LOCUS       NM_001552               2205 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens insulin like growth factor binding protein 4 (IGFBP4),
            mRNA.
ACCESSION   NM_001552
VERSION     NM_001552.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2205)
  AUTHORS   Dya,G.A., Lebedeva,O.S., Gushchevarov,D.A., Volovikov,E.A.,
            Belikova,L.D., Kopylova,I.V., Postnikov,A.B., Artemieva,M.M.,
            Medvedeva,N.A., Lagarkova,M.A., Katrukha,A.G. and Serebryanaya,D.V.
  TITLE     Specific cleavage of IGFBP-4 by papp-a in nervous tissue
  JOURNAL   Biochem Biophys Res Commun 733, 150655 (2024)
   PUBMED   39244846
  REMARK    GeneRIF: Specific cleavage of IGFBP-4 by papp-a in nervous tissue.
REFERENCE   2  (bases 1 to 2205)
  AUTHORS   Chen,W., Hu,L., Lu,X., Wang,X., Zhao,C., Guo,C., Li,X., Ding,Y.,
            Zhao,H., Tong,D., Wang,L. and Huang,C.
  TITLE     The RNA binding protein MEX3A promotes tumor progression of breast
            cancer by post-transcriptional regulation of IGFBP4
  JOURNAL   Breast Cancer Res Treat 201 (3), 353-366 (2023)
   PUBMED   37433992
  REMARK    GeneRIF: The RNA binding protein MEX3A promotes tumor progression
            of breast cancer by post-transcriptional regulation of IGFBP4.
REFERENCE   3  (bases 1 to 2205)
  AUTHORS   AlMajed,H.T., Abu-Farha,M., Alshawaf,E., Devarajan,S.,
            Alsairafi,Z., Elhelaly,A., Cherian,P., Al-Khairi,I., Ali,H.,
            Jose,R.M., Thanaraj,T.A., Al-Ozairi,E., Al-Mulla,F., Al Attar,A.
            and Abubaker,J.
  TITLE     Increased Levels of Circulating IGFBP4 and ANGPTL8 with a
            Prospective Role in Diabetic Nephropathy
  JOURNAL   Int J Mol Sci 24 (18), 14244 (2023)
   PUBMED   37762544
  REMARK    GeneRIF: Increased Levels of Circulating IGFBP4 and ANGPTL8 with a
            Prospective Role in Diabetic Nephropathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2205)
  AUTHORS   Adasheva,D.A., Lebedeva,O.S., Goliusova,D.V., Postnikov,A.B.,
            Teriakova,M.V., Kopylova,I.V., Lagarkova,M.A., Katrukha,A.G. and
            Serebryanaya,D.V.
  TITLE     PAPP-A-Specific IGFBP-4 Proteolysis in Human Induced Pluripotent
            Stem Cell-Derived Cardiomyocytes
  JOURNAL   Int J Mol Sci 24 (9), 8420 (2023)
   PUBMED   37176126
  REMARK    GeneRIF: PAPP-A-Specific IGFBP-4 Proteolysis in Human Induced
            Pluripotent Stem Cell-Derived Cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2205)
  AUTHORS   Shi,Y., Xu,X., He,Z., Tao,H., Chen,Y., Zhang,L., Tao,S., Ding,B.,
            Wang,C. and Yu,L.
  TITLE     AKAP12 and IGFBP4 Are Prognostic Factors for Chronic Lymphocytic
            Leukemia
  JOURNAL   Acta Haematol 146 (6), 474-481 (2023)
   PUBMED   37605556
  REMARK    GeneRIF: AKAP12 and IGFBP4 Are Prognostic Factors for Chronic
            Lymphocytic Leukemia.
REFERENCE   6  (bases 1 to 2205)
  AUTHORS   Zhou,J. and Bondy,C.
  TITLE     Insulin-like growth factor-II and its binding proteins in placental
            development
  JOURNAL   Endocrinology 131 (3), 1230-1240 (1992)
   PUBMED   1380437
REFERENCE   7  (bases 1 to 2205)
  AUTHORS   Kiefer,M.C., Schmid,C., Waldvogel,M., Schlapfer,I., Futo,E.,
            Masiarz,F.R., Green,K., Barr,P.J. and Zapf,J.
