LOCUS       NM_178822               8562 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens immunoglobulin superfamily member 10 (IGSF10),
            transcript variant 1, mRNA.
ACCESSION   NM_178822
VERSION     NM_178822.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8562)
  AUTHORS   Ling,B., Ye,G., Qin,C., Liao,X., Yang,R., Su,L. and Qi,G.
  TITLE     IGSF10 inhibits the metastasis of lung adenocarcinoma via the
            Spi-B/Integrin-beta1 signaling pathway
  JOURNAL   J Biochem Mol Toxicol 38 (4), e23693 (2024)
   PUBMED   38622980
  REMARK    GeneRIF: IGSF10 inhibits the metastasis of lung adenocarcinoma via
            the Spi-B/Integrin-beta1 signaling pathway.
REFERENCE   2  (bases 1 to 8562)
  AUTHORS   Budny,B., Zemojtel,T., Kaluzna,M., Gut,P., Niedziela,M.,
            Obara-Moszynska,M., Rabska-Pietrzak,B., Karmelita-Katulska,K.,
            Stajgis,M., Ambroziak,U., Bednarczuk,T., Wrotkowska,E.,
            Bukowska-Olech,E., Jamsheer,A., Ruchala,M. and Ziemnicka,K.
  TITLE     SEMA3A and IGSF10 Are Novel Contributors to Combined Pituitary
            Hormone Deficiency (CPHD)
  JOURNAL   Front Endocrinol (Lausanne) 11, 368 (2020)
   PUBMED   32612575
  REMARK    GeneRIF: SEMA3A and IGSF10 Are Novel Contributors to Combined
            Pituitary Hormone Deficiency (CPHD).
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8562)
  AUTHORS   Howard,S.R., Guasti,L., Ruiz-Babot,G., Mancini,A., David,A.,
            Storr,H.L., Metherell,L.A., Sternberg,M.J., Cabrera,C.P.,
            Warren,H.R., Barnes,M.R., Quinton,R., de Roux,N., Young,J.,
            Guiochon-Mantel,A., Wehkalampi,K., Andre,V., Gothilf,Y.,
            Cariboni,A. and Dunkel,L.
  TITLE     IGSF10 mutations dysregulate gonadotropin-releasing hormone
            neuronal migration resulting in delayed puberty
  JOURNAL   EMBO Mol Med 8 (6), 626-642 (2016)
   PUBMED   27137492
  REMARK    GeneRIF: These data strongly suggest that mutations in IGSF10 cause
            delayed puberty in humans, and points to a common genetic basis for
            conditions of functional hypogonadotropic hypogonadism (HH).
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024886.20.
            
            On Jul 8, 2020 this sequence version replaced NM_178822.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2701072.1,
                                           SRR14038195.23712.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282466.4/ ENSP00000282466.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC024886.20        5370-5485
            117-203             AC024886.20        6084-6170
            204-398             AC024886.20        7721-7915
            399-528             AC024886.20        9276-9405
            529-919             AC024886.20        12657-13047
            920-5266            AC024886.20        17166-21512
            5267-6167           AC024886.20        22547-23447
            6168-8562           AC024886.20        27834-30228
FEATURES             Location/Qualifiers
     source          1..8562
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.1"
     gene            1..8562
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
                     /note="immunoglobulin superfamily member 10"
                     /db_xref="GeneID:285313"
                     /db_xref="HGNC:HGNC:26384"
                     /db_xref="MIM:617351"
     exon            1..116
