LOCUS       NM_001135050            4059 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens immunoglobulin superfamily member 9 (IGSF9),
            transcript variant 1, mRNA.
ACCESSION   NM_001135050
VERSION     NM_001135050.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4059)
  AUTHORS   Han,Y., Fu,Y., Shi,Q., Liu,H., Sun,H., Niu,C. and Fu,L.
  TITLE     The ALDH2, IGSF9, and PRDM16 Proteins as Predictive Biomarkers for
            Prognosis in Breast Cancer
  JOURNAL   Clin Breast Cancer 23 (3), e140-e150 (2023)
   PUBMED   36639264
  REMARK    GeneRIF: The ALDH2, IGSF9, and PRDM16 Proteins as Predictive
            Biomarkers for Prognosis in Breast Cancer.
REFERENCE   2  (bases 1 to 4059)
  AUTHORS   Li,Y., Deng,Y., Zhao,Y., Zhang,W., Zhang,S., Zhang,L., Wang,B.,
            Xu,Y. and Chen,S.
  TITLE     Immunoglobulin superfamily 9 (IGSF9) is trans-activated by p53,
            inhibits breast cancer metastasis via FAK
  JOURNAL   Oncogene 41 (41), 4658-4672 (2022)
   PUBMED   36088502
  REMARK    GeneRIF: Immunoglobulin superfamily 9 (IGSF9) is trans-activated by
            p53, inhibits breast cancer metastasis via FAK.
REFERENCE   3  (bases 1 to 4059)
  AUTHORS   Shi,Q., Shao,K., Jia,H., Cao,B., Li,W., Dong,S., Liu,J., Wu,K.,
            Liu,M., Liu,F., Zhou,H., Lv,J., Gu,F., Li,L., Zhu,S., Li,S., Li,G.
            and Fu,L.
  TITLE     Genomic alterations and evolution of cell clusters in metastatic
            invasive micropapillary carcinoma of the breast
  JOURNAL   Nat Commun 13 (1), 111 (2022)
   PUBMED   35013309
  REMARK    GeneRIF: Genomic alterations and evolution of cell clusters in
            metastatic invasive micropapillary carcinoma of the breast.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4059)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4059)
  AUTHORS   Koruyucu,M., Kasimoglu,Y., Seymen,F., Bayram,M., Patir,A.,
            Ergoz,N., Tuna,E.B., Gencay,K., Deeley,K., Bussaneli,D., Modesto,A.
            and Vieira,A.R.
  TITLE     Rethinking isolated cleft lip and palate as a syndrome
  JOURNAL   Oral Surg Oral Med Oral Pathol Oral Radiol 125 (4), 307-312 (2018)
   PUBMED   29500156
  REMARK    GeneRIF: In the group that combined individuals affected by
            isolated cleft lip and palate, tooth agenesis, supernumerary teeth,
            molar incisor hypomineralization, or dental caries, we found an
            association with rs622260 but not with the rs10798049 marker. We
            determined that the allele C of rs622260 was overrepresented in all
            individuals studied compared with a group of unrelated individuals
            who did not present any of
REFERENCE   6  (bases 1 to 4059)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 4059)
  AUTHORS   Doudney,K., Murdoch,J.N., Braybrook,C., Paternotte,C., Bentley,L.,
            Copp,A.J. and Stanier,P.
  TITLE     Cloning and characterization of Igsf9 in mouse and human: a new
            member of the immunoglobulin superfamily expressed in the
            developing nervous system
  JOURNAL   Genomics 79 (5), 663-670 (2002)
   PUBMED   11991715
REFERENCE   8  (bases 1 to 4059)
  AUTHORS   Bodily,K.D., Morrison,C.M., Renden,R.B. and Broadie,K.
