LOCUS       NM_000599               6239 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens insulin like growth factor binding protein 5 (IGFBP5),
            mRNA.
ACCESSION   NM_000599
VERSION     NM_000599.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6239)
  AUTHORS   Rodriguez-Rojas,K., Cortes-Reynosa,P., Torres-Alamilla,P.,
            Rodriguez-Ochoa,N. and Salazar,E.P.
  TITLE     A novel role of IGFBP5 in the migration, invasion and spheroids
            formation induced by IGF-I and insulin in MCF-7 breast cancer cells
  JOURNAL   Breast Cancer Res Treat 208 (1), 79-88 (2024)
   PUBMED   38896333
  REMARK    GeneRIF: A novel role of IGFBP5 in the migration, invasion and
            spheroids formation induced by IGF-I and insulin in MCF-7 breast
            cancer cells.
REFERENCE   2  (bases 1 to 6239)
  AUTHORS   Xiao,J., Deng,Y., Xie,J., Liu,H., Yang,Q., Zhang,Y., Huang,X. and
            Cao,Z.
  TITLE     Apoptotic vesicles from macrophages exacerbate periodontal bone
            resorption in periodontitis via delivering miR-143-3p targeting
            Igfbp5
  JOURNAL   J Nanobiotechnology 22 (1), 658 (2024)
   PUBMED   39456001
  REMARK    GeneRIF: Apoptotic vesicles from macrophages exacerbate periodontal
            bone resorption in periodontitis via delivering miR-143-3p
            targeting Igfbp5.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6239)
  AUTHORS   Xie,J., Chen,P., Mao,S., Zang,X., Cao,R., Liu,W., Wang,X. and
            Dai,Y.
  TITLE     Mir-204-5p alleviates mitochondrial dysfunction by targeting IGFBP5
            in diabetic cataract
  JOURNAL   Mol Biol Rep 51 (1), 755 (2024)
   PUBMED   38874707
  REMARK    GeneRIF: Mir-204-5p alleviates mitochondrial dysfunction by
            targeting IGFBP5 in diabetic cataract.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6239)
  AUTHORS   Song,F., Hu,Y., Hong,Y.X., Sun,H., Han,Y., Mao,Y.J., Wu,W.Y., Li,G.
            and Wang,Y.
  TITLE     Deletion of endothelial IGFBP5 protects against ischaemic hindlimb
            injury by promoting angiogenesis
  JOURNAL   Clin Transl Med 14 (6), e1725 (2024)
   PUBMED   38886900
  REMARK    GeneRIF: Deletion of endothelial IGFBP5 protects against ischaemic
            hindlimb injury by promoting angiogenesis.
REFERENCE   5  (bases 1 to 6239)
  AUTHORS   Alessio,N., Aprile,D., Peluso,G., Mazzone,V., Patrone,D., Di
            Bernardo,G. and Galderisi,U.
  TITLE     IGFBP5 is released by senescent cells and is internalized by
            healthy cells, promoting their senescence through interaction with
            retinoic receptors
  JOURNAL   Cell Commun Signal 22 (1), 122 (2024)
   PUBMED   38351010
  REMARK    GeneRIF: IGFBP5 is released by senescent cells and is internalized
            by healthy cells, promoting their senescence through interaction
            with retinoic receptors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6239)
  AUTHORS   Ilvesmaki,V., Blum,W.F. and Voutilainen,R.
  TITLE     Insulin-like growth factor binding proteins in the human adrenal
            gland
  JOURNAL   Mol Cell Endocrinol 97 (1-2), 71-79 (1993)
   PUBMED   7511544
REFERENCE   7  (bases 1 to 6239)
  AUTHORS   Shimasaki,S., Shimonaka,M., Zhang,H.P. and Ling,N.
  TITLE     Identification of five different insulin-like growth factor binding
            proteins (IGFBPs) from adult rat serum and molecular cloning of a
            novel IGFBP-5 in rat and human
  JOURNAL   J Biol Chem 266 (16), 10646-10653 (1991)
   PUBMED   1709938
REFERENCE   8  (bases 1 to 6239)
  AUTHORS   Ehrenborg,E., Vilhelmsdotter,S., Bajalica,S., Larsson,C., Stern,I.,
            Koch,J., Brondum-Nielsen,K. and Luthman,H.
  TITLE     Structure and localization of the human insulin-like growth
            factor-binding protein 2 gene
  JOURNAL   Biochem Biophys Res Commun 176 (3), 1250-1255 (1991)
   PUBMED   1710112
REFERENCE   9  (bases 1 to 6239)
  AUTHORS   Kiefer,M.C., Ioh,R.S., Bauer,D.M. and Zapf,J.
