LOCUS       NM_001007189            3456 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens IgA inducing protein (IGIP), mRNA.
ACCESSION   NM_001007189
VERSION     NM_001007189.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3456)
  AUTHORS   Estes,D.M.
  TITLE     Regulation of IgA responses in cattle, humans and mice
  JOURNAL   Vet Immunol Immunopathol 138 (4), 312-317 (2010)
   PUBMED   21074276
  REMARK    Review article
REFERENCE   2  (bases 1 to 3456)
  AUTHORS   Endsley,M.A., Njongmeta,L.M., Shell,E., Ryan,M.W., Indrikovs,A.J.,
            Ulualp,S., Goldblum,R.M., Mwangi,W. and Estes,D.M.
  TITLE     Human IgA-inducing protein from dendritic cells induces IgA
            production by naive IgD+ B cells
  JOURNAL   J Immunol 182 (4), 1854-1859 (2009)
   PUBMED   19201837
  REMARK    GeneRIF: IgA-inducing protein stimulation drives the production of
            mu-alpha switch circles from IgM(+)IgD(+) naive human B cells,
            indicating its role as an IgA switch factor.
REFERENCE   3  (bases 1 to 3456)
  AUTHORS   Austin,A.S., Haas,K.M., Naugler,S.M., Bajer,A.A., Garcia-Tapia,D.
            and Estes,D.M.
  TITLE     Identification and characterization of a novel regulatory factor:
            IgA-inducing protein
  JOURNAL   J Immunol 171 (3), 1336-1342 (2003)
   PUBMED   12874223
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC041380.1, CD516511.1, BC017422.1 and AC011379.7.
            
            On May 17, 2019 this sequence version replaced NM_001007189.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB073888.1, SRR1803617.41316.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333305.5/ ENSP00000327344.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1059              BC041380.1         6-1064
            1060-1696           CD516511.1         147-783
            1697-2844           BC041380.1         1702-2849
            2845-2870           BC017422.1         438-463
            2871-3456           AC011379.7         77744-78329         c
FEATURES             Location/Qualifiers
     source          1..3456
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..3456
                     /gene="IGIP"
                     /gene_synonym="C5orf53"
                     /note="IgA inducing protein"
                     /db_xref="GeneID:492311"
                     /db_xref="HGNC:HGNC:33847"
     exon            1..3456
                     /gene="IGIP"
                     /gene_synonym="C5orf53"
                     /inference="alignment:Splign:2.1.0"
     CDS             2541..2702
                     /gene="IGIP"
                     /gene_synonym="C5orf53"
                     /note="IgA-inducing protein homolog (Bos taurus)"
                     /codon_start=1
                     /product="IgA-inducing protein homolog precursor"
                     /protein_id="NP_001007190.1"
                     /db_xref="CCDS:CCDS34244.1"
                     /db_xref="GeneID:492311"
                     /db_xref="HGNC:HGNC:33847"
                     /translation="MCSYYHMKKRSVSGCNITIFAVMFSHLSAGKSPCGNQANVLCIS
                     RLEFVQYQS"
     polyA_site      2822
                     /gene="IGIP"
                     /gene_synonym="C5orf53"
                     /note="major polyA site"
     regulatory      2826..2831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGIP"
                     /gene_synonym="C5orf53"
                     /note="hexamer: AATAAA"
     regulatory      2843..2848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGIP"
                     /gene_synonym="C5orf53"
                     /note="hexamer: AATAAA"
     polyA_site      2844
                     /gene="IGIP"
                     /gene_synonym="C5orf53"
                     /note="major polyA site"
     polyA_site      2879
                     /gene="IGIP"
                     /gene_synonym="C5orf53"
     regulatory      3247..3252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGIP"
                     /gene_synonym="C5orf53"
                     /note="hexamer: AATAAA"
     polyA_site      3272
                     /gene="IGIP"
                     /gene_synonym="C5orf53"
ORIGIN      
        1 gaaagatttt tgagtctaca actgacaaaa tgtcttcttc aaattaaaaa aaattgagaa
