LOCUS       NM_207393                680 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens IGF like family member 3 (IGFL3), mRNA.
ACCESSION   NM_207393
VERSION     NM_207393.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 680)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: IGFL3 expression is significantly downregulated in human
            masticatory mucosa during wound healing
REFERENCE   2  (bases 1 to 680)
  AUTHORS   Lobito,A.A., Ramani,S.R., Tom,I., Bazan,J.F., Luis,E.,
            Fairbrother,W.J., Ouyang,W. and Gonzalez,L.C.
  TITLE     Murine insulin growth factor-like (IGFL) and human IGFL1 proteins
            are induced in inflammatory skin conditions and bind to a novel
            tumor necrosis factor receptor family member, IGFLR1
  JOURNAL   J Biol Chem 286 (21), 18969-18981 (2011)
   PUBMED   21454693
REFERENCE   3  (bases 1 to 680)
  AUTHORS   Emtage,P., Vatta,P., Arterburn,M., Muller,M.W., Park,E., Boyle,B.,
            Hazell,S., Polizotto,R., Funk,W.D. and Tang,Y.T.
  TITLE     IGFL: A secreted family with conserved cysteine residues and
            similarities to the IGF superfamily
  JOURNAL   Genomics 88 (4), 513-520 (2006)
   PUBMED   16890402
REFERENCE   4  (bases 1 to 680)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   5  (bases 1 to 680)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007785.1 and AY358434.1.
            
            On Nov 22, 2018 this sequence version replaced NM_207393.1.
            
            Summary: IGFL3 belongs to the insulin-like growth factor (IGF; see
            MIM 147440) family of signaling molecules that play critical roles
            in cellular energy metabolism and in growth and development,
            especially prenatal growth (Emtage et al., 2006 [PubMed
            16890402]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358434.1, AY672113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147596 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341415.3/ ENSP00000344860.2
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC007785.1         122409-122422       c
            15-676              AY358434.1         1-662
            677-680             AC007785.1         117801-117804       c
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..680
                     /gene="IGFL3"
                     /gene_synonym="UNQ483"
                     /note="IGF like family member 3"
                     /db_xref="GeneID:388555"
                     /db_xref="HGNC:HGNC:32930"
                     /db_xref="MIM:610546"
     exon            1..64
                     /gene="IGFL3"
                     /gene_synonym="UNQ483"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..417
                     /gene="IGFL3"
                     /gene_synonym="UNQ483"
                     /note="insulin growth factor-like family member 3;
                     RPRC483"
                     /codon_start=1
                     /product="insulin growth factor-like family member 3
                     precursor"
                     /protein_id="NP_997276.1"
                     /db_xref="CCDS:CCDS33058.1"
                     /db_xref="GeneID:388555"
                     /db_xref="HGNC:HGNC:32930"
                     /db_xref="MIM:610546"
                     /translation="MRPRCCILALVCWITVFLLQCSKGTTDAPVGSGLWLCQPTPRCG
                     NKIYNPSEQCCYDDAILSLKETRRCGSTCTFWPCFELCCPESFGPQQKFLVKLRVLGM
                     KSQCHLSPISRSCTRNRRHVLYP"
     exon            65..118
                     /gene="IGFL3"
                     /gene_synonym="UNQ483"
                     /inference="alignment:Splign:2.1.0"
     exon            119..389
                     /gene="IGFL3"
                     /gene_synonym="UNQ483"
                     /inference="alignment:Splign:2.1.0"
     exon            390..680
                     /gene="IGFL3"
                     /gene_synonym="UNQ483"
                     /inference="alignment:Splign:2.1.0"
     regulatory      651..656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGFL3"
                     /gene_synonym="UNQ483"
                     /note="hexamer: AATAAA"
     polyA_site      680
                     /gene="IGFL3"
                     /gene_synonym="UNQ483"
                     /note="major polyA site"
ORIGIN      
        1 accactcttc ttcaattctc ctagagcatc tttggaagca tgaggccacg atgctgcatc
       61 ttggctcttg tctgctggat aacagtcttc ctcctccagt gttcaaaagg aactacagac
      121 gctcctgttg gctcaggact gtggctgtgc cagccgacac ccaggtgtgg gaacaagatc
      181 tacaaccctt cagagcagtg ctgttatgat gatgccatct tatccttaaa ggagacccgc
      241 cgctgtggct ccacctgcac cttctggccc tgctttgagc tctgctgtcc cgagtctttt
      301 ggcccccagc agaagtttct tgtgaagttg agggttctgg gtatgaagtc tcagtgtcac
      361 ttatctccca tctcccggag ctgtaccagg aacaggaggc acgtcctgta cccataaaaa
      421 ccccaggctc cactggcaga cggcagacaa ggggagaaga gacgaagcag ctggacatcg
      481 gagactacag ttgaacttcg gagagaagca acttgacttc agagggatgg ctcaatgaca
      541 tagctttgga gaggagccca gctggggatg gccagacttc aggggaagaa tgccttcctg
      601 cttcatcccc tttccagctc cccttcccgc tgagagccac tttcatcggc aataaaatcc
      661 cccacattta ccatcttcaa
//
