LOCUS       NM_001205280            1056 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens immunoglobulin superfamily member 23 (IGSF23), mRNA.
ACCESSION   NM_001205280 XM_097278
VERSION     NM_001205280.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1056)
  AUTHORS   Yuan,Y., Yang,L., Liu,T., Zhang,H. and Lu,Q.
  TITLE     Osteoclastogenesis inhibition by mutated IGSF23 results in human
            osteopetrosis
  JOURNAL   Cell Prolif 52 (6), e12693 (2019)
   PUBMED   31560140
REFERENCE   2  (bases 1 to 1056)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC243964.3, BX112065.1 and
            BG197674.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001205280.1.
            
            Summary: This gene encodes a protein that has one immunoglobulin
            (Ig) domain and is a member of the immunoglobulin superfamily.
            Proteins in this superfamily are usually found on or in cell
            membranes and act as receptors in immune response pathways.
            [provided by RefSeq, Nov 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX112065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2152474
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402988.6/ ENSP00000385592.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC243964.3         128671-128737       c
            68-768              BX112065.1         1-701
            769-1056            BG197674.1         145-432
FEATURES             Location/Qualifiers
     source          1..1056
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..1056
                     /gene="IGSF23"
                     /note="immunoglobulin superfamily member 23"
                     /db_xref="GeneID:147710"
                     /db_xref="HGNC:HGNC:40040"
     exon            1..208
                     /gene="IGSF23"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..662
                     /gene="IGSF23"
                     /codon_start=1
                     /product="immunoglobulin superfamily member 23"
                     /protein_id="NP_001192209.1"
                     /db_xref="CCDS:CCDS54277.1"
                     /db_xref="GeneID:147710"
                     /db_xref="HGNC:HGNC:40040"
                     /translation="MRAKPQSPLPRNPVPAWSPPTTTTDPMLEKDAAGGDFPANLVLQ
                     LMPLKTFPAAIRGVIQSELNYSVILQWVVTMDPEPVLSWTFSGVPCGMGEKLFIRRLS
                     CEQLGTYMCIATNSKKQLVSEPVTISLPKPIMQPTEAEPMEPDPTLSLSGGSAIGLLA
                     AGILGAGALIAGMCFIIIQSLRTDRQRIGICS"
     exon            209..474
                     /gene="IGSF23"
                     /inference="alignment:Splign:2.1.0"
     exon            475..628
                     /gene="IGSF23"
                     /inference="alignment:Splign:2.1.0"
     exon            629..693
                     /gene="IGSF23"
                     /inference="alignment:Splign:2.1.0"
     exon            694..1056
                     /gene="IGSF23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1037..1042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGSF23"
                     /note="hexamer: AATAAA"
     polyA_site      1056
                     /gene="IGSF23"
                     /note="major polyA site"
ORIGIN      
        1 attccttgcc tttgatgtga gtgataggag cgggcgattc tgcttctccc tccatctccc
       61 ggcggggatt gtacggtgag agaatgagag caaaacctca gagccccctt cccaggaacc
      121 ctgtcccagc ctggtcccca cccaccacca ccactgaccc gatgctagag aaggatgcgg
      181 ctggaggtga cttcccagcc aacttggtcc tccaactaat gccactgaag acattcccag
      241 ctgctatccg gggagtcatc cagagtgagc tcaactattc tgtgatcctg cagtgggtgg
      301 tgacaatgga ccctgagcct gtgctgagct ggaccttcag tggggtgccc tgtgggatgg
      361 gagagaagct gttcatccga cggttgtcct gtgagcagct gggcacctac atgtgcatag
      421 ccacaaacag caagaaacag ctggtctctg agcctgtaac catctcgctg ccaaaaccca
      481 tcatgcagcc cacagaagca gagcccatgg agccagaccc cactctgtcc ctgtcaggag
      541 gctctgccat cgggctcctt gcggctggga tcctgggagc cggggcactg attgcaggca
      601 tgtgtttcat catcatccag agcctaagga ctgacaggca gagaatagga atatgcagct
      661 gaaatgtggg caactctcct gtcagctgaa gagatgggtg ctttgtacct ctctatccac
      721 gtggaaaaaa aaacccatcc catagcttcc aagtctacaa catctctgtt caagggaaca
      781 acccaacgta accagactcc ctttgccctg tttctgaaac acctgaagaa aacatctgat
      841 gggttgactc ggtgccatcc ttggtcccat cgccgtgaca cgttgtgcaa gcaaagcatc
      901 agaggctcat ccctgtctgt gggagctcag tgctcagaaa acagggggga ggttttacct
      961 tggaaattgg ccagacccca aaatatgtct tttacacatg ctgctttttt tttctctttt
     1021 tcaaaaagaa ccaaaaaata aattaaaaca ccacca
//
