LOCUS       NM_001555               4461 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens immunoglobulin superfamily member 1 (IGSF1),
            transcript variant 1, mRNA.
ACCESSION   NM_001555
VERSION     NM_001555.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4461)
  AUTHORS   Zhang,C., Chen,L., Chen,X., Xie,R., Wang,F., Chen,T., Wang,X.,
            Sun,H., Zhang,D. and Wu,H.
  TITLE     [Clinical characteristics and genetic analysis of four patients
            with central hypothyroidism due to IGSF1 gene variants]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 40 (3), 322-327 (2023)
   PUBMED   36854408
  REMARK    GeneRIF: [Clinical characteristics and genetic analysis of four
            patients with central hypothyroidism due to IGSF1 gene variants].
REFERENCE   2  (bases 1 to 4461)
  AUTHORS   Costas Eimil,J. and Sanchez-Sobrino,P.
  TITLE     IGSF1 mutation as a cause of isolated central hypothyroidism
  JOURNAL   Endocrinol Diabetes Nutr (Engl Ed) 69 (10), 913-914 (2022)
   PUBMED   36464600
  REMARK    GeneRIF: IGSF1 mutation as a cause of isolated central
            hypothyroidism.
REFERENCE   3  (bases 1 to 4461)
  AUTHORS   Fourneaux,R., Reynaud,R., Mougel,G., Castets,S., Bretones,P.,
            Dauriat,B., Edouard,T., Raverot,G., Barlier,A., Brue,T.,
            Castinetti,F. and Saveanu,A.
  TITLE     IGSF1 mutations are the most frequent genetic aetiology of
            thyrotropin deficiency
  JOURNAL   Eur J Endocrinol 187 (6), 787-795 (2022)
   PUBMED   36201163
  REMARK    GeneRIF: IGSF1 mutations are the most frequent genetic aetiology of
            thyrotropin deficiency.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4461)
  AUTHORS   Elizabeth,M.S.M., Hokken-Koelega,A., Visser,J.A., Joustra,S.D. and
            de Graaff,L.C.G.
  TITLE     Case Report: A Detailed Phenotypic Description of Patients and
            Relatives with Combined Central Hypothyroidism and Growth Hormone
            Deficiency Carrying IGSF1 Mutations
  JOURNAL   Genes (Basel) 13 (4), 623 (2022)
   PUBMED   35456429
  REMARK    GeneRIF: Case Report: A Detailed Phenotypic Description of Patients
            and Relatives with Combined Central Hypothyroidism and Growth
            Hormone Deficiency Carrying IGSF1 Mutations.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4461)
  AUTHORS   Fourneaux,R., Castets,S., Godefroy,A., Grelet,M., Abeillon-du
            Payrat,J., Saveanu,A., Castinetti,F. and Reynaud,R.
  TITLE     Congenital Central Hypothyroidism Caused by a Novel IGSF1 Variant
            Identified in a French Family
  JOURNAL   Horm Res Paediatr 95 (3), 296-303 (2022)
   PUBMED   35350016
  REMARK    GeneRIF: Congenital Central Hypothyroidism Caused by a Novel IGSF1
            Variant Identified in a French Family.
REFERENCE   6  (bases 1 to 4461)
  AUTHORS   Tanaka,S., Tatsumi,K., Okubo,K., Itoh,K., Kawamoto,S., Matsubara,K.
            and Amino,N.
  TITLE     Expression profile of active genes in the human pituitary gland
  JOURNAL   J Mol Endocrinol 28 (1), 33-44 (2002)
   PUBMED   11854097
REFERENCE   7  (bases 1 to 4461)
  AUTHORS   Gui,Y. and Murphy,L.J.
  TITLE     Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) binds
            to fibronectin (FN): demonstration of IGF-I/IGFBP-3/fn ternary
            complexes in human plasma
  JOURNAL   J Clin Endocrinol Metab 86 (5), 2104-2110 (2001)
   PUBMED   11344214
REFERENCE   8  (bases 1 to 4461)
  AUTHORS   Chapman,S.C. and Woodruff,T.K.