  TITLE     Characterization of recombinant human insulin-like growth factor
            binding proteins 4, 5, and 6 produced in yeast
  JOURNAL   J Biol Chem 267 (18), 12692-12699 (1992)
   PUBMED   1377672
REFERENCE   8  (bases 1 to 2205)
  AUTHORS   Bajalica,S., Allander,S.V., Ehrenborg,E., Brondum-Nielsen,K.,
            Luthman,H. and Larsson,C.
  TITLE     Localization of the human insulin-like growth-factor-binding
            protein 4 gene to chromosomal region 17q12-21.1
  JOURNAL   Hum Genet 89 (2), 234-236 (1992)
   PUBMED   1375185
REFERENCE   9  (bases 1 to 2205)
  AUTHORS   Giudice,L.C., Dsupin,B.A., Irwin,J.C. and Eckert,R.L.
  TITLE     Identification of insulin-like growth factor binding proteins in
            human oviduct
  JOURNAL   Fertil Steril 57 (2), 294-301 (1992)
   PUBMED   1370941
REFERENCE   10 (bases 1 to 2205)
  AUTHORS   Shimasaki,S., Uchiyama,F., Shimonaka,M. and Ling,N.
  TITLE     Molecular cloning of the cDNAs encoding a novel insulin-like growth
            factor-binding protein from rat and human
  JOURNAL   Mol Endocrinol 4 (10), 1451-1458 (1990)
   PUBMED   1704481
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN431519.1, AC018629.12 and
            BC016041.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001552.2.
            
            Summary: This gene is a member of the insulin-like growth factor
            binding protein (IGFBP) family and encodes a protein with an IGFBP
            domain and a thyroglobulin type-I domain. The protein binds both
            insulin-like growth factors (IGFs) I and II and circulates in the
            plasma in both glycosylated and non-glycosylated forms. Binding of
            this protein prolongs the half-life of the IGFs and alters their
            interaction with cell surface receptors. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016041.1, AK290810.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269593.5/ ENSP00000269593.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CN431519.1         32-42
            12-635              AC018629.12        98528-99151
            636-793             AC018629.12        108052-108209
            794-928             AC018629.12        108995-109129
            929-2187            AC018629.12        111516-112774
            2188-2205           BC016041.1         2024-2041
FEATURES             Location/Qualifiers
     source          1..2205
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..2205
                     /gene="IGFBP4"
                     /gene_synonym="BP-4; HT29-IGFBP; IBP4; IGFBP-4"
                     /note="insulin like growth factor binding protein 4"
                     /db_xref="GeneID:3487"
                     /db_xref="HGNC:HGNC:5473"
                     /db_xref="MIM:146733"
     exon            1..635
                     /gene="IGFBP4"
                     /gene_synonym="BP-4; HT29-IGFBP; IBP4; IGFBP-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1063
                     /gene="IGFBP4"
                     /gene_synonym="BP-4; HT29-IGFBP; IBP4; IGFBP-4"
                     /note="IGF-binding protein 4; IBP-4"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 4
                     precursor"
                     /protein_id="NP_001543.2"
                     /db_xref="CCDS:CCDS11367.1"
                     /db_xref="GeneID:3487"
                     /db_xref="HGNC:HGNC:5473"
                     /db_xref="MIM:146733"
                     /translation="MLPLCLVAALLLAAGPGPSLGDEAIHCPPCSEEKLARCRPPVGC
                     EELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCME
                     LAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNG
                     APREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPA
                     LDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFRE"
     exon            636..793
                     /gene="IGFBP4"
                     /gene_synonym="BP-4; HT29-IGFBP; IBP4; IGFBP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            794..928
                     /gene="IGFBP4"
                     /gene_synonym="BP-4; HT29-IGFBP; IBP4; IGFBP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            929..2205
                     /gene="IGFBP4"
                     /gene_synonym="BP-4; HT29-IGFBP; IBP4; IGFBP-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2185..2190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGFBP4"
                     /gene_synonym="BP-4; HT29-IGFBP; IBP4; IGFBP-4"
                     /note="hexamer: AACAAA"
     polyA_site      2205
                     /gene="IGFBP4"
                     /gene_synonym="BP-4; HT29-IGFBP; IBP4; IGFBP-4"
                     /note="major polyA site"
ORIGIN      
        1 agccgctcag ccccctgccc ctcgccgccc gccgcctgcc tgggccgggc cgaggatgcg
       61 gcgcagcgcc tcggcggcca ggcttgctcc cctccggcac gcctgctaac ttcccccgct
      121 acgtccccgt tcgcccgccg ggccgccccg tctccccgcg ccctccgggt cgggtcctcc
      181 aggagcgcca ggcgctgccg ccgtgtgccc tccgccgctc gcccgcgcgc ccgcgctccc
      241 cgcctgcgcc cagcgccccg cgcccgcgcc cagtcctcgg gcggtcatgc tgcccctctg
      301 cctcgtggcc gccctgctgc tggccgccgg gcccgggccg agcctgggcg acgaagccat
      361 ccactgcccg ccctgctccg aggagaagct ggcgcgctgc cgcccccccg tgggctgcga
      421 ggagctggtg cgagagccgg gctgcggctg ttgcgccact tgcgccctgg gcttggggat
      481 gccctgcggg gtgtacaccc cccgttgcgg ctcgggcctg cgctgctacc cgccccgagg
      541 ggtggagaag cccctgcaca cactgatgca cgggcaaggc gtgtgcatgg agctggcgga
      601 gatcgaggcc atccaggaaa gcctgcagcc ctctgacaag gacgagggtg accaccccaa
      661 caacagcttc agcccctgta gcgcccatga ccgcaggtgc ctgcagaagc acttcgccaa
      721 aattcgagac cggagcacca gtgggggcaa gatgaaggtc aatggggcgc cccgggagga
      781 tgcccggcct gtgccccagg gctcctgcca gagcgagctg caccgggcgc tggagcggct
      841 ggccgcttca cagagccgca cccacgagga cctctacatc atccccatcc ccaactgcga
      901 ccgcaacggc aacttccacc ccaagcagtg tcacccagct ctggatgggc agcgtggcaa
      961 gtgctggtgt gtggaccgga agacgggggt gaagcttccg gggggcctgg agccaaaggg
     1021 ggagctggac tgccaccagc tggctgacag ctttcgagag tgaggcctgc cagcaggcca
     1081 gggactcagc gtcccctgct actcctgtgc tctggaggct gcagagctga cccagagtgg
     1141 agtctgagtc tgagtcctgt ctctgcctgc ggcccagaag tttccctcaa atgcgcgtgt
     1201 gcacgtgtgc gtgtgcgtgc gtgtgtgtgt gtttgtgagc atgggtgtgc ccttggggta
     1261 agccagagcc tggggtgttc tctttggtgt tacacagccc aagaggactg agactggcac
     1321 ttagcccaag aggtctgagc cctggtgtgt ttccagatcg atcctggatt cactcactca
     1381 ctcattcctt cactcatcca gccacctaaa aacatttact gaccatgtac tacgtgccag
     1441 ctctagtttt cagccttggg aggttttatt ctgacttcct ctgattttgg catgtggaga
     1501 cactcctata aggagagttc aagcctgtgg gagtagaaaa atctcattcc cagagtcaga
     1561 ggagaagaga catgtacctt gaccatcgtc cttcctctca agctagccag agggtgggag
     1621 cctaaggaag cgtggggtag cagatggagt aatggtcacg aggtccagac ccactcccaa
     1681 agctcagact tgccaggctc cctttctctt cttccccagg tccttccttt aggtctggtt
     1741 gttgcaccat ctgcttggtt ggctggcagc tgagagccct gctgtgggag agcgaagggg
     1801 gtcaaaggaa gacttgaagc acagagggct agggaggtgg ggtacatttc tctgagcagt
     1861 cagggtggga agaaagaatg caagagtgga ctgaatgtgc ctaatggaga agacccacgt
     1921 gctaggggat gaggggcttc ctgggtcctg ttccctaccc catttgtggt cacagccatg
     1981 aagtcaccgg gatgaaccta tccttccagt ggctcgctcc ctgtagctct gcctccctct
     2041 ccatatctcc ttcccctaca cctccctccc cacacctccc tactcccctg ggcatcttct
     2101 ggcttgactg gatggaagga gacttaggaa cctaccagtt ggccatgatg tcttttcttc
     2161 tttttctttt ttttaacaaa acagaacaaa accaaaaaat gtcca
//
