LOCUS       NM_001101372            3347 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens IgLON family member 5 (IGLON5), mRNA.
ACCESSION   NM_001101372 XM_380008 XM_936991
VERSION     NM_001101372.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3347)
  AUTHORS   Li,X., Chen,J.J., Hur,M., Paton,G.R., McKeon,A. and Zekeridou,A.
  TITLE     Papillitis associated with IgLON5 autoimmunity: A novel clinical
            phenotype
  JOURNAL   J Neuroimmunol 388, 578312 (2024)
   PUBMED   38364528
  REMARK    GeneRIF: Papillitis associated with IgLON5 autoimmunity: A novel
            clinical phenotype.
REFERENCE   2  (bases 1 to 3347)
  AUTHORS   Werner,J., Jelcic,I., Schwarz,E.I., Probst-Muller,E., Nilsson,J.,
            Schwizer,B., Bloch,K.E., Lutterotti,A., Jung,H.H. and Schreiner,B.
  TITLE     Anti-IgLON5 Disease: A New Bulbar-Onset Motor Neuron Mimic Syndrome
  JOURNAL   Neurol Neuroimmunol Neuroinflamm 8 (2), e962 (2021)
   PUBMED   33531378
  REMARK    GeneRIF: Anti-IgLON5 Disease: A New Bulbar-Onset Motor Neuron Mimic
            Syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3347)
  AUTHORS   Ranaivoson,F.M., Turk,L.S., Ozgul,S., Kakehi,S., von Daake,S.,
            Lopez,N., Trobiani,L., De Jaco,A., Denissova,N., Demeler,B.,
            Ozkan,E., Montelione,G.T. and Comoletti,D.
  TITLE     A Proteomic Screen of Neuronal Cell-Surface Molecules Reveals
            IgLONs as Structurally Conserved Interaction Modules at the Synapse
  JOURNAL   Structure 27 (6), 893-906 (2019)
   PUBMED   30956130
  REMARK    GeneRIF: Findings report 89 unpublished cell-surface
            ligand-receptor pairs and describe structural models of trans
            interactions of cell adhesion molecules, neuronal (IgLON5), showing
            that their structures are compatible with a model of interaction
            across the synaptic cleft.
REFERENCE   4  (bases 1 to 3347)
  AUTHORS   Sabater,L., Gaig,C., Gelpi,E., Bataller,L., Lewerenz,J.,
            Torres-Vega,E., Contreras,A., Giometto,B., Compta,Y., Embid,C.,
            Vilaseca,I., Iranzo,A., Santamaria,J., Dalmau,J. and Graus,F.
  TITLE     A novel non-rapid-eye movement and rapid-eye-movement parasomnia
            with sleep breathing disorder associated with antibodies to IgLON5:
            a case series, characterisation of the antigen, and post-mortem
            study
  JOURNAL   Lancet Neurol 13 (6), 575-586 (2014)
   PUBMED   24703753
  REMARK    GeneRIF: The target antigen of patients with rapid-eye-movement
            parasomnia who produce antibodies (mainly IgG4) against IgLON5 is a
            neuronal cell adhesion molecule that suggests a tauopathy
            Erratum:[Lancet Neurol. 2015 Jan;14(1):28]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC063977.6.
