LOCUS       NM_001135113             602 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens IGF like family member 2 (IGFL2), transcript variant
            2, mRNA.
ACCESSION   NM_001135113
VERSION     NM_001135113.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 602)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 602)
  AUTHORS   Lobito,A.A., Ramani,S.R., Tom,I., Bazan,J.F., Luis,E.,
            Fairbrother,W.J., Ouyang,W. and Gonzalez,L.C.
  TITLE     Murine insulin growth factor-like (IGFL) and human IGFL1 proteins
            are induced in inflammatory skin conditions and bind to a novel
            tumor necrosis factor receptor family member, IGFLR1
  JOURNAL   J Biol Chem 286 (21), 18969-18981 (2011)
   PUBMED   21454693
REFERENCE   3  (bases 1 to 602)
  AUTHORS   Emtage,P., Vatta,P., Arterburn,M., Muller,M.W., Park,E., Boyle,B.,
            Hazell,S., Polizotto,R., Funk,W.D. and Tang,Y.T.
  TITLE     IGFL: A secreted family with conserved cysteine residues and
            similarities to the IGF superfamily
  JOURNAL   Genomics 88 (4), 513-520 (2006)
   PUBMED   16890402
REFERENCE   4  (bases 1 to 602)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007785.1, AY358692.1, BC130490.1 and AW009166.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001135113.1.
            
            Summary: IGFL2 belongs to the insulin-like growth factor (IGF; see
            MIM 147440) family of signaling molecules that play critical roles
            in cellular energy metabolism and in growth and development,
            especially prenatal growth (Emtage et al., 2006 [PubMed
            16890402]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region, compared to variant 1, resulting in an isoform (b)
            that has a distinct N-terminus and is shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377693.5/ ENSP00000366922.3
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC007785.1         145972-145976
            6-455               AY358692.1         1-450
            456-537             BC130490.1         540-621
            538-602             AW009166.1         22-86               c
FEATURES             Location/Qualifiers
     source          1..602
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..602
                     /gene="IGFL2"
                     /gene_synonym="UNQ645; VPRI645"
                     /note="IGF like family member 2"
                     /db_xref="GeneID:147920"
                     /db_xref="HGNC:HGNC:32929"
                     /db_xref="MIM:610545"
     exon            1..60
                     /gene="IGFL2"
                     /gene_synonym="UNQ645; VPRI645"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..401
                     /gene="IGFL2"
                     /gene_synonym="UNQ645; VPRI645"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; insulin growth factor-like family member 2"
                     /codon_start=1
                     /product="insulin growth factor-like family member 2
                     isoform b precursor"
                     /protein_id="NP_001128585.1"
                     /db_xref="CCDS:CCDS46121.1"
                     /db_xref="GeneID:147920"
                     /db_xref="HGNC:HGNC:32929"
                     /db_xref="MIM:610545"
                     /translation="MVPRIFAPAYVSVCLLLLCPREVIAPAGSEPWLCQPAPRCGDKI
                     YNPLEQCCYNDAIVSLSETRQCGPPCTFWPCFELCCLDSFGLTNDFVVKLKVQGVNSQ
                     CHSSPISSKCESRRRFP"
     exon            61..114
                     /gene="IGFL2"
                     /gene_synonym="UNQ645; VPRI645"
                     /inference="alignment:Splign:2.1.0"
     exon            115..382
                     /gene="IGFL2"
                     /gene_synonym="UNQ645; VPRI645"
                     /inference="alignment:Splign:2.1.0"
     exon            383..602
                     /gene="IGFL2"
                     /gene_synonym="UNQ645; VPRI645"
                     /inference="alignment:Splign:2.1.0"
     regulatory      580..585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGFL2"
                     /gene_synonym="UNQ645; VPRI645"
                     /note="hexamer: AATAAA"
     polyA_site      602
                     /gene="IGFL2"
                     /gene_synonym="UNQ645; VPRI645"
                     /note="major polyA site"
ORIGIN      
        1 catttgcact gctgctgtcc catcagctgc tctgaagctc catggtgccc agaatcttcg
       61 ctcctgctta tgtgtcagtc tgtctcctcc tcttgtgtcc aagggaagtc atcgctcccg
      121 ctggctcaga accatggctg tgccagccgg cacccaggtg tggagacaag atctacaacc
      181 ccttggagca gtgctgttac aatgacgcca tcgtgtccct gagcgagacc cgccaatgtg
      241 gtcccccctg caccttctgg ccctgctttg agctctgctg tcttgattcc tttggcctca
      301 caaacgattt tgttgtgaag ctgaaggttc agggtgtgaa ttcccagtgc cactcatctc
      361 ccatctccag taaatgtgaa agcagaagac gttttccctg agaagacata gaaagaaaat
      421 caactttcac taaggcatct cagaaacata ggctaaggta atatgtgtac cagtagagaa
      481 gcctgaggaa tttacaaaat gatgcagctc caagccattg tatggcccat gtgggagact
      541 gatgggacat ggagaatgac agtagattat caggaaataa ataaagtggt ttttccaatg
      601 ta
//
