LOCUS       NM_006546               8796 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens insulin like growth factor 2 mRNA binding protein 1
            (IGF2BP1), transcript variant 1, mRNA.
ACCESSION   NM_006546
VERSION     NM_006546.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8796)
  AUTHORS   Luo,J., Yang,C., Xu,S., Ji,Z., Zhang,Y., Bai,H., Deng,Z., Liang,J.,
            Huang,Y., Zhi,E., Tian,R., Li,P., Zhao,F., Zhou,Z., Li,Z. and
            Yao,C.
  TITLE     RNA-binding protein IGF2BP1 is required for spermatogenesis in an
            age-dependent manner
  JOURNAL   Commun Biol 7 (1), 1362 (2024)
   PUBMED   39433965
  REMARK    GeneRIF: RNA-binding protein IGF2BP1 is required for
            spermatogenesis in an age-dependent manner.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8796)
  AUTHORS   Bai,W., Xiao,G., Xie,G., Chen,Z., Xu,X., Zeng,J. and Xie,J.
  TITLE     METTL3/IGF2BP1 influences the development of non-small-cell lung
            cancer by mediating m6A methylation modification of TRPV1
  JOURNAL   Thorac Cancer 15 (26), 1871-1881 (2024)
   PUBMED   39090761
  REMARK    GeneRIF: METTL3/IGF2BP1 influences the development of
            non-small-cell lung cancer by mediating m6A methylation
            modification of TRPV1.
REFERENCE   3  (bases 1 to 8796)
  AUTHORS   Zhang,Q., Du,Z., Zhou,W., Li,W., Yang,Q., Yu,H. and Liu,T.
  TITLE     ZDHHC1 downregulates LIPG and inhibits colorectal cancer growth via
            IGF2BP1 Palmitoylation
  JOURNAL   Cancer Gene Ther 31 (9), 1427-1437 (2024)
   PUBMED   39069526
  REMARK    GeneRIF: ZDHHC1 downregulates LIPG and inhibits colorectal cancer
            growth via IGF2BP1 Palmitoylation.
REFERENCE   4  (bases 1 to 8796)
  AUTHORS   Leclair,N.K., Lucas,C.G., Mirchia,K., McCortney,K., Horbinski,C.M.,
            Raleigh,D.R. and Anczukow,O.
  TITLE     The RNA-binding protein IGF2BP1 regulates stability of mRNA
            transcribed from FOXM1 target genes in hypermitotic meningiomas
  JOURNAL   Acta Neuropathol 148 (1), 28 (2024)
   PUBMED   39179895
  REMARK    GeneRIF: The RNA-binding protein IGF2BP1 regulates stability of
            mRNA transcribed from FOXM1 target genes in hypermitotic
            meningiomas.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8796)
  AUTHORS   Xiao,B., Li,Y., Yang,Y., Chen,C., Gong,S., Li,H., Yao,Q. and
            Wang,L.
  TITLE     METTL3 and IGF2BP1-Mediated m6A Modification of ZHX2 Promotes Tumor
            Property of Renal Cell Carcinoma
  JOURNAL   Kidney Blood Press Res 49 (1), 787-798 (2024)
   PUBMED   39159608
  REMARK    GeneRIF: METTL3 and IGF2BP1-Mediated m6A Modification of ZHX2
            Promotes Tumor Property of Renal Cell Carcinoma.
REFERENCE   6  (bases 1 to 8796)
  AUTHORS   Runge,S., Nielsen,F.C., Nielsen,J., Lykke-Andersen,J., Wewer,U.M.
            and Christiansen,J.
  TITLE     H19 RNA binds four molecules of insulin-like growth factor II
            mRNA-binding protein
  JOURNAL   J Biol Chem 275 (38), 29562-29569 (2000)
   PUBMED   10875929
REFERENCE   7  (bases 1 to 8796)
  AUTHORS   Doyle,G.A., Bourdeau-Heller,J.M., Coulthard,S., Meisner,L.F. and
            Ross,J.
  TITLE     Amplification in human breast cancer of a gene encoding a c-myc
            mRNA-binding protein
  JOURNAL   Cancer Res 60 (11), 2756-2759 (2000)
   PUBMED   10850408
REFERENCE   8  (bases 1 to 8796)
  AUTHORS   Nielsen,J., Christiansen,J., Lykke-Andersen,J., Johnsen,A.H.,
            Wewer,U.M. and Nielsen,F.C.
