LOCUS       NM_001556               3938 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens inhibitor of nuclear factor kappa B kinase subunit
            beta (IKBKB), transcript variant 1, mRNA.
ACCESSION   NM_001556 XM_032491
VERSION     NM_001556.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3938)
  AUTHORS   Chang,X., Guo,Y., Zhang,Q., Zheng,X., Cui,X., Hu,J., Zhang,Z.,
            Zhang,F. and Wang,X.
  TITLE     GRP78 recognizes EV-F 3D protein and activates NF-kappaB to repress
            virus replication by interacting with CHUK/IKBKB
  JOURNAL   J Virol 98 (6), e0026824 (2024)
   PUBMED   38775480
  REMARK    GeneRIF: GRP78 recognizes EV-F 3D protein and activates NF-kappaB
            to repress virus replication by interacting with CHUK/IKBKB.
REFERENCE   2  (bases 1 to 3938)
  AUTHORS   Iguchi,Y., Takahashi,Y., Li,J., Araki,K., Amakusa,Y., Kawakami,Y.,
            Kobayashi,K., Yokoi,S. and Katsuno,M.
  TITLE     IkappaB kinase phosphorylates cytoplasmic TDP-43 and promotes its
            proteasome degradation
  JOURNAL   J Cell Biol 223 (2) (2024)
   PUBMED   38197897
  REMARK    GeneRIF: IkappaB kinase phosphorylates cytoplasmic TDP-43 and
            promotes its proteasome degradation.
REFERENCE   3  (bases 1 to 3938)
  AUTHORS   Mahmood,A.A., Abbas,R.F. and Hussein,H.M.
  TITLE     Novel association between single-nucleotide polymorphisms of
            IKKbeta at rs17875746 and rs12676482 and periodontitis
  JOURNAL   Dent Med Probl 60 (4), 627-634 (2023)
   PUBMED   37930783
  REMARK    GeneRIF: Novel association between single-nucleotide polymorphisms
            of IKKbeta at rs17875746 and rs12676482 and periodontitis.
REFERENCE   4  (bases 1 to 3938)
  AUTHORS   Nie,Y., Mou,L., Long,Q., Deng,D., Hu,R., Cheng,J. and Wu,J.
  TITLE     SARS-CoV-2 ORF3a positively regulates NF-kappaB activity by
            enhancing IKKbeta-NEMO interaction
  JOURNAL   Virus Res 328, 199086 (2023)
   PUBMED   36894068
  REMARK    GeneRIF: SARS-CoV-2 ORF3a positively regulates NF-kappaB activity
            by enhancing IKKbeta-NEMO interaction.
REFERENCE   5  (bases 1 to 3938)
  AUTHORS   Sripathi,S.R., Hu,M.W., Turaga,R.C., Mikeasky,R., Satyanarayana,G.,
            Cheng,J., Duan,Y., Maruotti,J., Wahlin,K.J., Berlinicke,C.A.,
            Qian,J., Esumi,N. and Zack,D.J.
  TITLE     IKKbeta Inhibition Attenuates Epithelial Mesenchymal Transition of
            Human Stem Cell-Derived Retinal Pigment Epithelium
  JOURNAL   Cells 12 (8), 1155 (2023)
   PUBMED   37190063
  REMARK    GeneRIF: IKKbeta Inhibition Attenuates Epithelial Mesenchymal
            Transition of Human Stem Cell-Derived Retinal Pigment Epithelium.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3938)
  AUTHORS   Zandi,E., Rothwarf,D.M., Delhase,M., Hayakawa,M. and Karin,M.
  TITLE     The IkappaB kinase complex (IKK) contains two kinase subunits,
            IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and
            NF-kappaB activation
  JOURNAL   Cell 91 (2), 243-252 (1997)
   PUBMED   9346241
REFERENCE   7  (bases 1 to 3938)
  AUTHORS   DiDonato,J.A., Hayakawa,M., Rothwarf,D.M., Zandi,E. and Karin,M.
