LOCUS       NM_006547               4274 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens insulin like growth factor 2 mRNA binding protein 3
            (IGF2BP3), mRNA.
ACCESSION   NM_006547
VERSION     NM_006547.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4274)
  AUTHORS   Fujiwara,Y., Takahashi,R.U., Saito,M., Umakoshi,M., Shimada,Y.,
            Koyama,K., Yatabe,Y., Watanabe,S.I., Koyota,S., Minamiya,Y.,
            Tahara,H., Kono,K., Shiraishi,K., Kohno,T., Goto,A. and Tsuchiya,N.
  TITLE     Oncofetal IGF2BP3-mediated control of microRNA structural diversity
            in the malignancy of early-stage lung adenocarcinoma
  JOURNAL   Proc Natl Acad Sci U S A 121 (36), e2407016121 (2024)
   PUBMED   39196622
  REMARK    GeneRIF: Oncofetal IGF2BP3-mediated control of microRNA structural
            diversity in the malignancy of early-stage lung adenocarcinoma.
REFERENCE   2  (bases 1 to 4274)
  AUTHORS   Dai,F., Zhang,Y., Deng,Z., Zhang,J., Wang,R., Chen,J., Yang,D.,
            Mao,S., Liu,H., Cheng,Y. and Hu,M.
  TITLE     IGF2BP3 participates in the pathogenesis of recurrent spontaneous
            abortion by regulating ferroptosis
  JOURNAL   J Reprod Immunol 165, 104271 (2024)
   PUBMED   39054220
  REMARK    GeneRIF: IGF2BP3 participates in the pathogenesis of recurrent
            spontaneous abortion by regulating ferroptosis.
REFERENCE   3  (bases 1 to 4274)
  AUTHORS   Liu,C., Dou,X., Zhao,Y., Zhang,L., Zhang,L., Dai,Q., Liu,J., Wu,T.,
            Xiao,Y. and He,C.
  TITLE     IGF2BP3 promotes mRNA degradation through internal m7G modification
  JOURNAL   Nat Commun 15 (1), 7421 (2024)
   PUBMED   39198433
  REMARK    GeneRIF: IGF2BP3 promotes mRNA degradation through internal m[7]G
            modification.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4274)
  AUTHORS   Gong,S., Liu,H., Gou,H. and Sun,W.
  TITLE     METTL5: A Potential Biomarker for Nonsmall Cell Lung Cancer That
            Promotes Cancer Cell Proliferation by Interacting with IGF2BP3
  JOURNAL   Genet Test Mol Biomarkers 28 (8), 311-321 (2024)
   PUBMED   39023781
  REMARK    GeneRIF: METTL5: A Potential Biomarker for Nonsmall Cell Lung
            Cancer That Promotes Cancer Cell Proliferation by Interacting with
            IGF2BP3.
REFERENCE   5  (bases 1 to 4274)
  AUTHORS   Salum,S.O.R., Candido,E.B., Domingues,M.A.C., Ojopi,E.P.B.,
            Tonon,A.F.S. and da Silva-Filho,A.L.
  TITLE     Association of insulin-like growth factor II mrna-binding protein 3
            (IMP3) expression with prognostic and morphological factors in
            endometrial cancer
  JOURNAL   Rev Bras Ginecol Obstet 46 (2024)
   PUBMED   39176196
  REMARK    GeneRIF: Association of insulin-like growth factor II mrna-binding
            protein 3 (IMP3) expression with prognostic and morphological
            factors in endometrial cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4274)
  AUTHORS   Yaniv,K. and Yisraeli,J.K.
  TITLE     The involvement of a conserved family of RNA binding proteins in
            embryonic development and carcinogenesis
  JOURNAL   Gene 287 (1-2), 49-54 (2002)
   PUBMED   11992722
  REMARK    Review article
REFERENCE   7  (bases 1 to 4274)
  AUTHORS   Zhang,J.Y., Chan,E.K., Peng,X.X., Lu,M., Wang,X., Mueller,F. and
            Tan,E.M.
  TITLE     Autoimmune responses to mRNA binding proteins p62 and Koc in
            diverse malignancies
  JOURNAL   Clin Immunol 100 (2), 149-156 (2001)
   PUBMED   11465943
REFERENCE   8  (bases 1 to 4274)
  AUTHORS   Mueller-Pillasch,F., Pohl,B., Wilda,M., Lacher,U., Beil,M.,
            Wallrapp,C., Hameister,H., Knochel,W., Adler,G. and Gress,T.M.