  TITLE     A family of insulin-like growth factor II mRNA-binding proteins
            represses translation in late development
  JOURNAL   Mol Cell Biol 19 (2), 1262-1270 (1999)
   PUBMED   9891060
REFERENCE   9  (bases 1 to 8796)
  AUTHORS   Doyle,G.A., Betz,N.A., Leeds,P.F., Fleisig,A.J., Prokipcak,R.D. and
            Ross,J.
  TITLE     The c-myc coding region determinant-binding protein: a member of a
            family of KH domain RNA-binding proteins
  JOURNAL   Nucleic Acids Res 26 (22), 5036-5044 (1998)
   PUBMED   9801297
REFERENCE   10 (bases 1 to 8796)
  AUTHORS   Prokipcak,R.D., Herrick,D.J. and Ross,J.
  TITLE     Purification and properties of a protein that binds to the
            C-terminal coding region of human c-myc mRNA
  JOURNAL   J Biol Chem 269 (12), 9261-9269 (1994)
   PUBMED   8132663
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091133.11, BP238821.1,
            AF198254.1, AK074915.1 and AC105030.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_006546.3.
            
            Summary: This gene encodes a member of the insulin-like growth
            factor 2 mRNA-binding protein family. The protein encoded by this
            gene contains four K homology domains and two RNA recognition
            motifs. It functions by binding to the mRNAs of certain genes,
            including insulin-like growth factor 2, beta-actin and
            beta-transducin repeat-containing protein, and regulating their
            translation. Two transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, May 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF198254.1, AF117106.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290341.8/ ENSP00000290341.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC091133.11        43356-43382         c
            28-56               BP238821.1         1-29
            57-1201             AF198254.1         1-1145
            1202-1204           AK074915.1         178-180
            1205-1453           AF198254.1         1149-1397
            1454-1456           AK074915.1         430-432
            1457-2085           AF198254.1         1401-2029
            2086-3803           AK074915.1         1062-2779
            3804-8796           AC105030.11        65879-70871         c
FEATURES             Location/Qualifiers
     source          1..8796
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..8796
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /note="insulin like growth factor 2 mRNA binding protein
                     1"
                     /db_xref="GeneID:10642"
                     /db_xref="HGNC:HGNC:28866"
                     /db_xref="MIM:608288"
     exon            1..536
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..2095
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coding region determinant-binding protein; zipcode-binding
                     protein 1; VICKZ family member 1; IGF2 mRNA-binding
                     protein 1; ZBP-1; IGF-II mRNA-binding protein 1;
                     insulin-like growth factor 2 mRNA binding protein 1 deltaN
                     CRDBP"
                     /codon_start=1
                     /product="insulin-like growth factor 2 mRNA-binding
                     protein 1 isoform 1"
                     /protein_id="NP_006537.3"
