LOCUS       NM_024660               1647 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens IGF like family receptor 1 (IGFLR1), transcript
            variant 1, mRNA.
ACCESSION   NM_024660
VERSION     NM_024660.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1647)
  AUTHORS   Lobito,A.A., Ramani,S.R., Tom,I., Bazan,J.F., Luis,E.,
            Fairbrother,W.J., Ouyang,W. and Gonzalez,L.C.
  TITLE     Murine insulin growth factor-like (IGFL) and human IGFL1 proteins
            are induced in inflammatory skin conditions and bind to a novel
            tumor necrosis factor receptor family member, IGFLR1
  JOURNAL   J Biol Chem 286 (21), 18969-18981 (2011)
   PUBMED   21454693
  REMARK    GeneRIF: Murine insulin growth factor-like (IGFL) and human IGFL1
            proteins are induced in inflammatory skin conditions and bind to a
            novel tumor necrosis factor receptor family member, IGFLR1.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AD000671.1, AK026226.1 and BU621457.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024660.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026226.1, SRR1163657.212401.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246532.6/ ENSP00000246532.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AD000671.1         37961-37962         c
            3-1198              AK026226.1         2-1197
            1199-1647           BU621457.1         15-463              c
FEATURES             Location/Qualifiers
     source          1..1647
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..1647
                     /gene="IGFLR1"
                     /gene_synonym="TMEM149"
                     /note="IGF like family receptor 1"
                     /db_xref="GeneID:79713"
                     /db_xref="HGNC:HGNC:23620"
                     /db_xref="MIM:614143"
     exon            1..57
                     /gene="IGFLR1"
                     /gene_synonym="TMEM149"
                     /inference="alignment:Splign:2.1.0"
     exon            58..257
                     /gene="IGFLR1"
                     /gene_synonym="TMEM149"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1168
                     /gene="IGFLR1"
                     /gene_synonym="TMEM149"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; transmembrane protein 149"
                     /codon_start=1
                     /product="IGF-like family receptor 1 isoform a precursor"
                     /protein_id="NP_078936.1"
                     /db_xref="CCDS:CCDS12472.1"
                     /db_xref="GeneID:79713"
                     /db_xref="HGNC:HGNC:23620"
                     /db_xref="MIM:614143"
                     /translation="MGPGRCLLTALLLLALAPPPEASQYCGRLEYWNPDNKCCSSCLQ
                     RFGPPPCPDYEFRENCGLNDHGDFVTPPFRKCSSGQCNPDGAELCSPCGGGAVTPTPA
                     AGGGRTPWRCRERPVPAKGHCPLTPGNPGAPSSQERSSPASSIAWRTPEPVPQQAWPN
                     FLPLVVLVLLLTLAVIAILLFILLWHLCWPKEKADPYPYPGLVCGVPNTHTPSSSHLS
                     SPGALETGDTWKEASLLPLLSRELSSLASQPLSRLLDELEVLEELIVLLDPEPGPGGG
                     MAHGTTRHLAARYGLPAAWSTFAYSLRPSRSPLRALIEMVVAREPSASLGQLGTHLAQ
                     LGRADALRVLSKLGSSGVCWA"
     exon            258..442
                     /gene="IGFLR1"
                     /gene_synonym="TMEM149"
                     /inference="alignment:Splign:2.1.0"
     exon            443..821
                     /gene="IGFLR1"
                     /gene_synonym="TMEM149"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1647
                     /gene="IGFLR1"
                     /gene_synonym="TMEM149"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1174..1179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGFLR1"
                     /gene_synonym="TMEM149"
                     /note="hexamer: AATAAA"
     polyA_site      1206
                     /gene="IGFLR1"
                     /gene_synonym="TMEM149"
                     /note="major polyA site"
     regulatory      1627..1632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGFLR1"
                     /gene_synonym="TMEM149"
                     /note="hexamer: AATAAA"
     polyA_site      1647
                     /gene="IGFLR1"
                     /gene_synonym="TMEM149"
ORIGIN      
        1 gccacaactt cagctgagga acttggcacg gccagcttgg gacccaggac cctaacgcag
       61 aggcgctgtg tttggaagtc ccgctatcac ggccccccag atggggcctg gacgatgcct
      121 cctgacggcc ttgttgcttc tggccctggc gccaccgccg gaagcctccc agtactgcgg
      181 ccgccttgaa tactggaacc cagacaacaa gtgctgcagc agctgcctgc aacgcttcgg
      241 gccgcccccc tgcccggact atgagttccg ggaaaactgc ggactcaatg accacggcga
      301 tttcgtaacg cccccgttcc gaaagtgttc ttctgggcag tgcaaccccg acggcgcgga
      361 gctatgtagc ccctgcggcg gcggagccgt gacccctact cccgccgcgg gcgggggcag
      421 aaccccgtgg cgctgcagag agaggccggt ccctgccaag gggcactgcc ccctcacacc
      481 tggaaaccca ggcgccccta gctcccagga gcgcagctca ccagcaagtt ccattgcctg
      541 gaggacccct gagcctgtcc ctcagcaggc ctggccgaat ttccttccgc tcgtggtgct
      601 ggtcctgctc ctgaccttgg cggtgatagc gatcctcctg tttattctgc tctggcatct
      661 ctgctggccc aaggagaaag ccgaccccta tccctatcct ggcttggtct gcggagtccc
      721 caacacccac accccttcct cctcgcatct gtcctcccca ggcgccctgg agacagggga
      781 cacatggaag gaggcctcac tacttccact cctgagcagg gaactgtcca gtctggcgtc
      841 acaacccctg tctcgcctcc tggatgagct ggaggtgctg gaagagctga ttgtactgct
      901 ggaccctgag cctgggccag gtgggggtat ggcccatggc actactcgac acctggccgc
      961 aagatatggg ctgcctgctg cctggtccac ctttgcctat tcgctgaggc cgagtcgctc
     1021 gccgctgcgg gctctgattg agatggtggt ggcaagggag ccctctgcct ccctgggcca
     1081 gcttggcaca cacctcgccc agctagggcg ggcagatgca ttgcgggtgc tgtccaagct
     1141 tggctcatct ggggtttgct gggcttaaca cccaataaag aactttgctg actactaagc
     1201 ccagtataca attagcactg aagtacttct tgaagtacaa tcctaattgg gcaaagaccc
     1261 aacagatagc ctcactgctc ttcgccctag aagggcctat tccaacatac acacagggcc
     1321 acatgtggga gggctgaccc caggtgcctc tgggccacca gaatcccctc tgggaaacaa
     1381 ccctgctaca gacagttgct gtgttgtgtt gttctgaagc cgtaacagac cccatgactg
     1441 acttctaatt ctgaatgatg gcctcaccta cctgttgagg ctgatgaact tccttgggtc
     1501 atgatgggtg ggtgtgtaga agtggggttc ctacctgccc ccacagccta caaatgggaa
     1561 gaccacctct ccaaacattg acagacttta ttgtgggggg gttcccacct gggaccccac
     1621 ctcttaaata aaaaagtgca tagaaaa
//
