LOCUS       NM_012481               9788 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens IKAROS family zinc finger 3 (IKZF3), transcript
            variant 1, mRNA.
ACCESSION   NM_012481
VERSION     NM_012481.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9788)
  AUTHORS   Yang,X., Yang,L., Luo,A., Liu,S., Zhang,X., Liu,X., Liu,X., Luo,A.,
            Cai,M., Yan,Y., Wu,X., Huang,K., Xu,L. and Jiang,H.
  TITLE     IKZF3 polymorphisms contribute to the increased risk of acute
            lymphoblastic leukemia in children
  JOURNAL   Cancer 130 (6), 973-984 (2024)
   PUBMED   38018448
  REMARK    GeneRIF: IKZF3 polymorphisms contribute to the increased risk of
            acute lymphoblastic leukemia in children.
REFERENCE   2  (bases 1 to 9788)
  AUTHORS   Kuehn,H.S., Sakovich,I.S., Niemela,J.E., Gil Silva,A.A.,
            Stoddard,J.L., Polyakova,E.A., Esteve Sole,A., Aleshkevich,S.N.,
            Uglova,T.A., Belevtsev,M.V., Vertelko,V.R., Shman,T.V.,
            Kupchinskaya,A.N., Walter,J.E., Fleisher,T.A., Notarangelo,L.D.,
            Peng,X.P., Delmonte,O.M., Sharapova,S.O. and Rosenzweig,S.D.
  TITLE     Disease-associated AIOLOS variants lead to immune
            deficiency/dysregulation by haploinsufficiency and redefine AIOLOS
            functional domains
  JOURNAL   J Clin Invest 134 (3), e172573 (2024)
   PUBMED   38015619
  REMARK    GeneRIF: Disease-associated AIOLOS variants lead to immune
            deficiency/dysregulation by haploinsufficiency and redefine AIOLOS
            functional domains.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9788)
  AUTHORS   Paniri,A., Hosseini,M.M., Fattahi,S., Amiribozorgi,G., Asouri,M.,
            Maadi,M., Motamed,N., Zamani,F. and Akhavan-Niaki,H.
  TITLE     Genetic variations in IKZF3, LET7-a2, and CDKN2B-AS1: Exploring
            associations with metabolic syndrome susceptibility and clinical
            manifestations
  JOURNAL   J Clin Lab Anal 38 (1-2), e24999 (2024)
   PUBMED   38193570
  REMARK    GeneRIF: Genetic variations in IKZF3, LET7-a2, and CDKN2B-AS1:
            Exploring associations with metabolic syndrome susceptibility and
            clinical manifestations.
REFERENCE   4  (bases 1 to 9788)
  AUTHORS   Li,H., Ye,M., Hu,Z., Lu,H., Zheng,D., Wu,M., Ge,T., Xu,S., Ge,Z.,
            Zhang,S., Xu,G. and Chen,H.
  TITLE     IKZF3 is a novel prognostic biomarker for head and neck squamous
            cell carcinoma: A study based on bioinformatics analysis
  JOURNAL   Medicine (Baltimore) 102 (11), e33124 (2023)
   PUBMED   36930079
  REMARK    GeneRIF: IKZF3 is a novel prognostic biomarker for head and neck
            squamous cell carcinoma: A study based on bioinformatics analysis.
REFERENCE   5  (bases 1 to 9788)
  AUTHORS   Caballero,R., Setien,F., Lopez-Serra,L., Boix-Chornet,M.,
            Fraga,M.F., Ropero,S., Megias,D., Alaminos,M., Sanchez-Tapia,E.M.,
            Montoya,M.C., Esteller,M., Gonzalez-Sarmiento,R. and Ballestar,E.
  TITLE     Combinatorial effects of splice variants modulate function of
            Aiolos
  JOURNAL   J Cell Sci 120 (Pt 15), 2619-2630 (2007)
   PUBMED   17646674
  REMARK    GeneRIF: this work demonstrates that the cellular activities of
            Aiolos isoforms are dependent on combinations of various functional
            domains arising from the differential splicing of mRNA transcripts
REFERENCE   6  (bases 1 to 9788)
  AUTHORS   Liippo,J., Nera,K.P., Veistinen,E., Lahdesmaki,A., Postila,V.,
            Kimby,E., Riikonen,P., Hammarstrom,L., Pelkonen,J. and Lassila,O.