            
            On Sep 30, 2020 this sequence version replaced NM_001101372.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853561.15247.1,
                                           SRR14038194.3898229.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270642.9/ ENSP00000270642.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               AC063977.6         190805-191087
            284-362             AC063977.6         201225-201303
            363-595             AC063977.6         202823-203055
            596-715             AC063977.6         204507-204626
            716-850             AC063977.6         205925-206059
            851-971             AC063977.6         206241-206361
            972-1126            AC063977.6         206893-207047
            1127-3347           AC063977.6         207832-210052
FEATURES             Location/Qualifiers
     source          1..3347
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..3347
                     /gene="IGLON5"
                     /note="IgLON family member 5"
                     /db_xref="GeneID:402665"
                     /db_xref="HGNC:HGNC:34550"
                     /db_xref="MIM:618861"
     exon            1..283
                     /gene="IGLON5"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1215
                     /gene="IGLON5"
                     /note="Ig-like domain-containing protein ENSP00000270642;
                     hCG1651476"
                     /codon_start=1
                     /product="igLON family member 5 precursor"
                     /protein_id="NP_001094842.1"
                     /db_xref="CCDS:CCDS46158.1"
                     /db_xref="GeneID:402665"
                     /db_xref="HGNC:HGNC:34550"
                     /db_xref="MIM:618861"
                     /translation="MPPPAPGARLRLLAAAALAGLAVISRGLLSQSLEFNSPADNYTV
                     CEGDNATLSCFIDEHVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITEV
                     GLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLAVGRP
                     EPTVTWRQLRDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPP
                     TITDVTSARTALGRAALLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSML
                     LFANVSARHYGNYTCRAANRLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWW
                     RM"
     exon            284..362
                     /gene="IGLON5"
                     /inference="alignment:Splign:2.1.0"
     exon            363..595
                     /gene="IGLON5"
                     /inference="alignment:Splign:2.1.0"
     exon            596..715
                     /gene="IGLON5"
                     /inference="alignment:Splign:2.1.0"
     exon            716..850
                     /gene="IGLON5"
                     /inference="alignment:Splign:2.1.0"
     exon            851..971
                     /gene="IGLON5"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1126
                     /gene="IGLON5"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..3347
                     /gene="IGLON5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2791..2796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGLON5"
                     /note="hexamer: AATAAA"
     polyA_site      2810
                     /gene="IGLON5"
                     /note="major polyA site"
     regulatory      3320..3325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGLON5"
                     /note="hexamer: AATAAA"
     polyA_site      3347
                     /gene="IGLON5"
ORIGIN      
        1 gtcagcgccg cccccctccc cgggtctgca gcagctccag ccgcctcgtc gcgccccccc
       61 agccccctcc ccccgccccc gccgcccccc gggccggtgc agcgcaggcg gggtccccct
      121 ccccctcccc cctctccccc caggcctcgc gcgccccgga ccggcccccc ctttcccctc
      181 cccctccgcg ccgcctctgc cgcgatgccc ccccctgcgc ccggggcccg gctccggctt
