LOCUS       NM_198541                779 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens IGF like family member 1 (IGFL1), mRNA.
ACCESSION   NM_198541 XM_353187
VERSION     NM_198541.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 779)
  AUTHORS   Wang,H., Shi,Y., Chen,C.H., Wen,Y., Zhou,Z., Yang,C., Sun,J.,
            Du,G., Wu,J., Mao,X., Liu,R. and Chen,C.
  TITLE     KLF5-induced lncRNA IGFL2-AS1 promotes basal-like breast cancer
            cell growth and survival by upregulating the expression of IGFL1
  JOURNAL   Cancer Lett 515, 49-62 (2021)
   PUBMED   34052325
  REMARK    GeneRIF: KLF5-induced lncRNA IGFL2-AS1 promotes basal-like breast
            cancer cell growth and survival by upregulating the expression of
            IGFL1.
REFERENCE   2  (bases 1 to 779)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 779)
  AUTHORS   Lobito,A.A., Ramani,S.R., Tom,I., Bazan,J.F., Luis,E.,
            Fairbrother,W.J., Ouyang,W. and Gonzalez,L.C.
  TITLE     Murine insulin growth factor-like (IGFL) and human IGFL1 proteins
            are induced in inflammatory skin conditions and bind to a novel
            tumor necrosis factor receptor family member, IGFLR1
  JOURNAL   J Biol Chem 286 (21), 18969-18981 (2011)
   PUBMED   21454693
  REMARK    GeneRIF: Murine insulin growth factor-like (IGFL) and human IGFL1
            proteins are induced in inflammatory skin conditions and bind to a
            novel tumor necrosis factor receptor family member, IGFLR1.
REFERENCE   4  (bases 1 to 779)
  AUTHORS   Ester,W.A., van Meurs,J.B., Arends,N.J., Uitterlinden,A.G., de
            Ridder,M.A. and Hokken-Koelega,A.C.
  TITLE     The -G1245A IGF1 polymorphism is related with small head size and
            less brain sparing in small for gestational age born children
  JOURNAL   Eur J Endocrinol 160 (4), 549-555 (2009)
   PUBMED   19147602
  REMARK    GeneRIF: The -1245 A-allele of the IGF1 promoter single nucleotide
            polymorphism is associated with a small head size and less brain
            sparing in small for gestational age born subjects
REFERENCE   5  (bases 1 to 779)
  AUTHORS   Emtage,P., Vatta,P., Arterburn,M., Muller,M.W., Park,E., Boyle,B.,
            Hazell,S., Polizotto,R., Funk,W.D. and Tang,Y.T.
  TITLE     IGFL: A secreted family with conserved cysteine residues and
            similarities to the IGF superfamily
  JOURNAL   Genomics 88 (4), 513-520 (2006)
   PUBMED   16890402
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006262.2 and AY359013.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198541.1.
            
            Summary: The protein encoded by this gene is a member of the
            insulin-like growth factor family of signaling molecules. The
            encoded protein is synthesized as a precursor protein and is
            proteolytically cleaved to form a secreted mature peptide. The
            mature peptide binds to a receptor, which in mouse was found on the
            cell surface of T cells. Increased expression of this gene may be
            linked to psoriasis. [provided by RefSeq, Aug 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY359013.1, DN995474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000437936.2/ ENSP00000415823.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC006262.2         81272-81281
            11-779              AY359013.1         1-769
FEATURES             Location/Qualifiers
     source          1..779
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..779
                     /gene="IGFL1"
                     /gene_synonym="APRG644; UNQ644"
                     /note="IGF like family member 1"
                     /db_xref="GeneID:374918"
                     /db_xref="HGNC:HGNC:24093"
                     /db_xref="MIM:610544"
     exon            1..58
                     /gene="IGFL1"
                     /gene_synonym="APRG644; UNQ644"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..366
                     /gene="IGFL1"
                     /gene_synonym="APRG644; UNQ644"
                     /note="insulin growth factor-like family member 1"
                     /codon_start=1
                     /product="insulin growth factor-like family member 1
                     precursor"
                     /protein_id="NP_940943.1"
                     /db_xref="CCDS:CCDS46123.1"
                     /db_xref="GeneID:374918"
                     /db_xref="HGNC:HGNC:24093"
                     /db_xref="MIM:610544"
                     /translation="MAPRGCIVAVFAIFCISRLLCSHGAPVAPMTPYLMLCQPHKRCG
                     DKFYDPLQHCCYDDAVVPLARTQTCGNCTFRVCFEQCCPWTFMVKLINQNCDSARTSD
                     DRLCRSVS"
     exon            59..112
                     /gene="IGFL1"
                     /gene_synonym="APRG644; UNQ644"
                     /inference="alignment:Splign:2.1.0"
     exon            113..356
                     /gene="IGFL1"
                     /gene_synonym="APRG644; UNQ644"
                     /inference="alignment:Splign:2.1.0"
     exon            357..779
                     /gene="IGFL1"
                     /gene_synonym="APRG644; UNQ644"
                     /inference="alignment:Splign:2.1.0"
     regulatory      753..758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGFL1"
                     /gene_synonym="APRG644; UNQ644"
                     /note="hexamer: AATAAA"
     polyA_site      779
                     /gene="IGFL1"
                     /gene_synonym="APRG644; UNQ644"
                     /note="major polyA site"
ORIGIN      
        1 cccctcctca ctccactgca accacccaga gccatggctc cccgaggctg catcgtagct
       61 gtctttgcca ttttctgcat ctccaggctc ctctgctcac acggagcccc agtggccccc
      121 atgactcctt acctgatgct gtgccagcca cacaagagat gtggggacaa gttctacgac
      181 cccctgcagc actgttgcta tgatgatgcc gtcgtgccct tggccaggac ccagacgtgt
      241 ggaaactgca ccttcagagt ctgctttgag cagtgctgcc cctggacctt catggtgaag
      301 ctgataaacc agaactgcga ctcagcccgg acctcggatg acaggctttg tcgcagtgtc
      361 agctaatgga acatcagggg aacgatgact cctggattct ccttcctggg tgggcctgga
      421 gaaagaggct ggtgttacct gagatctggg atgctgagtg gctgtttggg ggccagagaa
      481 acacacactc aactgcccac ttcattctgt gacctgtctg aggcccaccc tgcagctgcc
      541 ctgaggaggc ccacaggtcc ccttctagaa ttctggacag catgagatgc gtgtgctgat
      601 gggggcccag ggactctgaa ccctcctgat gacccctatg gccaacatca acccggcacc
      661 accccaaggc tggctgggga acccttcacc cttctgtgag attttccatc atctcaagtt
      721 ctcttctatc caggagcaaa gcacaggatc ataataaatt tatgtacttt ataaatgaa
//