  TITLE     Both normal and leukemic B lymphocytes express multiple isoforms of
            the human Aiolos gene
  JOURNAL   Eur J Immunol 31 (12), 3469-3474 (2001)
   PUBMED   11745366
REFERENCE   7  (bases 1 to 9788)
  AUTHORS   Hosokawa,Y., Maeda,Y., Takahashi,Ei., Suzuki,M. and Seto,M.
  TITLE     Human aiolos, an ikaros-related zinc finger DNA binding protein:
            cDNA cloning, tissue expression pattern, and chromosomal mapping
  JOURNAL   Genomics 61 (3), 326-329 (1999)
   PUBMED   10552935
REFERENCE   8  (bases 1 to 9788)
  AUTHORS   Romero,F., Martinez-A,C., Camonis,J. and Rebollo,A.
  TITLE     Aiolos transcription factor controls cell death in T cells by
            regulating Bcl-2 expression and its cellular localization
  JOURNAL   EMBO J 18 (12), 3419-3430 (1999)
   PUBMED   10369681
REFERENCE   9  (bases 1 to 9788)
  AUTHORS   Wang,J.H., Avitahl,N., Cariappa,A., Friedrich,C., Ikeda,T.,
            Renold,A., Andrikopoulos,K., Liang,L., Pillai,S., Morgan,B.A. and
            Georgopoulos,K.
  TITLE     Aiolos regulates B cell activation and maturation to effector state
  JOURNAL   Immunity 9 (4), 543-553 (1998)
   PUBMED   9806640
REFERENCE   10 (bases 1 to 9788)
  AUTHORS   Morgan,B., Sun,L., Avitahl,N., Andrikopoulos,K., Ikeda,T.,
            Gonzales,E., Wu,P., Neben,S. and Georgopoulos,K.
  TITLE     Aiolos, a lymphoid restricted transcription factor that interacts
            with Ikaros to regulate lymphocyte differentiation
  JOURNAL   EMBO J 16 (8), 2004-2013 (1997)
   PUBMED   9155026
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090844.7, AF129512.1,
            AC079199.9 and AI866838.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_012481.4.
            
            Summary: This gene encodes a member of the Ikaros family of
            zinc-finger proteins. Three members of this protein family (Ikaros,
            Aiolos and Helios) are hematopoietic-specific transcription factors
            involved in the regulation of lymphocyte development. This gene
            product is a transcription factor that is important in the
            regulation of B lymphocyte proliferation and differentiation. Both
            Ikaros and Aiolos can participate in chromatin remodeling.
            Regulation of gene expression in B lymphocytes by Aiolos is complex
            as it appears to require the sequential formation of Ikaros
            homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers.
            Several alternative transcripts encoding different isoforms have
            been described, as well as some non-protein coding variants.
            [provided by RefSeq, Apr 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1, also known as Aio-1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032707.1, AF129512.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000346872.8/ ENSP00000344544.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AC090844.7         160764-160887
            125-146             AF129512.1         1-22
            147-147             AC090844.7         160910-160910
            148-1146            AF129512.1         24-1022
            1147-9755           AC079199.9         102210-110818       c
