LOCUS       NM_006548               4283 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens insulin like growth factor 2 mRNA binding protein 2
            (IGF2BP2), transcript variant 1, mRNA.
ACCESSION   NM_006548
VERSION     NM_006548.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4283)
  AUTHORS   Du,X., Guo,Y., Zhao,X., Zhang,L., Fan,R. and Li,Y.
  TITLE     METTL3-mediated TIM1 promotes macrophage M1 polarization and
            inflammation through IGF2BP2-dependent manner
  JOURNAL   J Biochem Mol Toxicol 38 (10), e23845 (2024)
   PUBMED   39267336
  REMARK    GeneRIF: METTL3-mediated TIM1 promotes macrophage M1 polarization
            and inflammation through IGF2BP2-dependent manner.
REFERENCE   2  (bases 1 to 4283)
  AUTHORS   Jia,Y., Liu,S., Zhang,M., Wu,X., Chen,X., Xing,M., Hou,X. and
            Jiang,W.
  TITLE     The m6A reader IGF2BP2 promotes ESCC progression by stabilizing
            HDGF mRNA
  JOURNAL   J Cancer Res Ther 20 (4), 1173-1185 (2024)
   PUBMED   39206979
  REMARK    GeneRIF: The m6A reader IGF2BP2 promotes ESCC progression by
            stabilizing HDGF mRNA.
REFERENCE   3  (bases 1 to 4283)
  AUTHORS   Wang,G., Zhuang,T., Zhen,F., Zhang,C., Wang,Q., Miao,X., Qi,N. and
            Yao,R.
  TITLE     IGF2BP2 inhibits invasion and migration of clear cell renal cell
            carcinoma via targeting Netrin-4 in an m6A-dependent manner
  JOURNAL   Mol Carcinog 63 (8), 1572-1587 (2024)
   PUBMED   38780170
  REMARK    GeneRIF: IGF2BP2 inhibits invasion and migration of clear cell
            renal cell carcinoma via targeting Netrin-4 in an m[6]A-dependent
            manner.
REFERENCE   4  (bases 1 to 4283)
  AUTHORS   Li,Y., Wang,Z., Gao,P., Cao,D., Dong,R., Zhu,M., Fei,Y., Zuo,X. and
            Cai,J.
  TITLE     CircRHBDD1 promotes immune escape via IGF2BP2/PD-L1 signaling and
            acts as a nanotherapeutic target in gastric cancer
  JOURNAL   J Transl Med 22 (1), 704 (2024)
   PUBMED   39080693
  REMARK    GeneRIF: CircRHBDD1 promotes immune escape via IGF2BP2/PD-L1
            signaling and acts as a nanotherapeutic target in gastric cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4283)
  AUTHORS   Mashayekhi,V., Schomisch,A., Rasheed,S., Aparicio-Puerta,E.,
            Risch,T., Yildiz,D., Koch,M., Both,S., Ludwig,N., Legroux,T.M.,
            Keller,A., Muller,R., Fuhrmann,G., Hoppstadter,J. and Kiemer,A.K.
  TITLE     The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer
            cell-derived extracellular vesicles supporting tumor-associated
            macrophages
  JOURNAL   Cell Commun Signal 22 (1), 344 (2024)
   PUBMED   38937789
  REMARK    GeneRIF: The RNA binding protein IGF2BP2/IMP2 alters the cargo of
            cancer cell-derived extracellular vesicles supporting
            tumor-associated macrophages.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4283)
  AUTHORS   Le,H.T., Sorrell,A.M. and Siddle,K.
  TITLE     Two isoforms of the mRNA binding protein IGF2BP2 are generated by
            alternative translational initiation
  JOURNAL   PLoS One 7 (3), e33140 (2012)
   PUBMED   22427968
  REMARK    GeneRIF: Two isoforms of the mRNA binding protein IGF2BP2 are
            generated by alternative translational initiation.
REFERENCE   7  (bases 1 to 4283)
  AUTHORS   Moraes,K.C., Quaresma,A.J., Maehnss,K. and Kobarg,J.
  TITLE     Identification and characterization of proteins that selectively
            interact with isoforms of the mRNA binding protein AUF1 (hnRNP D)
  JOURNAL   Biol Chem 384 (1), 25-37 (2003)
   PUBMED   12674497
REFERENCE   8  (bases 1 to 4283)
  AUTHORS   Zhang,J. and Chan,E.K.
