LOCUS       NM_173588               4285 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens immunoglobulin superfamily member 22 (IGSF22),
            transcript variant 1, mRNA.
ACCESSION   NM_173588
VERSION     NM_173588.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4285)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103974.6.
            
            On Jan 3, 2019 this sequence version replaced NM_173588.3.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1968189
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000513874.6/ ENSP00000421191.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AC103974.6         155882-155996
            116-257             AC103974.6         157801-157942
            258-389             AC103974.6         160029-160160
            390-526             AC103974.6         160399-160535
            527-626             AC103974.6         161785-161884
            627-666             AC103974.6         161967-162006
            667-844             AC103974.6         162177-162354
            845-958             AC103974.6         163342-163455
            959-1121            AC103974.6         163977-164139
            1122-1394           AC103974.6         165070-165342
            1395-1679           AC103974.6         166354-166638
            1680-1804           AC103974.6         167446-167570
            1805-1946           AC103974.6         167652-167793
            1947-2243           AC103974.6         167922-168218
            2244-2546           AC103974.6         169686-169988
            2547-2720           AC103974.6         171242-171415
            2721-2849           AC103974.6         171615-171743
            2850-3146           AC103974.6         172387-172683
            3147-3235           AC103974.6         173775-173863
            3236-3428           AC103974.6         174074-174266
            3429-3728           AC103974.6         174857-175156
            3729-4058           AC103974.6         175924-176253
            4059-4285           AC103974.6         177532-177758
FEATURES             Location/Qualifiers
     source          1..4285
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..4285
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /note="immunoglobulin superfamily member 22"
                     /db_xref="GeneID:283284"
                     /db_xref="HGNC:HGNC:26750"
     exon            1..115
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            116..257
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..4129
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /codon_start=1
                     /product="immunoglobulin superfamily member 22"
                     /protein_id="NP_775859.4"
                     /db_xref="CCDS:CCDS41625.2"
                     /db_xref="GeneID:283284"
                     /db_xref="HGNC:HGNC:26750"
                     /translation="MTTIHSRQMLQEHVSMEFSSSTTHVQTFSQTTKIVGEEVVRRKS
                     SSIVEFFSLVTRSSNIPAGDSVPEFVEKPQPVTAPEGDKAVFRARVQGNAKPHISWKR
                     ESGIPIKESAKIFYDSINKEHVLKLEPLTSDDSDNYKCIASNDHADAIYTVSLLVTEG
                     QEKMDFKKMLKKRAPPAPKKKQKKVANEKEMLEILSKVPKKDFEKVCMEYGFTDFRGL
                     LRKLKEMKKKVEVEAIRILKPLEDKETKVDTTVVFDCIMELKDPNVKMIWIKGTEPLR
                     IQYSLGKYDVKQMGTKYMLVISNVNMNDAGIYSLSVGDKRMSAELTVLDEPLKFLGEM
                     KPVKVTERQTAVFEIRLSKKEPNFVWKFNGKELKRDDKYEITVSEDGLTHTLKIKDAR
                     LSDSGEFSAEAGNLVQKAQLTVDRIPIKFVSNLKNVRVKERSRACLECELTSKDVTLR
                     WKKDGQLLMHGTKYSMNHEGKRAELIIEDAQLSDGGEYTVVAMQDGDPTEYYSTAIVT
                     VEERLATVKSGMSDVHAATGSPAELCVVLNDEKVEGVWLKDGKEITDLPGMQIVKQGA
                     VHKLIFPSMGPEHEGKYTFRAKGTESEASVFIADPPTIDPSVLEALAAHAITVKVGHT
                     AHIKVPFRGKPLPKVTWYKDGMEVTEEERVSMERGEDQALLTISNCVREDSGLILLKL
                     KNDHGSATATLHLSVLDRPKPPQGRVEFLELSGSCVHMKWKAPKDNGGRPVTQFIVER