            9756-9788           AI866838.1         23-55               c
FEATURES             Location/Qualifiers
     source          1..9788
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12-q21.1"
     gene            1..9788
                     /gene="IKZF3"
                     /gene_synonym="AIO; AIOLOS; IMD84; ZNFN1A3"
                     /note="IKAROS family zinc finger 3"
                     /db_xref="GeneID:22806"
                     /db_xref="HGNC:HGNC:13178"
                     /db_xref="MIM:606221"
     exon            1..193
                     /gene="IKZF3"
                     /gene_synonym="AIO; AIOLOS; IMD84; ZNFN1A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1716
                     /gene="IKZF3"
                     /gene_synonym="AIO; AIOLOS; IMD84; ZNFN1A3"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein, subfamily 1A, 3 (Aiolos); zinc finger DNA
                     binding protein Aiolos"
                     /codon_start=1
                     /product="zinc finger protein Aiolos isoform 1"
                     /protein_id="NP_036613.2"
                     /db_xref="CCDS:CCDS11346.1"
                     /db_xref="GeneID:22806"
                     /db_xref="HGNC:HGNC:13178"
                     /db_xref="MIM:606221"
                     /translation="MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGE
                     GPANEDEDIGDDSMKVKDEYSERDENVLKSEPMGNAEEPEIPYSYSREYNEYENIKLE
                     RHVVSFDSSRPTSGKMNCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGN
                     LLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLE
                     EHKERCRTFLQSTDPGDTASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIG
                     EKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEM
                     VPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSN
                     HEERQNHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMD
                     VYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRALL
                     K"
     exon            194..247
                     /gene="IKZF3"
                     /gene_synonym="AIO; AIOLOS; IMD84; ZNFN1A3"
                     /inference="alignment:Splign:2.1.0"
     exon            248..349
                     /gene="IKZF3"
                     /gene_synonym="AIO; AIOLOS; IMD84; ZNFN1A3"
                     /inference="alignment:Splign:2.1.0"
     exon            350..610
                     /gene="IKZF3"
                     /gene_synonym="AIO; AIOLOS; IMD84; ZNFN1A3"
                     /inference="alignment:Splign:2.1.0"
     exon            611..778
                     /gene="IKZF3"
                     /gene_synonym="AIO; AIOLOS; IMD84; ZNFN1A3"
                     /inference="alignment:Splign:2.1.0"
     exon            779..895
                     /gene="IKZF3"
                     /gene_synonym="AIO; AIOLOS; IMD84; ZNFN1A3"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1012
                     /gene="IKZF3"
                     /gene_synonym="AIO; AIOLOS; IMD84; ZNFN1A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..9788
                     /gene="IKZF3"
