LOCUS       NM_000596               1514 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens insulin like growth factor binding protein 1 (IGFBP1),
            mRNA.
ACCESSION   NM_000596
VERSION     NM_000596.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1514)
  AUTHORS   Yang,H., Yang,M., Zhang,Y., Shi,Z., Zhang,X. and Zhang,C.
  TITLE     Elevated serum IGFBP-1 levels correlate with cognitive deficits in
            treatment-resistant and chronic medicated schizophrenia patients
  JOURNAL   Cytokine 182, 156728 (2024)
   PUBMED   39126767
  REMARK    GeneRIF: Elevated serum IGFBP-1 levels correlate with cognitive
            deficits in treatment-resistant and chronic medicated schizophrenia
            patients.
REFERENCE   2  (bases 1 to 1514)
  AUTHORS   Yuan,Z., Wang,W., Song,S., Ling,Y., Xu,J. and Tao,Z.
  TITLE     IGFBP1 stabilizes Umod expression through m6A modification to
            inhibit the occurrence and development of cystitis by blocking
            NF-kappaB and ERK signaling pathways
  JOURNAL   Int Immunopharmacol 134, 111997 (2024)
   PUBMED   38759370
  REMARK    GeneRIF: IGFBP1 stabilizes Umod expression through m6A modification
            to inhibit the occurrence and development of cystitis by blocking
            NF-kappaB and ERK signaling pathways.
REFERENCE   3  (bases 1 to 1514)
  AUTHORS   Hivert,M.F., White,F., Allard,C., James,K., Majid,S., Aguet,F.,
            Ardlie,K.G., Florez,J.C., Edlow,A.G., Bouchard,L., Jacques,P.E.,
            Karumanchi,S.A. and Powe,C.E.
  TITLE     Placental IGFBP1 levels during early pregnancy and the risk of
            insulin resistance and gestational diabetes
  JOURNAL   Nat Med 30 (6), 1689-1695 (2024)
   PUBMED   38627562
  REMARK    GeneRIF: Placental IGFBP1 levels during early pregnancy and the
            risk of insulin resistance and gestational diabetes.
REFERENCE   4  (bases 1 to 1514)
  AUTHORS   Huang,B.L., Wei,L.F., Lin,Y.W., Huang,L.S., Qu,Q.Q., Li,X.H.,
            Chu,L.Y., Xu,Y.W., Wang,W.D., Peng,Y.H. and Wu,F.C.
  TITLE     Serum IGFBP-1 as a promising diagnostic and prognostic biomarker
            for colorectal cancer
  JOURNAL   Sci Rep 14 (1), 1839 (2024)
   PUBMED   38246959
  REMARK    GeneRIF: Serum IGFBP-1 as a promising diagnostic and prognostic
            biomarker for colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1514)
  AUTHORS   Jin,Y., Sun,F., Yang,A., Yu,X., Li,Y., Liang,S., Jing,X., Wang,K.,
            Zhang,L., Xiao,S., Zhang,W., Wang,X., Zhao,G. and Gao,B.
  TITLE     Insulin-like growth factor binding protein-1 and insulin in
            polycystic ovary syndrome: a systematic review and meta-analysis
  JOURNAL   Front Endocrinol (Lausanne) 14, 1279717 (2023)
   PUBMED   38174331
  REMARK    GeneRIF: Insulin-like growth factor binding protein-1 and insulin
            in polycystic ovary syndrome: a systematic review and
            meta-analysis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1514)
  AUTHORS   Ehrenborg,E., Larsson,C., Stern,I., Janson,M., Powell,D.R. and
            Luthman,H.
  TITLE     Contiguous localization of the genes encoding human insulin-like
            growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on
            chromosome 7
  JOURNAL   Genomics 12 (3), 497-502 (1992)
   PUBMED   1373120
REFERENCE   7  (bases 1 to 1514)
  AUTHORS   Brinkman,A., Kortleve,D.J., Schuller,A.G., Zwarthoff,E.C. and
            Drop,S.L.
