LOCUS       NM_001414007            7159 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens insulin like growth factor 1 (IGF1), transcript
            variant 7, mRNA.
ACCESSION   NM_001414007
VERSION     NM_001414007.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7159)
  AUTHORS   Li,X., Lin,S., Yang,X., Chen,C., Cao,S., Zhang,Q., Ma,J., Zhu,G.,
            Zhang,Q., Fang,Q., Zheng,C., Liang,W. and Wu,X.
  TITLE     When IGF-1 Meets Metabolic Inflammation and Polycystic Ovary
            Syndrome
  JOURNAL   Int Immunopharmacol 138, 112529 (2024)
   PUBMED   38941670
  REMARK    GeneRIF: When IGF-1 Meets Metabolic Inflammation and Polycystic
            Ovary Syndrome.
            Review article
REFERENCE   2  (bases 1 to 7159)
  AUTHORS   Abudoureyimu,M., Tayier,T. and Zhang,L.
  TITLE     The role and mechanism of action of miR-483-3p in mediating the
            effects of IGF-1 on human renal tubular epithelial cells induced by
            high glucose
  JOURNAL   Sci Rep 14 (1), 15635 (2024)
   PUBMED   38972889
  REMARK    GeneRIF: The role and mechanism of action of miR-483-3p in
            mediating the effects of IGF-1 on human renal tubular epithelial
            cells induced by high glucose.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7159)
  AUTHORS   Smolarz,B., Szaflik,T., Romanowicz,H., Brys,M., Forma,E. and
            Szyllo,K.
  TITLE     Analysis of VEGF, IGF1/2 and the Long Noncoding RNA (lncRNA) H19
            Expression in Polish Women with Endometriosis
  JOURNAL   Int J Mol Sci 25 (10), 5271 (2024)
   PUBMED   38791310
  REMARK    GeneRIF: Analysis of VEGF, IGF1/2 and the Long Noncoding RNA
            (lncRNA) H19 Expression in Polish Women with Endometriosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7159)
  AUTHORS   Dreher,S.I., Grubba,P., von Toerne,C., Moruzzi,A., Maurer,J.,
            Goj,T., Birkenfeld,A.L., Peter,A., Loskill,P., Hauck,S.M. and
            Weigert,C.
  TITLE     IGF1 promotes human myotube differentiation toward a mature
            metabolic and contractile phenotype
  JOURNAL   Am J Physiol Cell Physiol 326 (5), C1462-C1481 (2024)
   PUBMED   38690930
  REMARK    GeneRIF: IGF1 promotes human myotube differentiation toward a
            mature metabolic and contractile phenotype.
REFERENCE   5  (bases 1 to 7159)
  AUTHORS   Boussouf,F.Z., Medjdoub,A., Tahari,Z., Messatfa,M., Bouras,N.,
            Dahmani,C.A., Seddiki,S.A. and Sahraoui,T.
  TITLE     Characterisation of IGF-1 (rs7136446) and IL-6 (rs1800795)
            polymorphisms among breast cancer patients in western Algeria
  JOURNAL   Pol J Pathol 75 (3), 205-214 (2024)
   PUBMED   39451175
  REMARK    GeneRIF: Characterisation of IGF-1 (rs7136446) and IL-6 (rs1800795)
            polymorphisms among breast cancer patients in western Algeria.
REFERENCE   6  (bases 1 to 7159)
  AUTHORS   Sato,A., Nishimura,S., Ohkubo,T., Kyogoku,Y., Koyama,S.,
            Kobayashi,M., Yasuda,T. and Kobayashi,Y.
  TITLE     1H-NMR assignment and secondary structure of human insulin-like
            growth factor-I (IGF-I) in solution
  JOURNAL   J Biochem 111 (4), 529-536 (1992)
   PUBMED   1319992
REFERENCE   7  (bases 1 to 7159)
  AUTHORS   Ding,L., Becker,A.B., Suzuki,A. and Roth,R.A.
  TITLE     Comparison of the enzymatic and biochemical properties of human
            insulin-degrading enzyme and Escherichia coli protease III
  JOURNAL   J Biol Chem 267 (4), 2414-2420 (1992)
   PUBMED   1733942
REFERENCE   8  (bases 1 to 7159)
  AUTHORS   Antoniades,H.N., Galanopoulos,T., Neville-Golden,J. and Maxwell,M.
  TITLE     Expression of insulin-like growth factors I and II and their
            receptor mRNAs in primary human astrocytomas and meningiomas; in
            vivo studies using in situ hybridization and immunocytochemistry
  JOURNAL   Int J Cancer 50 (2), 215-222 (1992)
   PUBMED   1370435
REFERENCE   9  (bases 1 to 7159)
  AUTHORS   Sandberg-Nordqvist,A.C., Stahlbom,P.A., Lake,M. and Sara,V.R.