                     /gene_synonym="AIO; AIOLOS; IMD84; ZNFN1A3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9762..9767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IKZF3"
                     /gene_synonym="AIO; AIOLOS; IMD84; ZNFN1A3"
                     /note="hexamer: AATAAA"
     polyA_site      9788
                     /gene="IKZF3"
                     /gene_synonym="AIO; AIOLOS; IMD84; ZNFN1A3"
                     /note="major polyA site"
ORIGIN      
        1 aaccccgcgc accggcaggt cgccggctcc tgcccttttc agtctgcgcc gacgcggctg
       61 ccggatcccg gggactcccc gcgccgggaa tctcccgcca gctgcgcgct gagtccaggc
      121 gacggcagga gcacgtggag aggccgagta gccacagcgg cagctccagc ccggcccggc
      181 agcgacatgg aagatataca aacaaatgcg gaactgaaaa gcactcagga gcagtctgtg
      241 cccgcagaaa gtgcagcggt tttgaatgac tacagtttaa ccaaatctca tgaaatggaa
      301 aatgtggaca gtggagaagg cccagccaat gaagatgaag acataggaga tgattcaatg
      361 aaagtgaaag atgaatacag tgaaagagat gagaatgttt taaagtcaga acccatggga
      421 aatgcagaag agcctgaaat cccttacagc tattcaagag aatataatga atatgaaaac
      481 attaagttgg agagacatgt tgtctcattc gatagtagca ggccaaccag tggaaagatg
      541 aactgcgatg tgtgtggatt atcctgcatc agcttcaatg tcttaatggt tcataagcga
      601 agccatactg gtgaacgccc attccagtgt aatcagtgtg gggcatcttt tactcagaaa
      661 ggtaacctcc tccgccacat taaactgcac acaggggaaa aaccttttaa gtgtcacctc
      721 tgcaactatg catgccaaag aagagatgcg ctcacggggc atcttaggac acattctgtg
      781 gagaaaccct acaaatgtga gttttgtgga aggagttaca agcagagaag ttcccttgag
      841 gagcacaagg agcgctgccg tacatttctt cagagcactg acccagggga cactgcaagt
      901 gcggaggcaa gacacatcaa agcagagatg ggaagtgaaa gagctctcgt actggacaga
      961 ttagcaagca atgtggcaaa acgaaaaagc tcaatgcctc agaaattcat tggtgagaag
     1021 cgccactgct ttgatgtcaa ctataattca agttacatgt atgagaaaga gagtgagctc
     1081 atacagaccc gcatgatgga ccaagccatc aataacgcca tcagctatct tggcgccgaa
     1141 gccctgcgcc ccttggtcca gacaccgcct gctcccacct cggagatggt tccagttatc
     1201 agcagcatgt atcccatagc cctcacccgg gctgagatgt caaacggtgc ccctcaagag
     1261 ctggaaaaga aaagcatcca ccttccagag aagagcgtgc cttctgagag aggcctctct
     1321 cccaacaata gtggccacga ctccacggac actgacagca accatgaaga acgccagaat
     1381 cacatctatc agcaaaatca catggtcctg tctcgggccc gcaatgggat gccacttctg
     1441 aaggaggttc cccgctctta cgaactcctc aagcccccgc ccatctgccc aagagactcc
     1501 gtcaaagtga tcaacaagga aggggaggtg atggatgtgt atcggtgtga ccactgccgc
     1561 gtcctcttcc tggactatgt gatgttcacg attcacatgg gctgccacgg cttccgtgac
     1621 cctttcgagt gtaacatgtg tggatatcga agccatgatc ggtatgagtt ctcgtctcac
     1681 atagccagag gagaacacag agccctgctg aagtgaatat ctggtctcag ggattgctcc
     1741 tatgtattca gcatcgtttc taaaaaccaa tgacctcgcc taacagattg ctctcaaaac
     1801 atactcagtt ccaaacttct tttcatacca tttttagctg tgttcacagg ggtagccagg
     1861 gaaacactgt cttccttcag aaattattcg caggtctagc atattattac ttttgtgaaa
     1921 cctttgtttt cccatcaggg acttgaattt tatggaattt aaaagccaaa aaggtatttg
     1981 gtcattatct tctacagcag tggaatgagt ggtcccggag atgtgctata tgaaacattc
     2041 tttctgagat atatcaacca cacgtggaaa agcctttcag tcatacatgc aaatccacaa
     2101 agaggaagag ctgaccagct gaccttgctg ggaagcctca cccttctgcc cttcacaggc