  TITLE     Modulation of activin signal transduction by inhibin B and
            inhibin-binding protein (INhBP)
  JOURNAL   Mol Endocrinol 15 (4), 668-679 (2001)
   PUBMED   11266516
REFERENCE   9  (bases 1 to 4461)
  AUTHORS   Frattini,A., Faranda,S., Redolfi,E., Allavena,P. and Vezzoni,P.
  TITLE     Identification and genomic organization of a gene coding for a new
            member of the cell adhesion molecule family mapping to Xq25
  JOURNAL   Gene 214 (1-2), 1-6 (1998)
   PUBMED   9729118
REFERENCE   10 (bases 1 to 4461)
  AUTHORS   Mazzarella,R., Pengue,G., Jones,J., Jones,C. and Schlessinger,D.
  TITLE     Cloning and expression of an immunoglobulin superfamily gene
            (IGSF1) in Xq25
  JOURNAL   Genomics 48 (2), 157-162 (1998)
   PUBMED   9521868
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590806.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001555.4.
            
            Summary: This gene encodes a member of the immunoglobulin-like
            domain-containing superfamily. Proteins in this superfamily contain
            varying numbers of immunoglobulin-like domains and are thought to
            participate in the regulation of interactions between cells.
            Multiple transcript variants encoding different isoforms have been
            found for this gene.[provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site in a 3' exon compared to variant 3. The resulting
            protein (isoform 1) is shorter compared to isoform 3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063884.1, SRR1803615.4201.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361420.8/ ENSP00000355010.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AL590806.6         46379-46471         c
            94-230              AL590806.6         43770-43906         c
            231-257             AL590806.6         43602-43628         c
            258-539             AL590806.6         42932-43213         c
            540-827             AL590806.6         42344-42631         c
            828-1112            AL590806.6         40145-40429         c
            1113-1406           AL590806.6         39609-39902         c
            1407-1685           AL590806.6         38831-39109         c
            1686-1806           AL590806.6         38383-38503         c
            1807-1877           AL590806.6         36436-36506         c
            1878-1910           AL590806.6         36308-36340         c
            1911-2201           AL590806.6         35626-35916         c
            2202-2480           AL590806.6         35021-35299         c
            2481-2768           AL590806.6         34104-34391         c
            2769-3056           AL590806.6         33126-33413         c
            3057-3344           AL590806.6         32643-32930         c
            3345-3632           AL590806.6         32164-32451         c
            3633-3911           AL590806.6         31764-32042         c
            3912-4035           AL590806.6         31248-31371         c
            4036-4461           AL590806.6         30671-31096         c
FEATURES             Location/Qualifiers
     source          1..4461
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.1"
     gene            1..4461