  TITLE     Site-directed mutagenesis of the N-terminal region of IGF binding
            protein 1; analysis of IGF binding capability
  JOURNAL   FEBS Lett 291 (2), 264-268 (1991)
   PUBMED   1718783
REFERENCE   8  (bases 1 to 1514)
  AUTHORS   Suwanichkul,A., Cubbage,M.L. and Powell,D.R.
  TITLE     The promoter of the human gene for insulin-like growth factor
            binding protein-1. Basal promoter activity in HEP G2 cells depends
            upon liver factor B1
  JOURNAL   J Biol Chem 265 (34), 21185-21193 (1990)
   PUBMED   1701175
REFERENCE   9  (bases 1 to 1514)
  AUTHORS   Ekstrand,J., Ehrenborg,E., Stern,I., Stellan,B., Zech,L. and
            Luthman,H.
  TITLE     The gene for insulin-like growth factor-binding protein-1 is
            localized to human chromosomal region 7p14-p12
  JOURNAL   Genomics 6 (3), 413-418 (1990)
   PUBMED   1691735
REFERENCE   10 (bases 1 to 1514)
  AUTHORS   Brewer,M.T., Stetler,G.L., Squires,C.H., Thompson,R.C., Busby,W.H.
            and Clemmons,D.R.
  TITLE     Cloning, characterization, and expression of a human insulin-like
            growth factor binding protein
  JOURNAL   Biochem Biophys Res Commun 152 (3), 1289-1297 (1988)
   PUBMED   2454104
  REMARK    Erratum:[Biochem Biophys Res Commun 1988 Sep 30;155(3):1485]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX336957.2, M31145.1 and
            CA429917.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000596.3.
            
            Summary: This gene is a member of the insulin-like growth factor
            binding protein (IGFBP) family and encodes a protein with an IGFBP
            N-terminal domain and a thyroglobulin type-I domain. The encoded
            protein, mainly expressed in the liver, circulates in the plasma
            and binds both insulin-like growth factors (IGFs) I and II,
            prolonging their half-lives and altering their interaction with
            cell surface receptors. This protein is important in cell migration
            and metabolism. Low levels of this protein may be associated with
            impaired glucose tolerance, vascular disease and hypertension in
            human patients. [provided by RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057806.1, M31145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275525.8/ ENSP00000275525.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BX336957.2         135-135
            2-1511              M31145.1           1-1510
            1512-1514           CA429917.1         26-28               c
FEATURES             Location/Qualifiers
     source          1..1514
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p12.3"
     gene            1..1514
                     /gene="IGFBP1"
                     /gene_synonym="AFBP; hIGFBP-1; IBP1; IGF-BP25; PP12"
                     /note="insulin like growth factor binding protein 1"
                     /db_xref="GeneID:3484"
                     /db_xref="HGNC:HGNC:5469"
                     /db_xref="MIM:146730"
     exon            1..514
                     /gene="IGFBP1"
                     /gene_synonym="AFBP; hIGFBP-1; IBP1; IGF-BP25; PP12"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..945
                     /gene="IGFBP1"
                     /gene_synonym="AFBP; hIGFBP-1; IBP1; IGF-BP25; PP12"
                     /note="placental protein 12; amniotic fluid binding
                     protein; alpha-pregnancy-associated endometrial globulin;
                     growth hormone independent-binding protein; binding
                     protein-28; binding protein-26; binding protein-25;