  TITLE     Characterization of two cDNAs encoding insulin-like growth factor 1
            (IGF-1) in the human fetal brain
  JOURNAL   Brain Res Mol Brain Res 12 (1-3), 275-277 (1992)
   PUBMED   1372070
REFERENCE   10 (bases 1 to 7159)
  AUTHORS   Rinderknecht,E. and Humbel,R.E.
  TITLE     The amino acid sequence of human insulin-like growth factor I and
            its structural homology with proinsulin
  JOURNAL   J Biol Chem 253 (8), 2769-2776 (1978)
   PUBMED   632300
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010202.6.
            
            Summary: The protein encoded by this gene is similar to insulin in
            function and structure and is a member of a family of proteins
            involved in mediating growth and development. The encoded protein
            is processed from a precursor, bound by a specific receptor, and
            secreted. Defects in this gene are a cause of insulin-like growth
            factor I deficiency. Alternative splicing results in multiple
            transcript variants encoding different isoforms that may undergo
            similar processing to generate mature protein. [provided by RefSeq,
            Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138522.971233.1,
                                           SRR5189664.163321.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC010202.6         82833-82877
            46-127              AC010202.6         84180-84261
            128-284             AC010202.6         88781-88937
            285-466             AC010202.6         144890-145071
            467-7159            AC010202.6         162014-168706
FEATURES             Location/Qualifiers
     source          1..7159
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.2"
     gene            1..7159
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="insulin like growth factor 1"
                     /db_xref="GeneID:3479"
                     /db_xref="HGNC:HGNC:5464"
                     /db_xref="MIM:147440"
     exon            1..45
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /inference="alignment:Splign:2.1.0"
     exon            46..127
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..526
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="isoform 4 preproprotein is encoded by transcript
                     variant 7; insulin-like growth factor IB; somatomedin-C;
                     mechano growth factor; insulin-like growth factor 1
                     (somatomedin C)"
                     /codon_start=1
                     /product="insulin-like growth factor 1 isoform 4
                     preproprotein"
                     /protein_id="NP_001400936.1"
                     /db_xref="GeneID:3479"
                     /db_xref="HGNC:HGNC:5464"
                     /db_xref="MIM:147440"
                     /translation="MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTS
                     SATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDL
                     RRLEMYCAPLKPAKSARSVRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM"
     exon            128..284
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /inference="alignment:Splign:2.1.0"
     exon            285..466
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /inference="alignment:Splign:2.1.0"
     exon            467..7159
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      664..669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="hexamer: AATACA"
     polyA_site      685
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="major polyA site"
     regulatory      7103..7108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="hexamer: AATAAA"
     regulatory      7135..7140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="hexamer: ATTAAA"
     polyA_site      7141