                     RAVGKKSWIKIGEVDGKVTNFSTNKVEEGKAYQFRILAVNSEGVSDPLETEEVFAGNP
                     IEPPGFASQPQVTDVTKEAVTITWNAPTQDGGAPVLGYIVERRKKGSNLWVPVNKDPI
                     QGTKCTVDGLLEDTEYEFRVIAVNKAGPGQPSVPSSSVVAKDPVKPPGLVQDLHVSDS
                     SNSSISLAWREPAEGDPPSGYILEMRAEDTKEWSKCTKIPISGTCYTVGGLIERQKYF
                     FRIRAVNEAGVGEPVELDKGVRAMPPPAAPKFDLSARLKSHMVVRAGTALCIHAAFSG
                     SPPPDVIWQKDGVPTKGRETITKSKNHSQFLINSTKRSDSGVYRILLQNEFGEARYDI
                     HVRVADFPRPPTNLRLFEEVPNTVTLTWNHSPDVQEDGEAHYIIMKRDASTATWYTAA
                     ERVFSNKYTVTGLLPGRKYYFRVVARNEIGDSEPLDSRDTWLINKDQIQDLSAKLKPY
                     EKKDWRHAPRFVTPLKPHTVLRGQDCTMTCAFLGNPRPTVTLYKGDVNITANSKFWYN
                     STSGVCTLVIPTCTLKDSGDYSVLVENELGKDRSSCTLTVYDKDDKSVVASITESLQK
                     KSKHLM"
     exon            258..389
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            390..526
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            527..626
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            627..666
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            667..844
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..958
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1121
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1394
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1679
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1804
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1946
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2243
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2546
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2720
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2849
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..3146
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3235
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3428
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..3728
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3729..4058
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4059..4285
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4266..4271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /note="hexamer: AATAAA"
     polyA_site      4285
                     /gene="IGSF22"
                     /gene_synonym="IGFN2"
                     /note="major polyA site"
ORIGIN      
        1 actgttgggg caaaggaaga aggagacggg ccaccctaca gtccaggcac tagctgagcc
       61 tccaaagccg tggacacagc attcgagtgt tgggagggac tggtcagtgc tgaagtctca
      121 caggtgagtg cccacgcctg ctgtcaccat gacaaccatt cacagccggc agatgctgca
      181 ggagcacgtg tccatggagt tctccagctc caccacccac gtgcagacct tctcccagac
      241 aaccaagatc gtgggagagg aggtcgtgag gaggaagtcc tcgagcatag tggagttctt
      301 cagcttagtg acccggagct caaacatccc tgcgggcgac agcgtccctg agttcgtgga
      361 gaagcctcaa ccggtcaccg cgcccgaggg ggacaaagcc gtgttccgag cccgggtgca
      421 ggggaacgcc aaaccccaca tctcctggaa gagggagagc ggcatcccca tcaaggagtc
      481 cgccaagata ttctacgaca gcattaacaa ggaacacgtg ctgaagctgg agccactgac
      541 ttcggatgac tctgacaact ataagtgcat tgcaagcaat gaccatgcag atgccatcta
      601 taccgtatct ctgctggtaa cagaaggtca agagaaaatg gacttcaaaa agatgctgaa
      661 gaagagggca ccccctgctc ccaagaagaa gcagaagaag gtggcaaatg agaaagagat
      721 gctggagatt ttgtccaaag tgcccaagaa agactttgag aaggtgtgca tggagtatgg
      781 tttcaccgac tttcgggggc tgctcaggaa gctcaaagag atgaagaaga aagtagaggt
      841 ggaggccatc cggattctga agcccctgga agacaaagag accaaggttg acaccacagt
      901 ggtctttgac tgcataatgg aactgaaaga ccccaatgtc aagatgatat ggatcaaggg
      961 tactgagcca ctgaggatcc agtactccct gggcaagtac gatgtgaagc agatgggcac
     1021 caagtacatg ctggttatta gcaacgtgaa catgaacgat gctggcatct acagcctgtc
     1081 cgtgggcgat aagcggatga gtgcagagct cacagtgctg gatgagccac tgaagttcct
     1141 gggagagatg aagcctgtga aggtgacaga gcgccagaca gctgtgtttg agatccgcct
