LOCUS       NM_032880               1892 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens immunoglobin superfamily member 21 (IGSF21), mRNA.
ACCESSION   NM_032880
VERSION     NM_032880.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1892)
  AUTHORS   Tanabe,Y., Naito,Y., Vasuta,C., Lee,A.K., Soumounou,Y.,
            Linhoff,M.W. and Takahashi,H.
  TITLE     IgSF21 promotes differentiation of inhibitory synapses via binding
            to neurexin2alpha
  JOURNAL   Nat Commun 8 (1), 408 (2017)
   PUBMED   28864826
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1892)
  AUTHORS   Lin,X., Wang,J., Yun,L., Jiang,S., Li,L., Chen,X., Li,Z., Lu,Q.,
            Zhang,Y. and Ma,X.
  TITLE     Association between LEKR1-CCNL1 and IGSF21-KLHDC7A gene
            polymorphisms and diabetic retinopathy of type 2 diabetes mellitus
            in the Chinese Han population
  JOURNAL   J Gene Med 18 (10), 282-287 (2016)
   PUBMED   27607899
  REMARK    GeneRIF: Results suggest that LEKR1-CCNL1 and IGSF21-KLHDC7A gene
            polymorphisms influence the development of diabetic retinopathy
            (DR).
REFERENCE   3  (bases 1 to 1892)
  AUTHORS   Grassi,M.A., Tikhomirov,A., Ramalingam,S., Below,J.E., Cox,N.J. and
            Nicolae,D.L.
  TITLE     Genome-wide meta-analysis for severe diabetic retinopathy
  JOURNAL   Hum Mol Genet 20 (12), 2472-2481 (2011)
   PUBMED   21441570
REFERENCE   4  (bases 1 to 1892)
  AUTHORS   Kerns,S.L., Ostrer,H., Stock,R., Li,W., Moore,J., Pearlman,A.,
            Campbell,C., Shao,Y., Stone,N., Kusnetz,L. and Rosenstein,B.S.
  TITLE     Genome-wide association study to identify single nucleotide
            polymorphisms (SNPs) associated with the development of erectile
            dysfunction in African-American men after radiotherapy for prostate
            cancer
  JOURNAL   Int J Radiat Oncol Biol Phys 78 (5), 1292-1300 (2010)
   PUBMED   20932654
REFERENCE   5  (bases 1 to 1892)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK075316.1, BC007618.1 and
            AL356101.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_032880.4.
            
            Summary: This gene encodes a protein which has two immunoglobulin
            (Ig) domains and is a member of the immunoglobulin superfamily.
            Proteins in this superfamily are usually found on or in cell
            membranes and act as receptors in immune response pathways.
            [provided by RefSeq, Sep 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007618.1, AK075316.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251296.4/ ENSP00000251296.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AK075316.1         53-80
            29-1776             BC007618.1         1-1748
            1777-1777           AL356101.10        18622-18622
            1778-1892           BC007618.1         1750-1864
FEATURES             Location/Qualifiers
     source          1..1892
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..1892
                     /gene="IGSF21"
                     /note="immunoglobin superfamily member 21"
                     /db_xref="GeneID:84966"
                     /db_xref="HGNC:HGNC:28246"
     exon            1..401
                     /gene="IGSF21"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..1735
                     /gene="IGSF21"
                     /note="immunoglobulin superfamily member 21"
                     /codon_start=1
                     /product="immunoglobulin superfamily member 21 precursor"
                     /protein_id="NP_116269.3"
                     /db_xref="CCDS:CCDS184.1"
                     /db_xref="GeneID:84966"
                     /db_xref="HGNC:HGNC:28246"
                     /translation="MRTAPSLRRCVCLLLAAILDLARGYLTVNIEPLPPVVAGDAVTL
                     KCNFKTDGRMREIVWYRVTDGGTIKQKIFTFDAMFSTNYSHMENYRKREDLVYQSTVR
                     LPEVRISDNGPYECHVGIYDRATREKVVLASGNIFLNVMAPPTSIEVVAADTPAPFSR