  TITLE     Molecular cloning of a new human insulin-like growth factor binding
            protein
  JOURNAL   Biochem Biophys Res Commun 176 (1), 219-225 (1991)
   PUBMED   1850258
REFERENCE   10 (bases 1 to 6239)
  AUTHORS   Andress,D.L. and Birnbaum,R.S.
  TITLE     A novel human insulin-like growth factor binding protein secreted
            by osteoblast-like cells
  JOURNAL   Biochem Biophys Res Commun 176 (1), 213-218 (1991)
   PUBMED   1850257
  REMARK    Erratum:[Biochem Biophys Res Commun 1991 Jun 14;177(2):895]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007563.2.
            
            On Nov 23, 2018 this sequence version replaced NM_000599.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF055033.1, ERR279874.3369.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233813.5/ ENSP00000233813.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1111              AC007563.2         135367-136477
            1112-1341           AC007563.2         151837-152066
            1342-1461           AC007563.2         152685-152804
            1462-6239           AC007563.2         154034-158811
FEATURES             Location/Qualifiers
     source          1..6239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..6239
                     /gene="IGFBP5"
                     /gene_synonym="IBP5"
                     /note="insulin like growth factor binding protein 5"
                     /db_xref="GeneID:3488"
                     /db_xref="HGNC:HGNC:5474"
                     /db_xref="MIM:146734"
     exon            1..1111
                     /gene="IGFBP5"
                     /gene_synonym="IBP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             775..1593
                     /gene="IGFBP5"
                     /gene_synonym="IBP5"
                     /note="IBP-5; IGFBP-5; IGF-binding protein 5"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 5
                     precursor"
                     /protein_id="NP_000590.1"
                     /db_xref="CCDS:CCDS2405.1"
                     /db_xref="GeneID:3488"
                     /db_xref="HGNC:HGNC:5474"
                     /db_xref="MIM:146734"
                     /translation="MVLLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLG
                     CELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLN
                     EKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKL
                     TQSKFVGGAENTAHPRIISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPN
                     CDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE"
     exon            1112..1341
                     /gene="IGFBP5"
                     /gene_synonym="IBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1461
                     /gene="IGFBP5"
                     /gene_synonym="IBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..6239
                     /gene="IGFBP5"
                     /gene_synonym="IBP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6218..6223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGFBP5"
                     /gene_synonym="IBP5"
                     /note="hexamer: AATAAA"
     polyA_site      6239
                     /gene="IGFBP5"
                     /gene_synonym="IBP5"
                     /note="major polyA site"
ORIGIN      
        1 gtagtctctt tggaaacttc tgcaggggaa aagagctagg aaagagctgc aaagcagtgt
       61 gggctttttc ccttttttgc tccttttcat tacccctcct ccgttttcac ccttctccgg
      121 acttcgcgta gaacctgcga atttcgaaga ggaggtggca aagtgggaga aaagaggtgt
      181 tagggtttgg ggtttttttg tttttgtttt tgttttttaa tttcttgatt tcaacatttt
      241 ctcccaccct ctcggctgca gccaacgcct cttacctgtt ctgcggcgcc gcgcaccgct
