LOCUS       NM_000875              12235 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens insulin like growth factor 1 receptor (IGF1R),
            transcript variant 1, mRNA.
ACCESSION   NM_000875 NM_015883
VERSION     NM_000875.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12235)
  AUTHORS   Smith,T.J.
  TITLE     TSHR-IGF-IR complex drives orbital fibroblast misbehavior in
            thyroid eye disease
  JOURNAL   Curr Opin Endocrinol Diabetes Obes 31 (5), 177-183 (2024)
   PUBMED   39082947
  REMARK    GeneRIF: TSHR-IGF-IR complex drives orbital fibroblast misbehavior
            in thyroid eye disease.
            Review article
REFERENCE   2  (bases 1 to 12235)
  AUTHORS   Josefson,J.L., Kuang,A., Allard,C., Bianco,M.E., Lowe,W. Jr.,
            Scholtens,D.M., Bouchard,L. and Hivert,M.F.
  TITLE     Newborn adiposity is associated with cord blood DNA methylation at
            IGF1R and KLF7
  JOURNAL   Obesity (Silver Spring) 32 (10), 1923-1933 (2024)
   PUBMED   39165088
  REMARK    GeneRIF: Newborn adiposity is associated with cord blood DNA
            methylation at IGF1R and KLF7.
REFERENCE   3  (bases 1 to 12235)
  AUTHORS   Zheng,H., Ye,W., Huang,K., Chen,Q., Yang,J. and Luo,L.
  TITLE     KLF15 alleviates oxidative stress and apoptosis of H/R-induced
            trophoblast cells to improve invasion and migration capacity via
            the activation of IGF1R
  JOURNAL   Tissue Cell 90, 102485 (2024)
   PUBMED   39067323
  REMARK    GeneRIF: KLF15 alleviates oxidative stress and apoptosis of
            H/R-induced trophoblast cells to improve invasion and migration
            capacity via the activation of IGF1R.
REFERENCE   4  (bases 1 to 12235)
  AUTHORS   Lopez-Cerda,M., Lorenzo-Sanz,L., da Silva-Diz,V., Llop,S.,
            Penin,R.M., Bermejo,J.O., de Goeij-de Haas,R., Piersma,S.R.,
            Pham,T.V., Jimenez,C.R., Martin-Liberal,J. and Munoz,P.
  TITLE     IGF1R signaling induces epithelial-mesenchymal plasticity via ITGAV
            in cutaneous carcinoma
  JOURNAL   J Exp Clin Cancer Res 43 (1), 211 (2024)
   PUBMED   39075581
  REMARK    GeneRIF: IGF1R signaling induces epithelial-mesenchymal plasticity
            via ITGAV in cutaneous carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12235)
  AUTHORS   Meng,Z., Jackson,N.L., Choi,H., King,P.H., Emanuel,P.D. and
            Blume,S.W.
  TITLE     Alterations in RNA-binding activities of IRES-regulatory proteins
            as a mechanism for physiological variability and pathological
            dysregulation of IGF-IR translational control in human breast tumor
            cells
  JOURNAL   J Cell Physiol 217 (1), 172-183 (2008)
   PUBMED   18452152
  REMARK    GeneRIF: dysregulation of the IGF-IR internal ribosomal entry site
            through changes in the activities of RNA-binding
            translation-regulatory proteins could be responsible for IGF-IR
            overexpression in a proportion of human breast tumors.
REFERENCE   6  (bases 1 to 12235)
  AUTHORS   Abbott,A.M., Bueno,R., Pedrini,M.T., Murray,J.M. and Smith,R.J.
  TITLE     Insulin-like growth factor I receptor gene structure
  JOURNAL   J Biol Chem 267 (15), 10759-10763 (1992)
   PUBMED   1316909
REFERENCE   7  (bases 1 to 12235)
  AUTHORS   Cooke,D.W., Bankert,L.A., Roberts,C.T. Jr., LeRoith,D. and
            Casella,S.J.