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
                     /inference="alignment:Splign:2.1.0"
     exon            117..203
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
                     /inference="alignment:Splign:2.1.0"
     exon            204..398
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..8076
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; calvaria mechanical force protein 608"
                     /codon_start=1
                     /product="immunoglobulin superfamily member 10 isoform 1
                     precursor"
                     /protein_id="NP_849144.2"
                     /db_xref="CCDS:CCDS3160.1"
                     /db_xref="GeneID:285313"
                     /db_xref="HGNC:HGNC:26384"
                     /db_xref="MIM:617351"
                     /translation="MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCT
                     FRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFS
                     DLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHL
                     EGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHG
                     NPWTCDCHLKWLSDWIQEKPDVIKCKKDRSPSSAQQCPLCMNPRTSKGKPLAMVSAAA
                     FQCAKPTIDSSLKSKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSGNEANMVCSI
                     QKPSRTSPIAFTEENDYIVLNTSFSTFLVCNIDYGHIQPVWQILALYSDSPLILERSH
                     LLSETPQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQI
                     QYSSDAQITLPRAEMRPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVD
                     WLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRI
                     TVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKV
                     LNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRPLEHDGETEGSGLD
                     ESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRFREN
                     RRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPPPVVTQLPNIPGEEDDSSG
                     MLALHEEFMVPATKALNLPARTVTADSRTISDSPMTNINYGTEFSPVVNSQILPPEEP
                     TDFKLSTAIKTTAMSKNINPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMGRGRE
                     HFQSRPPITVRTMIKDVNVKMLSSTTNKLLLESVNTTNSHQTSVREVSEPRHNHFYSH
                     TTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRRFGRQRKIGGRGRIISPYRTPV
                     LRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATAALSFPSAAPIT
                     FPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTYA
                     PTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIP
                     WQQNFVNNHNPKGRLRNQHKVSLQKSTAVMLPKTSPALPRDKVSPFHFTTLSTSVMQI
                     PSNTLTTAHHTTTKTHNPGSLPTKKELPFPPLNPMLPSIISKDSSTKSIISTQTAIPA
                     TTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFTTPTAMTPPV
                     LTTAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTI
                     ASETTLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPI
                     SGLMTNTVVKLHESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPM
                     PALTTVKSQNSKLTPSPWAENQFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDW
                     DGQKNTKKSDFDKKPVQEATTSKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFL
                     PCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSAS
                     NLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQ
                     TVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP
                     VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNG
                     TLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDK
                     LLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLC
                     VARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSL
                     PDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKV
                     HLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRY
                     TFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIK
                     ATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLS
                     DSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGN
                     PPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEK
                     LVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQIN
                     GKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSI
                     VTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQ
                     TSDSGIYKCTAKNPLGSDYAATYIQVI"
     exon            399..528
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
                     /inference="alignment:Splign:2.1.0"
     exon            529..919
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
                     /inference="alignment:Splign:2.1.0"
     exon            920..5266
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
                     /inference="alignment:Splign:2.1.0"
     exon            5267..6167
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
                     /inference="alignment:Splign:2.1.0"
     exon            6168..8562
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8206..8211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
                     /note="hexamer: AATAAA"
     regulatory      8222..8227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
                     /note="hexamer: AATAAA"
     polyA_site      8231
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
                     /note="major polyA site"
     polyA_site      8242
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
                     /note="major polyA site"
     regulatory      8379..8384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
                     /note="hexamer: AGTAAA"
     polyA_site      8404
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
     regulatory      8471..8476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
                     /note="hexamer: ATTAAA"
     polyA_site      8502
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
     regulatory      8532..8537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
                     /note="hexamer: TATAAA"
     polyA_site      8562
                     /gene="IGSF10"
                     /gene_synonym="CMF608"
ORIGIN      
        1 cttccttccc tcccagagct ccggaccagc tccgcacgac cccagcagct gagcccggga
       61 ccgagcccgg gacctagccc gggcagctcg agcccattgg tcaccagggc aaacaggttt
      121 ggacacaatt ttccatttcc tgggaagatt ttctgtctct gcctatgtca caagaggact
      181 caggacctga aagaagagct caggatgaag gtaaaaggca gaggaatcac ctgcttgctg
      241 gtctcctttg ctgtgatctg cctggtcgcc acccctgggg gcaaggcctg tcctcgccgc
      301 tgtgcctgtt atatgcctac ggaggtacac tgcacatttc ggtacctgac ttccatccca