  TITLE     Autoantibodies to IGF-II mRNA binding protein p62 and
            overexpression of p62 in human hepatocellular carcinoma
  JOURNAL   Autoimmun Rev 1 (3), 146-153 (2002)
   PUBMED   12849008
  REMARK    Review article
REFERENCE   9  (bases 1 to 4283)
  AUTHORS   Zhang,J.Y., Chan,E.K., Peng,X.X. and Tan,E.M.
  TITLE     A novel cytoplasmic protein with RNA-binding motifs is an
            autoantigen in human hepatocellular carcinoma
  JOURNAL   J Exp Med 189 (7), 1101-1110 (1999)
   PUBMED   10190901
REFERENCE   10 (bases 1 to 4283)
  AUTHORS   Nielsen,J., Christiansen,J., Lykke-Andersen,J., Johnsen,A.H.,
            Wewer,U.M. and Nielsen,F.C.
  TITLE     A family of insulin-like growth factor II mRNA-binding proteins
            represses translation in late development
  JOURNAL   Mol Cell Biol 19 (2), 1262-1270 (1999)
   PUBMED   9891060
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY795845.2, AK290664.1,
            BC021290.2, AI348863.1, AC016961.28 and BX106919.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_006548.5.
            
            Summary: This gene encodes a protein that binds the 5' UTR of
            insulin-like growth factor 2 (IGF2) mRNA and regulates its
            translation. It plays an important role in metabolism and variation
            in this gene is associated with susceptibility to diabetes.
            Alternative splicing and promoter usage results in multiple
            transcript variants. Related pseudogenes are found on several
            chromosomes. [provided by RefSeq, Sep 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021290.2, SRR11853561.21709.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382199.7/ ENSP00000371634.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BY795845.2         15-17
            4-2048              AK290664.1         2-2046
            2049-2822           BC021290.2         2031-2804
            2823-2860           AI348863.1         251-288
            2861-3643           BC021290.2         2842-3624
            3644-3759           AC016961.28        25742-25857         c
            3760-4282           BX106919.1         1-523
            4283-4283           AC016961.28        25218-25218         c
FEATURES             Location/Qualifiers
     source          1..4283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.2"
     gene            1..4283
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /note="insulin like growth factor 2 mRNA binding protein
                     2"
                     /db_xref="GeneID:10644"
                     /db_xref="HGNC:HGNC:28867"
                     /db_xref="MIM:608289"
     exon            1..260
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1882
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /note="isoform a is encoded by transcript variant 1;
                     IGF-II mRNA-binding protein 2; VICKZ family member 2; IGF2
                     mRNA-binding protein 2"
                     /codon_start=1
                     /product="insulin-like growth factor 2 mRNA-binding
                     protein 2 isoform a"
                     /protein_id="NP_006539.3"
                     /db_xref="CCDS:CCDS3273.2"
                     /db_xref="GeneID:10644"
                     /db_xref="HGNC:HGNC:28867"
                     /db_xref="MIM:608289"
                     /translation="MMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVD
                     YPDQNWAIRAIETLSGKVELHGKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLL
                     AQYGTVENVEQVNTDTETAVVNVTYATREEAKIAMEKLSGHQFENYSFKISYIPDEEV
                     SSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKN
                     ITKQTQSRVDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQKEADETKLAEEIP
                     LKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQDLSIYNPERTITVKGTVEAC
                     ASAEIEIMKKLREAFENDMLAVNQQANLIPGLNLSALGIFSTGLSVLSPPAGPRGAPP
                     AAPYHPFTTHSGYFSSLYPHHQFGPFPHHHSYPEQEIVNLFIPTQAVGAIIGKKGAHI
                     KQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEEV
                     KLEAHIRVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFF
                     ASQTAQRKIREIVQQVKQQEQKYPQGVASQRSK"
     exon            261..321
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            322..370
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            371..422
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            423..486
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            487..759
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            760..894
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1017
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1153
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1282
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1351
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1468
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1543
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1675
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1789
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..4283
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3655..3660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /note="hexamer: AATATA"
     polyA_site      3674
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /note="major polyA site"
     regulatory      4261..4266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
                     /note="hexamer: AATAAA"
     polyA_site      4283
                     /gene="IGF2BP2"
                     /gene_synonym="IMP-2; IMP2; VICKZ2"
ORIGIN      
        1 gaggagagac gagggcagcg gaggaggcga ggagcgccgg gtaccgggcc gggggagccg
       61 cgggctctcg gggaagagac ggatgatgaa caagctttac atcgggaacc tgagccccgc
      121 cgtcaccgcc gacgacctcc ggcagctctt tggggacagg aagctgcccc tggcgggaca
      181 ggtcctgctg aagtccggct acgccttcgt ggactacccc gaccagaact gggccatccg
      241 cgccatcgag accctctcgg gtaaagtgga attgcatggg aaaatcatgg aagttgatta
      301 ctcagtctct aaaaagctaa ggagcaggaa aattcagatt cgaaacatcc ctcctcacct
      361 gcagtgggag gtgttggatg gacttttggc tcaatatggg acagtggaga atgtggaaca
      421 agtcaacaca gacacagaaa ccgccgttgt caacgtcaca tatgcaacaa gagaagaagc
      481 aaaaatagcc atggagaagc taagcgggca tcagtttgag aactactcct tcaagatttc
      541 ctacatcccg gatgaagagg tgagctcccc ttcgccccct cagcgagccc agcgtgggga
      601 ccactcttcc cgggagcaag gccacgcccc tgggggcact tctcaggcca gacagattga
      661 tttcccgctg cggatcctgg tccccaccca gtttgttggt gccatcatcg gaaaggaggg
      721 cttgaccata aagaacatca ctaagcagac ccagtcccgg gtagatatcc atagaaaaga
      781 gaactctgga gctgcagaga agcctgtcac catccatgcc accccagagg ggacttctga
      841 agcatgccgc atgattcttg aaatcatgca gaaagaggca gatgagacca aactagccga
      901 agagattcct ctgaaaatct tggcacacaa tggcttggtt ggaagactga ttggaaaaga
      961 aggcagaaat ttgaagaaaa ttgaacatga aacagggacc aagataacaa tctcatcttt
     1021 gcaggatttg agcatataca acccggaaag aaccatcact gtgaagggca cagttgaggc
     1081 ctgtgccagt gctgagatag agattatgaa gaagctgcgt gaggcctttg aaaatgatat
     1141 gctggctgtt aaccaacaag ccaatctgat cccagggttg aacctcagcg cacttggcat
     1201 cttttcaaca ggactgtccg tgctatctcc accagcaggg ccccgcggag ctccccccgc
     1261 tgccccctac caccccttca ctacccactc cggatacttc tccagcctgt acccccatca
     1321 ccagtttggc ccgttcccgc atcatcactc ttatccagag caggagattg tgaatctctt
