LOCUS       NM_000597               1414 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens insulin like growth factor binding protein 2 (IGFBP2),
            transcript variant 1, mRNA.
ACCESSION   NM_000597
VERSION     NM_000597.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1414)
  AUTHORS   Alicea,G.M., Patel,P., Portuallo,M.E., Fane,M.E., Wei,M.,
            Chhabra,Y., Dixit,A., Carey,A.E., Wang,V., Rocha,M.R., Behera,R.,
            Speicher,D.W., Tang,H.Y., Kossenkov,A.V., Rebecca,V.W., Wirtz,D.
            and Weeraratna,A.T.
  TITLE     Age-Related Increases in IGFBP2 Increase Melanoma Cell Invasion and
            Lipid Synthesis
  JOURNAL   Cancer Res Commun 4 (8), 1908-1918 (2024)
   PUBMED   39007351
  REMARK    GeneRIF: Age-Related Increases in IGFBP2 Increase Melanoma Cell
            Invasion and Lipid Synthesis.
REFERENCE   2  (bases 1 to 1414)
  AUTHORS   Ferrero,R., Rainer,P.Y., Rumpler,M., Russeil,J., Zachara,M.,
            Pezoldt,J., van Mierlo,G., Gardeux,V., Saelens,W., Alpern,D.,
            Favre,L., Vionnet,N., Mantziari,S., Zingg,T., Pitteloud,N.,
            Suter,M., Matter,M., Schlaudraff,K.U., Canto,C. and Deplancke,B.
  TITLE     A human omentum-specific mesothelial-like stromal population
            inhibits adipogenesis through IGFBP2 secretion
  JOURNAL   Cell Metab 36 (7), 1566-1585 (2024)
   PUBMED   38729152
  REMARK    GeneRIF: A human omentum-specific mesothelial-like stromal
            population inhibits adipogenesis through IGFBP2 secretion.
REFERENCE   3  (bases 1 to 1414)
  AUTHORS   Zheng,Y., Li,W., Huang,Y. and Cheng,H.
  TITLE     Exosomal IGFBP2 derived from highly metastatic promotes
            hepatocellular carcinoma metastasis by inducing epithelial
            mesenchymal transition
  JOURNAL   Gene 913, 148374 (2024)
   PUBMED   38490505
  REMARK    GeneRIF: Exosomal IGFBP2 derived from highly metastatic promotes
            hepatocellular carcinoma metastasis by inducing epithelial
            mesenchymal transition.
REFERENCE   4  (bases 1 to 1414)
  AUTHORS   Lu,H., Ai,J., Zheng,Y., Zhou,W., Zhang,L., Zhu,J., Zhang,H. and
            Wang,S.
  TITLE     IGFBP2/ITGA5 promotes gefitinib resistance via activating
            STAT3/CXCL1 axis in non-small cell lung cancer
  JOURNAL   Cell Death Dis 15 (6), 447 (2024)
   PUBMED   38918360
  REMARK    GeneRIF: IGFBP2/ITGA5 promotes gefitinib resistance via activating
            STAT3/CXCL1 axis in non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1414)
  AUTHORS   Qian,S., Wang,F., Liao,W. and Liu,J.
  TITLE     The role of HMGA2 in activating the IGFBP2 expression to promote
            angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling
            pathway
  JOURNAL   Neoplasma 71 (1), 22-36 (2024)
   PUBMED   38506034
  REMARK    GeneRIF: The role of HMGA2 in activating the IGFBP2 expression to
            promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA
            signaling pathway.
REFERENCE   6  (bases 1 to 1414)
  AUTHORS   Zhou,J. and Bondy,C.
  TITLE     Insulin-like growth factor-II and its binding proteins in placental
            development
  JOURNAL   Endocrinology 131 (3), 1230-1240 (1992)
   PUBMED   1380437
REFERENCE   7  (bases 1 to 1414)
  AUTHORS   Binkert,C., Margot,J.B., Landwehr,J., Heinrich,G. and Schwander,J.
  TITLE     Structure of the human insulin-like growth factor binding protein-2
            gene
  JOURNAL   Mol Endocrinol 6 (5), 826-836 (1992)
   PUBMED   1376411
REFERENCE   8  (bases 1 to 1414)
  AUTHORS   Ehrenborg,E., Vilhelmsdotter,S., Bajalica,S., Larsson,C., Stern,I.,
            Koch,J., Brondum-Nielsen,K. and Luthman,H.
  TITLE     Structure and localization of the human insulin-like growth
            factor-binding protein 2 gene
  JOURNAL   Biochem Biophys Res Commun 176 (3), 1250-1255 (1991)
   PUBMED   1710112
REFERENCE   9  (bases 1 to 1414)
  AUTHORS   Agarwal,N., Hsieh,C.L., Sills,D., Swaroop,M., Desai,B., Francke,U.
            and Swaroop,A.
  TITLE     Sequence analysis, expression and chromosomal localization of a
            gene, isolated from a subtracted human retina cDNA library, that
            encodes an insulin-like growth factor binding protein (IGFBP2)
  JOURNAL   Exp Eye Res 52 (5), 549-561 (1991)
   PUBMED   1712312
REFERENCE   10 (bases 1 to 1414)
  AUTHORS   Zapf,J., Kiefer,M., Merryweather,J., Musiarz,F., Bauer,D., Born,W.,
            Fischer,J.A. and Froesch,E.R.
  TITLE     Isolation from adult human serum of four insulin-like growth factor
            (IGF) binding proteins and molecular cloning of one of them that is
            increased by IGF I administration and in extrapancreatic tumor
            hypoglycemia
  JOURNAL   J Biol Chem 265 (25), 14892-14898 (1990)
   PUBMED   1697583
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC071967.1 and M35410.1.