      301 ggcagctgag ggttagaaag cggggtgtat tttagatttt aagcaaaaat tttaaagata
      361 aatccatttt tctctcccac ccccaacgcc atctccactg catccgatct cattatttcg
      421 gtggttgctt gggggtgaac aattttgtgg ctttttttcc cctataattc tgacccgctc
      481 aggcttgagg gtttctccgg cctccgctca ctgcgtgcac ctggcgctgc cctgcttccc
      541 ccaacctgtt gcaaggcttt aattcttgca actgggacct gctcgcaggc accccagccc
      601 tccacctctc tctacatttt tgcaagtgtc tgggggaggg cacctgctct acctgccaga
      661 aattttaaaa caaaaacaaa aacaaaaaaa tctccggggg ccctcttggc ccctttatcc
      721 ctgcactctc gctctcctgc cccaccccga ggtaaagggg gcgactaaga gaagatggtg
      781 ttgctcaccg cggtcctcct gctgctggcc gcctatgcgg ggccggccca gagcctgggc
      841 tccttcgtgc actgcgagcc ctgcgacgag aaagccctct ccatgtgccc ccccagcccc
      901 ctgggctgcg agctggtcaa ggagccgggc tgcggctgct gcatgacctg cgccctggcc
      961 gaggggcagt cgtgcggcgt ctacaccgag cgctgcgccc aggggctgcg ctgcctcccc
     1021 cggcaggacg aggagaagcc gctgcacgcc ctgctgcacg gccgcggggt ttgcctcaac
     1081 gaaaagagct accgcgagca agtcaagatc gagagagact cccgtgagca cgaggagccc
     1141 accacctctg agatggccga ggagacctac tcccccaaga tcttccggcc caaacacacc
     1201 cgcatctccg agctgaaggc tgaagcagtg aagaaggacc gcagaaagaa gctgacccag
     1261 tccaagtttg tcgggggagc cgagaacact gcccaccccc ggatcatctc tgcacctgag
     1321 atgagacagg agtctgagca gggcccctgc cgcagacaca tggaggcttc cctgcaggag
     1381 ctcaaagcca gcccacgcat ggtgccccgt gctgtgtacc tgcccaattg tgaccgcaaa
     1441 ggattctaca agagaaagca gtgcaaacct tcccgtggcc gcaaacgtgg catctgctgg
     1501 tgcgtggaca agtacgggat gaagctgcca ggcatggagt acgttgacgg ggactttcag
     1561 tgccacacct tcgacagcag caacgttgag tgatgcgtcc ccccccaacc tttccctcac
     1621 cccctcccac ccccagcccc gactccagcc agcgcctccc tccaccccag gacgccactc
     1681 atttcatctc atttaaggga aaaatatata tctatctatt tgaggaaact gaggacctcg
     1741 gaatctctag caagggctca acttcgaaaa tggcaacaac agagatgcaa aaagctaaaa
     1801 agacaccccc cccctttaaa tggttttctt tttgaggcaa gttggatgaa cagagaaggg
     1861 aagagaggaa gaacgagagg aagagaaggg aaggaagtgt ttgtgtagaa gagagagaaa
     1921 gacgaataga gttaggaaaa ggaagacaag caggtgggca ggaaggacat gcaccgagac
     1981 caggcagggg cccaactttc acgtccagcc ctggcctggg gtcgggagag gtgggcgcta
     2041 gaagatgcag cccaggatgt ggcaatcaat gacactattg gggtttccca ggatggattg
     2101 gtcaggggga gaaaggaaaa ggcaaaacac tccaggacct ctcccggatc tgtctcctcc
     2161 tctagccagc agtatggaca gctggacccc tgaacttcct ctcctcttac ctgggcagag
     2221 tgttgtctct ccccaaattt ataaaaacta aaatgcattc cattcctctg aaagcaaaac
     2281 aaattcataa ttgagtgata ttaaatagag aggttttcgg aagcagatct gtgaatatga
     2341 aatacatgtg catatttcat tccccaggca gacatttttt agaaatcaat acatgcccca
     2401 atattggaaa gacttgttct tccacggtga ctacagtaca tgctgaagcg tgccgtttca
     2461 gccctcattt aattcaattt gtaagtagcg cagcagcctc tgtgggggag gataggctga
     2521 aaaaaaaaag tgggctcgta tttatctaca ggactccata tagtcatata taggcatata
     2581 aatctattct ttttctttgt ttttttcttt cttcctttct ttcaaaggtt tgcattaact
     2641 tttcaaagta gttcctatag gggcattgag gagcttcctc attctgggaa aactgagaaa
     2701 acccatattc tcctaataca acccgtaata gcatttttgc ctgcctcgag gcagagtttc
     2761 ccgtgagcaa taaactcagc ttttttgtgg ggcacagtac tggatttgac agtgattccc
     2821 cacgtgtgtt catctgcacc caccgagcca ggcagaggcc agccctccgt ggtgcacaca
     2881 gcacgcgcct cagtccatcc cattttagtc tttaaaccct caggaagtca cagtctccgg
     2941 acaccacacc acatgagccc aacaggtcca cgatggatcc accagtccca ccccagcctt
     3001 ttcctttcat ctgaacagaa tgtgcatttt tggaagcctc cctcactctc catgctggca
     3061 gagcaggagg gagactgaag taagagatgg cagagggaga tggtggcaaa aaggtttaga
     3121 tgcaggagaa cagtaagatg gatggttccg gccagagtcg atgtggggag gaacagaggg
     3181 ctgaagggag agggggctga ctgttccatt ctagctttgg cacaaagcag cagaaagggg
     3241 gaaaagccaa tagaaatttc cttagcttcc ccaccatatg tattttctag gatttgagag