      361 gacagcatcc cgcccaatgt ggaacgcatc aatttaggat acaacagctt ggttagattg
      421 atggaaacag atttttctgg cctgaccaaa ctggagttac tcatgcttca cagcaatggc
      481 attcacacaa tccctgacaa gaccttctca gatttgcagg ccttgcaggt cttaaaaatg
      541 agctataata aagtccgaaa acttcagaaa gatacttttt atggcctcag gagcttgaca
      601 cgattgcaca tggaccacaa caatattgag tttataaacc cagaggtttt ttatgggctc
      661 aactttctcc gcctggtgca cttggaagga aatcagctca ctaagctcca cccagataca
      721 tttgtctctt tgagctacct ccagatattt aaaatctctt tcattaagtt cctatacttg
      781 tctgataact tcctgacctc cctccctcaa gagatggtct cctatatgcc tgacctagac
      841 agcctttacc tgcatggaaa cccatggacc tgtgattgcc atttaaagtg gttgtctgac
      901 tggatacagg agaagccaga tgtaataaaa tgcaaaaaag atagaagtcc ctctagtgct
      961 cagcagtgtc cactttgcat gaaccctagg acttctaaag gcaagccgtt agctatggtc
     1021 tcagctgcag ctttccagtg tgccaagcca accattgact catccctgaa atcaaagagc
     1081 ctgactattc tggaagacag tagttctgct ttcatctctc cccaaggttt catggcaccc
     1141 tttggctccc tcactttgaa tatgacagat cagtctggaa atgaagctaa catggtctgc
     1201 agtattcaaa agccctcaag gacatcaccc attgcattca ctgaagaaaa tgactacatc
     1261 gtgctaaata cttcattttc aacatttttg gtgtgcaaca tagattacgg tcacattcag
     1321 ccagtgtggc aaattttggc tttgtacagt gattctcctc tgatactaga aaggagccac
     1381 ttgcttagtg aaacaccgca gctctattac aaatataaac aggtggctcc taagcctgaa
     1441 gacattttta ccaacataga ggcagatctc agagcagatc cctcttggtt aatgcaagac
     1501 caaatttcct tgcagctgaa cagaactgcc accacattca gtacattaca gatccagtac
     1561 tccagtgatg ctcaaatcac tttaccaaga gcagagatga ggccagtgaa acacaaatgg
     1621 actatgattt caagggataa caatactaag ctggaacata ctgtcttggt aggtggaacc
     1681 gttggcctga actgcccagg ccaaggagac cccaccccac acgtggattg gcttctagct
     1741 gatggaagta aagtgagagc cccttatgtc agtgaggatg gacggatcct aatagacaaa
     1801 agtggaaaat tggaactcca gatggctgat agttttgaca caggcgtata tcactgtata
     1861 agcagcaatt atgatgatgc agatattctc acctatagga taactgtggt agaacctttg
     1921 gtcgaagcct atcaggaaaa tgggattcat cacacagttt tcattggtga aacacttgat
     1981 cttccatgcc attctactgg tatcccagat gcctctatta gctgggttat tccaggaaac
     2041 aatgtgctct atcagtcatc aagagacaag aaagttctaa acaatggcac attaagaata
     2101 ttacaggtca ccccgaaaga ccaaggttat tatcgctgtg tggcagccaa cccatcaggg
     2161 gttgattttt tgattttcca agtttcagtc aagatgaaag gacaaaggcc cttggagcat
     2221 gatggagaaa cagagggatc tggacttgat gagtccaatc ctattgctca tcttaaggag
     2281 ccaccaggtg cacaactccg tacatctgct ctgatggagg ctgaggttgg aaaacacacc
     2341 tcaagcacaa gtaagaggca caactatcgg gaattaacac tccagcgacg tggagattca
     2401 acacatcgac gttttaggga gaataggagg catttccctc cctctgctag gagaattgac
     2461 ccacaacatt gggcggcact gttggagaaa gctaaaaaga atgctatgcc agacaagcga
     2521 gaaaatacca cagtgagccc acccccagtg gtcacccaac tcccaaacat acctggtgaa
     2581 gaagacgatt cctcaggcat gctcgctcta catgaggaat ttatggtccc ggccactaaa
     2641 gctttgaacc ttccagcaag gacagtgact gctgactcca gaacaatatc tgatagtcct
     2701 atgacaaaca taaattatgg cacagaattc tctcctgttg tgaattcaca aatactacca
     2761 cctgaagaac ccacagattt caaactgtct actgctatta aaactacagc catgtcaaag
     2821 aatataaacc caaccatgtc aagccaaata caaggcacaa ccaatcaaca ttcatccact
     2881 gtctttccac tgctacttgg agcaactgaa tttcaggact ctgaccagat gggaagagga
     2941 agagagcatt tccaaagtag acccccaata acagtaagga ctatgatcaa agatgtcaat
     3001 gtcaaaatgc ttagtagcac caccaacaaa ctattattag agtcagtaaa taccacaaat
     3061 agtcatcaga catctgtaag agaagtgagt gaacccaggc acaatcactt ctattctcac