                     /db_xref="CCDS:CCDS11543.1"
                     /db_xref="GeneID:10642"
                     /db_xref="HGNC:HGNC:28866"
                     /db_xref="MIM:608288"
                     /translation="MNKLYIGNLNESVTPADLEKVFAEHKISYSGQFLVKSGYAFVDC
                     PDEHWAMKAIETFSGKVELQGKRLEIEHSVPKKQRSRKIQIRNIPPQLRWEVLDSLLA
                     QYGTVENCEQVNTESETAVVNVTYSNREQTRQAIMKLNGHQLENHALKVSYIPDEQIA
                     QGPENGRRGGFGSRGQPRQGSPVAAGAPAKQQQVDIPLRLLVPTQYVGAIIGKEGATI
                     RNITKQTQSKIDVHRKENAGAAEKAISVHSTPEGCSSACKMILEIMHKEAKDTKTADE
                     VPLKILAHNNFVGRLIGKEGRNLKKVEQDTETKITISSLQDLTLYNPERTITVKGAIE
                     NCCRAEQEIMKKVREAYENDVAAMSLQSHLIPGLNLAAVGLFPASSSAVPPPPSSVTG
                     AAPYSSFMQAPEQEMVQVFIPAQAVGAIIGKKGQHIKQLSRFASASIKIAPPETPDSK
                     VRMVIITGPPEAQFKAQGRIYGKLKEENFFGPKEEVKLETHIRVPASAAGRVIGKGGK
                     TVNELQNLTAAEVVVPRDQTPDENDQVIVKIIGHFYASQMAQRKIRDILAQVKQQHQK
                     GQSNQAQARRK"
     exon            537..597
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..646
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..698
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..762
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..1044
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1179
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1302
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1438
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1561
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1681
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1756
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1888
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2002
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..8796
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8279..8284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /note="hexamer: AATAAA"
     polyA_site      8299
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /note="major polyA site"
     regulatory      8768..8773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
                     /note="hexamer: AATAAA"
     polyA_site      8796
                     /gene="IGF2BP1"
                     /gene_synonym="CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1"
ORIGIN      
        1 cgctccattt tttttcaagt cgattttatt tagaggcggc gccagggcgg ccgcggagaa
       61 acgtgacaca ccagccctct cggaggggtt tcggaccgaa gggaagaagc tgcgccgtgt
      121 cgtccgtctc cctgcgcgcc gcgggcactt ctcctgggct ctccccgaac tctcccgcga
      181 cctctgcgcg ccctcaggcc gccttccccg ccctgggctc gggacaactt ctggggtggg
      241 gtgcaaagaa agtttgcggc tcctgccgcc ggcctctccg cctcttggcc taggaggctc
      301 gccgcccgcg cccgctcgtt cggccttgcc cgggaccgcg tcctgccccg agaccgccac
      361 catgaacaag ctttacatcg gcaacctcaa cgagagcgtg acccccgcgg acttggagaa
      421 agtgtttgcg gagcacaaga tctcctacag cggccagttc ttggtcaaat ccggctacgc
      481 cttcgtggac tgcccggacg agcactgggc gatgaaggcc atcgaaactt tctccgggaa
      541 agtagaatta caaggaaaac gcttagagat tgaacattcg gtgcccaaaa aacaaaggag
      601 ccggaaaatt caaatccgaa atattccacc ccagctccga tgggaagtac tggacagcct
      661 gctggctcag tatggtacag tagagaactg tgagcaagtg aacaccgaga gtgagacggc
      721 agtggtgaat gtcacctatt ccaaccggga gcagaccagg caagccatca tgaagctgaa
      781 tggccaccag ttggagaacc atgccctgaa ggtctcctac atccccgatg agcagatagc