  TITLE     Analysis of the human type I insulin-like growth factor receptor
            promoter region
  JOURNAL   Biochem Biophys Res Commun 177 (3), 1113-1120 (1991)
   PUBMED   1711844
REFERENCE   8  (bases 1 to 12235)
  AUTHORS   Burguera,B., Frank,B.H., DiMarchi,R., Long,S. and Caro,J.F.
  TITLE     The interaction of proinsulin with the insulin-like growth factor-I
            receptor in human liver, muscle, and adipose tissue
  JOURNAL   J Clin Endocrinol Metab 72 (6), 1238-1241 (1991)
   PUBMED   1851182
REFERENCE   9  (bases 1 to 12235)
  AUTHORS   Rom,W.N. and Paakko,P.
  TITLE     Activated alveolar macrophages express the insulin-like growth
            factor-I receptor
  JOURNAL   Am J Respir Cell Mol Biol 4 (5), 432-439 (1991)
   PUBMED   1850606
REFERENCE   10 (bases 1 to 12235)
  AUTHORS   Tollefsen,S.E., Stoszek,R.M. and Thompson,K.
  TITLE     Interaction of the alpha beta dimers of the insulin-like growth
            factor I receptor is required for receptor autophosphorylation
  JOURNAL   Biochemistry 30 (1), 48-54 (1991)
   PUBMED   1846292
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC118658.4, AB425196.1,
            X04434.1, BC113610.1, AC069029.9 and BC088377.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000875.4.
            
            Summary: This receptor binds insulin-like growth factor with a high
            affinity. It has tyrosine kinase activity. The insulin-like growth
            factor I receptor plays a critical role in transformation events.
            Cleavage of the precursor generates alpha and beta subunits. It is
            highly overexpressed in most malignant tissues where it functions
            as an anti-apoptotic agent by enhancing cell survival.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been found for this gene. [provided by RefSeq, May
            2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X04434.1, BC113610.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000650285.1/ ENSP00000497069.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1011              AC118658.4         151388-152398
            1012-3825           AB425196.1         498-3311
            3826-4552           X04434.1           2828-3554
            4553-5533           BC113610.1         3542-4522
            5534-11418          AC069029.9         22095-27979         c
            11419-12235         BC088377.1         450-1266
FEATURES             Location/Qualifiers
     source          1..12235
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.3"
     gene            1..12235
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /note="insulin like growth factor 1 receptor"
                     /db_xref="GeneID:3480"
                     /db_xref="HGNC:HGNC:5465"
                     /db_xref="MIM:147370"
     exon            1..1137
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     CDS             1044..5147
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; IGF-I receptor"
                     /codon_start=1
                     /product="insulin-like growth factor 1 receptor isoform 1
                     precursor"
