LOCUS       NM_001178126            1300 bp    mRNA    linear   PRI 14-JUN-2023
DEFINITION  Homo sapiens immunoglobulin lambda like polypeptide 5 (IGLL5),
            transcript variant 1, mRNA.
ACCESSION   NM_001178126
VERSION     NM_001178126.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1300)
  AUTHORS   Alsoussi WB, Malladi SK, Zhou JQ, Liu Z, Ying B, Kim W, Schmitz AJ,
            Lei T, Horvath SC, Sturtz AJ, McIntire KM, Evavold B, Han F,
            Scheaffer SM, Fox IF, Mirza SF, Parra-Rodriguez L, Nachbagauer R,
            Nestorova B, Chalkias S, Farnsworth CW, Klebert MK, Pusic I, Strnad
            BS, Middleton WD, Teefey SA, Whelan SPJ, Diamond MS, Paris R,
            O'Halloran JA, Presti RM, Turner JS and Ellebedy AH.
  TITLE     SARS-CoV-2 Omicron boosting induces de novo B cell response in
            humans
  JOURNAL   Nature 617 (7961), 592-598 (2023)
   PUBMED   37011668
REFERENCE   2  (bases 1 to 1300)
  AUTHORS   Xia ZN, Wang XY, Cai LC, Jian WG and Zhang C.
  TITLE     IGLL5 is correlated with tumor-infiltrating immune cells in clear
            cell renal cell carcinoma
  JOURNAL   FEBS Open Bio 11 (3), 898-910 (2021)
   PUBMED   33449444
  REMARK    GeneRIF: IGLL5 is correlated with tumor-infiltrating immune cells
            in clear cell renal cell carcinoma.
REFERENCE   3  (bases 1 to 1300)
  AUTHORS   Lindner JM, Cornacchione V, Sathe A, Be C, Srinivas H, Riquet E,
            Leber XC, Hein A, Wrobel MB, Scharenberg M, Pietzonka T, Wiesmann
            C, Abend J and Traggiai E.
  TITLE     Human Memory B Cells Harbor Diverse Cross-Neutralizing Antibodies
            against BK and JC Polyomaviruses
  JOURNAL   Immunity 50 (3), 668-676 (2019)
   PUBMED   30824324
REFERENCE   4  (bases 1 to 1300)
  AUTHORS   Krause JC, Tsibane T, Tumpey TM, Huffman CJ, Briney BS, Smith SA,
            Basler CF and Crowe JE Jr.
  TITLE     Epitope-specific human influenza antibody repertoires diversify by
            B cell intraclonal sequence divergence and interclonal convergence
  JOURNAL   J Immunol 187 (7), 3704-3711 (2011)
   PUBMED   21880983
REFERENCE   5  (bases 1 to 1300)
  AUTHORS   Bellavia D, Abraham RS, Pellikka PA, Dispenzieri A, Burnett JC Jr,
            Al-Zahrani GB, Green TD, Manske MK, Gertz MA, Miller FA Jr and
            Abraham TP.
  TITLE     Utility of Doppler myocardial imaging, cardiac biomarkers, and
            clonal immunoglobulin genes to assess left ventricular performance
            and stratify risk following peripheral blood stem cell
            transplantation in patients with systemic light chain amyloidosis
            (Al)
  JOURNAL   J Am Soc Echocardiogr 24 (4), 444-454 (2011)
   PUBMED   21315556
REFERENCE   6  (bases 1 to 1300)
  AUTHORS   Fang Q, Kannapell CC, Gaskin F, Solomon A, Koopman WJ and Fu SM.
  TITLE     Human rheumatoid factors with restrictive specificity for rabbit
            immunoglobulin G: auto- and multi-reactivity, diverse VH gene
            segment usage and preferential usage of V lambda IIIb
  JOURNAL   J Exp Med 179 (5), 1445-1456 (1994)
   PUBMED   7545920
REFERENCE   7  (bases 1 to 1300)
  AUTHORS   Pritsch O, Magnac C, Dumas G, Egile C and Dighiero G.
  TITLE     V gene usage by seven hybrids derived from CD5+ B-cell chronic
            lymphocytic leukemia and displaying autoantibody activity
  JOURNAL   Blood 82 (10), 3103-3112 (1993)
   PUBMED   7693035
REFERENCE   8  (bases 1 to 1300)
  AUTHORS   Bossy D, Milili M, Zucman J, Thomas G, Fougereau M and Schiff C.
  TITLE     Organization and expression of the lambda-like genes that
            contribute to the mu-psi light chain complex in human pre-B cells
  JOURNAL   Int Immunol 3 (11), 1081-1090 (1991)
   PUBMED   1760403
REFERENCE   9  (bases 1 to 1300)
  AUTHORS   Evans RJ and Hollis GF.
  TITLE     Genomic structure of the human Ig lambda 1 gene suggests that it
            may be expressed as an Ig lambda 14.1-like protein or as a
            canonical B cell Ig lambda light chain: implications for Ig lambda
            gene evolution
  JOURNAL   J Exp Med 173 (2), 305-311 (1991)
   PUBMED   1703205
REFERENCE   10 (bases 1 to 1300)
  AUTHORS   Guglielmi P and Davi F.
  TITLE     Expression of a novel type of immunoglobulin C lambda transcripts
            in human mature B lymphocytes producing kappa light chains
  JOURNAL   Eur J Immunol 21 (2), 501-508 (1991)
   PUBMED   1900243
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ318022.1, BG756003.1,
            AA847784.1 and AC245028.2.
            
            On May 17, 2019 this sequence version replaced NM_001178126.1.