      841 acagggacct gagaatgggc gccgaggggg ctttggctct cggggtcagc cccgccaggg
      901 ctcacctgtg gcagcggggg ccccagccaa gcagcagcaa gtggacatcc cccttcggct
      961 cctggtgccc acccagtatg tgggtgccat tattggcaag gagggggcca ccatccgcaa
     1021 catcacaaaa cagacccagt ccaagataga cgtgcatagg aaggagaacg caggtgcagc
     1081 tgaaaaagcc atcagtgtgc actccacccc tgagggctgc tcctccgctt gtaagatgat
     1141 cttggagatt atgcataaag aggctaagga caccaaaacg gctgacgagg ttcccctgaa
     1201 gatcctggcc cataataact ttgtagggcg tctcattggc aaggaaggac ggaacctgaa
     1261 gaaggtagag caagataccg agacaaaaat caccatctcc tcgttgcaag accttaccct
     1321 ttacaaccct gagaggacca tcactgtgaa gggggccatc gagaattgtt gcagggccga
     1381 gcaggaaata atgaagaaag ttcgggaggc ctatgagaat gatgtggctg ccatgagcct
     1441 gcagtctcac ctgatccctg gcctgaacct ggctgctgta ggtcttttcc cagcttcatc
     1501 cagcgcagtc ccgccgcctc ccagcagcgt tactggggct gctccctata gctcctttat
     1561 gcaggctccc gagcaggaga tggtgcaggt gtttatcccc gcccaggcag tgggcgccat
     1621 catcggcaag aaggggcagc acatcaaaca gctctcccgg tttgccagcg cctccatcaa
     1681 gattgcacca cccgaaacac ctgactccaa agttcgtatg gttatcatca ctggaccgcc
     1741 agaggcccaa ttcaaggctc agggaagaat ctatggcaaa ctcaaggagg agaacttctt
     1801 tggtcccaag gaggaagtga agctggagac ccacatacgt gtgccagcat cagcagctgg
     1861 ccgggtcatt ggcaaaggtg gaaaaacggt gaacgagttg cagaatttga cggcagctga
     1921 ggtggtagta ccaagagacc agacccctga tgagaacgac caggtcatcg tgaaaatcat
     1981 cggacatttc tatgccagtc agatggctca acggaagatc cgagacatcc tggcccaggt
     2041 taagcagcag catcagaagg gacagagtaa ccaggcccag gcacggagga agtgaccagc
     2101 ccctccctgt cccttcgagt ccaggacaac aacgggcaga aatcgagagt gtgctctccc
     2161 cggcaggcct gagaatgagt gggaatccgg gacacctggg ccgggctgta gatcaggttt
     2221 gcccacttga ttgagaaaga tgttccagtg aggaaccctg atctctcagc cccaaacacc
     2281 cacccaattg gcccaacact gtctgcccct cggggtgtca gaaattctag cgcaaggcac
     2341 ttttaaacgt ggattgttta aagaagctct ccaggcccca ccaagagggt ggatcacacc
     2401 tcagtgggaa gaaaaataaa atttccttca ggttttaaaa acatgcagag aggtgtttta
     2461 atcagcctta aaggatggtt catttcttga ccttaatgtt tttccaatct tcttccccct
     2521 acttgggtaa ttgattaaaa tacctccatt tacggcctct ttctatattt acactaattt
     2581 ttttatcttt attgctacca gaaaaaaatg cgaacgaatg cattgctttg cttacagtat
     2641 tgactcaagg gaaaagaact gtcagtatct gtagattaat tccaatcact ccctaaccaa
     2701 taggtacaat acggaatgaa gaagagggga aaatggggag aaagatggtt aaaatacata
     2761 ataatccacg tttaaaagga gcgcacttgt ggctgatcta tgccagatca ccatcttcaa
     2821 attggcacaa ctgaaatttc cccactctgt tggggcttcc ccaccacatt catgtccctc
     2881 tcccgtgtag gtttcacatt atgtccaggt gcacataggt ggtattgaat gctcagcagg
     2941 gtaggggctg accactgtcc ctgattccca tcgttctcag gcggatttta tattttttta
     3001 aagtctattt taatgattgg atatgagcac tgggaagggg acgctaactc cccttgataa
     3061 agtctcggtt ccatggagga cttgagtggc cccaaaggct gccacggtgc cctcacccca
     3121 gcccatgtgc tcccataagg gctggttcct agaggcaggg gttgtggggc actcccagcc
     3181 acggcactgt taccttggtg gtgggacttg gaacccaacc ctgagctccc gataaagcta
     3241 aagtccatca tctggcaaat tcagtaaatt ggagagtact tgcttctgtt tgtatctgag
     3301 aggaattttt aactgacggc ttctgtctcc atgaatcatt atcagcatga tgaaaggtgt
     3361 gtctaaaaaa caattcagaa taccagcagc attgtacagc aaggggtaaa taagcttaat
     3421 ttattaattt accaggctta attaagatcc catggagtgt ttagcccttg tgggagacag