     2161 tgaagggtta agatctaatc tccctaatct aaatgacagt ctaagagtaa gtaaaagaac
     2221 agccataaaa taagtatctg ttacgagtaa ctgaagaccc cattctccaa gcatcagatc
     2281 catttcctat cacaacattt ttaaaaaatg tcatctgatg gcacttctgc ttctgtcctt
     2341 taccttccca tctccagtga aaagctgagc tgctttgggc taaaccagtt gtctatagaa
     2401 gaaaatctat gccagaagaa ctcatggttt taaatataga ccatcatcga aactccagaa
     2461 atttatccac tgtggatgat gacatcgctt tcctttggtc aaggttggca gagcaagggt
     2521 ataaaggggg aaattgtttg gcagcaccaa cagaaaacaa acaaacaaaa aacagctacc
     2581 taaaacttct tgaaagagtt catggagaat tggtgataca gacccaaagc aaatttgcca
     2641 atgatatttt ccacaaaaaa agtccaaaaa gtatggctca gcctccccct ccccacagga
     2701 gaggaattgg agatagatgg catgtgtgtt tagatcggag ttgagctccg gaatggggtg
     2761 aggagggaca cctctattga gaggttctcc ttgatcaggc aggcttcggc cctttttttc
     2821 ccatttaaat ggaactgctg tattccatga aaattcctga aagtctgatc acggttctgc
     2881 agatgtataa gtcatccttg tcactcataa tatgtacata ctatcaggag gagtgctgtt
     2941 atcatggtaa aattagcact ggaataggag gtcacaaaat gctggctaat tagctatgtg
     3001 actttgagaa atcgtttaac tttttttttt tttttttttt tgagacagga tctcactctg
     3061 ttgcccaggc tggagtgcag tggtgcaatc atggctcagt gcagcctcga cctccccagg
     3121 ctcaggtgat cctcccacct cagcctcttg agtactggga caacaagtgc acaccaccat
     3181 gtctggctac attttgttct ttttgtagag ataggggtct cactatgttg cccatgctgg
     3241 tcttgaactc ctgggctcaa gcaatcagcc cgcctcagcc tcctaaagtg ctgggattac
     3301 aggtgtgagc caccacaccc agccttattt aactcttaaa actcagtttc cggccaggct
     3361 cggtggctca cacctgtaat cccaacactt tgggaagccg aggcaggcgc atcatttgag
     3421 gtcaggagtt cgagaccagc ctgacccaca tggtgaaacc ctgtctctac taaaaataca
     3481 aaaattagct gggcagtagt ggcacatgcc tgtaatccca gctactccgg aggctgaggc
     3541 agaaaaatcg cttaagcctg ggaggttgag gttgcggtga gtggagatca cactactgca
     3601 ctccagtctg ggcgacagag tgagaccctg tctcaaacaa aacaaaacaa aaacaaacaa
     3661 acaaaaacaa aaaaaactca gtttcctcat ccataaaata ggaattagat ttcaatgttc
     3721 tcttaggtcc cttctagctt taattcatat gtgattatgc agtaaccaca aggtattttt
     3781 taaacctcct aatgtatgga tattaagcag aagagtattt atatgaatac atgtttcaca
     3841 ttcctttggt atgaaaatgg tgtgttaagt ttttccttta accactgagt tgtgaatgtg
     3901 aagaaggtgg tggagaggaa caaaaaacag aaaggtattt tgatcttgcc acaaagcata
     3961 cacacaaatt ggcacatgca gctgtttgcc aaagccttct tttttttttt actttttaag
     4021 aaattatgtt agggaaaata aattctgctt ccagggacaa cttcatggag cctatttaca
     4081 aattaagagt cagcttaatt tgtaacattt ctaccagagc caagaatccc aaattcctgg
     4141 tagattagtg ttttatttct aaggggctta tgcattcggc tccaactcaa ctcgtctatg
     4201 tgctgccagt aattaaaatg ttccacctca gactgcacaa atggcttatc cttctttgtg
     4261 gcatggcgtc tgtctcagga aaaaaggttt tatgaaattc catggcaaca gtcccaacat
     4321 gtttgagact tcagctaaag gaatggatgt attttggtgt gtagtcttca gtatatcact
     4381 gtatttccgt aatactagac tccaagctat gccagattgc ttattccctt tgtgaaagag
     4441 gagttgctca ttacgttctt gaaatatcgc acatcctgtt ggttcttcaa gggacaagag
     4501 aaagagaatt tggaagcagg gattagtaga agagaaaacg agggaaagga agcctttcca
     4561 ccagattagt gttcaagtct ttgcagagga gaccaacttt ttttgttttc ttttgttttg
     4621 agacagtctc tcgctctgtt gcccaggctg gagtgcagtg gcgcgatctc ggctcacggc