     3301 gaaagagagg aaaatggggg aatgggttgc aaaatagaaa tgagcttaat ccaggccgca
     3361 gagccaggga aggtgagtaa ctttaggagg gtgctagact ttagaagcca gataggaaga
     3421 atcagtctaa actggccatg ctttggaagg gacaagacta tgtgctccgc tgcccacctt
     3481 cagcctgcaa tgagggactg aggcccacga gtctttccag ctcttcctcc attctggcca
     3541 gtccctgcat cctccctggg gtggaggatg gaaggaaagc tgggacaagc agggaacgca
     3601 tgattcaggg atgctgtcac tcggcagcca gattccgaaa ctcccattct ccaatgactt
     3661 cctcaaccaa tgggtggcct tgtgactgtt ctttaaggct gaagatatcc aggaaagggg
     3721 gcttggacac tggccaagga gaccccttcg tgctgtggac acagctctct tcactctttg
     3781 ctcatggcat gacacagcgg agaccgcctc caacaacgaa tttggggcta cgaagaggaa
     3841 tagcgaaaaa gcaaatctgt ttcaactgat gggaacccta tagctataga acttgggggc
     3901 tatctcctat gcccctggac aggacagttg gctggggaca ggagaagtgc tcaatcttca
     3961 tgagacaaag gggcccgata gggccagcag ccacaaggcc ttgacctgcc gagtcagcat
     4021 gccccatctc tctgcacagc tgtcccctaa acccaactca cgtttctgta tgtcttaggc
     4081 cagtatccca aacctcttcc acgtcactgt tctttccacc cattctccct ttgcatcttg
     4141 agcagttatc caactaggat ctgccaagtg gatactgggg tgccactccc ctgagaaaag
     4201 actgagccag gaactacaag ctccccccac attcctccca gcctggacct aattcttgag
     4261 aggggctctc tcttcacgga ctgtgtctgg actttgagca ggcttctgcc ccttgcgttg
     4321 gctctttgct gccagccatc aggtggggga ttagagcctg gtgtaagtgc gccagactct
     4381 tccggtttcc aaagttcgtg cctgcgaacc caaacctgtg agtctcttct gcatgcagga
     4441 gtttctcctg ggcagctggt cactccccag agaagctggg ccttcatgga cacatggaac
     4501 taagcctccc aaatgggagt tctggctgag cccagggtgg ggagatcctg ggaagggagg
     4561 cactggagga agacggcacc tcttccccca tggcagggtg tgagggaggc aggtttggaa
     4621 tggtgcgagt atggcaatct aagcaggggt ctggtctctt tgactccagg ctggcctttg
     4681 gccgactgtc tgctcaccca gagaccttgg actccggact atccatggct ccgaatctaa
     4741 gtgctgccca ctcccatgct cacacccaca gaaggtcttc ccatcccctt tagattcgtg
     4801 cctcactcca ccagtgagga agatgcctct gtctttccca cgactgccag gagataggga
     4861 agcccagcca ggactgaccc tccttcctcc agcctgccct gacccacctg gcaaagcagg
     4921 gcacatgggg aggaagagac tggaaccttt ctttgacagc caggcctaga cagacaggcc
     4981 tggggacact ggccccatga ggggaggaag gcaggcgcac gaggtccagg gaggcccttt
     5041 tctgatcatg ccccttctct cccaccccat ctccccacca ccacctctgt ggcctccatg
     5101 gtacccccac agggctggcc tcccctagag ggtgggcctc aaccacctgc tcccgccacg
     5161 caccggttag tgagacaggg ctgccacggc aaccgccaag cccccctcaa ggtgggacag
     5221 taccccggac ccatccactc actcctgaga gggctccggc ccagaatggg aacctcagag
     5281 aagagctcta aggagaagaa accccatagc gtcagagagg atatgtctgg cttccaagag
     5341 aaaggaggct ccgttttgca aagtggagga gggacgaggg acaggggttt caccagccag
     5401 caacctgggc cttgtactgt ctgtgttttt aaaaccacta aagtgcaaga attacattgc
     5461 actgtttctc cactttttat tttctcttag gcttttgttt ctatttcaaa catactttct
     5521 tggttttcta atggagtata tagtttagtc atttcacaga ctctggcctc ctctcctgaa
     5581 atccttttgg atggggaaag ggaaggtggg gagggtccga ggggaagggg accccagctt
     5641 ccctgtgccc gctcacccca ctccaccagt ccccggtcgc cagccggagt ctcctctcta
     5701 ccgccactgt cacaccgtag cccacatgga tagcacagtt gtcagacaag attccttcag
     5761 attccgagtt gcctaccggt tgttttcgtt gttgttgttg ttgtttttct ttttcttttt
     5821 ttttttgaag acagcaataa ccacagtaca tattactgta gttctctata gttttacata
     5881 cattcatacc ataactctgt tctctcctct tttttgtttt caactttaaa aacaaaaata
     5941 aacgatgata atctttactg gtgaaaagga tggaaaaata aatcaacaaa tgcaaccagt
     6001 ttgtgagaaa aaaaaaaaaa agccgaaaaa aaaaaaaaaa acacctgaat gcggaagagc
     6061 tcggctcccg tttagcattt tgtacttaag gaaataaaaa accaacaaag gatctcacat
     6121 tttcttaaaa agtgaagatt gctgtatact atttattcaa cttataattt atgttactcc
     6181 ttgatctttg tcttttgtca tgacaaagca tttatttaat aaagttatgc attcagtta
//
