LOCUS       NM_014002               3240 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens inhibitor of nuclear factor kappa B kinase subunit
            epsilon (IKBKE), transcript variant 1, mRNA.
ACCESSION   NM_014002 XM_375834
VERSION     NM_014002.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3240)
  AUTHORS   Wang,Y., Yang,Y., Liang,C. and Zhang,H.
  TITLE     Exploring the Roles of Key Mediators IKBKE and HSPA1A in
            Alzheimer's Disease and Hepatocellular Carcinoma through
            Bioinformatics Analysis
  JOURNAL   Int J Mol Sci 25 (13), 6934 (2024)
   PUBMED   39000042
  REMARK    GeneRIF: Exploring the Roles of Key Mediators IKBKE and HSPA1A in
            Alzheimer's Disease and Hepatocellular Carcinoma through
            Bioinformatics Analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3240)
  AUTHORS   Zhu,L., Guo,G., Jin,Y., Hu,A. and Liu,Y.
  TITLE     IKBKE regulates angiogenesis by modulating VEGF expression and
            secretion in glioblastoma
  JOURNAL   Tissue Cell 84, 102180 (2023)
   PUBMED   37573607
  REMARK    GeneRIF: IKBKE regulates angiogenesis by modulating VEGF expression
            and secretion in glioblastoma.
REFERENCE   3  (bases 1 to 3240)
  AUTHORS   Wegner,J., Hunkler,C., Ciupka,K., Hartmann,G. and Schlee,M.
  TITLE     Increased IKK protein stability ensures efficient type I interferon
            responses in conditions of TBK1 deficiency
  JOURNAL   Front Immunol 14, 1073608 (2023)
   PUBMED   36936901
  REMARK    GeneRIF: Increased IKK protein stability ensures efficient type I
            interferon responses in conditions of TBK1 deficiency.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3240)
  AUTHORS   Hiscott,J., Lacoste,J. and Lin,R.
  TITLE     Recruitment of an interferon molecular signaling complex to the
            mitochondrial membrane: disruption by hepatitis C virus NS3-4A
            protease
  JOURNAL   Biochem Pharmacol 72 (11), 1477-1484 (2006)
   PUBMED   16876765
REFERENCE   5  (bases 1 to 3240)
  AUTHORS   Wang,N., Ahmed,S. and Haqqi,T.M.
  TITLE     Genomic structure and functional characterization of the promoter
            region of human IkappaB kinase-related kinase IKKi/IKKvarepsilon
            gene
  JOURNAL   Gene 353 (1), 118-133 (2005)
   PUBMED   15939554
REFERENCE   6  (bases 1 to 3240)
  AUTHORS   Gangloff,M. and Gay,N.J.
  TITLE     MD-2: the Toll 'gatekeeper' in endotoxin signalling
  JOURNAL   Trends Biochem Sci 29 (6), 294-300 (2004)
   PUBMED   15276183
REFERENCE   7  (bases 1 to 3240)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
REFERENCE   8  (bases 1 to 3240)
  AUTHORS   Fitzgerald,K.A., McWhirter,S.M., Faia,K.L., Rowe,D.C., Latz,E.,
            Golenbock,D.T., Coyle,A.J., Liao,S.M. and Maniatis,T.
  TITLE     IKKepsilon and TBK1 are essential components of the IRF3 signaling
            pathway
  JOURNAL   Nat Immunol 4 (5), 491-496 (2003)
   PUBMED   12692549
  REMARK    GeneRIF: IKKepsilon and TBK1 have a pivotal role in coordinating
            the activation of IRF3 and NF-kappaB in the innate immune response.
REFERENCE   9  (bases 1 to 3240)
  AUTHORS   Peters,R.T., Liao,S.M. and Maniatis,T.
  TITLE     IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex
  JOURNAL   Mol Cell 5 (3), 513-522 (2000)
   PUBMED   10882136
REFERENCE   10 (bases 1 to 3240)
  AUTHORS   Shimada,T., Kawai,T., Takeda,K., Matsumoto,M., Inoue,J.,
            Tatsumi,Y., Kanamaru,A. and Akira,S.
  TITLE     IKK-i, a novel lipopolysaccharide-inducible kinase that is related
            to IkappaB kinases
  JOURNAL   Int Immunol 11 (8), 1357-1362 (1999)
   PUBMED   10421793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA990116.1, DB152295.1, BC105923.1, D63485.1 and CB243308.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014002.3.