     4681 aacctccgcc tcccgggttc aagcaattct cctgcctcag cctcccaagt agctgggatt
     4741 acaggtgctc accaccaagc ccggctaatt tttgtatttt tagtagagac aaggtttcac
     4801 catgttggcc aggccagtct caaactcctg acctcaggtg atctgcccgc cttggcctcc
     4861 cacagtgctg ggattacagg catgagctac cgcacccagc ctgagaccac cttttgcatc
     4921 tcaagattgt gaaaccaagg cccattccac cagcctgggg actcttttta tagatatgat
     4981 cctccttttt cctgtgacta atgaatttgc tgcatgattt ctattcttct gaggttagtt
     5041 ttctgagtaa ggtgaccact cacaaaggca ctttctttgt ggcattctga gcctagattg
     5101 gggcccatca attccagaaa aaatttatgt gtggaaactc tgcatcctta agtcttgaag
     5161 ttgaaccaga tatgcagtgg ttaccatcac acagataaac gctgccttct gtacataccc
     5221 cttatgctgt actaattaac aaaccccttg ccagggctgg ggaggtgagg gtgaaggaga
     5281 atcttagcag aagggcagag tcaggacttg catctgccac tgctgggcac tgaagccctg
     5341 gagcagcttc agatagtacc tgtactttct catgcagact ccctctgaac aagagccttg
     5401 taggcccctc tccttcattt cccaccagcc tcttatcagg cgggctttcc accatacacc
     5461 caggaggcca cggtctgagg aacaaccaaa cccatgcaaa gggccgggcg cgatagctca
     5521 cgcctgtaat gccagcactt tgggaggctg gggcaggcag atcacctgag gttgggagtt
     5581 cgagacctgc ctgaccaaca tggagaaacc cccatctcta ctaaaaatac aaaattagcc
     5641 gggcgtgatg gcacatgcct gtaatcccag ctactcagga ggctgaggca ggagaatcgc
     5701 ttgaacccgg gaggcggagg ttgcggtgag ccgagatggc accactgcac tccagcctcg
     5761 gcaacaagag cgaaactctg tctaaaacaa aaacaaacaa acaaacaaaa aaacccaggc
     5821 aaagtttcct tgcagccaag gtgacagaac tgggctgagg gtggaaaaga aacagaacca
     5881 gtgctccagg tgttttttaa ttttttaatt tatttttatt ttttttgtat atgtatatat
     5941 atgtatgtat attttagagg accagggtct cactatgttg cctaggccag actcaaactc
     6001 ctgtgctcaa gcaatcctgc ctcagcctcc caagtagctg ggattacagg catgcacaaa
     6061 caatgcccag ctctccaaat gttttctgtc actacctgaa gtgttgcatc ggtacttcct
     6121 acggaaagaa aactaaatag aagtgtctct cccgtgagcc cccaccacta ccaccagaaa
     6181 aaaaaaagag agaaaatgaa ctcatcagtc tttagtttcc tcaagttatt ctcccaaaaa
     6241 gacattcgcc ttggcacaga taagccagct aatcttatgc tttatgaccc actgtgagct
     6301 gttcctgaca cagcttctga ctttgtcagt gacaaaattt ctcacctttt aaatgcagtg
     6361 cttaacattt tgttaggccc atactcaaaa tcggccagat ataaaatgac ctcagatttt
     6421 gatctcctag gctcaaacaa tcctcctacc tcagcctccc aagtagctgg gactataggc
     6481 acaccaccat gcacagctaa ttttttttgt atttttctgc agagatggcg tttcgccata
     6541 ctgcccaggc tagtctcaaa atcctgggct caagcaatct gcccacctca gcctcccaaa
     6601 gtgctggaac tacaggcaag agccactgcg cccagccaca acctcagatt tctttggcaa
     6661 acagaaatgt ttaaaaacac aaaattttgc tcaggtgaaa cactgtgtta ctatcaaatc
     6721 tcacatccac ataaagtttt tcttttcggc tttgtttcgt gaggaacaga cagaacaaag
     6781 tttttccagg tagcatctgt atcactatta ttctcctatt tcctgtacca cccccacctc
     6841 cccaagccct actgaatgtg aggtttagaa tgttttaagg agggtcaggt gcggtggctc
     6901 acgcctgtaa tcccagcact ttgggaggcc aaggcgggcg gatcacctga gtttgggagt
     6961 tcgagaccag cctgaccaac atggagaaac cctgtctcta ctaaaaatac aaaattagcc
     7021 aggcgtggtg gcacatgcct gtaatcccag ctacttagga ggctgaggca ggagaatcgc
     7081 ttgaacccag gaggaggagg ttgtggtgag ccgagatcgt gccattgcac tccagcctgg
     7141 gtgacagagt gagactccat ctcgaaaaaa aaaatacaaa aattagctgg gtgtggtggt
     7201 gcacacctgt aatcccagct actcgggagg ctgacgcagg agaattgctt gaacctggga