  TITLE     A cytokine-responsive IkappaB kinase that activates the
            transcription factor NF-kappaB
  JOURNAL   Nature 388 (6642), 548-554 (1997)
   PUBMED   9252186
REFERENCE   8  (bases 1 to 3938)
  AUTHORS   Schouten,G.J., Vertegaal,A.C., Whiteside,S.T., Israel,A.,
            Toebes,M., Dorsman,J.C., van der Eb,A.J. and Zantema,A.
  TITLE     IkappaB alpha is a target for the mitogen-activated 90 kDa
            ribosomal S6 kinase
  JOURNAL   EMBO J 16 (11), 3133-3144 (1997)
   PUBMED   9214631
REFERENCE   9  (bases 1 to 3938)
  AUTHORS   DiDonato,J., Mercurio,F., Rosette,C., Wu-Li,J., Suyang,H., Ghosh,S.
            and Karin,M.
  TITLE     Mapping of the inducible IkappaB phosphorylation sites that signal
            its ubiquitination and degradation
  JOURNAL   Mol Cell Biol 16 (4), 1295-1304 (1996)
   PUBMED   8657102
REFERENCE   10 (bases 1 to 3938)
  AUTHORS   Chen,Z.J., Parent,L. and Maniatis,T.
  TITLE     Site-specific phosphorylation of IkappaBalpha by a novel
            ubiquitination-dependent protein kinase activity
  JOURNAL   Cell 84 (6), 853-862 (1996)
   PUBMED   8601309
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA709000.1, AF080158.1,
            BC090865.1 and AI379342.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 27, 2018 this sequence version replaced NM_001556.2.
            
            Summary: The protein encoded by this gene phosphorylates the
            inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation
            of the inhibitor and activation of NF-kappa-B. The encoded protein
            itself is found in a complex of proteins. Several transcript
            variants, some protein-coding and some not, have been found for
            this gene. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.162535.1, AF080158.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000520810.6/ ENSP00000430684.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               DA709000.1         1-148
            149-3086            AF080158.1         106-3043
            3087-3928           BC090865.1         3111-3952
            3929-3938           AI379342.1         194-203             c
FEATURES             Location/Qualifiers
     source          1..3938
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.21"
     gene            1..3938
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /note="inhibitor of nuclear factor kappa B kinase subunit
                     beta"
                     /db_xref="GeneID:3551"
                     /db_xref="HGNC:HGNC:5960"
                     /db_xref="MIM:603258"
     exon            1..168
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            169..291
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..2457
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear factor NF-kappa-B inhibitor kinase beta; I-kappa-B
                     kinase 2; I-kappa-B-kinase beta; serine/threonine protein
                     kinase IKBKB; nuclear factor kappa B kinase subunit beta;
                     inhibitor of kappa light polypeptide gene enhancer in
                     B-cells, kinase beta"
                     /codon_start=1
                     /product="inhibitor of nuclear factor kappa-B kinase
                     subunit beta isoform 1"
                     /protein_id="NP_001547.1"
                     /db_xref="CCDS:CCDS6128.1"
                     /db_xref="GeneID:3551"
                     /db_xref="HGNC:HGNC:5960"
                     /db_xref="MIM:603258"
                     /translation="MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIK
                     QCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGG
                     DLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRL
                     IHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITG
                     FRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKW
                     LQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQ
                     SLKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDN
                     SKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQG
                     QRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSD
                     KLLLAWREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQ
                     ARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALE
                     LLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLS
                     QPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWS
                     WLQTEEEEHSCLEQAS"
     exon            292..386
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            387..504
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            505..574
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            575..663
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            664..753
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            754..878
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            879..986
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1116
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1311
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1426
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1550
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1702
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1764
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1874
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1924
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2024
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2172
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2300
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2391
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..3938
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3787..3792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /note="hexamer: AAGAAA"
     polyA_site      3814
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
     regulatory      3908..3913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /note="hexamer: AATAAA"
     polyA_site      3928
                     /gene="IKBKB"
                     /gene_synonym="IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A;
                     IMD15B; NFKBIKB"
                     /note="major polyA site"
ORIGIN      
        1 gtgacgtcag agcaggaagt gtttgaggaa gtcgcgccgc gctgcccgcg ttaagattcc
       61 cgcattttaa tgttttcagg ggggtgtcat agccccgggt ttggccgccc cagccccgcc
      121 ttccccgccc cggggagccc gccccctgcc ccgcgtccct gccgacagag ttagcacgac
      181 atcagtatga gctggtcacc ttccctgaca acgcagacat gtggggcctg ggaaatgaaa
      241 gagcgccttg ggacaggggg atttggaaat gtcatccgat ggcacaatca ggaaacaggt
      301 gagcagattg ccatcaagca gtgccggcag gagctcagcc cccggaaccg agagcggtgg
      361 tgcctggaga tccagatcat gagaaggctg acccacccca atgtggtggc tgcccgagat
      421 gtccctgagg ggatgcagaa cttggcgccc aatgacctgc ccctgctggc catggagtac
      481 tgccaaggag gagatctccg gaagtacctg aaccagtttg agaactgctg tggtctgcgg
      541 gaaggtgcca tcctcacctt gctgagtgac attgcctctg cgcttagata ccttcatgaa
      601 aacagaatca tccatcggga tctaaagcca gaaaacatcg tcctgcagca aggagaacag
      661 aggttaatac acaaaattat tgacctagga tatgccaagg agctggatca gggcagtctt
      721 tgcacatcat tcgtggggac cctgcagtac ctggccccag agctactgga gcagcagaag
      781 tacacagtga ccgtcgacta ctggagcttc ggcaccctgg cctttgagtg catcacgggc
      841 ttccggccct tcctccccaa ctggcagccc gtgcagtggc attcaaaagt gcggcagaag
      901 agtgaggtgg acattgttgt tagcgaagac ttgaatggaa cggtgaagtt ttcaagctct