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="major polyA site"
     polyA_site      7159
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
ORIGIN      
        1 accactcctg ggaaaccagg cctggagagc tctctaggga aagagacttt gtacttcaga
       61 agcaatggga aaaatcagca gtcttccaac ccaattattt aagtgctgct tttgtgattt
      121 cttgaaggtg aagatgcaca ccatgtcctc ctcgcatctc ttctacctgg cgctgtgcct
      181 gctcaccttc accagctctg ccacggctgg accggagacg ctctgcgggg ctgagctggt
      241 ggatgctctt cagttcgtgt gtggagacag gggcttttat ttcaacaagc ccacagggta
      301 tggctccagc agtcggaggg cgcctcagac aggcatcgtg gatgagtgct gcttccggag
      361 ctgtgatcta aggaggctgg agatgtattg cgcacccctc aagcctgcca agtcagctcg
      421 ctctgtccgt gcccagcgcc acaccgacat gcccaagacc cagaaggaag tacatttgaa
      481 gaacgcaagt agagggagtg caggaaacaa gaactacagg atgtaggaag accctcctga
      541 ggagtgaaga gtgacatgcc accgcaggat cctttgctct gcacgagtta cctgttaaac
      601 tttggaacac ctaccaaaaa ataagtttga taacatttaa aagatgggcg tttcccccaa
      661 tgaaatacac aagtaaacat tccaacattg tctttaggag tgatttgcac cttgcaaaaa
      721 tggtcctgga gttggtagat tgctgttgat cttttatcaa taatgttcta tagaaaagaa
      781 aaaaaaaata tatatatata tatatcttag tccctgcctc tcaagagcca caaatgcatg
      841 ggtgttgtat agatccagtt gcactaaatt cctctctgaa tcttggctgc tggagccatt
      901 cattcagcaa ccttgtctaa gtggtttatg aattgtttcc ttatttgcac ttctttctac
      961 acaactcggg ctgtttgttt tacagtgtct gataatcttg ttagtctata cccaccacct
     1021 cccttcataa cctttatatt tgccgaattt ggcctcctca aaagcagcag caagtcgtca
     1081 agaagcacac caattctaac ccacaagatt ccatctgtgg catttgtacc aaatataagt
     1141 tggatgcatt ttattttaga cacaaagctt tatttttcca catcatgctt acaaaaaaga
     1201 ataatgcaaa tagttgcaac tttgaggcca atcattttta ggcatatgtt ttaaacatag
     1261 aaagtttctt caactcaaaa gagttccttc aaatgatgag ttaatgtgca acctaattag
     1321 taactttcct ctttttattt tttccatata gagcactatg taaatttagc atatcaatta
     1381 tacaggatat atcaaacagt atgtaaaact ctgtttttta gtataatggt gctattttgt
     1441 agtttgttat atgaaagagt ctggccaaaa cggtaatacg tgaaagcaaa acaatagggg
     1501 aagcctggag ccaaagatga cacaagggga agggtactga aaacaccatc catttgggaa
     1561 agaaggcaaa gtccccccag ttatgccttc caagaggaac ttcagacaca aaagtccact
     1621 gatgcaaatt ggactggcga gtccagagag gaaactgtgg aatggaaaaa gcagaaggct
     1681 aggaatttta gcagtcctgg tttctttttc tcatggaaga aatgaacatc tgccagctgt
     1741 gtcatggact caccactgtg tgaccttggg caagtcactt cacctctctg tgcctcagtt
     1801 tcctcatctg caaaatgggg gcaatatgtc atctacctac ctcaaagggg tggtataagg
     1861 tttaaaaaga taaagattca gatttttttt accctgggtt gctgtaaggg tgcaacatca
     1921 gggcgcttga gttgctgaga tgcaaggaat tctataaata acccattcat agcatagcta
     1981 gagattggtg aattgaatgc tcctgacatc tcagttcttg tcagtgaagc tatccaaata
     2041 actggccaac tagttgttaa aagctaacag ctcaatctct taaaacactt ttcaaaatat
     2101 gtgggaagca tttgattttc aatttgattt tgaattctgc atttggtttt atgaatacaa
     2161 agataagtga aaagagagaa aggaaaagaa aaaggagaaa aacaaagaga tttctaccag
     2221 tgaaagggga attaattact ctttgttagc actcactgac tcttctatgc agttactaca
     2281 tatctagtaa aacctcgttt aatactataa ataatattct attcattttg aaaaacacaa
     2341 tgattccttc ttttctaggc aatataagga aagtgatcca aaatttgaaa tattaaaata
     2401 atatctaata aaaagtcaca aagttatctt ctttaacaaa ctttactctt attcttagct
     2461 gtatatacat ttttttaaaa gtttgttaaa atatgcttga ctagagtttc cagttgaaag
     2521 gcaaaaactt ccatcacaac aagaaatttc ccatgcctgc tcagaagggt agcccctagc
     2581 tctctgtgaa tgtgttttat ccattcaact gaaaattggt atcaagaaag tccactggtt
     2641 agtgtactag tccatcatag cctagaaaat gatccctatc tgcagatcaa gattttctca
     2701 ttagaacaat gaattatcca gcattcagat ctttctagtc accttagaac tttttggtta
     2761 aaagtaccca ggcttgatta tttcatgcaa attctatatt ttacattctt ggaaagtcta
     2821 tatgaaaaac aaaaataaca tcttcagttt ttctcccact gggtcacctc aaggatcaga
     2881 ggccaggaaa aaaaaaaaaa agactccctg gatctctgaa tatatgcaaa aagaaggccc
     2941 catttagtgg agccagcaat cctgttcagt caacaagtat tttaactctc agtccaacat