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /note="immunoglobulin superfamily member 1"
                     /db_xref="GeneID:3547"
                     /db_xref="HGNC:HGNC:5948"
                     /db_xref="MIM:300137"
     exon            1..93
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            94..230
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..4171
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; inhibin-binding protein; pituitary
                     gland-specific factor 2; immunoglobulin-like
                     domain-containing protein 1"
                     /codon_start=1
                     /product="immunoglobulin superfamily member 1 isoform 1
                     precursor"
                     /protein_id="NP_001546.2"
                     /db_xref="CCDS:CCDS14629.1"
                     /db_xref="GeneID:3547"
                     /db_xref="HGNC:HGNC:5948"
                     /db_xref="MIM:300137"
                     /translation="MTLDRPGEGATMLKTFTVLLFCIRMSLGMTSIVMDPQPELWIES
                     NYPQAPWENITLWCRSPSRISSKFLLLKDKTQMTWIRPSHKTFQVSFLIGALTESNAG
                     LYRCCYWKETGWSKPSKVLELEAPGQLPKPIFWIQAETPALPGCNVNILCHGWLQDLV
                     FMLFKEGYAEPVDYQVPTGTMAIFSIDNLTPEDEGVYICRTHIQMLPTLWSEPSNPLK
                     LVVAGLYPKPTLTAHPGPIMAPGESLNLRCQGPIYGMTFALMRVEDLEKSFYHKKTIK
                     NEANFFFQSLKIQDTGHYLCFYYDASYRGSLLSDVLKIWVTDTFPKTWLLARPSAVVQ
                     MGQNVSLRCRGPVDGVGLALYKKGEDKPLQFLDATSIDDNTSFFLNNVTYSDTGIYSC
                     HYLLTWKTSIRMPSHNTVELMVVDKPPKPSLSAWPSTVFKLGKAITLQCRVSHPVLEF
                     SLEWEERETFQKFSVNGDFIISNVDGKGTGTYSCSYRVETHPNIWSHRSEPLKLMGPA
                     GYLTWNYVLNEAIRLSLIMQLVALLLVVLWIRWKCRRLRIREAWLLGTAQGVTMLFIV
                     TALLCCGLCNGVLIEETEIVMPTPKPELWAETNFPLAPWKNLTLWCRSPSGSTKEFVL
                     LKDGTGWIATRPASEQVRAAFPLGALTQSHTGSYHCHSWEEMAVSEPSEALELVGTDI
                     LPKPVISASPTIRGQELQLRCKGWLAGMGFALYKEGEQEPVQQLGAVGREAFFTIQRM
                     EDKDEGNYSCRTHTEKRPFKWSEPSEPLELVIKEMYPKPFFKTWASPVVTPGARVTFN
                     CSTPHQHMSFILYKDGSEIASSDRSWASPGASAAHFLIISVGIGDGGNYSCRYYDFSI
                     WSEPSDPVELVVTEFYPKPTLLAQPGPVVFPGKSVILRCQGTFQGMRFALLQEGAHVP
                     LQFRSVSGNSADFLLHTVGAEDSGNYSCIYYETTMSNRGSYLSMPLMIWVTDTFPKPW
                     LFAEPSSVVPMGQNVTLWCRGPVHGVGYILHKEGEATSMQLWGSTSNDGAFPITNISG
                     TSMGRYSCCYHPDWTSSIKIQPSNTLELLVTGLLPKPSLLAQPGPMVAPGENMTLQCQ
                     GELPDSTFVLLKEGAQEPLEQQRPSGYRADFWMPAVRGEDSGIYSCVYYLDSTPFAAS
                     NHSDSLEIWVTDKPPKPSLSAWPSTMFKLGKDITLQCRGPLPGVEFVLEHDGEEAPQQ
                     FSEDGDFVINNVEGKGIGNYSCSYRLQAYPDIWSEPSDPLELVGAAGPVAQECTVGNI
                     VRSSLIVVVVVALGVVLAIEWKKWPRLRTRGSETDGRDQTIALEECNQEGEPGTPANS
                     PSSTSQRISVELPVPI"
     exon            231..257
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            258..539
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            540..827
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1112
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1406
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1685
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1806
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1877