      961 ttaccctacc ccaataatct taacagtgtc ctggctgagc gactggagaa gtggctgcaa
     1021 ctgatgctga tgtggcaccc ccgacagagg ggcacggatc ccacgtatgg gcccaatggc
     1081 tgcttcaagg ccctggatga catcttaaac ttaaagctgg ttcatatctt gaacatggtc
     1141 acgggcacca tccacaccta ccctgtgaca gaggatgaga gtctgcagag cttgaaggcc
     1201 agaatccaac aggacacggg catcccagag gaggaccagg agctgctgca ggaagcgggc
     1261 ctggcgttga tccccgataa gcctgccact cagtgtattt cagacggcaa gttaaatgag
     1321 ggccacacat tggacatgga tcttgttttt ctctttgaca acagtaaaat cacctatgag
     1381 actcagatct ccccacggcc ccaacctgaa agtgtcagct gtatccttca agagcccaag
     1441 aggaatctcg ccttcttcca gctgaggaag gtgtggggcc aggtctggca cagcatccag
     1501 accctgaagg aagattgcaa ccggctgcag cagggacagc gagccgccat gatgaatctc
     1561 ctccgaaaca acagctgcct ctccaaaatg aagaattcca tggcttccat gtctcagcag
     1621 ctcaaggcca agttggattt cttcaaaacc agcatccaga ttgacctgga gaagtacagc
     1681 gagcaaaccg agtttgggat cacatcagat aaactgctgc tggcctggag ggaaatggag
     1741 caggctgtgg agctctgtgg gcgggagaac gaagtgaaac tcctggtaga acggatgatg
     1801 gctctgcaga ccgacattgt ggacttacag aggagcccca tgggccggaa gcagggggga
     1861 acgctggacg acctagagga gcaagcaagg gagctgtaca ggagactaag ggaaaaacct
     1921 cgagaccagc gaactgaggg tgacagtcag gaaatggtac ggctgctgct tcaggcaatt
     1981 cagagcttcg agaagaaagt gcgagtgatc tatacgcagc tcagtaaaac tgtggtttgc
     2041 aagcagaagg cgctggaact gttgcccaag gtggaagagg tggtgagctt aatgaatgag
     2101 gatgagaaga ctgttgtccg gctgcaggag aagcggcaga aggagctctg gaatctcctg
     2161 aagattgctt gtagcaaggt ccgtggtcct gtcagtggaa gcccggatag catgaatgcc
     2221 tctcgactta gccagcctgg gcagctgatg tctcagccct ccacggcctc caacagctta
     2281 cctgagccag ccaagaagag tgaagaactg gtggctgaag cacataacct ctgcaccctg
     2341 ctagaaaatg ccatacagga cactgtgagg gaacaagacc agagtttcac ggccctagac
     2401 tggagctggt tacagacgga agaagaagag cacagctgcc tggagcaggc ctcatgatgt
     2461 ggggggactc gaccccctga catggggcag cccatagcag gccttgtgca gtggggggac
     2521 tcgaccccct gacatggggc tgcctggagc aggccgcgtg acgtggggct gcctggccgc
     2581 ggctctcaca tggtggttcc tgctgcactg atggcccagg ggtctctggt atccagatgg
     2641 agctctcgct tcctcagcag ctgtgacttt cacccaggac ccaggacgca gccctccgtg
     2701 ggcactgccg gcgccttgtc tgcacactgg aggtcctcca ttacagaggc ccagcgcaca
     2761 tcgctggccc cacaaacgtt caggggtaca gccatggcag ctccttcctc tgccgtgaga
     2821 aaagtgcttg gagtacggtt tgccacacac gtgactggac agtgtccaat tcaaatcttt
     2881 cagggcagag tccgagcagc gcttggtgac agcctgtcct ctcctgctct ccaaaggccc
     2941 tgctccctgt cctctctcac tttacagctt gtgtttcttc tggattcagc ttctcctaaa
     3001 cagacagttt aattatagtt gcggcctggc cccatcctca cttcctcttt ttatttcact
     3061 gctgctaaaa ttgtgttttt acctactact ttggtggttg tcctcttttc ggcaaagttg
     3121 gagcgagtgc caagctctcc atctgtggtc ctttctgcca agagcgactc atagtaacca
     3181 ggatgggaga gcagctgcct tattctgaat cccaaaaatt acttgggggt gattgtcaca
     3241 gaggagggac agaaagggta tctgctgacc accagcctgc ctacccatgc ccatgtctcc
     3301 attcctgctc aagcgtgtgt gctgggccgg ggagtccctg tctctcacag catctagcag
     3361 tattattaaa tggattcatt ttaaaaatag ctcctatatt ttgtaacatg tctcaaacac
     3421 tcatactggg ttccacaatc cactgttaga atacctatgg ttagggcttc tgaactaaaa
     3481 taatggaaaa ttttaacaat ttgtatagtg cctggatcat tactagtgcc ataaccctgc
     3541 ttcttcaaca tttcacagaa cttctctttt atataaaggc aagagcacaa aatgagttca
     3601 gatgatcaca aacaggtgag ttttgttgga gaagaaagtt ggagtaggag actttcacaa
     3661 gtggtttcca tggagataga atgaagcatt ctgtggtcaa gtaagtttag ggagctattc
     3721 atgtttcact tgctttgtgg agattcacac tatgcactgg gaaagtatct gaaaagtctt
     3781 ataataaaga aacaggctta actttgtgta agaacactgt ttatcaatgt catttggcta
     3841 tagaaacatt ttctcctgct gattgtgtgt gtgaaacatg tattaacatt ccaatgaact
     3901 agcatttaat aaagcacaat tttggaaacc ctggtaaa
//