                     /protein_id="NP_000866.1"
                     /db_xref="CCDS:CCDS10378.1"
                     /db_xref="GeneID:3480"
                     /db_xref="HGNC:HGNC:5465"
                     /db_xref="MIM:147370"
                     /translation="MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQ
                     QLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPN
                     LTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLI
                     LDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPST
                     CGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRC
                     VDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEE
                     EKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRH
                     SHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAF
                     NPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIIT
                     WHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGI
                     LLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSS
                     SQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEE
                     VTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRR
                     DVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTL
                     YRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPE
                     NPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNG
                     SWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVL
                     YASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRV
                     AIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLK
                     SYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED
                     FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWE
                     IATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI
                     ISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRH
                     SGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC"
     exon            1138..1683
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1996
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2145
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2290
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2505
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2632
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2871
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..3039
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3244
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3528
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            3529..3665
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            3666..3825
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..3928
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            3929..3999
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            4000..4229
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            4230..4340
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            4341..4500
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            4501..4630
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            4631..4765
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     exon            4766..12235
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12215..12220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /note="hexamer: AATAAA"
     polyA_site      12235
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgtggc agcggcggcg gcggcgcggc gaggctgggg ctcttgttta ccagcattaa
       61 ctccgctgag cggaaaaaaa aagggaaaaa acccgaggag gagcgagcgc accaggcgaa
      121 ctcgagagag gcgggagagc gagagggacg ccgccagcga gcctgcccac ggccggcgct
      181 cgcagaccct cggccccgct ccccggatcc ccccgcgccc tccacgcccc tcccgcgcgg
      241 gggcagctcc acggcgcgcc tcgcctcggc tgtgaccttc agcgagccgg agcccccgcg
      301 cagagcaggc ggcggcgggc gggggccggg cgggggccgg cgcggggcgg gcggcggcgc
      361 agagccgggc ggcgcggcgg gagtgctgag cgcggcgcgg ccggcccgcc gctttgtgtg
      421 tgtcctggat ttgggaagga gctcgccgcg gcggcggcgg cgctgaggga ggaggcggcg
      481 gcgagcggag ccaggaggag gaggaggagg gggagccgct cattcatttt gactccgcgt
      541 ttctgcccct cgccggcctc gcctgtgacc cggacttcgg ggcgatcttg cgaactgcgt
      601 cgcgccctcc cgcggcggaa gctcgggcgt ccggccgcct cccgcgcggc cagggccggg
      661 cttgtttttc ctcgcctagg cagatttggg ctttgccccc tttctttgca gttttccccc
      721 cttcctgcct ctccgggttt gaaaatggag gccgacgacg ccgacagccc gccccggcgc
      781 gcctcgggtt cccgactccg ccgagccctg ggccgctgct gccggcgctg aggggccgcc
      841 ccgcgccgcc cgccccgtcc gcgcacccgg agggccccgg cggcgccgcc ttcggagtat
      901 tgtttccttc gcccttgttt ttggaggggg agcgaagact gagtttgaga cttgtttcct
      961 ttcatttcct ttttttcttt tcttttcttt tttttttttt tttttttttt tgagaaaggg
     1021 gaatttcatc ccaaataaaa ggaatgaagt ctggctccgg aggagggtcc ccgacctcgc
     1081 tgtgggggct cctgtttctc tccgccgcgc tctcgctctg gccgacgagt ggagaaatct
     1141 gcgggccagg catcgacatc cgcaacgact atcagcagct gaagcgcctg gagaactgca
     1201 cggtgatcga gggctacctc cacatcctgc tcatctccaa ggccgaggac taccgcagct
     1261 accgcttccc caagctcacg gtcattaccg agtacttgct gctgttccga gtggctggcc
     1321 tcgagagcct cggagacctc ttccccaacc tcacggtcat ccgcggctgg aaactcttct
     1381 acaactacgc cctggtcatc ttcgagatga ccaatctcaa ggatattggg ctttacaacc
     1441 tgaggaacat tactcggggg gccatcagga ttgagaaaaa tgctgacctc tgttacctct
     1501 ccactgtgga ctggtccctg atcctggatg cggtgtccaa taactacatt gtggggaata
     1561 agcccccaaa ggaatgtggg gacctgtgtc cagggaccat ggaggagaag ccgatgtgtg
     1621 agaagaccac catcaacaat gagtacaact accgctgctg gaccacaaac cgctgccaga
     1681 aaatgtgccc aagcacgtgt gggaagcggg cgtgcaccga gaacaatgag tgctgccacc
     1741 ccgagtgcct gggcagctgc agcgcgcctg acaacgacac ggcctgtgta gcttgccgcc
     1801 actactacta tgccggtgtc tgtgtgcctg cctgcccgcc caacacctac aggtttgagg
     1861 gctggcgctg tgtggaccgt gacttctgcg ccaacatcct cagcgccgag agcagcgact
     1921 ccgaggggtt tgtgatccac gacggcgagt gcatgcagga gtgcccctcg ggcttcatcc
     1981 gcaacggcag ccagagcatg tactgcatcc cttgtgaagg tccttgcccg aaggtctgtg
     2041 aggaagaaaa gaaaacaaag accattgatt ctgttacttc tgctcagatg ctccaaggat
     2101 gcaccatctt caagggcaat ttgctcatta acatccgacg ggggaataac attgcttcag