  TITLE     Expression of the highly conserved RNA binding protein KOC in
            embryogenesis
  JOURNAL   Mech Dev 88 (1), 95-99 (1999)
   PUBMED   10525192
REFERENCE   9  (bases 1 to 4274)
  AUTHORS   Nielsen,J., Christiansen,J., Lykke-Andersen,J., Johnsen,A.H.,
            Wewer,U.M. and Nielsen,F.C.
  TITLE     A family of insulin-like growth factor II mRNA-binding proteins
            represses translation in late development
  JOURNAL   Mol Cell Biol 19 (2), 1262-1270 (1999)
   PUBMED   9891060
REFERENCE   10 (bases 1 to 4274)
  AUTHORS   Mueller-Pillasch,F., Lacher,U., Wallrapp,C., Micha,A.,
            Zimmerhackl,F., Hameister,H., Varga,G., Friess,H., Buchler,M.,
            Beger,H.G., Vila,M.R., Adler,G. and Gress,T.M.
  TITLE     Cloning of a gene highly overexpressed in cancer coding for a novel
            KH-domain containing protein
  JOURNAL   Oncogene 14 (22), 2729-2733 (1997)
   PUBMED   9178771
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079780.6, AC021876.5 and
            AC005082.3.
            
            On Nov 26, 2018 this sequence version replaced NM_006547.2.
            
            Summary: The protein encoded by this gene is primarily found in the
            nucleolus, where it can bind to the 5' UTR of the insulin-like
            growth factor II leader 3 mRNA and may repress translation of
            insulin-like growth factor II during late development. The encoded
            protein contains several KH domains, which are important in RNA
            binding and are known to be involved in RNA synthesis and
            metabolism. A pseudogene exists on chromosome 7, and there are
            putative pseudogenes on other chromosomes. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF117108.1, U97188.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258729.8/ ENSP00000258729.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-556               AC079780.6         34252-34807         c
            557-617             AC079780.6         32798-32858         c
            618-666             AC021876.5         85764-85812         c
            667-718             AC021876.5         28678-28729         c
            719-782             AC021876.5         28522-28585         c
            783-1064            AC021876.5         18293-18574         c
            1065-1199           AC021876.5         14588-14722         c
            1200-1322           AC021876.5         12928-13050         c
            1323-1458           AC021876.5         10706-10841         c
            1459-1584           AC021876.5         9052-9177           c
            1585-1701           AC005082.3         155665-155781       c
            1702-1776           AC005082.3         154166-154240       c
            1777-1908           AC005082.3         150049-150180       c
            1909-2022           AC005082.3         149262-149375       c
            2023-4274           AC005082.3         146736-148987       c
FEATURES             Location/Qualifiers
     source          1..4274
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..4274
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /note="insulin like growth factor 2 mRNA binding protein
                     3"
                     /db_xref="GeneID:10643"
                     /db_xref="HGNC:HGNC:28868"
                     /db_xref="MIM:608259"
     exon            1..556
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /inference="alignment:Splign:2.1.0"
     CDS             382..2121
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /note="cancer/testis antigen 98; IGF-II mRNA-binding
                     protein 3; KH domain containing protein overexpressed in
                     cancer; VICKZ family member 3; IGF2 mRNA-binding protein
                     3"
                     /codon_start=1