                     IGF-binding protein 1; IBP-1; IGFBP-1"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 1
                     precursor"
                     /protein_id="NP_000587.1"
                     /db_xref="CCDS:CCDS5504.1"
                     /db_xref="GeneID:3484"
                     /db_xref="HGNC:HGNC:5469"
                     /db_xref="MIM:146730"
                     /translation="MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPV
                     SASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQG
                     ACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDG
                     SKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCE
                     TSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN"
     exon            515..684
                     /gene="IGFBP1"
                     /gene_synonym="AFBP; hIGFBP-1; IBP1; IGF-BP25; PP12"
                     /inference="alignment:Splign:2.1.0"
     exon            685..813
                     /gene="IGFBP1"
                     /gene_synonym="AFBP; hIGFBP-1; IBP1; IGF-BP25; PP12"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1514
                     /gene="IGFBP1"
                     /gene_synonym="AFBP; hIGFBP-1; IBP1; IGF-BP25; PP12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1494..1499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGFBP1"
                     /gene_synonym="AFBP; hIGFBP-1; IBP1; IGF-BP25; PP12"
                     /note="hexamer: AATAAA"
     polyA_site      1514
                     /gene="IGFBP1"
                     /gene_synonym="AFBP; hIGFBP-1; IBP1; IGF-BP25; PP12"
                     /note="major polyA site"
ORIGIN      
        1 atcggccacc gccatcccat ccagcgagca tctgccgccg cgccgccgcc accctcccag
       61 agagcactgg ccaccgctcc accatcactt gcccagagtt tgggccaccg cccgccgcca
      121 ccagcccaga gagcatcggc ccctgtctgc tgctcgcgcc tggagatgtc agaggtcccc
      181 gttgctcgcg tctggctggt actgctcctg ctgactgtcc aggtcggcgt gacagccggc
      241 gctccgtggc agtgcgcgcc ctgctccgcc gagaagctcg cgctctgccc gccggtgtcc
      301 gcctcgtgct cggaggtcac ccggtccgcc ggctgcggct gttgcccgat gtgcgccctg
      361 cctctgggcg ccgcgtgcgg cgtggcgact gcacgctgcg cccggggact cagttgccgc
      421 gcgctgccgg gggagcagca acctctgcac gccctcaccc gcggccaagg cgcctgcgtg
      481 caggagtctg acgcctccgc tccccatgct gcagaggcag ggagccctga aagcccagag
      541 agcacggaga taactgagga ggagctcctg gataatttcc atctgatggc cccttctgaa
      601 gaggatcatt ccatcctttg ggacgccatc agtacctatg atggctcgaa ggctctccat
      661 gtcaccaaca tcaaaaaatg gaaggagccc tgccgaatag aactctacag agtcgtagag
      721 agtttagcca aggcacagga gacatcagga gaagaaattt ccaaatttta cctgccaaac
      781 tgcaacaaga atggatttta tcacagcaga cagtgtgaga catccatgga tggagaggcg
      841 ggactctgct ggtgcgtcta cccttggaat gggaagagga tccctgggtc tccagagatc
      901 aggggagacc ccaactgcca gatatatttt aatgtacaaa actgaaacca gatgaaataa
      961 tgttctgtca cgtgaaatat ttaagtatat agtatattta tactctagaa catgcacatt
     1021 tatatatata tgtatatgta tatatatata gtaactactt tttatactcc atacataact
     1081 tgatatagaa agctgtttat ttattcactg taagtttatt ttttctacac agtaaaaact
     1141 tgtactatgt taataacttg tcctatgtca atttgtatat catgaaacac ttctcatcat
     1201 attgtatgta agtaattgca tttctgctct tccaaagctc ctgcgtctgt ttttaaagag
     1261 catggaaaaa tactgcctag aaaatgcaaa atgaaataag agagagtagt ttttcagcta
     1321 gtttgaagga ggacggttaa cttgtatatt ccaccattca catttgatgt acatgtgtag
     1381 ggaaagttaa aagtgttgat tacataatca aagctacctg tggtgatgtt gccacctgtt
     1441 aaaatgtaca ctggatatgt tgttaaacac gtgtctataa tggaaacatt tacaataaat
     1501 attctgcatg gaaa
//