            
            Summary: IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase
            (IKK) that is essential for regulating antiviral signaling
            pathways. IKBKE has also been identified as a breast cancer (MIM
            114480) oncogene and is amplified and overexpressed in over 30% of
            breast carcinomas and breast cancer cell lines (Hutti et al., 2009
            [PubMed 19481526]).[supplied by OMIM, Oct 2009].
            
            Transcript Variant: This variant (1) is the longest transcript and
            it encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D63485.1, BC105923.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000581977.7/ ENSP00000464030.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-510               DA990116.1         30-539
            511-715             DB152295.1         247-451
            716-2625            BC105923.1         697-2606
            2626-2717           D63485.1           2607-2698
            2718-3240           CB243308.1         20-542              c
FEATURES             Location/Qualifiers
     source          1..3240
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..3240
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /note="inhibitor of nuclear factor kappa B kinase subunit
                     epsilon"
                     /db_xref="GeneID:9641"
                     /db_xref="HGNC:HGNC:14552"
                     /db_xref="MIM:605048"
     exon            1..223
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            224..313
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            314..432
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..2496
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /EC_number="2.7.11.10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     inducible IkappaB kinase; IKK-related kinase epsilon;
                     IKK-epsilon; I-kappa-B kinase epsilon; inducible I kappa-B
                     kinase; inhibitor of kappa light polypeptide gene enhancer
                     in B-cells, kinase epsilon"
                     /codon_start=1
                     /product="inhibitor of nuclear factor kappa-B kinase
                     subunit epsilon isoform 1"
                     /protein_id="NP_054721.1"
                     /db_xref="CCDS:CCDS30996.1"
                     /db_xref="GeneID:9641"
                     /db_xref="HGNC:HGNC:14552"
                     /db_xref="MIM:605048"
                     /translation="MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTS
                     YLRPREVQVREFEVLRKLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPE
                     NAFGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGA
                     ARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGS
                     LPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQ
                     LVPILANILEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAI
                     FQEAVHKQTSVAPRHQEYLFEGHLCVLEPSVSAQHIAHTTASSPLTLFSTAIPKGLAF
                     RDPALDVPKFVPKVDLQADYNTAKGVLGAGYQALRLARALLDGQELMFRGLHWVMEVL
                     QATCRRTLEVARTSLLYLSSSLGTERFSSVAGTPEIQELKAAAELRSRLRTLAEVLSR
                     CSQNITETQESLSSLNRELVKSRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGL
                     GYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLV
                     GCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLH
                     MQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV"
     exon            433..573
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            574..703
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            704..885
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1046
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1157
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1337
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1528
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1593
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1685
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1772
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1848
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1961
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2038
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2078
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2180
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2277
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2390