     2161 agctggagaa cttcatgggg ctcatcgagg tggtgacggg ctacgtgaag atccgccatt
     2221 ctcatgcctt ggtctccttg tccttcctaa aaaaccttcg cctcatccta ggagaggagc
     2281 agctagaagg gaattactcc ttctacgtcc tcgacaacca gaacttgcag caactgtggg
     2341 actgggacca ccgcaacctg accatcaaag cagggaaaat gtactttgct ttcaatccca
     2401 aattatgtgt ttccgaaatt taccgcatgg aggaagtgac ggggactaaa gggcgccaaa
     2461 gcaaagggga cataaacacc aggaacaacg gggagagagc ctcctgtgaa agtgacgtcc
     2521 tgcatttcac ctccaccacc acgtcgaaga atcgcatcat cataacctgg caccggtacc
     2581 ggccccctga ctacagggat ctcatcagct tcaccgttta ctacaaggaa gcacccttta
     2641 agaatgtcac agagtatgat gggcaggatg cctgcggctc caacagctgg aacatggtgg
     2701 acgtggacct cccgcccaac aaggacgtgg agcccggcat cttactacat gggctgaagc
     2761 cctggactca gtacgccgtt tacgtcaagg ctgtgaccct caccatggtg gagaacgacc
     2821 atatccgtgg ggccaagagt gagatcttgt acattcgcac caatgcttca gttccttcca
     2881 ttcccttgga cgttctttca gcatcgaact cctcttctca gttaatcgtg aagtggaacc
     2941 ctccctctct gcccaacggc aacctgagtt actacattgt gcgctggcag cggcagcctc
     3001 aggacggcta cctttaccgg cacaattact gctccaaaga caaaatcccc atcaggaagt
     3061 atgccgacgg caccatcgac attgaggagg tcacagagaa ccccaagact gaggtgtgtg
     3121 gtggggagaa agggccttgc tgcgcctgcc ccaaaactga agccgagaag caggccgaga
     3181 aggaggaggc tgaataccgc aaagtctttg agaatttcct gcacaactcc atcttcgtgc
     3241 ccagacctga aaggaagcgg agagatgtca tgcaagtggc caacaccacc atgtccagcc
     3301 gaagcaggaa caccacggcc gcagacacct acaacatcac cgacccggaa gagctggaga
     3361 cagagtaccc tttctttgag agcagagtgg ataacaagga gagaactgtc atttctaacc
     3421 ttcggccttt cacattgtac cgcatcgata tccacagctg caaccacgag gctgagaagc
     3481 tgggctgcag cgcctccaac ttcgtctttg caaggactat gcccgcagaa ggagcagatg
     3541 acattcctgg gccagtgacc tgggagccaa ggcctgaaaa ctccatcttt ttaaagtggc
     3601 cggaacctga gaatcccaat ggattgattc taatgtatga aataaaatac ggatcacaag
     3661 ttgaggatca gcgagaatgt gtgtccagac aggaatacag gaagtatgga ggggccaagc
     3721 taaaccggct aaacccgggg aactacacag cccggattca ggccacatct ctctctggga
     3781 atgggtcgtg gacagatcct gtgttcttct atgtccaggc caaaacagga tatgaaaact
     3841 tcatccatct gatcatcgct ctgcccgtcg ctgtcctgtt gatcgtggga gggttggtga
     3901 ttatgctgta cgtcttccat agaaagagaa ataacagcag gctggggaat ggagtgctgt
     3961 atgcctctgt gaacccggag tacttcagcg ctgctgatgt gtacgttcct gatgagtggg
     4021 aggtggctcg ggagaagatc accatgagcc gggaacttgg gcaggggtcg tttgggatgg
     4081 tctatgaagg agttgccaag ggtgtggtga aagatgaacc tgaaaccaga gtggccatta
     4141 aaacagtgaa cgaggccgca agcatgcgtg agaggattga gtttctcaac gaagcttctg
     4201 tgatgaagga gttcaattgt caccatgtgg tgcgattgct gggtgtggtg tcccaaggcc
     4261 agccaacact ggtcatcatg gaactgatga cacggggcga tctcaaaagt tatctccggt
     4321 ctctgaggcc agaaatggag aataatccag tcctagcacc tccaagcctg agcaagatga
     4381 ttcagatggc cggagagatt gcagacggca tggcatacct caacgccaat aagttcgtcc
     4441 acagagacct tgctgcccgg aattgcatgg tagccgaaga tttcacagtc aaaatcggag
     4501 attttggtat gacgcgagat atctatgaga cagactatta ccggaaagga gggaaagggc
     4561 tgctgcccgt gcgctggatg tctcctgagt ccctcaagga tggagtcttc accacttact
     4621 cggacgtctg gtccttcggg gtcgtcctct gggagatcgc cacactggcc gagcagccct