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..1910
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2201
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2480
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2768
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..3056
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3344
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3632
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3911
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3912..4035
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4036..4461
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4428..4433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /note="hexamer: AATAAA"
     polyA_site      4461
                     /gene="IGSF1"
                     /gene_synonym="CHTE; IGCD1; IGDC1; INHBP; p120; PGSF2"
                     /note="major polyA site"
ORIGIN      
        1 gtccttagac agctcttctc atgccgggca gtttgctgca tctggaggag ctcactggag
       61 aatctccaac atcggagcgg gccttcaact accatcccac cacctgctga ggagaaaaat
      121 tcttcaagac tcagagcaca cagccagcac cagaggcccc atgaccctgg acagaccagg
      181 ggagggggcc accatgctga agacattcac tgttttgctc ttttgcattc ggatgagtct
      241 gggtatgaca tcaatagtga tggaccctca accagagttg tggatagagt ccaactaccc
      301 ccaggcccct tgggagaaca tcacgctttg gtgccgaagc ccctctcgga tatcaagcaa
      361 gttcctgctg ctgaaggata agacacagat gacctggatc cgcccttccc acaagacctt
      421 ccaagtttca ttccttatag gtgcccttac tgagtccaat gcaggtcttt accggtgctg
      481 ctactggaag gagacaggct ggtcaaagcc cagtaaagtt ctagagttgg aggcaccagg
      541 ccaactgccc aagcccatct tctggattca ggctgagacc cccgctcttc ctgggtgtaa
      601 tgttaacatc ctctgccatg gctggctgca ggatttggta ttcatgctgt ttaaagaggg
      661 atatgcagag cctgtggatt accaagtccc aactgggaca atggccatat tctccattga
      721 caacctgaca cctgaggatg aaggggttta catctgccgc actcatatcc agatgctccc
      781 caccctgtgg tcagagccca gcaaccccct gaagctggtt gtagcaggac tctaccccaa
      841 accaactttg acagcccatc ctgggcccat catggcacct ggagaaagcc tgaatctcag
      901 gtgccaaggg ccaatctatg gaatgacctt tgctctaatg agggttgaag acttggagaa
      961 gtccttttac cacaagaaga caataaaaaa tgaggcaaat ttcttcttcc agtctttgaa
     1021 gatccaagat actggacatt acctctgttt ttactatgac gcatcatata gaggttcact
     1081 ccttagtgat gtcctgaaaa tctgggtgac tgacactttc cccaagacct ggctacttgc
     1141 tcggcccagt gctgtggtcc aaatgggtca gaatgtgagc ctacggtgtc gaggaccagt
     1201 ggatggagtg ggtcttgcac tctataagaa aggagaagac aaaccacttc aatttttgga
     1261 tgccaccagc atcgatgaca acacatcatt cttcctcaac aatgtaacct acagtgatac
     1321 tggcatctat agctgccact atcttctcac ctggaagacc tccattagga tgccatcaca
     1381 caacactgtg gagcttatgg ttgtagataa gccccccaaa ccctccctgt cagcttggcc
     1441 aagcactgtg ttcaagctag gaaaggccat cacccttcag tgccgagtat ctcatccagt
     1501 actggaattt tctctggaat gggaagaaag agaaacattc caaaaattct cagtaaacgg
     1561 agacttcatc atcagtaatg ttgacgggaa aggcacaggg acctacagtt gcagctatcg
     1621 cgtagagaca catcctaaca tctggtcaca tcgcagtgag cccctgaagc tgatggggcc
     1681 agcaggctat ctcacctgga attacgttct gaatgaagct atcaggttgt ctctaatcat
     1741 gcagcttgtt gccttgctgt tggtagtgct gtggataagg tggaagtgtc ggagactcag
     1801 aatcagagaa gcctggttgc tgggaacagc tcaaggggtc accatgctct tcatagtcac
