LOCUS       NP_071910                585 aa            linear   PRI 27-APR-2025
DEFINITION  zinc finger protein Eos isoform a [Homo sapiens].
ACCESSION   NP_071910
VERSION     NP_071910.3
DBSOURCE    REFSEQ: accession NM_022465.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 585)
  AUTHORS   Miao,Y., Qi,S., Hu,R., Sheng,Y. and Yang,Q.
  TITLE     Association analysis of the IKZF4 gene with Alopecia Areata in the
            Chinese Han population
  JOURNAL   Altern Ther Health Med 30 (10), 314-317 (2024)
   PUBMED   38330583
  REMARK    GeneRIF: Association analysis of the IKZF4 gene with Alopecia
            Areata in the Chinese Han population.
REFERENCE   2  (residues 1 to 585)
  AUTHORS   Weng,N., Zhou,C., Zhou,Y., Zhong,Y., Jia,Z., Rao,X., Qiu,H.,
            Zeng,G., Jin,X., Zhang,J., Zhuang,Z., Liang,Z., Deng,Y., Li,Q.,
            Yang,S., Luo,H., Wang,H. and Wu,X.
  TITLE     IKZF4/NONO-RAB11FIP3 axis promotes immune evasion in gastric cancer
            via facilitating PD-L1 endosome recycling
  JOURNAL   Cancer Lett 584, 216618 (2024)
   PUBMED   38211652
  REMARK    GeneRIF: IKZF4/NONO-RAB11FIP3 axis promotes immune evasion in
            gastric cancer via facilitating PD-L1 endosome recycling.
REFERENCE   3  (residues 1 to 585)
  AUTHORS   Wang,Y., Zhao,H., He,Y., Zhang,P., Zeng,C., Du,T., Shen,Q., Chen,Y.
            and Zhao,S.
  TITLE     IKZF4 acts as a novel tumor suppressor in non-small cell lung
            cancer by suppressing Notch signaling pathway
  JOURNAL   Cell Signal 107, 110679 (2023)
   PUBMED   37044192
  REMARK    GeneRIF: IKZF4 acts as a novel tumor suppressor in non-small cell
            lung cancer by suppressing Notch signaling pathway.
REFERENCE   4  (residues 1 to 585)
  AUTHORS   Vandewalle,J., Van der Auwera,B.J., Amin,H., Quartier,E.,
            Desouter,A.K., Tenoutasse,S., Gillard,P., De Block,C.,
            Keymeulen,B., Gorus,F.K. and Van de Casteele,M.
  CONSRTM   Belgian Diabetes Registry
  TITLE     Genetic variation at ERBB3/IKZF4 and sexual dimorphism in epitope
            spreading in single autoantibody-positive relatives
  JOURNAL   Diabetologia 64 (11), 2511-2516 (2021)
   PUBMED   34448034
  REMARK    GeneRIF: Genetic variation at ERBB3/IKZF4 and sexual dimorphism in
            epitope spreading in single autoantibody-positive relatives.
REFERENCE   5  (residues 1 to 585)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (residues 1 to 585)
  AUTHORS   Westman,B.J., Perdomo,J., Matthews,J.M., Crossley,M. and
            Mackay,J.P.
  TITLE     Structural studies on a protein-binding zinc-finger domain of Eos
            reveal both similarities and differences to classical zinc fingers
  JOURNAL   Biochemistry 43 (42), 13318-13327 (2004)
   PUBMED   15491138
REFERENCE   7  (residues 1 to 585)
  AUTHORS   Perdomo,J. and Crossley,M.
  TITLE     The Ikaros family protein Eos associates with C-terminal-binding
            protein corepressors
  JOURNAL   Eur J Biochem 269 (23), 5885-5892 (2002)
   PUBMED   12444977
REFERENCE   8  (residues 1 to 585)
  AUTHORS   Koipally,J. and Georgopoulos,K.
  TITLE     A molecular dissection of the repression circuitry of Ikaros
  JOURNAL   J Biol Chem 277 (31), 27697-27705 (2002)
   PUBMED   12015313
REFERENCE   9  (residues 1 to 585)
  AUTHORS   Perdomo,J., Holmes,M., Chong,B. and Crossley,M.