       61 gcagcacttt aagtctaact ctacaccatt ttattgcatg tattagtttt attaatgatt
      121 tttggtgcat gcctttgggc ttattcaaaa gtgtacaata ggaaagtata tttcctttct
      181 tagaaaggag atgttttcta ctttgcaaca tgtgattaca aaaatcttcc tctgtgggaa
      241 gattaaccat gtattgaact actgaaaagt atatattttt agatatacag aaggaatcta
      301 catggagcag cattcagacc tatatagaag tcatagcatt ctgtatagga ccaaaaagga
      361 aataacatta aacacttaaa cagacgttgt tgggtagaaa tacctttaga tcttgcattt
      421 acttccaaaa agaaaaaatg ccacagaagt ttgctgaaaa cttttgtcgt ttgaattttc
      481 tctgtcagtg tatttagccc aaatacaaca gctttgggtt agcacacaca taagaatcaa
      541 aaaaacaaag ctcactaaat aaatcagtct ggtttgccaa tccagcttga ctgaaataag
      601 taaaccaatc acttgcaaca tgaaaaactg tccaactcct ctaaggttct gacaaaataa
      661 ccttggctga tgtgggaaga ctcccacttt gattactgac ctgacagtga agattcatgc
      721 ttgacatgat ttcagacttg acaatgtctg tttaaggagc tatggtacag tttgctaatt
      781 caatcccaga tacctgttga ttacctgtga gatctagagt ccaaagtagc cagcagccat
      841 atccctgagt gctctgtgcc catcagatat cttaaagtaa gcagggttgg gacaggtcac
      901 agcttggatg attgacctca ggtgccgtag acagccccag attcaagaat tgtatctgct
      961 ttcttggcag tcgtcactga actaatgtcc catactgtgt tacttactgt agatgctctc
     1021 ttttagagga ggcccagagc acacatccta atcgctagcg gtactcagag agggggtgct
     1081 aactctgatg ccctggccaa attccagttt agggatgtgg gtcttcttct tgtcattcta
     1141 attggaaatg tgcatcactt cccatttttc ttactgatct cagtgcaaac tacactagtc
     1201 tgtttctttg ccctggtctc aagtctctaa gacgctggtg tgtattatgt gggctaagtt
     1261 catgtgttat cctaaggcac aagagttgag gaatgggtga gcttggtgtc agagcactgt
     1321 gtggttggag ggtggactct tgtgatgctg tggggatgaa attggccctc ttttagcata
     1381 agttggggag tgtgcactgg ctggaggctt ccagaggctt ccagccatga ggtgtgagct
     1441 gaaaccaatt tttcctcttt ccttatagca tgttgagaaa atctgttggg ttttcagcag
     1501 tcagggaagg ccggagttct gctttaatct gggtaactga ggctaatatg agcaagactt
     1561 tggttaatta actgggttct cagatgccac agactccgtg agaagtcacc attattttca
     1621 atggttgtga tagaatttcc cccagtagcc attattttaa gattatattg cagagttgct
     1681 ttattttgag ctttttgtgt atacacaatc ccaaactgga agaaatttta aaaaaaggaa
     1741 tcctgctgtg aaaggtatat attactctag atttttctta ctgtaaatat tgtaagattg
     1801 taatactgtc gatattttat taaccaacaa atgttaatct atgtgaaatc agacttattt
     1861 taaatgtgct tcttatttac tgtgtgtggt ccctgttgct gacagtatta agttatattc
     1921 tgatgtaaga ttaactttat taaagaatgt aaacattaat gtttccttat gggaaaacaa
     1981 ataaagtata aagaagacaa ttcttttcat tgaaatatac tgtgtattta cacttgctag
     2041 acccagcacc acttataaat ttagtacact gttcagaatt ttagttaaca cagctgacat
     2101 ggttgtgctc tgtttgaaag tctaagaata ggtattgttg gaatatacag tttgtatttg
     2161 tctgctgtga atcataatct tgaaatttct aatcaagttt gtaaaatttt tatagtgaaa
     2221 cattttaatg acaatttaaa aatttatctt ctctaaagaa tggtcaaaac aatatccttt
     2281 cagaaataga attgttcttt aatatctttc caaaatgact ttggttaaat ggaccagatg
     2341 tatattagtt aaaatttagg actaagttgt tgatattctt tgagtttaca agttaatcct
     2401 tattggagat gtgccaatat acagttagaa tatcattaat ttgcactgtt tggggacccc
     2461 atttaagaat gctgaatttt gccaactaag aagtaagcaa atgcaattta aaaagtaaat
     2521 ttgagcattc tgtattaaat atgtgcagtt attatcacat gaagaaacgc agtgtgtcgg
     2581 gctgtaatat taccatattt gctgtcatgt tctcccatct cagtgctggg aaatcaccat
     2641 gtggaaacca agcaaacgtg ttgtgcatca gccggcttga gtttgttcaa tatcaaagct
     2701 gaaaactagc gaggtctgct gtactgctta ttgaagtatt gtgattattt taggcattga
     2761 ttcttacaaa atatatactg taacagtata ctttgtacag atttaaattt tatttgaaaa
     2821 aatgaaataa agtaggcaaa aaaataaaga tgtttatttt tcatgtgact gtataatcag
     2881 atcagtcttt tgtttcagtg ctttttgggg gaaggggtct ggttgcgatc ttggattttt
     2941 tttttttttg ataggtggaa actttttagg actcagtagc aggtatactt atgcttatga
     3001 attggctgca agcattaagt gtgctctcat actagagaac tctatcttct attttatttt
     3061 aaggtaggtt tgcttatttt taaaaatgtt atgtgaatgg cctccctatc ctggcatact
     3121 gggtcattta aaaaattctc tggtggtatg acagtgaacc tagccatcat gttgaagaga
     3181 agggaaacct tttcccaaag atcatgctcc attctcatgg aaggtttttt gttttctgtc
     3241 agttacaata aaaaaaatgt aattatcatg gatacatact agttatacat acttatgggg
     3301 tacatgtaac attttgaaac aagcgtacaa tgtactgatt aaatcaggat gattggggta
     3361 tccatcacct gaagtatgta taatttcttc gttttaggaa cattctaatt ccactcttag
     3421 ttatttgaaa tatataataa attattttta atagtt
//