     1861 ggcccttctc tgctgtggac tgtgcaatgg ggtattgata gaagagactg aaatagtcat
     1921 gccaacccct aagcctgagc tgtgggcaga gaccaacttt cctctggccc cgtggaagaa
     1981 cttaaccctc tggtgcagaa gcccttctgg ctcaactaag gagtttgtgt tgctgaagga
     2041 tgggaccggg tggatcgcca ctcgcccggc ctcagagcag gtccgggctg ccttccccct
     2101 tggcgccctg acccagagcc acaccgggag ctaccactgc cattcatggg aggagatggc
     2161 tgtatcggag cccagtgagg cacttgagct ggtggggaca gacatcctcc ccaaacctgt
     2221 catttctgct tcccccacaa tccggggcca ggaactacaa ctccggtgca aaggatggct
     2281 ggcaggcatg gggtttgctc tgtataagga gggagagcaa gaacctgtcc agcaacttgg
     2341 tgctgttgga agagaagcct tctttacaat ccagagaatg gaggataaag acgaaggcaa
     2401 ttacagctgc cgcactcaca ctgaaaaacg ccccttcaag tggtctgagc ccagtgagcc
     2461 gctggagctt gtcataaaag aaatgtaccc taagcccttc ttcaagacat gggccagccc
     2521 tgtggtcacc cctggtgccc gagtgacttt caattgctcc accccccacc agcatatgag
     2581 ctttattctt tacaaagatg gaagtgaaat agcatccagt gacaggtcct gggcaagtcc
     2641 gggggccagt gcagctcact ttctaatcat ttcggtgggc attggtgatg gagggaatta
     2701 cagctgccga tattatgact tttctatctg gtctgagccc agcgaccctg tggagctcgt
     2761 ggtgacagaa ttctacccca aacccactct cctggcacag ccaggtcctg tggtgtttcc
     2821 tgggaagagt gtgatcctgc gctgccaagg gactttccag ggcatgaggt tcgccctctt
     2881 gcaggaggga gcccatgttc ccttacagtt tcggagtgtc tcagggaact cagctgactt
     2941 ccttctccac actgttggag cagaggactc tgggaactat agctgtatct actatgagac
     3001 aaccatgtca aacagggggt catatctcag tatgcccctt atgatctggg tgactgacac
     3061 attccctaag ccatggttgt ttgctgagcc cagttctgtg gttcccatgg ggcagaatgt
     3121 tactctctgg tgccgagggc cggtccatgg agtaggatac attctgcaca aagaaggaga
     3181 agccacttca atgcagctct ggggatccac cagtaatgac ggggcattcc ccatcaccaa
     3241 tatatctggt actagcatgg ggcgttacag ctgctgctac caccctgact ggaccagttc
     3301 tatcaagata caacctagca acaccctgga actcctagtc acaggcttac tccccaaacc
     3361 cagcctatta gcccagcctg gtcccatggt ggcccctggc gaaaatatga ctcttcagtg
     3421 tcaaggggaa ctgccagact caacatttgt cctgttgaag gagggggctc aggagccttt
     3481 agagcaacag aggccaagtg ggtacagggc tgacttctgg atgccagcag tgagaggtga
     3541 agactctggg atctatagct gtgtttatta tttggactct actccctttg cagcttcaaa
     3601 tcacagtgac tccctggaga tctgggtgac tgataagccc cctaaaccct ctctgtcagc
     3661 ctggcccagc accatgttca agttagggaa ggacatcacc cttcagtgcc gaggacccct
     3721 gccaggtgtt gaatttgtcc tagaacatga tggagaagaa gcacctcagc agttttcaga
     3781 ggatggagac tttgtcatca acaacgtaga aggaaaaggc attggaaact acagctgcag
     3841 ctaccgcctc caggcctacc ctgatatctg gtcagagcct agtgatcccc tggagctggt
     3901 gggggcagca gggcctgttg ctcaggagtg cactgtaggg aacattgtcc gaagtagcct
     3961 aatcgtggtg gttgttgtag ccttgggggt agtgctagcc atagagtgga agaagtggcc
     4021 tcgactgcga accagaggct cagagacaga cggaagagac cagaccattg cccttgaaga
     4081 gtgtaaccaa gaaggagaac caggcacccc tgccaattct ccttcatcaa cctctcagag
     4141 aatctctgtg gaactgcccg ttccaatata ataatctcct cctttacaag agctttcctc
     4201 tcctctctct tgctctcaga gacctataaa tccaaccagt taccctgcaa gtcagcccca
     4261 tctgctgttc cttggtctct aatcacctga gctgggtaaa ggggattctg ggagttgaga
     4321 gctctgccag ggtgagatgt ttcctgaaga gaggttcccc acccctgtaa ctcctcactg
     4381 tactgattta ctggcgcatg aaattctatt aaaaatgcat tcttctgaat aaaaagagta
     4441 ttcactattt aacttcaaaa a
//