     1201 ctccaagaaa gagcccaact ttgtgtggaa gttcaatggg aaggagctga agagggatga
     1261 caagtatgaa atcacggtgt ccgaagatgg tctgacgcac acgcttaaga ttaaggatgc
     1321 cagactcagt gacagcggcg agttctctgc tgaggcgggg aacctggtac aaaaggccca
     1381 gctcactgtt gaccgcatcc ccatcaagtt tgtgagcaac ctcaaaaatg tacgtgtgaa
     1441 agagaggagt cgcgcatgcc tggagtgtga gctgacatcc aaggatgtga cactgcgctg
     1501 gaagaaggat gggcagctgc tgatgcatgg cactaagtac agcatgaacc atgagggcaa
     1561 gcgagcagag ctgatcattg aggatgcaca gctcagtgat ggtggcgagt acactgtggt
     1621 ggccatgcag gatggagacc ctactgaata ctacagtact gccatcgtca ctgtggagga
     1681 gcgtctggcc acagtgaaga gcgggatgtc cgacgtgcac gcggccactg ggagcccagc
     1741 tgagttgtgt gtagtgctga atgacgagaa ggtggagggt gtgtggctga aggatggcaa
     1801 ggagatcacg gacttgccag gcatgcagat tgtgaagcag ggtgcagtgc acaagctcat
     1861 ctttcccagt atgggccctg agcacgaggg caagtacaca ttccgggcca agggcacgga
     1921 aagtgaagcc tctgtattca tcgcagatcc tcctaccatc gacccgtcag tactggaggc
     1981 actggctgcg cacgccatca ctgtgaaggt aggccacacg gcccacatca aggtcccctt
     2041 ccggggaaaa ccactgccca aagtgacatg gtacaaggat ggcatggaag tgacggagga
     2101 ggaacgcgtg tccatggagc gcggggaaga ccaggcactg ctcaccatct ccaactgtgt
     2161 gcgtgaagac agcggcctca tcctgctcaa gctcaagaat gaccacggct cagccacggc
     2221 cactctgcac cttagtgtgc tggaccgtcc aaagcctcca cagggccggg tggagttcct
     2281 ggagctctca ggtagttgtg tgcacatgaa gtggaaggcc ccaaaggaca atggtggacg
     2341 acctgtgaca cagttcatag tggaacggag ggcagttggc aagaagtcct ggattaagat
     2401 aggcgaggtg gacggcaaag tcaccaactt ctccaccaac aaggtggaag agggaaaagc
     2461 ctaccagttc cgtatcctgg cagtcaattc agaaggtgtg agtgacccac tggagacaga
     2521 agaagtgttt gcaggaaatc ccatagagcc tcctggtttt gcctcccagc ctcaagtgac
     2581 tgatgtgact aaagaagccg tgaccatcac gtggaatgcc cctacccagg atgggggagc
     2641 cccagtgctc ggctacattg tagaacgaag gaagaaaggc agcaacctgt gggtgccagt
     2701 caacaaggac cccatccagg gcaccaagtg cactgtggat ggtctcctgg aggacacaga
     2761 atatgaattc cgagttatag ctgtaaataa ggcaggccct ggacagccca gtgtgccatc
     2821 cagctcagta gtggccaagg atcctgttaa acccccaggc ctggtccagg acctgcatgt
     2881 atctgattcc tccaactcca gcatttccct ggcctggcgg gagcctgcag agggagaccc
     2941 accctctggc tacatccttg agatgagggc tgaagacaca aaggagtggt ccaagtgcac
     3001 aaagatcccc atctcaggca cctgctacac agtgggagga ctcatcgaga ggcagaaata
     3061 cttcttccga atccgggctg tgaatgaggc tggggttggg gagcctgtgg agctagacaa
     3121 gggggtccgt gccatgccac caccagctgc acccaagttt gacctcagtg cccggctgaa
     3181 gagtcacatg gtggttcgcg ctgggacagc cctctgcatc catgcagcct tctctggctc
     3241 accaccacct gacgtgatct ggcagaaaga tggcgttccc accaagggcc gagagacaat
     3301 taccaagagc aaaaaccact cccagttcct cattaatagc accaagcgct ctgactcagg
     3361 ggtgtaccga atcttgcttc agaatgagtt tggagaagca cgctatgaca tccatgtgcg
     3421 cgtggcagat ttccctcggc cccccacaaa cctacggttg tttgaggaag tccccaacac
     3481 agtgactctg acctggaacc acagcccaga tgtgcaggag gacggtgagg ctcactacat
     3541 catcatgaag cgggatgcaa gcacagccac ctggtacacg gcagccgagc gtgtcttcag
     3601 caacaagtac acagtgacgg ggctgctccc aggcaggaag tactacttca gagtggtggc
     3661 tcggaatgaa atcggtgaca gtgagccact tgactccagg gacacctggc tcatcaataa
     3721 ggaccagatc caggacctga gcgccaagct caagccctac gagaagaagg actggcgcca
     3781 cgcgccgcgc ttcgtgacgc ccctcaagcc acacacggtg ctccgcggcc aggactgcac
     3841 catgacctgc gccttccttg ggaacccgcg gcccacagtg accctctaca agggcgacgt
     3901 caacatcacg gccaactcca agttctggta caactccacc agcggcgtgt gcaccctcgt
     3961 catccccacc tgcacgctca aggacagcgg cgattacagc gtgctggtgg agaacgagct
     4021 gggcaaggac cgcagcagct gcacgctcac cgtctatgac aaagatgata agtcagttgt
     4081 agcatccatc accgagagtc tgcagaagaa atcaaagcac ctcatgtgag ctccagccaa
     4141 gcccaggcat caggaggctg ttatgatgtg gagtttcttg gcctgtcctc tgcatggccc
     4201 agtgtaggaa gcccagtttg ctctctggtg tttgttaatg taaacattca gtgaagggat
     4261 ggggcaataa acgtaactca tcctt
//
