LOCUS       NM_001553               1427 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens insulin like growth factor binding protein 7 (IGFBP7),
            transcript variant 1, mRNA.
ACCESSION   NM_001553
VERSION     NM_001553.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1427)
  AUTHORS   He,R., Feng,B., Zhang,Y., Li,Y., Wang,D. and Yu,L.
  TITLE     IGFBP7 promotes endothelial cell repair in the recovery phase of
            acute lung injury
  JOURNAL   Clin Sci (Lond) 138 (13), 797-815 (2024)
   PUBMED   38840498
  REMARK    GeneRIF: IGFBP7 promotes endothelial cell repair in the recovery
            phase of acute lung injury.
REFERENCE   2  (bases 1 to 1427)
  AUTHORS   Xu,Y., Sun,Y., Zhu,Y. and Song,G.
  TITLE     Structural insight into CD93 recognition by IGFBP7
  JOURNAL   Structure 32 (3), 282-291 (2024)
   PUBMED   38218180
  REMARK    GeneRIF: Structural insight into CD93 recognition by IGFBP7.
REFERENCE   3  (bases 1 to 1427)
  AUTHORS   Wang,Y., Bo,J., Zhao,Z., Han,Y., Zhang,Q. and Liu,L.
  TITLE     Depletion of Igfbp7 alleviates zebrafish NAFLD progression through
            inhibiting hepatic ferroptosis
  JOURNAL   Life Sci 332, 122086 (2023)
   PUBMED   37714372
  REMARK    GeneRIF: Depletion of Igfbp7 alleviates zebrafish NAFLD progression
            through inhibiting hepatic ferroptosis.
REFERENCE   4  (bases 1 to 1427)
  AUTHORS   Liu,F., Yu,T., Liu,J., Yang,Q., Wu,J., Ren,J. and Zhu,N.
  TITLE     IGFBP-7 secreted by adipose-derived stem cells inhibits keloid
            formation via the BRAF/MEK/ERK signaling pathway
  JOURNAL   J Dermatol Sci 111 (1), 10-19 (2023)
   PUBMED   37316358
  REMARK    GeneRIF: IGFBP-7 secreted by adipose-derived stem cells inhibits
            keloid formation via the BRAF/MEK/ERK signaling pathway.
REFERENCE   5  (bases 1 to 1427)
  AUTHORS   Liu,C.T., Wu,F.C., Zhuang,Y.X., Huang,X.Y., Li,X.H., Qu,Q.Q.,
            Peng,Y.H., Xu,Y.W., Chen,S.L. and Huang,X.C.
  TITLE     The diagnostic value of serum insulin-like growth factor binding
            protein 7 in gastric cancer
  JOURNAL   PeerJ 11, e15419 (2023)
   PUBMED   37304887
  REMARK    GeneRIF: The diagnostic value of serum insulin-like growth factor
            binding protein 7 in gastric cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1427)
  AUTHORS   Oh,Y., Nagalla,S.R., Yamanaka,Y., Kim,H.S., Wilson,E. and
            Rosenfeld,R.G.
  TITLE     Synthesis and characterization of insulin-like growth
            factor-binding protein (IGFBP)-7. Recombinant human mac25 protein
            specifically binds IGF-I and -II
  JOURNAL   J Biol Chem 271 (48), 30322-30325 (1996)
   PUBMED   8939990
REFERENCE   7  (bases 1 to 1427)
  AUTHORS   Swisshelm,K., Ryan,K., Tsuchiya,K. and Sager,R.
  TITLE     Enhanced expression of an insulin growth factor-like binding
            protein (mac25) in senescent human mammary epithelial cells and
            induced expression with retinoic acid
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4472-4476 (1995)
   PUBMED   7538673
REFERENCE   8  (bases 1 to 1427)
  AUTHORS   Yamauchi,T., Umeda,F., Masakado,M., Isaji,M., Mizushima,S. and
            Nawata,H.
