LOCUS       NM_153687               2902 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens IKBKB interacting protein (IKBIP), transcript variant
            1, mRNA.
ACCESSION   NM_153687
VERSION     NM_153687.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2902)
  AUTHORS   Hu,J., Dai,C., Ding,Z., Pan,Y., Lu,L., Bao,J. and Zheng,J.
  TITLE     IKBIP promotes tumor development via the akt signaling pathway in
            esophageal squamous cell carcinoma
  JOURNAL   BMC Cancer 24 (1), 759 (2024)
   PUBMED   38914958
  REMARK    GeneRIF: IKBIP promotes tumor development via the akt signaling
            pathway in esophageal squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2902)
  AUTHORS   Li,Q., Zhao,Z., Pei,F., Kang,C. and Duan,F.
  TITLE     IKBIP is a Predictive Biomarker Related to Immunosuppressive
            Microenvironment in Digestive System Malignancies
  JOURNAL   Discov Med 35 (174), 57-72 (2023)
   PUBMED   37024442
  REMARK    GeneRIF: IKBIP is a Predictive Biomarker Related to
            Immunosuppressive Microenvironment in Digestive System
            Malignancies.
REFERENCE   3  (bases 1 to 2902)
  AUTHORS   Li,K., Huang,G., Wang,Z., Yang,R., Zhang,W., Ni,B., Guan,J., Yi,G.,
            Li,Z., Zhu,Q., Peng,Q., Yang,L., Qi,L. and Liu,Y.
  TITLE     IKBIP, a novel glioblastoma biomarker, maintains abnormal
            proliferation of tumor cells by inhibiting the ubiquitination and
            degradation of CDK4
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (1), 166571 (2023)
   PUBMED   36244542
  REMARK    GeneRIF: IKBIP, a novel glioblastoma biomarker, maintains abnormal
            proliferation of tumor cells by inhibiting the ubiquitination and
            degradation of CDK4.
REFERENCE   4  (bases 1 to 2902)
  AUTHORS   Liang,J., Li,X., Xu,J., Cai,G.M., Cao,J.X. and Zhang,B.
  TITLE     hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621,
            hsa_circ_0072387, and hsa_circ_0072391 aggravate glioma via
            miR-338-5p/IKBIP
  JOURNAL   Aging (Albany NY) 13 (23), 25213-25240 (2021)
   PUBMED   34897031
  REMARK    GeneRIF: hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621,
            hsa_circ_0072387, and hsa_circ_0072391 aggravate glioma via
            miR-338-5p/IKBIP.
REFERENCE   5  (bases 1 to 2902)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2902)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2902)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   8  (bases 1 to 2902)
  AUTHORS   Thiebaut,R., Esmiol,S., Lecine,P., Mahfouz,B., Hermant,A.,
            Nicoletti,C., Parnis,S., Perroy,J., Borg,J.P., Pascoe,L.,
            Hugot,J.P. and Ollendorff,V.
  TITLE     Characterization and Genetic Analyses of New Genes Coding for NOD2
            Interacting Proteins
  JOURNAL   PLoS One 11 (11), e0165420 (2016)
   PUBMED   27812135
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2902)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   10 (bases 1 to 2902)
  AUTHORS   Hofer-Warbinek,R., Schmid,J.A., Mayer,H., Winsauer,G., Orel,L.,
            Mueller,B., Wiesner,Ch., Binder,B.R. and de Martin,R.
  TITLE     A highly conserved proapoptotic gene, IKIP, located next to the
            APAF1 gene locus, is regulated by p53
  JOURNAL   Cell Death Differ 11 (12), 1317-1325 (2004)
   PUBMED   15389287
  REMARK    GeneRIF: We conclude that IKIP is a novel p53 target gene with
            proapoptotic function.(IKIP1 protein, human)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM468651.1, BC058933.1, AJ539425.1 and AC013283.23.