     3121 actactcaaa tacttagcac ctccacgttc ccttcagatc cacacacagc tgctcattct
     3181 cagtttccga tccctagaaa tagtacagtt aacatcccgc tgttcagacg ctttgggagg
     3241 cagaggaaaa ttggcggaag ggggcggatt atcagcccat atagaactcc agttctgcga
     3301 cggcatagat acagcatttt caggtcaaca accagaggtt cttctgaaaa aagcactact
     3361 gcattctcag ccacagtgct caatgtgaca tgtctgtcct gtcttcccag ggagaggctc
     3421 accactgcca cagcagcatt gtcttttcca agtgctgctc ccatcacctt ccccaaagct
     3481 gacattgcta gagtcccatc agaagagtct acaactctag tccagaatcc actattacta
     3541 cttgagaaca aacccagtgt agagaaaaca acacccacaa taaaatattt caggactgaa
     3601 atttcccaag tgactccaac tggtgcagtc atgacatatg ctccaacatc catacccatg
     3661 gaaaaaactc acaaagtaaa cgccagttac ccacgtgtgt ctagcaccaa tgaagctaaa
     3721 agagattcag tgattacatc gtcactttca ggtgctatca ccaagccacc aatgactatt
     3781 atagccatta caaggttttc aagaaggaaa attccctggc aacagaactt tgtaaataac
     3841 cataacccaa aaggcagatt aaggaatcaa cataaagtta gtttacaaaa aagcacagct
     3901 gtgatgcttc ctaaaacatc tcctgcttta cccagagaca aagtctcccc tttccatttc
     3961 accacacttt caacaagtgt gatgcaaatt ccatctaata ccttgactac cgctcaccac
     4021 actacgacca aaacacacaa tcctggaagt cttccaacaa agaaggagct tcccttccca
     4081 ccccttaacc ctatgcttcc tagtattata agcaaagact caagtacaaa aagcatcata
     4141 tcaacgcaaa cagcaatacc agcaacaact cctaccttcc ctgcatctgt catcacttat
     4201 gaaacccaaa cagagagatc tagagcacaa acaatacaaa gagaacagga gcctcaaaag
     4261 aagaacagga ctgacccaaa catctctcca gaccagagtt ctggcttcac tacacccact
     4321 gctatgacac ctcctgttct aaccacagcc gaaacttcag tcaagcccag tgtctctgca
     4381 ttcactcatt ccccaccaga aaacacaact gggatttcaa gcacaatcag ttttcattca
     4441 agaactctta atctgacaga tgtgattgaa gaactagccc aagcaagtac tcagactttg
     4501 aagagcacaa ttgcttctga aacaactttg tccagcaaat cacaccagag taccacaact
     4561 aggaaagcaa tcattagaca ctcaaccata ccaccattct tgagcagcag tgctactcta
     4621 atgccagttc ccatctcccc tccctttact cagagagcag ttactgacaa cgtggcgact
     4681 cccatttccg ggcttatgac aaatacagtg gtcaagctgc acgaatcctc aaggcacaat
     4741 gctaaaccac agcaattagt agcagaggtt gcaacatccc ccaaggttca cccaaatgcc
     4801 aagttcacaa ttggaaccac tcacttcatc tactctaatc tgttacattc tactcccatg
     4861 ccagcactaa caacagttaa atcacagaat tctaaattaa ctccatctcc ctgggcagaa
     4921 aaccaatttt ggcacaaacc atactcagaa attgctgaaa aaggcaaaaa gccagaagta
     4981 agcatgttgg ctactacagg cctgtccgag gccaccactc ttgtttcaga ttgggatgga
     5041 cagaagaaca caaagaagag tgactttgat aagaaaccag ttcaagaagc aacaacttcc
     5101 aaactccttc cctttgactc tttgtctagg tatatatttg aaaagcccag gatagttgga
     5161 ggaaaagctg caagttttac tattccagct aactcagatg cctttcttcc ctgtgaagct
     5221 gttggaaatc ccctgcccac cattcattgg accagagtcc catcaggact tgatttatct
     5281 aagaggaaac agaatagcag ggtccaggtt ctccccaatg gtaccctgtc catccagagg
     5341 gtggaaattc aggaccgcgg acagtacttg tgttccgcat ccaatctgtt tggcacagac
     5401 caccttcatg tcaccttgtc tgtggtttcc tatcctccca ggatcctgga gagacgtacc
     5461 aaagagatca cagttcattc cggaagcact gtggaactga agtgcagagc agaaggtagg
     5521 ccaagcccta cagttacctg gattcttgca aaccaaacag ttgtctcaga atcatcccag
     5581 ggaagtaggc aggctgtggt gacggttgac ggaacattgg tcctccacaa tctcagtatt
     5641 tatgaccgtg gcttttacaa atgtgtggcc agcaacccag gtggccagga ttcactgctg
     5701 gttaaaatac aagtcattgc agcaccacct gttattctag agcaaaggag gcaagtcatt
     5761 gtaggcactt ggggtgaaag tttaaaactg ccctgtactg caaaaggaac tcctcagccc