     7261 ggtggaggtt gcagtgagcc gagatcgcgc cattgcaatc cagcctggac aacagagtga
     7321 gactccatct caaaaaaaaa aaaaaaaaga atgttttaag gaaaaaaata gtactgttac
     7381 atataatccc aggtgataag accacaatgg aaatgtttaa gtcctcactt taaagagtac
     7441 cccactgaga agaggtatgt tggactctag cagagatttg gaaactctgg gacactcaag
     7501 atgtgaaaga gcctggctat ctgaggactc aaagagtcag catcgggact tgtgagctca
     7561 agaagagaaa agggagtggt gaaactttgt cctaaaagtt agcaccagga acagaagaaa
     7621 aaaacccgat atatagtgat acctcatctt ttagagaatg ggaagctatt tttgtgttca
     7681 cacagaaagt atagttcaaa aaacctctat atccagagtt cagacaagga gaatgatttg
     7741 agatataagt gccgatgaag gaggtcaatt ttgatctgaa accagcagct ggacctgggc
     7801 cacctcagga aaaggactct gttctccaag gcagcacgac tgaatggttc tgagaataag
     7861 ccagggttca ggactcctga ccctttagga ccatggactc agaagagcct gaaggacaat
     7921 tgtgggcttt aaacttctga gagcttgtaa agtaacacaa gactgtgcct ctcccttgcc
     7981 ccagctgtag atagtctttg ccccaccatt gttatgaaga tacacagggt tttgcagttt
     8041 gaataaattg gatacaagtt tcctcttttt ttttttcttt ttgagacaaa gtctcgctct
     8101 gtttccccag gctgagtgca gtggcacaat caaggcttac ttgccgcctc aacctcctgg
     8161 gctcaagcaa cgagccatcc tcccgtctta gcctcccaac tagctgagac tacaggcgtg
     8221 ggtcaccaca cccagctaat ttttgtactt tttgtagaga cagggtctca ccatgttgcc
     8281 caggctggtc ctgaactcct gggctcaagt aatctgccca cctcagcctc ccaaagtgtt
     8341 ggggttacag gcgtgaggca ccgcggctgg cctgagtttc ttcttaatac tgtatcacaa
     8401 ttgtgggctg tcttatgtgt tgatatcgat tgagctattt gaaataggaa tgttaatggg
     8461 tgtattaaat ttttgtaagg atataacaat atctaccttc caaggatgtt gtgaggtttt
     8521 ccatgatttt gtatatgagc taatgttacc tttgaggggt ggtgtgcatt atgttggatg
     8581 attgtaaatt ttcagtggaa aatgtaccgt gtcctaaatt taaagacatg aaaaatatcc
     8641 caagatcata ctagatcata atagcaattc ctttacaaat gaattatgga ggtaactgat
     8701 ctctaacagt ttccttcatg ttgttttaat gcacaagggc agaggatctg ctgacccttg
     8761 gaaccagcgt gagctaacca cgtgctatag acacttcatg gtgtcgcacc cagggaagtc
     8821 aaagcgcttt gctccctcac tgtctgtgag tcctcagcca ttagtacccc accccccgct
     8881 gctccaaaac ttgagttatt tcaaatgttt ctcactgttc atctctccac tgaccccact
     8941 ccagaaagcc tggagagagt cccaagatgc cacccacctt ccccaatccc tcgccacaga
     9001 tctgtgtcta tctcacactc tgtaagtgcc gctttgcttc ttcctctctt gaaaagactg
     9061 agaacacaca ttttaacatg ttaggaaaat ggggcagcct aaaaaatgac tgatcccacc
     9121 gccagtgact catgtatact ccaggctagc agacaaggcc ctttttggtg ggcctgcttc
     9181 tgtgggttca cagaaaccaa attactgtgg gttgcaaaga attagcaggt catttacaaa
     9241 gcagacatcc cttcacccag actgtggttt tgcatgctca ggttctcagt ctatgagctt
     9301 tggtgcagga tcattttggc tactggaaaa accatagctt attttaaatt tctggttgcc
     9361 aaagccacca cacgtgtggt ctgtggatga ccattgtctg cagaatgacg aggaaggaac
     9421 agaatgtggt ttggggctca gggtggcctt cccactggga gggaaggcgg gagggagccc
     9481 ttgccctggg ttttgacaca gcctgtgctc acagcctctc ctctcatctg catttctcag
     9541 aaatgccctc cctgcccagt ggtgactttc cctcgtcact cctatggagt tctacctgga
     9601 gcccagccat gtgtggaact gtgaagttta ctcctctgta aagatggttt aaagaaagtc
     9661 agcttctgaa atgtaacaat gctaaccctt gctggaaccc tgtaagaaat agccctgctg
     9721 atagttttct aggtttatca tgtttgattt ttacactgaa aaataaaaaa atcctggtat
     9781 gtttgaaa
//