     4681 accagggctt gtccaacgag caagtccttc gcttcgtcat ggagggcggc cttctggaca
     4741 agccagacaa ctgtcctgac atgctgtttg aactgatgcg catgtgctgg cagtataacc
     4801 ccaagatgag gccttccttc ctggagatca tcagcagcat caaagaggag atggagcctg
     4861 gcttccggga ggtctccttc tactacagcg aggagaacaa gctgcccgag ccggaggagc
     4921 tggacctgga gccagagaac atggagagcg tccccctgga cccctcggcc tcctcgtcct
     4981 ccctgccact gcccgacaga cactcaggac acaaggccga gaacggcccc ggccctgggg
     5041 tgctggtcct ccgcgccagc ttcgacgaga gacagcctta cgcccacatg aacgggggcc
     5101 gcaagaacga gcgggccttg ccgctgcccc agtcttcgac ctgctgatcc ttggatcctg
     5161 aatctgtgca aacagtaacg tgtgcgcacg cgcagcgggg tgggggggga gagagagttt
     5221 taacaatcca ttcacaagcc tcctgtacct cagtggatct tcagaactgc ccttgctgcc
     5281 cgcgggagac agcttctctg cagtaaaaca catttgggat gttccttttt tcaatatgca
     5341 agcagctttt tattccctgc ccaaaccctt aactgacatg ggcctttaag aaccttaatg
     5401 acaacactta atagcaacag agcacttgag aaccagtctc ctcactctgt ccctgtcctt
     5461 ccctgttctc cctttctctc tcctctctgc ttcataacgg aaaaataatt gccacaagtc
     5521 cagctgggaa gcccttttta tcagtttgag gaagtggctg tccctgtggc cccatccaac
     5581 cactgtacac acccgcctga caccgtgggt cattacaaaa aaacacgtgg agatggaaat
     5641 ttttaccttt atctttcacc tttctaggga catgaaattt acaaagggcc atcgttcatc
     5701 caaggctgtt accattttaa cgctgcctaa ttttgccaaa atcctgaact ttctccctca
     5761 tcggcccggc gctgattcct cgtgtccgga ggcatgggtg agcatggcag ctggttgctc
     5821 catttgagag acacgctggc gacacactcc gtccatccga ctgcccctgc tgtgctgctc
     5881 aaggccacag gcacacaggt ctcattgctt ctgactagat tattatttgg gggaactgga
     5941 cacaataggt ctttctctca gtgaaggtgg ggagaagctg aaccggcttc cctgccctgc
     6001 ctccccagcc ccctgcccaa cccccaagaa tctggtggcc atgggccccg aagcagcctg
     6061 gcggacaggc ttggagtcaa ggggccccat gcctgcttct ctcccagccc cagctccccc
     6121 gcccgccccc aaggacacag atgggaaggg gtttccaggg actcagcccc actgttgatg
     6181 caggtttgca aggaaagaaa ttcaaacacc acaacagcag taagaagaaa agcagtcaat
     6241 ggattcaagc attctaagct ttgttgacat tttctctgtt cctaggactt cttcatgggt
     6301 cttacagttc tatgttagac catgaaacat ttgcatacac atcgtcttta atgtcacttt
     6361 tataactttt ttacggttca gatattcatc tatacgtctg tacagaaaaa aaaaagctgc
     6421 tatttttttt gttcttgatc tttgtggatt taatctatga aaaccttcag gtccaccctc
     6481 tcccctttct gctcactcca agaaacttct tatgctttgt actagagtgc gtgactttct
     6541 tcctcttttc ccggtaatgg atacttctat cacataattt gccatgaact gttggatgcc
     6601 tttttataaa tacatccccc atccctgctc ccacctgccc ctttagttgt tttctaaccc
     6661 gtaggctctc tgggcacgag gcagaaagca ggccgggcac ccatcctgag agggccgcgc
     6721 tcctctcccc agcctgccct cacagcattg gagcctgtta cagtgcaaga catgatacaa
     6781 actcaggtca gaaaaacaaa ggttaaatat ttcacacgtc tttgttcagt gtttccactc
     6841 accgtggttg agaagcctca ccctctcttt cccttgcctt tgcttaggtt gtgacacaca
     6901 tatatatata tttttttaat tcttgggtac aacagcagtg ttaaccgcag acactaggca
     6961 tttggattac tatttttctt aatggctatt taatccttcc atcccacgaa aaacagctgc
     7021 tgagtccaag ggagcagcag agcgtggtcc ggcagggcct gttgtggccc tcgccacccc
     7081 cctcaccgga ccgactgacc tgtctttgga accagaacat cccaagggaa ctccttcgca
     7141 ctggcgttga gtgggacccc gggatccagg ctggcccagg gcggcaccct cagggctgtg