  TITLE     A novel member of the Ig superfamily, turtle, is a CNS-specific
            protein required for coordinated motor control
  JOURNAL   J Neurosci 21 (9), 3113-3125 (2001)
   PUBMED   11312296
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513485.10, AB037776.1, CK299326.1 and AI758999.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001135050.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB037776.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368094.6/ ENSP00000357073.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AL513485.10        33705-33721         c
            18-71               AB037776.1         1-54
            72-72               AL513485.10        31706-31706         c
            73-3763             AB037776.1         56-3746
            3764-3999           CK299326.1         75-310              c
            4000-4059           AI758999.1         7-66                c
FEATURES             Location/Qualifiers
     source          1..4059
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.2"
     gene            1..4059
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /note="immunoglobulin superfamily member 9"
                     /db_xref="GeneID:57549"
                     /db_xref="HGNC:HGNC:18132"
                     /db_xref="MIM:609738"
     exon            1..41
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            42..273
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..3755
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; protein turtle homolog A; immunoglobulin
                     superfamily member 9A"
                     /codon_start=1
                     /product="protein turtle homolog A isoform a precursor"
                     /protein_id="NP_001128522.1"
                     /db_xref="CCDS:CCDS44254.1"
                     /db_xref="GeneID:57549"
                     /db_xref="HGNC:HGNC:18132"
                     /db_xref="MIM:609738"
                     /translation="MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLL
                     PPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVED
                     QGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVA
                     RGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHA
                     TQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQP
                     RVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPL
                     PIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGE
                     YSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVV
                     SWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSP
                     HVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGA
                     AHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPL
                     SPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTETELL
                     VPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVV
                     GGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSGSP
                     DSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMG
                     PTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPP
                     SPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPET
                     PPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGSLTSQSSGRGS
                     ASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNTSVDENYEW
                     DSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEARCAALR
                     EEFLAFRRRRDATRARLPAYRQPVPHPEQATLL"
     exon            274..462
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..615
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..770
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..888
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1030
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1176
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1319
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1460
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1577
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1728
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1852
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..2028
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2279
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2364
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2541
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2584
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..3445
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3573
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     exon            3574..4059
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4040..4045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /note="hexamer: AATAAA"
     polyA_site      4059
                     /gene="IGSF9"
                     /gene_synonym="FP18798; IGSF9A; Nrt1"
                     /note="major polyA site"
ORIGIN      