            
            On Nov 23, 2018 this sequence version replaced NM_153687.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.233258.1, AJ539425.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267768 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299157.5/ ENSP00000299157.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                BM468651.1         264-335
            73-2170             BC058933.1         44-2141
            2171-2899           AJ539425.1         2194-2922
            2900-2902           AC013283.23        70859-70861         c
FEATURES             Location/Qualifiers
     source          1..2902
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.1"
     gene            1..2902
                     /gene="IKBIP"
                     /gene_synonym="IKIP"
                     /note="IKBKB interacting protein"
                     /db_xref="GeneID:121457"
                     /db_xref="HGNC:HGNC:26430"
                     /db_xref="MIM:609861"
     exon            1..266
                     /gene="IKBIP"
                     /gene_synonym="IKIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1221
                     /gene="IKBIP"
                     /gene_synonym="IKIP"
                     /note="isoform 1 is encoded by transcript variant 1; I
                     kappa B kinase interacting protein; inhibitor of nuclear
                     factor kappa-B kinase-interacting protein; IKK interacting
                     protein; i kappa-B kinase-interacting protein"
                     /codon_start=1
                     /product="inhibitor of nuclear factor kappa-B
                     kinase-interacting protein isoform 1"
                     /protein_id="NP_710154.1"
                     /db_xref="CCDS:CCDS9068.1"
                     /db_xref="GeneID:121457"
                     /db_xref="HGNC:HGNC:26430"
                     /db_xref="MIM:609861"
                     /translation="MSEVKSRKKSGPKGAPAAEPGKRSEGGKTPVARSSGGGGWADPR
                     TCLSLLSLGTCLGLAWFVFQQSEKFAKVENQYQLLKLETNEFQQLQSKISLISEKLES
                     TESILQEATSSMSLMTQFEQEVSNLQDIMHDIQNNEEVLTQRMQSLNEKFQNITDFWK
                     RSLEEMNINTDIFKSEAKHIHSQVTVQINSAEQEIKLLTERLKDLEDSTLRNIRTVKR
                     QEEEDLLRVEEQLGSDTKAIEKLEEEQHALFARDEDLTNKLSDYEPKVEECKTHLPTI
                     ESAIHSVLRVSQDLIETEKKMEDLTMQMFNMEDDMLKAVSEIMEMQKTLEGIQYDNSI
                     LKMQNELDILKEKVHDFIAYSSTGEKGTLKEYNIENKGIGGDF"
     exon            267..384
                     /gene="IKBIP"
                     /gene_synonym="IKIP"
                     /inference="alignment:Splign:2.1.0"
     exon            385..2902
                     /gene="IKBIP"
                     /gene_synonym="IKIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1560..1565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IKBIP"
                     /gene_synonym="IKIP"
                     /note="hexamer: AATAAA"
     polyA_site      1582
                     /gene="IKBIP"
                     /gene_synonym="IKIP"
                     /note="major polyA site"
     regulatory      2886..2891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IKBIP"
                     /gene_synonym="IKIP"
                     /note="hexamer: AATAGA"
     polyA_site      2902
                     /gene="IKBIP"
                     /gene_synonym="IKIP"
ORIGIN      
        1 agggttccca cgaacgccaa ggcggccacg tcctgctccc cctggtgaag aagctgccct
       61 gggcttgtcg tcctagggtc tccagacatg tctgaggtga agagccggaa gaagtcgggg