            
            Summary: This gene encodes one of the immunoglobulin lambda-like
            polypeptides. It is located within the immunoglobulin lambda locus
            but it does not require somatic rearrangement for expression. The
            first exon of this gene is unrelated to immunoglobulin variable
            genes; the second and third exons are the immunoglobulin lambda
            joining 1 and the immunoglobulin lambda constant 1 gene segments.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ318022.1, SRR1163658.428163.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000526893.6/ ENSP00000431254.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-377               AJ318022.1         37-413
            378-386             BG756003.1         358-366
            387-941             AJ318022.1         423-977
            942-1014            AJ318022.1         981-1053
            1015-1023           AA847784.1         18-26               c
            1024-1300           AC245028.2         44098-44374         c
FEATURES             Location/Qualifiers
     source          1..1300
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.22"
     gene            1..1300
                     /gene="IGLL5"
                     /gene_synonym="IGL; IGLV; VL-MAR"
                     /note="immunoglobulin lambda like polypeptide 5"
                     /db_xref="GeneID:100423062"
                     /db_xref="HGNC:HGNC:38476"
     exon            1..444
                     /gene="IGLL5"
                     /gene_synonym="IGL; IGLV; VL-MAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..883
                     /gene="IGLL5"
                     /gene_synonym="IGL; IGLV; VL-MAR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     immunoglobulin lambda-3 surrogate light chain; omega light
                     chain protein 14.1; G lambda-1; germline immunoglobulin
                     lambda 1; anti HBs antibody light-chain Fab fragment;
                     immunoglobin anti-granzymeB light chain variable region;
                     immunoglobulin lambda light chain variable region;
                     immunoglobulin light chain variable region EM1-PPS-4-L1-1;
                     immunoglobulin lambda 2 light chain; immunoglobulin lambda
                     3 light chain; immunoglobulin lambda 1 light chain;
                     immunoglobulin lambda chain; anti-SARS-CoV-2
                     immunoglobulin light chain"
                     /codon_start=1
                     /product="immunoglobulin lambda-like polypeptide 5 isoform
                     1"
                     /protein_id="NP_001171597.1"
                     /db_xref="CCDS:CCDS54506.1"
                     /db_xref="GeneID:100423062"
                     /db_xref="HGNC:HGNC:38476"
                     /translation="MRPKTGQVGCETPEELGPGPRQRWPLLLLGLAMVAHGLLRPMVA
                     PQSGDPDPGASVGSSRSSLRSLWGRLLLQPSPQRADPRCWPRGFWSEPQSLCYVFGTG
                     TKVTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAG
                     VETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS"
     exon            445..563
                     /gene="IGLL5"
                     /gene_synonym="IGL; IGLV; VL-MAR"
                     /inference="alignment:Splign:2.1.0"
     exon            564..1300
                     /gene="IGLL5"
                     /gene_synonym="IGL; IGLV; VL-MAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      996..1001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGLL5"
                     /gene_synonym="IGL; IGLV; VL-MAR"
                     /note="hexamer: AATAAA"
     polyA_site      1023
                     /gene="IGLL5"
                     /gene_synonym="IGL; IGLV; VL-MAR"
                     /note="major polyA site"
     regulatory      1274..1279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGLL5"
                     /gene_synonym="IGL; IGLV; VL-MAR"
                     /note="hexamer: AATAAA"
     polyA_site      1300
                     /gene="IGLL5"
                     /gene_synonym="IGL; IGLV; VL-MAR"
ORIGIN      
        1 gtgaccgctt cagggcagtt ggtagatgcc cctctgggag agatccccag gggtgacagc
       61 catggaccct ggaagggcct gggctaggga cagggaccag agccagtcca gggagaggac
      121 agagccaatg gactggggtg tactgtaaca gccctgctgg cgagagggac cagggcaccg
      181 tcctccaggg agcccatgct gcaagtcggg ccagaggtgc ccctgaacct gaaggccaat
      241 gagacccaag acaggccaag tgggttgtga gacccctgag gagctgggcc ctggtcccag
      301 gcagcgctgg cccctgctgc tgctgggtct ggccatggtc gcccatggcc tgctgcgccc
      361 aatggttgca ccgcaaagcg gggacccaga ccctggagcc tcagttggaa gcagccgatc
      421 cagcctgcgg agcctgtggg gcaggctcct gctccagccc agcccccaga gagcagaccc
      481 caggtgctgg ccccgggggt tttggtctga gcctcagtca ctgtgttatg tcttcggaac
      541 tgggaccaag gtcaccgtcc taggtcagcc caaggccaac cccactgtca ctctgttccc
      601 gccctcctct gaggagctcc aagccaacaa ggccacacta gtgtgtctga tcagtgactt
      661 ctacccggga gctgtgacag tggcctggaa ggcagatggc agccccgtca aggcgggagt
      721 ggagaccacc aaaccctcca aacagagcaa caacaagtac gcggccagca gctacctgag
      781 cctgacgccc gagcagtgga agtcccacag aagctacagc tgccaggtca cgcatgaagg
      841 gagcaccgtg gagaagacag tggcccctac agaatgttca taggttccca actctaaccc
      901 cacccacggg agcctggagc tgcaggatcc caggggaggg gtctctctcc ccatcccaag
      961 tcatccagcc cttctccctg cactcatgaa accccaataa atatcctcat tgacaaccag
     1021 aaatcttgtt ttatctcatt ttttttctca cataaattgc tagcctcccc ggggttctca
     1081 gtgtggggta cagggaattc tgcacccagt gtgaaaatca cccaagggag gaggctcaca
     1141 gcctccctga gtcatctccc cagagggtcc ttcctctccc agtcacccct tctccaactc
     1201 tccactgtac ccctgagcta ccagtctggc atcagttcag accagtccca caccctccta
     1261 aattttactt ctcaataaat acctgatcat gtaaaacgca
//