                     /product="insulin-like growth factor 2 mRNA-binding
                     protein 3"
                     /protein_id="NP_006538.2"
                     /db_xref="CCDS:CCDS5382.1"
                     /db_xref="GeneID:10643"
                     /db_xref="HGNC:HGNC:28868"
                     /db_xref="MIM:608259"
                     /translation="MNKLYIGNLSENAAPSDLESIFKDAKIPVSGPFLVKTGYAFVDC
                     PDESWALKAIEALSGKIELHGKPIEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLV
                     QYGVVESCEQVNTDSETAVVNVTYSSKDQARQALDKLNGFQLENFTLKVAYIPDEMAA
                     QQNPLQQPRGRRGLGQRGSSRQGSPGSVSKQKPCDLPLRLLVPTQFVGAIIGKEGATI
                     RNITKQTQSKIDVHRKENAGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTEE
                     IPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGNVE
                     TCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFPPTSGMPPPTSGPPSA
                     MTPPYPQFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAPDAK
                     VRMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGK
                     TVNELQNLSSAEVVVPRDQTPDENDQVVVKITGHFYACQVAQRKIQEILTQVKQHQQQ
                     KALQSGPPQSRRK"
     exon            557..617
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            618..666
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            667..718
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            719..782
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            783..1064
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1199
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1322
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1458
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1584
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1701
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1776
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1908
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2022
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..4274
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4248..4253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /note="hexamer: AATAAA"
     polyA_site      4274
                     /gene="IGF2BP3"
                     /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgatat tttcacagtc cgctggccga agccaaaggg gttgggaagg aagagacaaa
       61 aagtagtttt ttcccctcct cctcctcctt tctcttgcta atcccgcctc ctcctaagac
      121 ttaggaagac tggtggatgc gtttgggttg tagctaggct ttttcttttc tttctctttt
      181 aaaacacatc tagacaagga aaaaacaagc ctcggatctg atttttcact cctcgttctt
      241 gtgcttggtt cttactgtgt ttgtgtattt taaaggcgag aagacgaggg gaacaaaacc
      301 agctggatcc atccatcacc gtgggtggtt ttaatttttc gttttttctc gttatttttt
      361 tttaaacaac cactcttcac aatgaacaaa ctgtatatcg gaaacctcag cgagaacgcc
      421 gccccctcgg acctagaaag tatcttcaag gacgccaaga tcccggtgtc gggacccttc
      481 ctggtgaaga ctggctacgc gttcgtggac tgcccggacg agagctgggc cctcaaggcc
      541 atcgaggcgc tttcaggtaa aatagaactg cacgggaaac ccatagaagt tgagcactcg
      601 gtcccaaaaa ggcaaaggat tcggaaactt cagatacgaa atatcccgcc tcatttacag
      661 tgggaggtgc tggatagttt actagtccag tatggagtgg tggagagctg tgagcaagtg
      721 aacactgact cggaaactgc agttgtaaat gtaacctatt ccagtaagga ccaagctaga
      781 caagcactag acaaactgaa tggatttcag ttagagaatt tcaccttgaa agtagcctat
      841 atccctgatg aaatggccgc ccagcaaaac cccttgcagc agccccgagg tcgccggggg
      901 cttgggcaga ggggctcctc aaggcagggg tctccaggat ccgtatccaa gcagaaacca
      961 tgtgatttgc ctctgcgcct gctggttccc acccaatttg ttggagccat cataggaaaa
     1021 gaaggtgcca ccattcggaa catcaccaaa cagacccagt ctaaaatcga tgtccaccgt
     1081 aaagaaaatg cgggggctgc tgagaagtcg attactatcc tctctactcc tgaaggcacc
     1141 tctgcggctt gtaagtctat tctggagatt atgcataagg aagctcaaga tataaaattc
