LOCUS       NM_005849               2720 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens immunoglobulin superfamily member 6 (IGSF6), mRNA.
ACCESSION   NM_005849
VERSION     NM_005849.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2720)
  AUTHORS   Zheng,Q., Wang,T., Jiang,G., Li,M., Zhang,Z., Chen,Y. and Tian,X.
  TITLE     Immunoglobulin superfamily 6 is a molecule involved in the
            anti-tumor activity of macrophages in lung adenocarcinoma
  JOURNAL   BMC Cancer 23 (1), 1170 (2023)
   PUBMED   38037023
  REMARK    GeneRIF: Immunoglobulin superfamily 6 is a molecule involved in the
            anti-tumor activity of macrophages in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2720)
  AUTHORS   King,K., Moody,A., Fisher,S.A., Mirza,M.M., Cuthbert,A.P.,
            Hampe,J., Sutherland-Craggs,A., Sanderson,J., MacPherson,A.J.,
            Forbes,A., Mansfield,J., Schreiber,S., Lewis,C.M. and Mathew,C.G.
  TITLE     Genetic variation in the IGSF6 gene and lack of association with
            inflammatory bowel disease
  JOURNAL   Eur J Immunogenet 30 (3), 187-190 (2003)
   PUBMED   12786995
  REMARK    GeneRIF: There was no evidence for association of the common IGSF6
            single nucleotide polymorphisms with disease in a large cohort of
            patients with inflammatory bowel disease
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2720)
  AUTHORS   Bates,E.E., Kissenpfennig,A., Peronne,C., Mattei,M.G., Fossiez,F.,
            Malissen,B. and Lebecque,S.
  TITLE     The mouse and human IGSF6 (DORA) genes map to the inflammatory
            bowel disease 1 locus and are embedded in an intron of a gene of
            unknown function
  JOURNAL   Immunogenetics 52 (1-2), 112-120 (2000)
   PUBMED   11132146
REFERENCE   4  (bases 1 to 2720)
  AUTHORS   Bates,E.E., Dieu,M.C., Ravel,O., Zurawski,S.M., Patel,S.,
            Bridon,J.M., Ait-Yahia,S., Vega,F. Jr., Banchereau,J. and
            Lebecque,S.
  TITLE     CD40L activation of dendritic cells down-regulates DORA, a novel
            member of the immunoglobulin superfamily
  JOURNAL   Mol Immunol 35 (9), 513-524 (1998)
   PUBMED   9809579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC017844.1, AJ223183.1, CD369238.1 and AC092719.3.
            
            On Nov 22, 2018 this sequence version replaced NM_005849.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223286.1, SRR1660803.175963.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268389.6/ ENSP00000268389.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               BC017844.1         1-225
            226-236             AJ223183.1         260-270
            237-569             BC017844.1         237-569
            570-829             AJ223183.1         604-863
            830-972             AJ223183.1         865-1007
            973-986             CD369238.1         19-32               c
            987-2720            AC092719.3         36916-38649         c
FEATURES             Location/Qualifiers
     source          1..2720
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.2"
     gene            1..2720
                     /gene="IGSF6"
                     /gene_synonym="DORA"
                     /note="immunoglobulin superfamily member 6"
                     /db_xref="GeneID:10261"
                     /db_xref="HGNC:HGNC:5953"
                     /db_xref="MIM:606222"
     exon            1..77
                     /gene="IGSF6"
                     /gene_synonym="DORA"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..736
                     /gene="IGSF6"
                     /gene_synonym="DORA"
                     /note="down-regulated by activation (immunoglobulin
                     superfamily)"
                     /codon_start=1
                     /product="immunoglobulin superfamily member 6 precursor"
                     /protein_id="NP_005840.2"
                     /db_xref="CCDS:CCDS10599.1"
                     /db_xref="GeneID:10261"
                     /db_xref="HGNC:HGNC:5953"
                     /db_xref="MIM:606222"
                     /translation="MGTASRSNIARHLQTNLILFCVGAVGACTLSVTQPWYLEVDYTH
                     EAVTIKCTFSATGCPSEQPTCLWFRYGAHQPENLCLDGCKSEADKFTVREALKENQVS
                     LTVNRVTSNDSAIYICGIAFPSVPEARAKQTGGGTTLVVREIKLLSKELRSFLTALVS
                     LLSVYVTGVCVAFILLSKSKSNPLRNKEIKEDSQKKKSARRIFQEIAQELYHKRHVET
                     NQQSEKDNNTYENRRVLSNYERP"
     exon            78..437
                     /gene="IGSF6"
                     /gene_synonym="DORA"
                     /inference="alignment:Splign:2.1.0"
     exon            438..544
                     /gene="IGSF6"
                     /gene_synonym="DORA"
                     /inference="alignment:Splign:2.1.0"
     exon            545..595