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2462
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..3240
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3216..3221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /note="hexamer: AATAAA"
     polyA_site      3240
                     /gene="IKBKE"
                     /gene_synonym="IKK-E; IKK-i; IKKE; IKKI"
                     /note="major polyA site"
ORIGIN      
        1 agtgctgagc ttggtgtccc accgccacaa ggaggcaggg aagaaaccca ctagtcccag
       61 ctcctggggt ggcacagaca ttgcaactgg ccctgcctgt gggtcctagg ggcccttggc
      121 taccaggagg ctaagaacac tgctcatgaa tgacagtgag ccctgaaagc tctgggggtg
      181 tcacccagtc ccacaagcct gcatcccctg cagtggagat gggctcagct cctggacgtg
      241 ccacagacag aaagcataac atacactcgc caggaagagc ctttgcctga ctcagggcag
      301 ctcagagtgt ggggcagaag gtgaccagcc agctcagggc aggagatgca gagcacagcc
      361 aattacctgt ggcacacaga tgacctgctg gggcaggggg ccactgccag tgtgtacaag
      421 gcccgcaaca agaaatccgg agagctggtt gctgtgaagg tcttcaacac taccagctac
      481 ctgcggcccc gcgaggtgca ggtgagggag tttgaggtcc tgcggaagct gaaccaccag
      541 aacattgtca agctctttgc ggtggaggag acgggcggaa gccggcagaa ggtactggtg
      601 atggagtact gctccagtgg gagcctgctg agtgtgctgg agagccctga gaatgccttt
      661 gggctgcctg aggatgagtt cctggtggtg ctgcgctgtg tggtggccgg catgaaccac
      721 ctgcgggaga acggcattgt gcatcgcgac atcaagccgg ggaacatcat gcgcctcgta
      781 ggggaggagg ggcagagcat ctacaagctg acagacttcg gcgctgcccg ggagctggat
      841 gatgatgaga agttcgtctc ggtctatggg actgaggagt acctgcatcc cgacatgtat
      901 gagcgggcgg tgcttcgaaa gccccagcaa aaagcgttcg gggtgactgt ggatctctgg
      961 agcattggag tgaccttgta ccatgcagcc actggcagcc tgcccttcat cccctttggt
     1021 gggccacggc ggaacaagga gatcatgtac cggatcacca cggagaagcc ggctggggcc
     1081 attgcaggtg cccagaggcg ggagaacggg cccctggagt ggagctacac cctccccatc
     1141 acctgccagc tgtcactggg gctgcagagc cagctggtgc ccatcctggc caacatcctg
     1201 gaggtggagc aggccaagtg ctggggcttc gaccagttct ttgcggagac cagtgacatc
     1261 ctgcagcgag ttgtcgtcca tgtcttctcc ctgtcccagg cagtcctgca ccacatctat
     1321 atccatgccc acaacacgat agccattttc caggaggccg tgcacaagca gaccagtgtg
     1381 gccccccgac accaggagta cctctttgag ggtcacctct gtgtcctcga gcccagcgtc
     1441 tcagcacagc acatcgccca cacgacggca agcagccccc tgaccctctt cagcacagcc
     1501 atccctaagg ggctggcctt cagggaccct gctctggacg tccccaagtt cgtccccaaa
     1561 gtggacctgc aggcggatta caacactgcc aagggcgtgt tgggcgccgg ctaccaggcc
     1621 ctgcggctgg cacgggccct gctggatggg caggagctaa tgtttcgggg gctgcactgg
     1681 gtcatggagg tgctccaggc cacatgcaga cggactctgg aagtggcaag gacatccctc
     1741 ctctacctca gcagcagcct gggaactgag aggttcagca gcgtggctgg aacgcctgag
     1801 atccaggaac tgaaggcggc tgcagaactg aggtccaggc tgcggactct agcggaggtc
     1861 ctctccagat gctcccaaaa tatcacggag acccaggaga gcctgagcag cctgaaccgg
     1921 gagctggtga agagccggga tcaggtacat gaggacagaa gcatccagca gattcagtgc
     1981 tgtttggaca agatgaactt catctacaaa cagttcaaga agtctaggat gaggccaggg
     2041 cttggctaca acgaggagca gattcacaag ctggataagg tgaatttcag tcatttagcc
     2101 aaaagactcc tgcaggtgtt ccaggaggag tgcgtgcaga agtatcaagc gtccttagtc
     2161 acacacggca agaggatgag ggtggtgcac gagaccagga accacctgcg cctggttggc
     2221 tgttctgtgg ctgcctgtaa cacagaagcc cagggggtcc aggagagtct cagcaagctc
     2281 ctggaagagc tatctcacca gctccttcag gaccgagcaa agggggctca ggcctcgccg
     2341 cctcccatag ctccttaccc cagccctaca cgaaaggacc tgcttctcca catgcaagag
     2401 ctctgcgagg ggatgaagct gctggcatct gacctcctgg acaacaaccg catcatcgaa
     2461 cggctaaata gagtcccagc acctcctgat gtctgagctc catggggcac atgaggcatc
     2521 ctgaagcatt agaatgattc caacactgct cttctgcacc atgagaccaa cccagggcaa
     2581 gatcccatcc catcacatca gcctacctcc ctcctggctg ctggccagga tgtcgccagc
     2641 attaccttcc actgcctttc tccctgggaa gcagcacagc tgagactggg caccaggcca
     2701 cctctgttgg gacccacagg aaagagtgtg gcagcaactg cctggctgac ctttctatct
     2761 tctctaggct caggtactgc tcctccatgc ccatggctgg gccgtgggga gaagaagctc
     2821 tcatacgcct tcccactccc tctggtttat aggacttcac tccctagcca acaggagagg
     2881 aggcctcctg gggtttcccc agggcagtag gtcaaacgac ctcatcacag tcttccttcc
     2941 tcttcaagcg tttcatgttg aacacagctc tctccgctcc cttgtgattt ctgagggtca
     3001 ccactgccag cctcaggcaa catagagagc ctcctgttct ttctatgctt ggtctgactg
     3061 agcctaaagt tgagaaaatg ggtggccaag gccagtgcca gtgtcttggg gcccctttgg
     3121 ctctccctca ctctctgagg ctccagctgg tcctgggaca tgcagccagg actgtgagtc
     3181 tgggcaggtc caaggcctgc accttcaaga agtggaataa atgtggcctt tgcttctgtt
//