      241 ctcgccgccg ccgccctggc cggcttggcc gtcatcagcc gagggctgct ctcccagagc
      301 ctggagttca actctcctgc cgacaactac acagtgtgtg aaggtgacaa cgccaccctc
      361 agctgcttca tcgacgagca cgtgacccgc gtggcctggc tgaaccgctc caacatcctg
      421 tatgccggca atgaccgctg gaccagcgac ccgcgggtgc ggctgctcat caacaccccc
      481 gaggagttct ccatcctcat caccgaggtg gggctcggcg acgagggcct ctacacctgc
      541 tccttccaga cccgccacca gccgtacacc actcaggtct acctcattgt ccacgtccct
      601 gcccgcattg tgaacatctc gtcgcctgtg acggtgaatg aggggggcaa tgtgaacctg
      661 ctttgcctgg ccgtggggcg gccagagccc acggtcacct ggagacagct ccgagacggc
      721 ttcacctcgg agggagagat cctggagatc tctgacatcc agcggggcca ggccggggag
      781 tatgagtgcg tgactcacaa cggggttaac tcggcgcccg acagccgccg cgtgctggtc
      841 acagtcaact atcctccgac catcacggac gtgaccagcg cccgcaccgc gctgggccgg
      901 gccgccctcc tgcgctgcga agccatggcg gttccccccg cggatttcca gtggtacaag
      961 gatgacagac tgctgagcag cggcacggcc gaaggcctga aggtgcagac ggagcgcacc
     1021 cgctcgatgc ttctctttgc caacgtgagc gcccggcatt acggcaacta tacgtgtcgc
     1081 gccgccaacc gactgggagc gtccagcgcc tccatgcggc tcctgcgccc aggatccctg
     1141 gagaactcag ccccgaggcc cccagggctc ctggccctcc tctccgccct gggctggctg
     1201 tggtggagaa tgtaggcgca acccagtgga gctcacctcc ccctgcaggg ggcctcaggc
     1261 caagagtgag agaaacgggg gagcaagagc cgtgggtctc gtgggggcag aagagctctc
     1321 ggccaccaag gaagaagaga gaggagaaga ggaggaggca gaggaagaaa gatcttcaga
     1381 gaacccatca ctgtgaggga taacgcaaaa ttatgcatct ttctacagcc attctcgcca
     1441 cccgttcacg tttccgattg tgacccactc ccgccacccc atacccctct ctcttagctc
     1501 aggctgtcaa ctggcttgtg tgggtgtggg tgtgtgagtg tgagcctgca tgcatgtgta
     1561 ggtgtctgtg tctctgtttg tgtgtgtgtg ggggggtggg ctgggggaag ggactcagcc
     1621 gtcctcccgc ccccaaaacc cccatgtcca ctgtccccaa ccctattgcc tctcacctct
     1681 ggctggaggt aggtatgagg ctctgcagtg gaagctgtga agagaggctt accaggctcc
     1741 ctgcttcccc aatatatgca cgcacactac ccctccccct gtcgaaaggg caactcctgg
     1801 caggttggga gtggggaggg gcatcgcact cacctgtcaa gctgtcattc agcctttgtg
     1861 agtaagtggg ggacctccat ctaggctctg ggcttccctg ctgtcaacca ccagcttcct
     1921 gtagccagag gccccatcgc tggctcagtg gcctgagacc ttcccacttt tcctgtccct
     1981 ccacaccctg gattttctgg ccccctcctg ggccaatcgg tgcttccatc caactgtcag
     2041 actggtggca ggagtcacct gtctgtttca gtgctttgcc ctacccttgc caccactccc
     2101 cttggccttg atttccccac ctgcggcacc agccagctgc ccttggggcc tttgcagctg
     2161 gcccacaggt gtgagcttgc tggtctatca cttcctggcc tctccaccaa ctgtacctcc
     2221 caaaggctac ctgaccgccc tcacagacac tcagacgcac cacacacaca tacacacaca
     2281 cagacacaca cacacacaca cacacacaca ccagcgactg tgaccagcaa tagccccctg
     2341 gctccagctg tccggtagct ggtgactagc tgtatttccc cctgggtagg catctggtgt
     2401 caggaaggga cgctgagagg ccgcagcctc agctctgact gtaggaacac tccaccctgg
     2461 tacaccacac cacacaaagt gggggacaga gaggcatcac acagacatcc tgagcccaga
     2521 caaagatgcc atgtcaccaa ctccgactcc caggagaccc tctatataaa cacccacccc
     2581 aaaccacacc acccagagtc tggtggagaa aaggagaggg caaggcgcag tgactgtacc
     2641 tcagacgggg gcatgggccc catcccacat tgtcttccat tcccagggtc caggggatgg
     2701 ggtgggacag gggagggatg ctagggaggg ggtggggggc cctgggggcc atgtgttcca
     2761 attcatgggg agtgttgaga ccaccacacc aataaacgcc tttttccaaa gtctgcctgc
     2821 aggtgtcaat gtcattaagg attagagtta atgaagggca aagggtagca gtcaattggt
     2881 ggtgcctctc cagcatcatt cctaccgcct actttctcac tggtagactt ggaatggact
     2941 cattacagag atgccctgtg attggccgaa gacacccagc atagcccatt tcccaccgtg
     3001 attggctcag agatgggcac atgacccagt aaggctaatg agaaagtgaa tggattccca
     3061 agaagagatg cttttctgct ggatattgtg gctccgtgat gtgaagtcaa catctgtagg
     3121 gttgcttttc tccatcacat ggagagatct tggctctgtg gggatagcaa tggtggggag
     3181 gacagcatat ggagcctgag aaggatagga acactgtgaa gggcagagtg gaaaccttag
     3241 agaaactgag tccatgatta tatatcattt gagcagctgg atcaaaactt aactgatgcc
     3301 cattttcact tatataagca ataaagtccc ctgtatattt aaaccaa
//