                     /gene="IGSF6"
                     /gene_synonym="DORA"
                     /inference="alignment:Splign:2.1.0"
     exon            596..676
                     /gene="IGSF6"
                     /gene_synonym="DORA"
                     /inference="alignment:Splign:2.1.0"
     exon            677..2720
                     /gene="IGSF6"
                     /gene_synonym="DORA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      960..965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGSF6"
                     /gene_synonym="DORA"
                     /note="hexamer: AAGAAA"
     polyA_site      986
                     /gene="IGSF6"
                     /gene_synonym="DORA"
                     /note="major polyA site"
     regulatory      2344..2349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGSF6"
                     /gene_synonym="DORA"
                     /note="hexamer: AATAAA"
     polyA_site      2367
                     /gene="IGSF6"
                     /gene_synonym="DORA"
                     /note="major polyA site"
     regulatory      2679..2684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGSF6"
                     /gene_synonym="DORA"
                     /note="hexamer: AATAAA"
     polyA_site      2716
                     /gene="IGSF6"
                     /gene_synonym="DORA"
ORIGIN      
        1 atacacagaa atggggactg cgagcagaag caacatcgct cgccatctgc aaaccaatct
       61 cattctattt tgtgtcggtg ctgtgggcgc ctgtactctc tctgtcacac aaccgtggta
      121 cctagaagtg gactacactc atgaggccgt caccataaag tgtaccttct ccgcaaccgg
      181 atgcccttct gagcaaccaa catgcctgtg gtttcgctac ggtgctcacc agcctgagaa
      241 cctgtgcttg gacgggtgca aaagtgaggc agacaagttc acagtgaggg aggccctcaa
      301 agaaaaccaa gtttccctca ctgtaaacag agtgacttca aatgacagtg caatttacat
      361 ctgtggaata gcattcccca gtgtgccgga agcgagagct aaacagacag gaggagggac
      421 cacactggtg gtaagagaaa ttaagctgct cagcaaggaa ctgcggagct tcctgacagc
      481 tcttgtatca ctgctctctg tctatgtgac cggtgtgtgc gtggccttca tactcctctc
      541 caaatcaaaa tccaaccctc taagaaacaa agaaataaaa gaagactcac aaaagaagaa
      601 gagtgctcgg cgtatttttc aggaaattgc tcaagaacta taccataaga gacatgtgga
      661 aacaaatcag caatctgaga aagataacaa cacttatgaa aacagaagag tactttccaa
      721 ctatgaaagg ccatagaaac gttttaattt tcaatgaagt cactgaaaat ccaactccag
      781 gagctatggc agtgttaatg aacatatatc atcaggtctt aaaaaaaaat aaaggtaaac
      841 tgaaaagaca actggctaca aagaaggatg tcagaatgta aggaaactat aactaatagt
      901 cattaccaaa atactaaaac ccaacaaaat gcaactgaaa aataccttcc aaatttgcca
      961 agaaaaaaaa ttctatttta aacttgtatc ctgagtctgt ttcattcaac atgagatgtg
     1021 tgatgactgc catcctgaag atctgaagcc aaaccatgtg cctcagtctt gagtggaaga
     1081 atcaccttta tggtttgtgg aaatcatggc acaattaaaa taagttggga gggacaacgt
     1141 gacaaaattt gagttagaga cattcatttt gaaaagcacc ttagtaaagt tatttcctct
     1201 gatgttgtaa tggggcagtg gggtaacgca catttgcctg ccagggtatg caaagtaact
     1261 tacatcatgc tatcagcaaa atgagaataa tatagtggct agagtaagac cataaaagcc
     1321 aaaatacaga aaatccaaag ctgaaggtta aacagaggta acttcagaac aaataagcca
     1381 caacggactc tagatgtcag tgttgtgcca aataacagca ccagggaaga tgtgggcaac
     1441 acatctactt tacaagcacg tttgtaatac tgattttttt tcttttcttt tttttttttt
     1501 tttgagacag agtctcgttc tgttgcccag ggtggagtgc agtggtgcaa tctcggctca
     1561 ctacaacctc cacctcccgg gttcatgcca ttcttctgcc tcagtttccc aagtagctgg
     1621 gattacaggt acgcaccacc acgcccggct aatttttttt tttttttttt tttgtatttt
     1681 tagtagagac ggggtttcac catgttggcc aggctggtct caaactcaag acctcagatg
     1741 atctgcctga aatggcctcc caaagtgctg ggattacagg cgtgagccac cgcgcacagt
     1801 ctataatact gatttttaac caatttagga gggaaatgtc agataggagg catggtacaa
     1861 ggatatttat ggaattcatt accacttcac taagaaaaca tgatataaat tgtcctttga
     1921 aagctacttt ggtataaaaa aatctaaagt gcccataagt atgcattcat tattagacac
     1981 aaattacaac cttacaacct actatgttta tttcattaaa gtgtctcttt taggccgggt
     2041 gtggtggctc acgcctgtaa tcccaacact ttgggaggct gaggcaggtg aatcatgaga
     2101 tcaggagttc gagaccagcc tgaacaacat gatgaaaccc gtctctacta aaaatacaaa
     2161 aaaatttagc ggggtttggt ggcacacacc tgtaatccca gctatttggg aggctgaggc
     2221 aggagatcac ttgaacccag gatgcggagg ttgcagtgag ctgagatcac gccactgcac
     2281 cccagcctag gtgacagagc aagactgtct caaaaataaa taaataaata aataaataaa
     2341 taaaataaag tgtttctttt aaactggtat tgcctaaggt gtattcttta taaaacttag
     2401 aattgttaaa tattttaaga ttcctttgaa agtgtttttg cattgatggt ttaaatcagt
     2461 gatatcaaac tttcctgatc ctatgtgccc agaaaaatgg gcaggggaaa ggaggcagca
     2521 tggaacctca tttttttgtg tgtatctgtg tgtacacgtg agtgcacatg tgtatatgtg
     2581 tggggccaca tgtgttttgt atacggtata tgcatgaaaa tgtacctttg taccttatac
     2641 acaaaaacaa attaaacaat ggcataagca gcaatataaa taaaaaatgc taatactttc
     2701 ctgccatatt ccaaaataaa
//