     5821 agcgtttact gggtcctctc tgatggcact gaagtgaaac cattacagtt taccaattcc
     5881 aagttgttct tattttcaaa tgggactttg tatataagaa acctagcctc ttcagacagg
     5941 ggcacttatg aatgcattgc taccagttcc actggttcgg agcgaagagt agtaatgctt
     6001 acaatggaag agcgagtgac cagccccagg atagaagctg catcccagaa aaggactgaa
     6061 gtgaattttg gggacaaatt actactgaac tgctcagcca ctggggagcc caaaccccaa
     6121 ataatgtgga ggttaccatc caaggctgtg gtcgaccagc agcatagagt gggcagctgg
     6181 atccacgtct accctaatgg atccctgttt attggatcag taacagaaaa agacagtggt
     6241 gtctacttgt gtgtggcaag aaacaaaatg ggggatgatc tgatactgat gcatgttagc
     6301 ctaagactga aacctgccaa aattgaccac aagcagtatt ttagaaagca agtgctccat
     6361 gggaaagatt tccaagtaga ttgcaaagct tccggctccc cagtgccaga gatatcttgg
     6421 agtttgcctg atggaaccat gatcaacaat gcaatgcaag ccgatgacag tggccacagg
     6481 actaggagat ataccctttt caacaatgga actttatact tcaacaaagt tggggtagcg
     6541 gaggaaggag attatacttg ctatgcccag aacaccctag ggaaagatga aatgaaggtc
     6601 cacttaacag ttataacagc tgctccccgg ataaggcaga gtaacaaaac caacaagaga
     6661 atcaaagctg gagacacagc tgtccttgac tgtgaggtca ctggggatcc caaaccaaaa
     6721 atattttggt tgctgccttc caatgacatg atttccttct ccattgatag gtacacattt
     6781 catgccaatg ggtctttgac catcaacaaa gtgaaactgc tcgattctgg agagtacgta
     6841 tgtgtagccc gaaatcccag tggggatgac accaaaatgt acaaactgga tgtggtctct
     6901 aaacctccat taatcaatgg tctgtataca aacagaactg ttattaaagc cacagctgtg
     6961 agacattcca aaaaacactt tgactgcaga gctgaaggga caccatctcc tgaagtcatg
     7021 tggatcatgc cagacaatat tttcctcaca gccccatact atggaagcag aatcacagtc
     7081 cataaaaatg gaaccttgga aattaggaat gtgaggcttt cagattcagc cgactttatc
     7141 tgtgtggccc gaaatgaagg tggagagagc gtgttggtag tacagttaga agtactggaa
     7201 atgctgagaa gaccgacatt tagaaatcca tttaatgaaa aaatagttgc ccagctggga
     7261 aagtccacag cattgaattg ctctgttgat ggtaacccac cacctgaaat aatctggatt
     7321 ttaccaaatg gcacacgatt ttccaatgga ccacaaagtt atcagtatct gatagcaagc
     7381 aatggttctt ttatcatttc taaaacaact cgggaggatg caggaaaata tcgctgtgca
     7441 gctaggaata aagttggcta tattgagaaa ttagtcatat tagaaattgg ccagaagcca
     7501 gttattctta cctatgcacc agggacagta aaaggcatca gtggagaatc tctatcactg
     7561 cattgtgtgt ctgatggaat ccctaagcca aatatcaaat ggactatgcc aagtggttat
     7621 gtagtagaca ggcctcaaat taatgggaaa tacatattgc atgacaatgg caccttagtc
     7681 attaaagaag caacagctta tgacagagga aactatatct gtaaggctca aaatagtgtt
     7741 ggtcatacac tgattactgt tccagtaatg attgtagcct accctccccg aattacaaat
     7801 cgtccaccca ggagtattgt caccaggaca ggggcagcct ttcagctcca ctgtgtggcc
     7861 ttgggagttc ccaagccaga aatcacatgg gagatgcctg accactccct tctctcaacg
     7921 gcaagtaaag agaggacaca tggaagtgag cagcttcact tacaaggtac cctagtcatt
     7981 cagaatcccc aaacctccga ttctgggata tacaaatgca cagcaaagaa cccacttggt
     8041 agtgattatg cagcaacgta tattcaagta atctgacatg aaataataaa gtcaacaaca
     8101 tctgggcaga atttattttt tggaagaagt ttaatcaaag gcagccatag gcatgtaaat
     8161 gaatttgaat acatttacag tattaaattt acaatgaaca tgcaaaataa aaggacttgt
     8221 aaataaatgc attatgaact gatgatactg atttatttaa tggatctcaa aacaaacttt
     8281 taacttaagg cacttttatt ttgccaacaa ataacaataa acaaacattg aaacggttca
     8341 ctataaaata acaaatggct aatgtacctg aatttttcag taaaaaaatg aacttctaat
     8401 accagttgcc tagtgtccac ctcctatcaa tgttacaagc atggcactca gaacagagac
     8461 aatggaaaat attaaatctg caatctttat gatgtaaatt taccatcctg atgtataaat
     8521 attttgtggt ttataaattt ttttgctaaa acctacagaa aa
//