     1381 catcccaacc caggctgtgg gcgccatcat cgggaagaag ggggcacaca tcaaacagct
     1441 ggcgagattc gccggagcct ctatcaagat tgcccctgcg gaaggcccag acgtcagcga
     1501 aaggatggtc atcatcaccg ggccaccgga agcccagttc aaggcccagg gacggatctt
     1561 tgggaaactg aaagaggaaa acttctttaa ccccaaagaa gaagtgaagc tggaagcgca
     1621 tatcagagtg ccctcttcca cagctggccg ggtgattggc aaaggtggca agaccgtgaa
     1681 cgaactgcag aacttaacca gtgcagaagt catcgtgcct cgtgaccaaa cgccagatga
     1741 aaatgaggaa gtgatcgtca gaattatcgg gcacttcttt gctagccaga ctgcacagcg
     1801 caagatcagg gaaattgtac aacaggtgaa gcagcaggag cagaaatacc ctcagggagt
     1861 cgcctcacag cgcagcaagt gaggctccca caggcaccag caaaacaacg gatgaatgta
     1921 gcccttccaa cacctgacag aatgagacca aacgcagcca gccagatcgg gagcaaacca
     1981 aagaccatct gaggaatgag aagtctgcgg aggcggccag ggactctgcc gaggccctga
     2041 gaaccccagg ggccgaggag gggcggggaa ggtcagccag gtttgccaga accaccgagc
     2101 cccgcctccc gccccccagg gcttctgcag gcttcagcca tccacttcac catccactcg
     2161 gatctctcct gaactcccac gacgctatcc cttttagttg aactaacata ggtgaacgtg
     2221 ttcaaagcca agcaaaatgc acaccctttt tctgtggcaa atcgtctctg tacatgtgtg
     2281 tacatattag aaagggaaga tgttaagata tgtggcctgt gggttacaca gggtgcctgc
     2341 agcggtaata tattttagaa ataatatatc aaataactca actaactcca atttttaatc
     2401 aattattaat ttttttttct ttttaaagag aaagcaggct tttctagact ttaaagaata
     2461 aagtctttgg gaggtctcac ggtgtagaga ggagctttga ggccacccgc acaaaattca
     2521 cccagaggga aatctcgtcg gaaggacact cacggcagtt ctggatcacc tgtgtatgtc
     2581 aacagaaggg ataccgtctc cttgaagagg aaactctgtc actcctcatg cctgtctagc
     2641 tcatacaccc atttctcttt gcttcacagg ttttaaactg gttttttgca tactgctata
     2701 taattctctg tctctctctg tttatctctc ccctccctcc cctccccttc ttctccatct
     2761 ccattctttt gaatttcctc atccctccat ctcaatcccg tatctacgca cccccccccc
     2821 cccaggcaaa gcagtgctct gagtatcaca tcacacaaaa ggaacaaaag cgaaacacac
     2881 aaaccagcct caacttacac ttggttactc aaaagaacaa gagtcaatgg tacttgtcct
     2941 agcgttttgg aagaggaaaa caggaaccca ccaaaccaac caatcaacca aacaaagaaa
     3001 aaattccaca atgaaagaat gtattttgtc tttttgcatt ttggtgtata agccatcaat
     3061 attcagcaaa atgattcctt tctttaaaaa aaaaaaatgt ggaggaaagt agaaatttac
     3121 caaggttgtt ggcccagggc gttaaattca cagatttttt taacgagaaa aacacacaga
     3181 agaagctacc tcaggtgttt ttacctcagc accttgctct tgtgtttccc ttagagattt
     3241 tgtaaagctg atagttggag cattttttta tttttttaat aaaaatgagt tggaaaaaaa
     3301 ataagatatc aactgccagc ctggagaagg tgacagtcca agtgtgcaac agctgttctg
     3361 aattgtcttc cgctagccaa gaacctatat ggccttcttt tggacaaacc ttgaaaatgt
     3421 ttatttaaaa aaaaaaaaga tgacaaagaa aaacagagag agagaatatt ggagatgtcc
     3481 tgaattttaa tagggtacgc gccattaggg ctttttgcgc taaaggatga acatgtactg
     3541 gtttatgtgg acaagccatt ataccaccag actgcaatgc cagtttcctc tactgcaaac
     3601 agtgttctgt gacaaaaaaa aaaaaaaaaa aaagaaaaaa aaagaaaaaa cagaaatata
     3661 tccagctaac aagatcctgg tgtcttggtg ttttatttta ctaggcattg cctcatccca
     3721 ggtgtcagct gagtcctagc tctgagggac ctgggcagac aggcggtagg tgtgacctgg
     3781 atccacacag ctactctgag aaagctggtt ttgcccagga aagtctttgg gagaagctaa
     3841 actagatcgg tggtcaaagt gtagtcccca gaccagcagc atcagctatc atctgggaac
     3901 ttgttagaaa tgtagattct tggggtccac cttgaatcag aaatcctggg ggtgaggccc
     3961 agcaaccttt tcagcaaggc ctctgggtga ttgctgtgcg cactgaagtt tccgaacctc
     4021 ggagctagag ggatggatcg actgcatgtc aagctagaga agaccagtct atccttaagg
     4081 aactgcaagc ctggccaggc aaagctgctt tttaagtgga ggaaaggggg aggataatat
     4141 gcccggcagt tccgggaaga ggcacttcac gcctccacgg gaagctcact agtaagtgca
     4201 ggcatacctc aggaacgtcg caggttcagt tccagaccac cacagtaaag cgaactttgc
     4261 aataaaatga gtcatacacg ttt
//