     3481 aagccatcag ttaaatgagg ttaggcctct cctcctaata tactgattga caatgcatat
     3541 tagccaggta atgcacttta gctaccctgg acaatgctat caagtgtgct gggaagggag
     3601 gaaggcctct ctacatatgg aaaagcccat gcgtggagtt cccctccttt caacattgca
     3661 acaacagtaa caacaagaca accgcaacat gtgggcgtag tcaggcaatg ctgtgtgcga
     3721 agtaaactac ctcaaggtat gaagttacct cagcaattat tttccttttt gttcccccca
     3781 accccattaa aaaaattttt ttttgatttt tgtttttttg cagcttgctg atattttata
     3841 taaaaaagaa aagcaaagca aaagagaagc tgatagtctt gaatatttta tttttttaat
     3901 gaaaagaaaa aacaagaaag ttatgtttca taatttctta caacatgagc cagtaaccct
     3961 ttaggaactc tctatggaga acaggcctgg tgggaaaggc tttgggggct gcccccttag
     4021 gaggaggcta gtgctaagag ggaaggccca ggtttgagag agcccagagg ggcagagccc
     4081 agagccttgt ttggccctga tctctgactt ctagagcccc agctgctggc ggctgctgga
     4141 atatcctacc tgataggatt aaaaggccta gtggagctgg gggctctcag tggttaaaca
     4201 atgcccaaca accaaccagc tggcccttgg tctcctctct ttcctccttt ggttaaagag
     4261 catctcagcc agcttttccc accagtggtg ctgttgagat attttaaaat attgcctccg
     4321 ttttatcgag gagagaaata ataactaaaa aatataccct ttaaaaaaac ctatatttct
     4381 ctgtctaaaa atatgggagc tgagattccg ttcgtggaaa aaagacaagg ccaccctctc
     4441 gccctcagag aggtccacct ggtttgtcat tgcaatgctt ttcatttttt ttttttgtta
     4501 ttgtttcatt tcagttccgt cttgctattc ttcctaatct atatccatag atctaagggg
     4561 caaacagata ctagttaact gcccccacct ctgtctccct gtcttcttta gatcggtctg
     4621 attgatttta aaagtggacc caaacttagg gaattcttga tttagggtgg ctggtggcaa
     4681 ggaggggcag gggatatggg gacgtgactg ggacaggttc ctgccttatc attttctccc
     4741 taggacattc ccttgtagcc cccagaattg tctggcccaa attgaataga agcagaaaaa
     4801 catttaggga taacatcagg ccagtagaat taagcctctc cacctgtccc aaccataaaa
     4861 agggtctccc agctttccat ctctggctct atatgcttta tcccaaaaca aagcagataa
     4921 cgttcagacg tcggccattt agtaatttaa agcgaatttc cagcagcaag catgctttga
     4981 tatctggttc agactatcat caggaagaaa aaaaaatccc acagtacctg aaatgtgatt
     5041 gttgcagtgt tcagtttcct tgggggcctg ctcccttcac accttgagcc caagtccttt
     5101 tccgttggct gattcagctc ccagaagaga cgaggaagtg tgtggcaagg gactggaaaa
     5161 cttcacttgc ttggattagg caaggctcca ctcattgttg atatttgccc agcaggaaaa
     5221 tcatgtaagt tataccacca gaaagcaaaa ggagcatggt ttggtggtta aggtttagtg
     5281 ggatgaagga cctgtcttgg tgggccgggc cctcttgtgc cccgtaggct aggtcttagg
     5341 gcaactcctt gccctcctgc tcagcacctc catttcccca tccttggtga gataacaagc
     5401 tatcgcgaaa agcacttggg agatttggat gatttgagaa gagtgactta aaaaaaatgc
     5461 ttctgtgctc taagatatat atgtgtgtgt gtgtgctaca tatatatttt taagaaagga
     5521 ccatctcttt aggatatatt tttaaattct ttgaaacaca taaccaaaat ggtttgattc
     5581 actgactgac tttgaagctg catctgccag ttacacccca aatggcttta atcccctctc
     5641 gggtctggtt gccttttgca gtttgggttg tggactcagc tcctgtgagg ggtctggtta
     5701 ggagagagcc atttttaagg acagggagtt ttatagccct tttctacttt cctcccctcc
     5761 tcccagtcct tatcaatctt ttttcctttt tcctgacccc ctccttctgg aggcagttgg
     5821 gagctatcct tgtttatgcc tcactattgg cagaaaagac cccatttaaa acccagagaa
     5881 cactggaggg ggatgctcta gttggttctg tgtccatttt cctctgtgcc aaagacagac
     5941 agacagaggc tgagagaggc tgttcctgaa tcaaagcaat agccagcttt cgacacatac
     6001 ctggctgtct gaggaggaag gcctcctgga aactgggagc taagggcgag gcccttccct
     6061 tcagaggctc ctgggggatt agggtgtggt gtttgccaag ccaaggggta gggagccgag