  TITLE     Purification and molecular cloning of prostacyclin-stimulating
            factor from serum-free conditioned medium of human diploid
            fibroblast cells
  JOURNAL   Biochem J 303 (Pt 2) (Pt 2), 591-598 (1994)
   PUBMED   7980422
REFERENCE   9  (bases 1 to 1427)
  AUTHORS   Akaogi,K., Okabe,Y., Funahashi,K., Yoshitake,Y., Nishikawa,K.,
            Yasumitsu,H., Umeda,M. and Miyazaki,K.
  TITLE     Cell adhesion activity of a 30-kDa major secreted protein from
            human bladder carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 198 (3), 1046-1053 (1994)
   PUBMED   8117260
REFERENCE   10 (bases 1 to 1427)
  AUTHORS   Murphy,M., Pykett,M.J., Harnish,P., Zang,K.D. and George,D.L.
  TITLE     Identification and characterization of genes differentially
            expressed in meningiomas
  JOURNAL   Cell Growth Differ 4 (9), 715-722 (1993)
   PUBMED   7694637
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC066339.1, AI761388.1 and
            AC069307.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001553.2.
            
            Summary: This gene encodes a member of the insulin-like growth
            factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with
            high affinity, and regulate IGF availability in body fluids and
            tissues and modulate IGF binding to its receptors. This protein
            binds IGF-I and IGF-II with relatively low affinity, and belongs to
            a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin
            production and cell adhesion. Alternatively spliced transcript
            variants encoding different isoforms have been described for this
            gene, and one variant has been associated with retinal arterial
            macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066339.1, S75725.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295666.6/ ENSP00000295666.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1126              BC066339.1         1-1126
            1127-1129           AI761388.1         9-11                c
            1130-1427           AC069307.7         144630-144927       c
FEATURES             Location/Qualifiers
     source          1..1427
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..1427
                     /gene="IGFBP7"
                     /gene_synonym="AGM; FSTL2; IBP-7; IGFBP-7; IGFBP-7v;
                     IGFBPRP1; MAC25; PSF; RAMSVPS; TAF"
                     /note="insulin like growth factor binding protein 7"
                     /db_xref="GeneID:3490"
                     /db_xref="HGNC:HGNC:5476"
                     /db_xref="MIM:602867"
     exon            1..509
                     /gene="IGFBP7"
                     /gene_synonym="AGM; FSTL2; IBP-7; IGFBP-7; IGFBP-7v;
                     IGFBPRP1; MAC25; PSF; RAMSVPS; TAF"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..883
                     /gene="IGFBP7"
                     /gene_synonym="AGM; FSTL2; IBP-7; IGFBP-7; IGFBP-7v;
                     IGFBPRP1; MAC25; PSF; RAMSVPS; TAF"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; angiomodulin; IGFBP-rP1; IGF-binding protein 7;
                     PGI2-stimulating factor; tumor-derived adhesion factor;
                     prostacyclin-stimulating factor"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 7
                     isoform 1 precursor"
                     /protein_id="NP_001544.1"
                     /db_xref="CCDS:CCDS3512.1"
                     /db_xref="GeneID:3490"
                     /db_xref="HGNC:HGNC:5476"
                     /db_xref="MIM:602867"
                     /translation="MERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLP
                     PLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCAPGMECVKSRKRRKGKAGAAA
                     GGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGP
                     SIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGHYGVQRTELLPGDRDNLAI
                     QTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVVDALHEIPVKK
                     GEGAEL"
     exon            510..619
                     /gene="IGFBP7"
                     /gene_synonym="AGM; FSTL2; IBP-7; IGFBP-7; IGFBP-7v;
                     IGFBPRP1; MAC25; PSF; RAMSVPS; TAF"
                     /inference="alignment:Splign:2.1.0"
     exon            620..736
                     /gene="IGFBP7"
                     /gene_synonym="AGM; FSTL2; IBP-7; IGFBP-7; IGFBP-7v;
                     IGFBPRP1; MAC25; PSF; RAMSVPS; TAF"
                     /inference="alignment:Splign:2.1.0"
     exon            737..863
                     /gene="IGFBP7"
                     /gene_synonym="AGM; FSTL2; IBP-7; IGFBP-7; IGFBP-7v;
                     IGFBPRP1; MAC25; PSF; RAMSVPS; TAF"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1427
                     /gene="IGFBP7"
                     /gene_synonym="AGM; FSTL2; IBP-7; IGFBP-7; IGFBP-7v;
                     IGFBPRP1; MAC25; PSF; RAMSVPS; TAF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1101..1106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGFBP7"
                     /gene_synonym="AGM; FSTL2; IBP-7; IGFBP-7; IGFBP-7v;
                     IGFBPRP1; MAC25; PSF; RAMSVPS; TAF"
                     /note="hexamer: AATAAA"
     polyA_site      1122
                     /gene="IGFBP7"
                     /gene_synonym="AGM; FSTL2; IBP-7; IGFBP-7; IGFBP-7v;
                     IGFBPRP1; MAC25; PSF; RAMSVPS; TAF"
                     /note="major polyA site"
     regulatory      1400..1405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGFBP7"
                     /gene_synonym="AGM; FSTL2; IBP-7; IGFBP-7; IGFBP-7v;
                     IGFBPRP1; MAC25; PSF; RAMSVPS; TAF"
                     /note="hexamer: AATAAA"
     polyA_site      1427
                     /gene="IGFBP7"
                     /gene_synonym="AGM; FSTL2; IBP-7; IGFBP-7; IGFBP-7v;
                     IGFBPRP1; MAC25; PSF; RAMSVPS; TAF"
ORIGIN      
        1 actcgcgccc ttgccgctgc caccgcaccc cgccatggag cggccgtcgc tgcgcgccct
       61 gctcctcggc gccgctgggc tgctgctcct gctcctgccc ctctcctctt cctcctcttc
      121 ggacacctgc ggcccctgcg agccggcctc ctgcccgccc ctgcccccgc tgggctgcct
      181 gctgggcgag acccgcgacg cgtgcggctg ctgccctatg tgcgcccgcg gcgagggcga
      241 gccgtgcggg ggtggcggcg ccggcagggg gtactgcgcg ccgggcatgg agtgcgtgaa
      301 gagccgcaag aggcggaagg gtaaagccgg ggcagcagcc ggcggtccgg gtgtaagcgg
      361 cgtgtgcgtg tgcaagagcc gctacccggt gtgcggcagc gacggcacca cctacccgag
      421 cggctgccag ctgcgcgccg ccagccagag ggccgagagc cgcggggaga aggccatcac
      481 ccaggtcagc aagggcacct gcgagcaagg tccttccata gtgacgcccc ccaaggacat
      541 ctggaatgtc actggtgccc aggtgtactt gagctgtgag gtcatcggaa tcccgacacc
      601 tgtcctcatc tggaacaagg taaaaagggg tcactatgga gttcaaagga cagaactcct
      661 gcctggtgac cgggacaacc tggccattca gacccggggt ggcccagaaa agcatgaagt
      721 aactggctgg gtgctggtat ctcctctaag taaggaagat gctggagaat atgagtgcca
      781 tgcatccaat tcccaaggac aggcttcagc atcagcaaaa attacagtgg ttgatgcctt
      841 acatgaaata ccagtgaaaa aaggtgaagg tgccgagcta taaacctcca gaatattatt
      901 agtctgcatg gttaaaagta gtcatggata actacattac ctgttcttgc ctaataagtt
      961 tcttttaatc caatccacta acactttagt tatattcact ggttttacac agagaaatac
     1021 aaaataaaga tcacacatca agactatcta caaaaattta ttatatattt acagaagaaa
     1081 agcatgcata tcattaaaca aataaaatac tttttatcac aacacagtac atatttgtca
     1141 tttttaaaaa gccacacaat agaaacaaga caccaagata tttaattatc ttgttgactc
     1201 ctgtaaaata gctaaacact catcattcgc ggtgcaatac tcatagacat aagttcctga
     1261 aacaatagtt tgcatgcgta aggcattcgc accaaagaaa tctgaaaaga aaaaacaaat
     1321 ggtaattagc agaattgtat tgaagtgacc ccacttctct accccagaaa aagacaaaga
     1381 tctggtactg tagataatga ataaatgagt ggagctgaga acacaca
//