        1 attgtgtagc ggcgagagtg gagccgagcg gtgcggagca gatctggtgg ttctccggag
       61 agcagcttcc tcgggtgtta catgagccaa gccctcactg tacagaagag tgagagctga
      121 aacctgttcc ctgagctgat cagaaggaca tcccttggcc cctccatctg ggctcctgtg
      181 gataggaggg gctgggtgag caggccagct gggctatggt gtggtgcctc ggcctggccg
      241 tcctcagcct ggtcatcagc cagggggctg acggtcgagg gaagcctgag gtggtatcgg
      301 tggtgggccg ggctggggag agtgtggtgc tgggctgtga cctgctgccc ccggccggcc
      361 ggccccccct gcatgtcatc gagtggctgc gctttggatt cctgcttccc atcttcatcc
      421 agttcggcct ctactctccc cgaattgacc ctgattacgt gggacgagtc cggctgcaga
      481 agggggcctc tctccagatt gagggtctcc gggtggaaga ccagggctgg tacgagtgcc
      541 gcgtgttctt cctggaccag cacatccctg aagacgattt tgctaacggc tcctgggtgc
      601 atctgacagt caattcaccc cctcaattcc aggagacacc tcctgctgtg ttggaagtgc
      661 aggaactgga gcctgtgacc ctgcgttgtg tggcccgtgg cagccccctg cctcatgtga
      721 cgtggaagct ccgaggaaag gaccttggcc agggccaggg ccaggtgcaa gtgcagaacg
      781 ggacgctgcg gatccgccgg gtagagcgag gcagctctgg ggtctacacc tgccaagcct
      841 ccagcactga gggcagcgcc acccacgcca cccagctgct agtgctagga cccccagtca
      901 tcgtggtgcc ccccaagaac agcacagtca atgcctccca ggatgtttca ttggcctgcc
      961 atgctgaggc ataccctgct aacctcacct acagctggtt ccaggacaac atcaatgtct
     1021 tccacattag ccgcctgcag ccccgggtgc ggatcctggt ggacgggagc ctgcggctgc
     1081 tggccaccca gcctgatgat gccggctgct acacctgtgt gcccagcaat ggcctcctgc
     1141 atccaccctc agcctctgcc tacctcactg tgctctaccc agcccaggtg acagctatgc
     1201 ctcctgagac acccctgccc ataggcatgc cgggggtgat ccgctgcccg gttcgtgcca
     1261 accccccact gctctttgtc agctggacca aggatggaaa ggccctgcag ctggacaagt
     1321 tccctggctg gtcccagggc acagaaggct cactgatcat cgccctgggg aacgaggatg
     1381 ccctgggaga atactcctgc accccctaca acagtcttgg taccgccggg ccctctcctg
     1441 tgacccgcgt gctgctcaag gctcccccag cttttataga gcggcccaag gaagaatatt
     1501 tccaagaagt agggcgggag ctgctcatcc cctgctccgc ccaaggggac cctcctcctg
     1561 ttgtctcttg gaccaaggtg ggccgggggc tgcaaggcca ggcccaggtg gacagcaaca
     1621 gcagcctcat cctgcgacca ttgaccaagg aggcccacgg gcactgggaa tgcagtgcca
     1681 gcaatgctgt ggcccgagtg gccacctcca cgaacgtcta cgtgctgggc actagccctc
     1741 atgttgtcac caatgtgtcc gtggtggctt tgcccaaggg tgccaatgtc tcctgggagc
     1801 ctggctttga tggtggttat ctgcagagat tcagtgtctg gtacacccca ctggccaagc
     1861 gtcctgaccg aatgcaccat gactgggtgt ccttggcagt gcctgtgggg gctgctcacc
     1921 tcctagtgcc agggctgcag ccccacaccc agtaccagtt cagcgtgcta gctcagaaca
     1981 agctggggag tggtcccttc agcgaaatcg tcttgtctgc tccggaaggg cttcctacca
     2041 cgccagctgc acccgggctt cccccaacag agataccgcc tcccctgtcc cctccgcggg
     2101 gtctggtggc agtgaggaca ccccgggggg tactcctgca ttgggatccc ccagagctgg
     2161 tccctaagag actggatggc tacgtcttgg aaggccggca aggctcccag ggctgggagg
     2221 tgctggaccc ggctgtggca ggcacagaaa cagagctgct ggtgccaggc ctcatcaagg
     2281 atgttctcta cgagttccgc ctcgtggcct tcgcgggcag cttcgtcagc gaccccagca
     2341 acacggccaa cgtctccact tccggtctgg aggtctaccc ttcgcgcacg cagctgccgg
     2401 gcctcctgcc tcagcccgtg ctggccggcg tggtgggcgg agtctgcttt ctgggagtgg
     2461 ccgtccttgt gagcatcctg gccggctgcc tcctgaaccg gcgcagggct gcccgccgcc
     2521 gccgcaagcg cctccgccaa gatccacctc ttatcttctc tccgaccggg aagtcagctg
     2581 caccctctgc tctgggctca ggcagtcctg acagcgtggc gaagctgaag ctccagggat
     2641 ccccagtccc cagcctgcgc cagagtctgc tctgggggga tcctgccgga actcccagcc
     2701 cccacccgga tcctccatct agccggggac ccttacctct ggagcccatt tgccggggcc
     2761 cagacgggcg ctttgtgatg gggcccactg tggcggcccc ccaggaaagg tcaggccggg
     2821 agcaggcaga acctcggact ccagcccagc gtctggcccg gtcctttgac tgtagcagca
     2881 gcagccccag tggggcaccc cagcccctct gcattgaaga catcagccct gtggcacccc
     2941 ctccagcagc cccacccagt cccttgccag gtcctggacc cctgctccag tacctgagcc
     3001 tgcccttctt ccgagagatg aatgtggatg gggactggcc cccgcttgag gagcccagcc
     3061 ctgctgcacc cccagattac atggataccc ggcgctgtcc cacctcatct ttccttcgtt
     3121 ctccagaaac ccctcctgta tcccccaggg aatcacttcc tggggctgtg gtaggggctg
     3181 gggccactgc agagccccct tacacagccc tggctgactg gacactgagg gagcggctgc
     3241 tgccaggcct tctccctgct gcccctcgag gcagcctcac cagccagagc agtgggcgag
     3301 gcagcgcttc gttcctgcgg cccccctcca cagccccctc tgcaggaggc agctacctca
     3361 gccctgctcc aggagacacc agcagctggg ccagtggccc tgagagatgg ccccgaaggg
     3421 agcatgtggt gacagtcagc aagaggagga acacatctgt ggacgagaac tatgagtggg
     3481 actcagaatt ccctggggac atggaattgc tggagacttt gcacctgggc ttggccagct
     3541 cccggctcag acctgaagct gagccagagc taggtgtgaa gactccagag gagggctgcc
     3601 tcctgaacac tgcccatgtt actggccctg aggcccgctg tgctgccctt cgggaggaat
     3661 tcctggcctt ccgccgccgc cgagatgcta ctagggctcg gctaccagcc tatcgacagc
     3721 cagtccccca ccccgaacag gccactctgc tgtgaacatc cctgatgtga ggctgtgaaa
     3781 aggcatatgg acctgcaaag gaggccccca accagacaga cctagtttca aacgagggca
     3841 ctgcccctgc ctgccccttt ggtgcccagg cacagaccct gatagtgggt ttgggtcacc
     3901 ttggtatgga atgtatgtgc tgacccccta ggtgagtctg gggattggaa cagggatctt
     3961 aggtctgcct ctctctctct ctctctctct ctctctctct ctgtgtgtgt gtgtgtgtgt
     4021 gtgaagtttt ttacaggtga ataaacaaag tttgaaaga
//