                     YQAQNFTLVCIVSGGKPAPMVYFKRDGEPIDAVPLSEPPAASSGPLQDSRPFRSLLHR
                     DLDDTKMQKSLSLLDAENRGGRPYTERPSRGLTPDPNILLQPTTENIPETVVSREFPR
                     WVHSAEPTYFLRHSRTPSSDGTVEVRALLTWTLNPQIDNEALFSCEVKHPALSMPMQA
                     EVTLVAPKGPKIVMTPSRARVGDTVRILVHGFQNEVFPEPMFTWTRVGSRLLDGSAEF
                     DGKELVLERVPAELNGSMYRCTAQNPLGSTDTHTRLIVFENPNIPRGTEDSNGSIGPT
                     GARLTLVLALTVILELT"
     exon            402..514
                     /gene="IGSF21"
                     /inference="alignment:Splign:2.1.0"
     exon            515..636
                     /gene="IGSF21"
                     /inference="alignment:Splign:2.1.0"
     exon            637..755
                     /gene="IGSF21"
                     /inference="alignment:Splign:2.1.0"
     exon            756..871
                     /gene="IGSF21"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1346
                     /gene="IGSF21"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1432
                     /gene="IGSF21"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1625
                     /gene="IGSF21"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1664
                     /gene="IGSF21"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1892
                     /gene="IGSF21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1865..1870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGSF21"
                     /note="hexamer: ATTAAA"
     polyA_site      1892
                     /gene="IGSF21"
                     /note="major polyA site"
ORIGIN      
        1 gattcggctc caaactccgg cgctgcagcc gatcggactc tgggccgcgg tgggcaccgc
       61 gcgcagctag ggagccgaga accgcggcga gccccgagga cgcccagagc gcgagggtcg
      121 ctgcgcctcg cagagccgga gccgagtcga gccgggcgcc cgggctgcct ggccgcggcg
      181 gcatgggggc gcccccgcgg ctctccgcgc tgcccgccac cgcctcggcc agtggccgga
      241 ggcaggagcg cgtctgagcc catggcgagg ggacccgccg ccaccgcctc cacccccgcc
      301 gccccgccac cgccgccagc tcccgggcac catgcgaacc gccccgagcc tccgccgctg
      361 cgtctgcctg ctgctcgccg cgatcctgga cctggcgcgc ggctacctga cagtcaacat
      421 tgagcctctc ccccctgtgg tggctggaga cgccgtgact ttgaagtgta acttcaagac
      481 agatgggcgc atgcgggaga tcgtgtggta ccgggtgacg gatggtggca ccatcaagca
      541 aaagatcttc accttcgacg ccatgttctc caccaactac tcacacatgg agaactaccg
      601 caagcgagag gacctggtgt accagtccac tgtgaggctg cccgaggtcc ggatctcaga
      661 caatggtccc tatgagtgcc atgtgggcat ctacgaccgc gccaccaggg agaaggtggt
      721 cctggcatca ggcaacatct tcctcaacgt catggctcct cccacctcca ttgaagtggt
      781 ggctgctgac acaccagccc ccttcagccg ctaccaagcc cagaacttca cgctggtctg
      841 catcgtgtct ggaggaaaac cagcacccat ggtttatttc aaacgagatg gggaaccaat
      901 cgacgcagtg cccctatcag agccaccagc tgcgagctcc ggccccctac aggacagcag
      961 gcccttccgc agccttctgc accgtgacct ggatgacacc aagatgcaga agtcactgtc
     1021 cctcctggac gccgagaacc ggggtgggcg accctacacg gagcgcccct cccgtggcct
     1081 gaccccagat cccaacatcc tcctccagcc aaccacagag aacataccag agacggtcgt
     1141 gagccgtgag tttccccgct gggtccacag cgccgagccc acctacttcc tgcgccacag
     1201 ccgcaccccg agcagtgacg gcactgtgga agtacgtgcc ctgctcacct ggaccctcaa
     1261 cccacagatc gacaacgagg ccctcttcag ctgcgaggtc aagcacccag ctctgtcgat
     1321 gcccatgcag gcagaggtca cgctggttgc ccccaaagga cccaaaattg tgatgacgcc
     1381 cagcagagcc cgggtagggg acacagtgag gattctggtc catgggtttc agaacgaagt
     1441 cttcccggag cccatgttca cgtggacgcg ggttgggagc cgcctcctgg acggcagcgc
     1501 tgagttcgac gggaaggagc tggtgctgga gcgggttccc gccgagctca atggctccat
     1561 gtatcgctgc accgcccaga acccactggg ctccaccgac acgcacaccc ggctcatcgt
     1621 gtttgaaaac ccaaatatcc caagaggaac ggaggactct aatggttcca ttggccccac
     1681 tggtgcccgg ctcaccttgg tgctcgccct gacagtgatt ctggagctga cgtgaaggca
     1741 cccgccccgg ccactccatc aggcactgac atctccacga ccggttttca tttcttttct
     1801 aaactatttc cagtcttgtt cttagtctct ttccatctgt gtcttggctt cttcagtcgg
     1861 tttaattaaa acaaacagaa caattttccc ca
//