     7201 cccgctggag tgctaggtgg aggcagcaca gacgccacgg tggcccaaga gcccctttgc
     7261 ttcttgctgg gggaccaggg ctgtggtgct ggcccacttt ccctcggcca ggaatccagg
     7321 tccttggggc ccaggggtct tgtcttgttt catttttagc acttctcacc agagagatga
     7381 cagcacaaga gttgcttctg ggatagaaat gtttaggagt aagaacaaag ctgggatacg
     7441 gtgattgcta gttgtgactg aagattcaac acagaaaaga aagtttatac ggcttttttg
     7501 ctggtcagca gtttgtccca ctgctttctc tagtctctat cccatagcgt gttcccttta
     7561 aaaaaaaaaa aaaggtatta tatgtaggag ttttctttta atttattttg tgataaatta
     7621 ccagtttcaa tcactgtaga aaagccccat tatgaattta aatttcaagg aaagggtgtg
     7681 tgtgtgtgta tgtgtggggt gtgtgtgtgt gagagtgatg ggacagttct tgattttttg
     7741 ggtttttttt cccccaaaca tttatctacc tcactcttat tttttatatg tgtatataga
     7801 caaaagaata catctcacct ttctcagcac ctgacaatag gccgttgata ctggtaacct
     7861 catccacgcc acaggcgcca cacccaggtg atgcaggggg aagccaggct gtattccggg
     7921 gtcaaagcaa cactaactca cctctctgct catttcagac agcttgcctt tttctgagat
     7981 gtcctgtttt gtgttgcttt ttttgttttg ttttctatct tggtttccac caaggtgtta
     8041 gatttctcct cctcctagcc aggtggccct gtgaggccaa cgagggcacc agagcacacc
     8101 tgggggagcc accaggctgt ccctggctgg ttgtctttgg aacaaactgc ttctgtgcag
     8161 atggaatgac caacacattt cgtccttaag agagcagtgg ttcctcaggt tctgaggaga
     8221 ggaaggtgtc caggcagcac catctctgtg cgaatcccca gggtaaaggc gtggggcatt
     8281 gggtttgctc cccttgctgc tgctccatcc ctgcaggagg ctcgcgctga ggcaggaccg
     8341 tgcggccatg gctgctgcat tcattgagca caaaggtgca gctgcagcag cagctggaga
     8401 gcaagagtca cccagcctgt gcgccagaat gcagaggctc ctgacctcac agccagtccc
     8461 tgatagaaca cacgcaggag cagagtcccc tccccctcca ggctgccctc tcaacttctc
     8521 cctcacctcc ttccctaggg gtagacagag atgtaccaaa ccttccggct ggaaagccca
     8581 gtggccggcg ccgaggctcg tggcgtcacg ccccccccgc cagggctgta cctccgtctc
     8641 cctggtcctg ctgctcacag gacagacggc tcgctcccct cttccagcag ctgctcttac
     8701 aggcactgat gatttcgctg ggaagtgtgg cgggcagctt tgcctaagcg tggatggctc
     8761 ctcggcaatt ccagcctaag tgaaggcgct caggagcctc ctgctggaac gcgacccatc
     8821 tctcccagga ccccggggat cttaaggtca ttgagaaata ctgttggatc agggttttgt
     8881 tcttccacac tgtaggtgac cccttggaat aacggcctct cctctcgtgc acatacctac
     8941 cggtttccac aactggattt ctacagatca ttcagctggt tataagggtt ttgtttaaac
     9001 tgtccgagtt actgatgtca ttttgttttt gttttatgta ggtagctttt aagtagaaaa
     9061 cactaacagt gtagtgccca tcatagcaaa tgcttcagaa acacctcaat aaaagagaaa
     9121 acttggcttg tgtgatggtg cagtcacttt actggaccaa cccacccacc ttgactatac
     9181 caaggcatca tctatccaca gttctagcct aacttcatgc tgatttctct gcctcttgat
     9241 ttttctctgt gtgttccaaa taatcttaag ctgagttgtg gcattttcca tgcaacctcc
     9301 ttctgccagc agctcacact gcttgaagtc atatgaacca ctgaggcaca tcatggaatt
     9361 gatgtgagca ttaagacgtt ctcccacaca gcccttccct gaggcagcag gagctggtgt
     9421 gtactggaga cactgttgaa cttgatcaag acccagacca ccccaggtct ccttcgtggg
     9481 atgtcatgac gtttgacata cctttggaac gagcctcctc cttggaagat ggaagaccgt
     9541 gttcgtggcc gacctggcct ctcctggcct gtttcttaag atgcggagtc acatttcaat
     9601 ggtacgaaaa gtggcttcgt aaaatagaag agcagtcact gtggaactac caaatggcga
     9661 gatgctcggt gcacattggg gtgctttggg ataaaagatt tatgagccaa ctattctctg