     1201 acagaagaga tccccttgaa gattttagct cataataact ttgttggacg tcttattggt
     1261 aaagaaggaa gaaatcttaa aaaaattgag caagacacag acactaaaat cacgatatct
     1321 ccattgcagg aattgacgct gtataatcca gaacgcacta ttacagttaa aggcaatgtt
     1381 gagacatgtg ccaaagctga ggaggagatc atgaagaaaa tcagggagtc ttatgaaaat
     1441 gatattgctt ctatgaatct tcaagcacat ttaattcctg gattaaatct gaacgccttg
     1501 ggtctgttcc cacccacttc agggatgcca cctcccacct cagggccccc ttcagccatg
     1561 actcctccct acccgcagtt tgagcaatca gaaacggaga ctgttcatct gtttatccca
     1621 gctctatcag tcggtgccat catcggcaag cagggccagc acatcaagca gctttctcgc
     1681 tttgctggag cttcaattaa gattgctcca gcggaagcac cagatgctaa agtgaggatg
     1741 gtgattatca ctggaccacc agaggctcag ttcaaggctc agggaagaat ttatggaaaa
     1801 attaaagaag aaaactttgt tagtcctaaa gaagaggtga aacttgaagc tcatatcaga
     1861 gtgccatcct ttgctgctgg cagagttatt ggaaaaggag gcaaaacggt gaatgaactt
     1921 cagaatttgt caagtgcaga agttgttgtc cctcgtgacc agacacctga tgagaatgac
     1981 caagtggttg tcaaaataac tggtcacttc tatgcttgcc aggttgccca gagaaaaatt
     2041 caggaaattc tgactcaggt aaagcagcac caacaacaga aggctctgca aagtggacca
     2101 cctcagtcaa gacggaagta aaggctcagg aaacagccca ccacagaggc agatgccaaa
     2161 ccaaagacag attgcttaac caacagatgg gcgctgaccc cctatccaga atcacatgca
     2221 caagttttta cctagccagt tgtttctgag gaccaggcaa cttttgaact cctgtctctg
     2281 tgagaatgta tactttatgc tctctgaaat gtatgacacc cagctttaaa acaaacaaac
     2341 aaacaaacaa aaaaagggtg ggggagggag ggaaagagaa gagctctgca cttccctttg
     2401 ttgtagtctc acagtataac agatattcta attcttctta atattccccc ataatgccag
     2461 aaattggctt aatgatgctt tcactaaatt catcaaatag attgctccta aatccaattg
     2521 ttaaaattgg atcagaataa ttatcacagg aacttaaatg ttaagccatt agcatagaaa
     2581 aactgttctc agttttattt ttacctaaca ctaacatgag taacctaagg gaagtgctga
     2641 atggtgttgg caggggtatt aaacgtgcat ttttactcaa ctacctcagg tattcagtaa
     2701 tacaatgaaa agcaaaattg ttcctttttt ttgaaaattt tatatacttt ataatgatag
     2761 aagtccaacc gttttttaaa aaataaattt aaaatttaac agcaatcagc taacaggcaa
     2821 attaagattt ttacttctgg ctggtgacag taaagctgga aaattaattt cagggttttt
     2881 tgaggctttt gacacagtta ttagttaaat caaatgttca aaaatacgga gcagtgccta
     2941 gtatctggag agcagcacta ccatttattc tttcatttat agttgggaaa gtttttgacg
     3001 gtactaacaa agtggtcgca ggagattttg gaacggctgg tttaaatggc ttcaggagac
     3061 ttcagttttt tgtttagcta catgattgaa tgcataataa atgctttgtg cttctgacta
     3121 tcaataccta aagaaagtgc atcagtgaag agatgcaaga ctttcaactg actggcaaaa
     3181 agcaagcttt agcttgtctt ataggatgct tagtttgcca ctacacttca gaccaatggg
     3241 acagtcatag atggtgtgac agtgtttaaa cgcaacaaaa ggctacattt ccatggggcc
     3301 agcactgtca tgagcctcac taagctattt tgaagatttt taagcactga taaattaaaa
     3361 aaaaaaaatt agactccacc ttaagtagta aagtataaca ggatttctgt atactgtgca
     3421 atcagttctt tgaaaaaaaa gtcaaaagat agagaataca agaaaagttt ttgggatata
     3481 atttgaatga ctgtgaaaac atatgacctt tgataacgaa ctcatttgct cactccttga
     3541 cagcaaagcc cagtacgtac aattgtgttg ggtgtgggtg gtctccaagg ccacgctgct
     3601 ctctgaattg attttttgag ttttgtttgt aagatgatca cagtcatgtt acactgatct
     3661 aaaggacata tatataaccc tttaaaaaaa aaatcactgc ctcattctta tttcaagatg
     3721 aatttctata cagactagat gtttttctga agatcaatta gacattttga aaatgattta
     3781 aagtgttttc cttaatgttc tctgaaaaca agtttctttt gtagttttaa ccaaaaaagt
     3841 gccctttttg tcactggatt ctcctagcat tcatgatttt tttttcatac aatgaattaa
     3901 aattgctaaa atcatggact ggctttctgg ttggatttca ggtaagatgt gtttaaggcc
     3961 agagcttttc tcagtatttg atttttttcc ccaatatttg attttttaaa aatatacaca
     4021 taggtgctgc atttatatct gctggtttaa attctgtcat atttcacttc tagcctttta
     4081 gtatggcaaa tcatatttta cttttactta agcatttgta atttggagta tctggtacta
     4141 gctaagaaat aattctataa ttgagttttg tactcaccat atatggatca ttcctcatgt
     4201 ataatgtgcc ccaaatgcag cttcattttc cagatacctt gacgcagaat aaattttttc
     4261 atcatttagg tgca
//