     6121 aaattggtct gtcggctcct ggttgcactt tggggaagga gaggaagttt ggggctccag
     6181 gtagctccct gttgtgggac tgctctgtcc cctgccccta ctgcagagat agcactgccg
     6241 agttcccttc aggcctggca gacgggcagt gaggaggggc ctcagttagc tctcaagggt
     6301 gccttcccct cctcccaacc cagacatacc ctctgccaaa ctgggaacca gcagtgctag
     6361 taactacctc acagagcccc agagggcctg cttgagcctt cttgctccac aggagaagct
     6421 ggtgcctcta ggcaacccct tcctcccacc tctcatcagg ggtgggggtt ctcctttctt
     6481 tcccctgaag tgtttatggg gagatcctag tggctttgcc attcaaacca ctcgactgtt
     6541 tgcctgtttc ttgaaaacca gtagaaggga aacagcacag cctgtcacag taattgcagg
     6601 aagattgaag aaaaatcctc atcaatgcca ggggacataa aagccatttc ccttccaaat
     6661 actcgacaat ttagatgcag aacatttctc tgtattcaga cttagagtaa caccagctga
     6721 aaactgcagt ttctttcctt tggatacata aggcttctct atcggggtac gggacaggga
     6781 ggaggcctca tgtctgaagg gggatttagg ggcgagagcc ccagccctga ccctcggtcc
     6841 tgtgcaccgc tttggggcac agtctgatgg cgcctttgct ggcgccttag tatggttgac
     6901 tccggatgga caaaagaaaa aaaatttttt ttcttgaatg aaatagcagg aagctcctcg
     6961 ggagcatgtg ttttgattaa ccgcaggtga tggatgctac gagtataaat ggattaacta
     7021 cctcaatcct tacagtaaga ttggaactaa gggcagggac tcatgcataa gggtatgaat
     7081 cccagccagg acaagtgagt tgaggcttgt gccacaaaag gtttgtcctt ggggaacagg
     7141 caggcctgcc aggatccccc ccatatcgat tgggctggga gggctggcca tgaggtcccc
     7201 actttctgct ttccttgccc atgtgtcacc cctttggcct ccagcttgtc cctctctcac
     7261 tttctatagc tttgttggac cagatggtga ggaaaggaat ggcctcttcc cttctagagg
     7321 gggctggctg gagtgagacc tggggcttgg cctggaaccc accacacagc cccaaagtca
     7381 ggaagcctgg ggaaaccaga gctgagacct cttcaacagg gtttctttga gatcctacac
     7441 ctccattggg ccctttttca gtcttcaatg ggggcccagt tggctctaga aggagaagag
     7501 gtgaagcagg atcctttgcc ctgggggagt ctgagggcgc ggtccttgga ctcattcagg
     7561 ccgtctttgt agttggggga gttccactgg gcgatcccag cccctcccca cccaccctct
     7621 aatggacctc ctcatagaag ccccatttca cttttgtttt atctacctct tagcaaaaca
     7681 atagataaat taggtagtgg cagctccact tgcttaggtt agggggggaa aaagatttct
     7741 ttttccaaag gaaaaaaata ttaccttgag aatactttcc aaaaaataaa attaaaaaaa
     7801 aaaaaaccaa aaaaaaaaat ttttttttaa aagggagaca ttttccagtg accactggat
     7861 tgttttaatt tcccaagctt ttttttcccc cataaataag tttcactctt tggcgatttt
     7921 cttcacttgt ttaagataac gtgctagcta ttccaacagg taacagcttt cacagtctgc
     7981 ccctggcctg tctcacccca tcccccaccc tattcctgcc agtgagtcct tcctgtgctt
     8041 ctctcccttc tcccctccca gccagctgac ttcagtcacc cctgtccccc ctcccctgcc
     8101 aataagctcc cccaggaata aaggctttgt tttggggatg cttaaatctt gactggcact
     8161 tcccggctgt gggggctggg gagccacttg taacatttct gtgcagattt tatgttagcc
     8221 actgctatgt aaaagcacgt tcaaaatgaa tttcagcaga ttatgtgtta ccataatgaa
     8281 taaacgtcct ctatcaccat ttggagtctc ccttttctcc aggatcttga tcctggtccc
     8341 caaaaccaga gtgaatcaaa agagcttcct cccctgaggc aaagtggatt tgtaagcagt
     8401 tctgaaacat cacttactca gaagagggaa cgatgtattt tgatgagtgc aaattgggaa
     8461 gagctggagg cctactgctt gggacagttt tttttttttt ttttttttta aatatgagtg
     8521 ctagcttatt ctgtaattgc ggcaactttg aaaattgtat tttactggaa atctgccagc
     8581 catcaccacc cgattttgat tgtatccttc ctcccatcct ttaatctgtt cattgctttg
     8641 ggggaggtgg ggcagctggc tcacacgttg gagtttgttc tttgatggat gaacgaacac
     8701 tccagttttc tttcccgtga aggttgtttc agccacaaac cacttcattt tgctgtttca
     8761 atttcaaaat aaaaggaaac ttatattgaa agacaa
//