     9721 gcaccagatt ctaggccagt ttgttccact gaagcttttc ccacagcagt ccacctctgc
     9781 aggctggcag ccgaatggct tgccagtggc tctgtggcaa gatcacactg agatcgatgg
     9841 gtgagaaggc taggatgctt gtctagtgtt cttagctgtc acgttggctc cttccagggt
     9901 ggccagacgg tgttggccac tcccttctaa aacacaggcg ccctcctggt gacagtgacc
     9961 cgccgtggta tgccttggcc cattccagca gtcccagtta tgcatttcaa gtttggggtt
    10021 tgttcttttc gttaatgttc ctctgtgttg tcagctgtct tcatttcctg ggctaagcag
    10081 cattgggaga tgtggaccag agatccactc cttaagaacc agtggcgaaa gacactttct
    10141 ttcttcactc tgaagtagct ggtggtacaa atgagaactt caagagagga tgttatttag
    10201 actgaacctc tgttgccaga gatgctgaag atacagacct tggacaggtc agagggtttc
    10261 atttttggcc ttcatcttag atgactggtt gcgtcatttg gagaagtgag tgctccttga
    10321 tggtggaatg accgggtggt gggtacagaa ccattgtcac agggatcctg gcacagagaa
    10381 gagttacgag cagcagggtg cagggcttgg aaggaatgtg ggcaaggttt tgaacttgat
    10441 tgttcttgaa gctatcagac cacatcgagg ctcagcagtc atccgtgggc atttggtttc
    10501 aacaaagaaa cctaacatcc tactctggaa actgatctcg gagttaaggc gaattgttca
    10561 agaacacaaa ctacatcgca ctcgtcagtt gtcagttctg gggcatgact ttagcgtttt
    10621 gtttctgcga gaacataacg atcactcatt tttatgtccc acgtgtgtgt gtccgcatct
    10681 ttctggtcaa cattgtttta actagtcact cattagcgtt ttcaataggg ctcttaagtc
    10741 cagtagatta cgggtagtca gttgacgaag atctggttta caagaactaa ttaaatgttt
    10801 cattgcattt ttgtaagaac agaataattt tataaaatgt ttgtagttta taattgccga
    10861 aaataattta aagacacttt ttttttctct gtgtgtgcaa atgtgtgttt gtgatccatt
    10921 tttttttttt ttttttagga cacctgttta ctagctagct ttacaatatg ccaaaaaagg
    10981 atttctccct gaccccatcc gtggttcacc ctcttttccc cccatgcttt ttgccctagt
    11041 ttataacaaa ggaatgatga tgatttaaaa agtagttctg tatcttcagt atcttggtct
    11101 tccagaaccc tctggttggg aaggggatca ttttttactg gtcatttccc tttggagtgt
    11161 agctacttta acagatggaa agaacctcat tggccatgga aacagccgag gtgttggagc
    11221 ccagcagtgc atggcaccgt tcggcatctg gcttgattgg tctggctgcc gtcattgtca
    11281 gcacagtgcc atggacatgg gaagacttga ctgcacagcc aatggttttc atgatgatta
    11341 cagcatacac agtgatcaca taaacgatga cagctatggg gcacacaggc catttgctta
    11401 catgcctcgt atcatgactg attactgctt tgttagaaca cagaagagac cctattttat
    11461 ttaaggcaga accccgaaga tacgtatttc caatacagaa aagaattttt aataaaaact
    11521 ataacataca caaaaattgg ttttaaagtt gactccactt cctctaactc cagtggattg
    11581 ttggccatgt ctccccaact ccacaatatc tctatcatgg gaaacacctg gggtttttgc
    11641 gctacatagg agaaagatct ggaaactatt tgggttttgt tttcaacttt tcatttggat
    11701 gtttggcgtt gcacacacac atccaccggt ggaagagacg cccggtgaaa acacctgtct
    11761 gctttctaag ccagtgaggt tgaggtgaga ggtttgccag agtttgtcta cctctgggta
    11821 tccctttgtc tgggataaaa aaaatcaaac cagaaggcgg gatggaatgg atgcaccgca
    11881 aataatgcat tttctgagtt ttcttgttaa aaaaaaattt ttttaagtaa gaaaaaaaaa
    11941 ggtaataaca tggccaattt gttacataaa atgactttct gtgtataaat tattcctaaa
    12001 aaatcctgtt tatataaaaa atcagtagat gaaaaaaatt tcaaaatgtt tttgtatatt
    12061 ctgttgtaag aatttattcc tgttattgcg atatactctg gattctttac ataatggaaa
    12121 aaagaaactg tctattttga atggctgaag ctaaggcaac gttagtttct cttactctgc
    12181 ttttttctag taaagtacta catggtttaa gttaaataaa ataattctgt atgca
//