  TITLE     Eos and pegasus, two members of the Ikaros family of proteins with
            distinct DNA binding activities
  JOURNAL   J Biol Chem 275 (49), 38347-38354 (2000)
   PUBMED   10978333
REFERENCE   10 (residues 1 to 585)
  AUTHORS   Honma,Y., Kiyosawa,H., Mori,T., Oguri,A., Nikaido,T., Kanazawa,K.,
            Tojo,M., Takeda,J., Tanno,Y., Yokoya,S., Kawabata,I., Ikeda,H. and
            Wanaka,A.
  TITLE     Eos: a novel member of the Ikaros gene family expressed
            predominantly in the developing nervous system
  JOURNAL   FEBS Lett 447 (1), 76-80 (1999)
   PUBMED   10218586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC034102.32, DA797441.1 and BX647761.1.
            
            On Jan 17, 2007 this sequence version replaced NP_071910.2.
            
            Summary: Members of the Ikaros (ZNFN1A1; MIM 603023) family of
            transcription factors, which includes Eos, are expressed in
            lymphocytes and are implicated in the control of lymphoid
            development.[supplied by OMIM, Jul 2002].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BX647761.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1966682, SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000547167.6/ ENSP00000448419.1
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..585
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     Protein         1..585
                     /product="zinc finger protein Eos isoform a"
                     /note="zinc finger transcription factor Eos; zinc finger
                     protein, subfamily 1A, 4 (Eos); zinc finger protein Eos;
                     ikaros family zinc finger protein 4"
                     /calculated_mol_wt=63975
     Region          1..43
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2S9.2)"
     Region          68..98
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2S9.2)"
     Site            105
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UKS7; propagated from
                     UniProtKB/Swiss-Prot (Q9H2S9.2)"
     Region          161..181
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(166,168,170,172..173,176..177,180,194,196,200..201,
                     204..205,208,222,224,226,228..229,232..233,236)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          174..198
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          189..209
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          201..226
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          <211..271
                     /region_name="SFP1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; COG5189"
                     /db_xref="CDD:227516"
     Region          217..237
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          250..271
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          281..585
                     /region_name="Interaction with FOXP3.
                     /evidence=ECO:0000250|UniProtKB:Q8C208"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2S9.2)"
     Site            335
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9UKS7; propagated from
                     UniProtKB/Swiss-Prot (Q9H2S9.2)"
     Region          410..489
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2S9.2)"
     Region          425..429
                     /region_name="CTBP-binding motif PEDLA"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2S9.2)"
     CDS             1..585
                     /gene="IKZF4"
                     /gene_synonym="EOS; ZNFN1A4"
                     /coded_by="NM_022465.4:452..2209"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS44917.1"
                     /db_xref="GeneID:64375"
                     /db_xref="HGNC:HGNC:13179"
                     /db_xref="MIM:606239"
ORIGIN      
        1 mhtppalprr fqgggrvrtp gshrqgkdnl erdpsggcvp dflpqaqdsn hfimeslfce
       61 ssgdssleke flgapvgpsv stpnsqhssp srslsansik vemysdeess rllgpderll
      121 ekddsvived slseplgycd gsgpephspg girlpngklk cdvcgmvcig pnvlmvhkrs
      181 htgerpfhcn qcgasftqkg nllrhiklhs gekpfkcpfc nyacrrrdal tghlrthsvs
      241 sptvgkpykc nycgrsykqq stleehkerc hnylqslste aqalagqpgd eirdlemvpd
      301 smlhssserp tfidrlansl tkrkrstpqk fvgekqmrfs lsdlpydvns ggyekdvelv
      361 ahhslepgfg sslafvgaeh lrplrlpptn ciseltpvis svytqmqplp grlelpgsre
      421 agegpedlad ggpllyrprg pltdpgasps ngcqdstdte snhedrvagv vslpqgpppq
      481 ppptivvgrh spayakedpk pqegllrgtp gpskevlrvv gesgepvkaf kcehcrilfl
      541 dhvmftihmg chgfrdpfec nicgyhsqdr yefsshivrg ehkvg
//
