccacgtc atgttcacta tccacatggg
     2101 ctgccatggc ttcagagacc cttttgagtg caacatctgt ggttatcaca gccaggaccg
     2161 gtacgaattc tcttcccaca ttgtccgggg ggagcataag gtgggctagc aacctctccc
     2221 tctctcctca gtccaccact ccactgccct gactacaggc attgatccct gtccccacca
     2281 tttcccaagg agttttgctt tgtagccctc actactggcc acctgacctc acacctgacc
     2341 ctgacccctc ctcacctatt ctcttcctct atcctgaccg atgtaagcat tgtgatgaaa
     2401 cagatctttt gcttatgttt ttccttttta tcttctctca tcccagcata ctgagttatt
     2461 tattaattag ttgatttatt tttgcctttt taaattttaa cttatatcag tcacttgcca
     2521 ctcccccacc ctcctgtcca caactccttt ccactttagg ccaatttttc tctcttagat
     2581 cttccagcag ccccaggggt aggaagctcc tcttagtact aagagacttc aagcttcttg
     2641 ctttaagtcc tcacccttta cattatctaa ttcttcagtt ttgatgctga tacctgcccc
     2701 cggccctacc ttagctctgt ggcattatat ctcctctctg ggactcttca acctggtact
     2761 ccatacctct tgtgccctct cactttaggc agcttgcact attcttgaat gaatgaagaa
     2821 ttatttcctc atttggaagt aggagggact gaagaaattc tccccaggca ctgtgggact
     2881 gagagtccta ttcccctagt aataggtcat attcccctag taatatgagt tctcaaagcc
     2941 tacattcagg atctccctct aggatgtgat agatctggtc cctctccttg aactacccct
     3001 ccacacgctc tagtcccttc aacctaccgg tctattaagt ggtggctttt ctctccttgg
     3061 agtgccccaa ttttatattc tcaggggcca aggctaggtc tgcaaccctc tgtctctgac
     3121 agattgggag ccacaggtgc ctaattggga accagggcat gggaaaggag tgggtcaaaa
     3181 ttcttctctt tctcctccac ctctcaaact tcttcactat agtgaccttc ctaggctctc
     3241 aggggctcct tcagtcccca tcctatgaga aactagtggg ttgctgcctg atgacaaggg
     3301 gttgtttcag cccctcagtc atgctgcctt ctgctgctcc ctcccagcag gattcaccct
     3361 ctcattcccg ggctcctggg ccctgttctt aggatcagtg gcagggagaa acgggtatct
     3421 cttttctctc ttctaatttt cagtataacc aaaaattatc ccagcatgag cacgggcacg
     3481 tgcccttcac cccattccac ccttgttcca gcaagactgg gatgggtaca actgaactgg
     3541 ggtcttcctt tactaccccc ttctacactc agctcccaga cacagggtag gaggggggac
     3601 tgctggctac tgcagagacc cttggctatt tgagtaacct aggattagtg agaaggggca
     3661 gaaggagata caactccact gcaagtggag gtttctttct acaagagttt tctgcccaag
     3721 gccacagcca tcccactctc tgcttccttg agattcaaac caaaggctgt ttttctatgt
     3781 ttaaagaaaa aaaaaagtaa aaaccaaaca caacacctca caagttgtaa ctcttggtcc
     3841 ttctctctct ccttttctct tcccttcctt ccccttccat ctttctttcc acatgtcctt
     3901 tccttattgg ctcttttacc tcctactttt ctcactccct atcagggata ttttgggggg
     3961 ggatggtaaa gggtgggcta aggaacagac cctgggatta gggccttaag ggctctgaga
     4021 ggagtctacc ttgccttctt atgggaaggg agaccctaaa aaactttctc ctctttgtcc
     4081 tcctttttct cccccactct gaggtttccc caagagaacc agattggcag ggagaagcat
     4141 tgtggggcaa ttgttcctcc ttgacaatgt agcaataaat agatgctgcc aagggcagaa
     4201 aatggggagg ttagctcaga gcagagtagt ctctagagaa aggaagaatc ctcaacggca
     4261 ccctggggtg ctagctcctt tttagaatgt cagcagagct gagattaata tctgggcttt
     4321 tcctgaacta ttctggttat tgagcccttc ctgttagacc taccgcctcc cacctcttct
     4381 gtgtctgctg tgtatttggt gacacttcat aaggactagt cccttctggg gtatcagagc
     4441 cttagggtgc ccccatcccc ttccccagtc aactgtggca cctgtaacct cccggaacat
     4501 gaaggactat gctctgaggc tatactctgt gcccatgaga gcagagactg gaagggcaag
     4561 accaggtgct aaggagggga gagggggcat cctgtctctc tccagaccat cactgcactt
     4621 taaccagggt cttaggtaca aaatcctact tttcagagcc ttccagctct ggaacctcaa
     4681 acatcctcat gctctctccc agctcctttt gcataaaaaa aaaagtaaag aaaaagaaaa
     4741 aaaaatacac acacactgaa acccacatgg agaaaagagg tgtttccttt tatattgcta
     4801 ttcaaaatca ataccaccaa caaaatattt ctaagtagac acttttccag acctttgttt
     4861 ttttgtgtca gtgtccaagc tgcagatagg attttgtaat acttctggca gcttctttcc
     4921 ttgtgtacat aatatatata tatacatata tatatatatt tttaatcaga agttatgaag
     4981 aacaaaaaga aaaaataaac acagaagcaa gtgcaatacc acctctcttc tccctctctc
     5041 ctagggtttc ctttgtagcc tatgtttggt gtctcttttg acctttaccc cttcacctcc
     5101 tcctctcttc ttctgattcc cctccccccc ttttttaaag agtttttctc ctttctcaag
     5161 gggagttaaa ctagcttttg agacttattg caaagcattt tgtatatgta atatattgta
     5221 agtaaatatt tgtgtaacgg agatatacta ctgtaagttt tgtactgtac tggctgaaag
     5281 tctgttataa ataaacatga gtaatttaac acc
//