            
            On Aug 31, 2018 this sequence version replaced NM_000597.2.
            
            Summary: The protein encoded by this gene is one of six similar
            proteins that bind insulin-like growth factors I and II (IGF-I and
            IGF-II). The encoded protein can be secreted into the bloodstream,
            where it binds IGF-I and IGF-II with high affinity, or it can
            remain intracellular, interacting with many different ligands. High
            expression levels of this protein promote the growth of several
            types of tumors and may be predictive of the chances of recovery of
            the patient. Several transcript variants, one encoding a secreted
            isoform and the others encoding nonsecreted isoforms, have been
            found for this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            CCDS Note: The coding region was updated to make it identical to
            the current human reference genome sequence.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004312.1, M35410.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233809.9/ ENSP00000233809.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               BC071967.1         4-171
            169-1392            BC071967.1         181-1404
            1393-1414           M35410.1           1361-1382
FEATURES             Location/Qualifiers
     source          1..1414
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..1414
                     /gene="IGFBP2"
                     /gene_synonym="IBP2; IGF-BP53"
                     /note="insulin like growth factor binding protein 2"
                     /db_xref="GeneID:3485"
                     /db_xref="HGNC:HGNC:5471"
                     /db_xref="MIM:146731"
     exon            1..546
                     /gene="IGFBP2"
                     /gene_synonym="IBP2; IGF-BP53"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1082
                     /gene="IGFBP2"
                     /gene_synonym="IBP2; IGF-BP53"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; IGF-binding protein 2; insulin-like growth
                     factor binding protein 2, 36kDa"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 2
                     isoform a precursor"
                     /protein_id="NP_000588.3"
                     /db_xref="CCDS:CCDS42815.1"
                     /db_xref="GeneID:3485"
                     /db_xref="HGNC:HGNC:5471"
                     /db_xref="MIM:146731"
                     /translation="MLPRVGCPALPLPPPPLLPLLLLLLGASGGGGGARAEVLFRCPP
                     CTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACGVYT
                     PRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGGLVE
                     NHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKL
                     RPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSL
                     NGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQEARGVHTQRMQ"
     exon            547..776
                     /gene="IGFBP2"
                     /gene_synonym="IBP2; IGF-BP53"
                     /inference="alignment:Splign:2.1.0"
     exon            777..917
                     /gene="IGFBP2"
                     /gene_synonym="IBP2; IGF-BP53"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1414
                     /gene="IGFBP2"
                     /gene_synonym="IBP2; IGF-BP53"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1394..1399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGFBP2"
                     /gene_synonym="IBP2; IGF-BP53"
                     /note="hexamer: ATTAAA"
     polyA_site      1414
                     /gene="IGFBP2"
                     /gene_synonym="IBP2; IGF-BP53"
                     /note="major polyA site"
ORIGIN      
        1 gaggaagaag cggaggaggc ggctcccgcg ctcgcagggc cgtgccacct gcccgcccgc
       61 ccgctcgctc gctcgcccgc cgcgccgcgc tgccgaccgc cagcatgctg ccgagagtgg
      121 gctgccccgc gctgccgctg ccgccgccgc cgctgctgcc gctgctgctg ctgctactgg
      181 gcgcgagtgg cggcggcggc ggggcgcgcg cggaggtgct gttccgctgc ccgccctgca
      241 cacccgagcg cctggccgcc tgcgggcccc cgccggttgc gccgcccgcc gcggtggccg
      301 cagtggccgg aggcgcccgc atgccatgcg cggagctcgt ccgggagccg ggctgcggct
      361 gctgctcggt gtgcgcccgg ctggagggcg aggcgtgcgg cgtctacacc ccgcgctgcg
      421 gccaggggct gcgctgctat ccccacccgg gctccgagct gcccctgcag gcgctggtca
      481 tgggcgaggg cacttgtgag aagcgccggg acgccgagta tggcgccagc ccggagcagg
      541 ttgcagacaa tggcgatgac cactcagaag gaggcctggt ggagaaccac gtggacagca
      601 ccatgaacat gttgggcggg ggaggcagtg ctggccggaa gcccctcaag tcgggtatga
      661 aggagctggc cgtgttccgg gagaaggtca ctgagcagca ccggcagatg ggcaagggtg
      721 gcaagcatca ccttggcctg gaggagccca agaagctgcg accaccccct gccaggactc
      781 cctgccaaca ggaactggac caggtcctgg agcggatctc caccatgcgc cttccggatg
      841 agcggggccc tctggagcac ctctactccc tgcacatccc caactgtgac aagcatggcc
      901 tgtacaacct caaacagtgc aagatgtctc tgaacgggca gcgtggggag tgctggtgtg
      961 tgaaccccaa caccgggaag ctgatccagg gagcccccac catccggggg gaccccgagt
     1021 gtcatctctt ctacaatgag cagcaggagg ctcgcggggt gcacacccag cggatgcagt
     1081 agaccgcagc cagccggtgc ctggcgcccc tgccccccgc ccctctccaa acaccggcag
     1141 aaaacggaga gtgcttgggt ggtgggtgct ggaggatttt ccagttctga cacacgtatt
     1201 tatatttgga aagagaccag caccgagctc ggcacctccc cggcctctct cttcccagct
     1261 gcagatgcca cacctgctcc ttcttgcttt ccccggggga ggaagggggt tgtggtcggg
     1321 gagctggggt acaggtttgg ggagggggaa gagaaatttt tatttttgaa cccctgtgtc
     1381 ccttttgcat aagattaaag gaaggaaaag taaa
//