      121 cccaagggag cccctgctgc ggagcccggg aagcggagcg agggcgggaa gacccccgtg
      181 gcccggagca gcggaggcgg gggctgggca gacccccgaa cgtgcctgag cctgctgtcg
      241 ctggggacgt gcctgggcct ggcctggttt gtatttcagc agtcagaaaa atttgcaaag
      301 gtggaaaacc aataccagtt actgaaacta gaaaccaatg aattccaaca acttcaaagt
      361 aaaatcagtt taatttcaga aaagcttgag tctactgaaa gcatcctgca ggaagctaca
      421 tcatccatgt ctttgatgac ccagtttgag caggaagtat ccaacctcca agatatcatg
      481 catgacattc aaaataatga agaggtgctc actcaaagga tgcaaagcct taatgagaaa
      541 tttcagaata ttacggattt ctggaagaga agcctagaag aaatgaacat taatacagac
      601 attttcaaat cagaagcaaa acatatacat tctcaagtaa ctgtccaaat taactcagct
      661 gagcaggaaa taaaattgct cactgaacgg ctaaaagatt tggaagatag cacactaaga
      721 aatattagaa cagtaaaaag acaagaagaa gaagatctcc tgcgagtaga ggagcagcta
      781 ggctctgata caaaggcaat tgaaaagtta gaagaggaac agcatgccct ctttgccaga
      841 gatgaagatc tgactaataa actttccgac tacgaaccca aagttgaaga atgcaagaca
      901 catttgccaa caattgaaag tgctattcac tctgttctca gagtctctca ggatctgata
      961 gaaacagaaa agaaaatgga agacttgact atgcagatgt ttaatatgga agatgatatg
     1021 ctgaaagcag tgtctgaaat aatggagatg cagaaaaccc ttgaaggaat tcagtatgat
     1081 aatagcatat taaagatgca aaatgaactg gatattctaa aagaaaaagt tcatgatttt
     1141 atagcatact caagtacagg agaaaaggga actttaaaag aatataatat agaaaataaa
     1201 ggaattggtg gtgattttta aattcatgac atttattctg atgaaccata tcattataca
     1261 taaattgatt agtccattga ttttgagtta ctttgatacg cctcatctta tcctacatta
     1321 ttggaaaata aatgagatgt ccacacaaat ggattatcca cataatcaaa gcttatcttt
     1381 ttaagcacta aaacttactt cattgtaact atttgaaata gaaatagttc tttaaaaata
     1441 tttctctact tttaaaacaa gatacttaat atttttaatg ttttttaaag cattaatgaa
     1501 catcatcatt aatttcacct attatattgt acccacatat attgatgtct ccaggggcta
     1561 ataaagagta tttaccactt cactaaatga ccccaatttg ccattttcaa acctatgtct
     1621 catacctttt ctgtcacctg aacttactgt caggttggtt ggtaatgtgc ctgcctcagc
     1681 cagttcactt tcttaggtaa ttcactgcag gttaagaatc cacacaacca agttcatggg
     1741 aattttgtgt aaaataaaag ataacatgcc tgagggagag cctggtgcct ttgctatgaa
     1801 ttaatatgca ctttctgaaa actctaaagc ctgggaaaca ttttagtttt tgttaaggtt
     1861 ctaaactgtg ttacagatac ttgtaagact tttaaaatca gagtaagtat gttcttacat
     1921 aaggcctttc ttaggaatta tgtgtatata aatctttgaa atatctttat atacctgagt
     1981 tttaggttcc aactgtgtta gacatgagtt tgctagatcc atggtctcta gatggtttac
     2041 ttaaataggc caggcgcagt ggctcacacc tgtaatccta gcactttggg aggccgaggt
     2101 gggcagatca cgaagtcagg agatcaagac catctggcta acagggtgaa accctgtctc
     2161 tactaaaaaa tacaaaaaat tagccaggcg tggtggtggg tgcctgtagt cccagctact
     2221 caggaggctg aggcaggaga atggtgtgaa cccgggaggc agagcttgca gtgagccgag
     2281 atcgcgccac tgcactccag cctgagtggc aaagtgagac tctgtctcaa taaataaata
     2341 aataaataaa aataagcctg tggcctgttt tgagggaaaa gtaacataac tctgataatt
     2401 aattatgata ataactatga tagttaaaaa tacgtcattt taaagatttc ccaaaccaca
     2461 ccactaaatt tgttttatga attgatttta ttttatttga aattatataa tgtagtcaac
     2521 tgcaatatgg aagtttgttc ttgtttcttt gtcaataacc ttaccagttt tataatgcag
     2581 tttttgatgg aattaaacac aaagaacttg aaagcagtca gttacaaaaa ggtagttgtg
     2641 gtcaagtagt tttaatatgt aaatttgcaa gtttttggag aacccccaaa ctccttctcc
     2701 actggagtta ggagggcctg tggtagacag cgtgaatcat gaaaataagc ctggagagtt
     2761 ctgttattaa ggggcatagc attaattttt gcagtcttaa aattacactt cttgacttct
     2821 gaatgtctct tatttgcgtg cactgacaaa attctatttg tttactttta tattaatggt
     2881 aataaaatag attataaagt aa
//