     3001 tatttgaatt gagcacctca agcatgctta gcaatgttct aatcactatg gacagatgta
     3061 aaagaaacta tacatcattt ttgccctctg cctgttttcc agacatacag gttctgtgga
     3121 ataagatact ggactcctct tcccaagatg gcacttcttt ttatttcttg tccccagtgt
     3181 gtacctttta aaattattcc ctctcaacaa aactttatag gcagtcttct gcagacttaa
     3241 cgtgttttct gtcatagtta gatgtgataa ttctaagagt gtctatgact tatttccttc
     3301 acttaattct atccacagtc aaaaatcccc caaggaggaa agctgaaaga tgcactgcca
     3361 tattatcttt cttaactttt tccaacacat aatcctctcc aactggatta taaataaatt
     3421 gaaaataact cattatacca attcactatt ttatttttta atgaattaaa actagaaaac
     3481 aaattgatgc aaaccctgga agtcagttga ttactatata ctacagcaga atgactcaga
     3541 tttcatagaa aggagcaacc aaaatgtcac aacccaaaac tttacaagct ttgcttcaga
     3601 attagattgc tttataattc ttgaatgagg caatttcaag atatttgtaa aagaacagta
     3661 aacattggta agaatgagct ttcaactcat aggcttattt ccaatttaat tgaccatact
     3721 ggatacttag gtcaaatttc tgttctctct tccccaaata atattaaagt attatttgaa
     3781 ctttttaaga tgaggcagtt cccctgaaaa agttaatgca gctctccatc agaatccact
     3841 cttctaggga tatgaaaatc tcttaacacc caccctacat acacagacac acacacacac
     3901 acacacacac acacacacac acacattcac cctaaggatc caatggaata ctgaaaagaa
     3961 atcacttcct tgaaaatttt attaaaaaac aaacaaacaa acaaaaagcc tgtccaccct
     4021 tgagaatcct tcctctcctt ggaacgtcaa tgtttgtgta gatgaaacca tctcatgctc
     4081 tgtggctcca gggtttctgt tactatttta tgcacttggg agaaggctta gaataaaaga
     4141 tgtagcacat tttgctttcc catttattgt ttggccagct atgccaatgt ggtgctattg
     4201 tttctttaag aaagtacttg actaaaaaaa aaagaaaaaa agaaaaaaaa gaaagcatag
     4261 acatattttt ttaaagtata aaaacaacaa ttctatagat agatggctta ataaaatagc
     4321 attaggtcta tctagccacc accacctttc aactttttat cactcacaag tagtgtactg
     4381 ttcaccaaat tgtgaatttg ggggtgcagg ggcaggagtt ggaaattttt taaagttaga
     4441 aggctccatt gttttgttgg ctctcaaact tagcaaaatt agcaatatat tatccaatct
     4501 tctgaacttg atcaagagca tggagaataa acgcgggaaa aaagatctta taggcaaata
     4561 gaagaattta aaagataagt aagttcctta ttgatttttg tgcactctgc tctaaaacag
     4621 atattcagca agtggagaaa ataagaacaa agagaaaaaa tacatagatt tacctgcaaa
     4681 aaatagcttc tgccaaatcc cccttgggta ttctttggca tttactggtt tatagaagac
     4741 attctccctt cacccagaca tctcaaagag cagtagctct catgaaaagc aatcactgat
     4801 ctcatttggg aaatgttgga aagtatttcc ttatgagatg ggggttatct actgataaag
     4861 aaagaattta tgagaaattg ttgaaagaga tggctaacaa tctgtgaaga ttttttgttt
     4921 cttgtttttg tttttttttt ttttttactt tatacagtct ttatgaattt cttaatgttc
     4981 aaaatgactt ggttcttttc ttcttttttt atatcagaat gaggaataat aagttaaacc
     5041 cacatagact ctttaaaact ataggctaga tagaaatgta tgtttgactt gttgaagcta
     5101 taatcagact atttaaaatg ttttgctatt tttaatctta aaagattgtg ctaatttatt
     5161 agagcagaac ctgtttggct ctcctcagaa gaaagaatct ttccattcaa atcacatggc
     5221 tttccaccaa tattttcaaa agataaatct gatttatgca atggcatcat ttattttaaa
     5281 acagaagaat tgtgaaagtt tatgcccctc ccttgcaaag accataaagt ccagatctgg
     5341 taggggggca acaacaaaag gaaaatgttg ttgattcttg gttttggatt ttgttttgtt
     5401 ttcaatgcta gtgtttaatc ctgtagtaca tatttgctta ttgctatttt aatattttat
     5461 aagaccttcc tgttaggtat tagaaagtga tacatagata tcttttttgt gtaatttcta
     5521 tttaaaaaag agagaagact gtcagaagct ttaagtgcat atggtacagg ataaagatat
     5581 caatttaaat aaccaattcc tatctggaac aatgcttttg ttttttaaag aaacctctca
     5641 cagataagac agaggcccag gggatttttg aagctgtctt tattctgccc ccatcccaac
     5701 ccagccctta ttattttagt atctgcctca gaattttata gagggctgac caagctgaaa
     5761 ctctagaatt aaaggaacct cactgaaaac atatatttca cgtgttccct cttttttttt
     5821 ttcctttttg tgagatgggg tctcgcactg tcccccaggc tggagtgcag tggcatgatc
     5881 tcggctcact gcaacctcca cctcctgggt ttaagcgatt ctcctgcctc agcctcctga
     5941 gtagctggga ttacaggcac ccaccactat gcccggctaa ttttttggat ttttaataga
     6001 gacggggttt taccatgttg gccaggttgg tctcaaactc ctgaccttgt gatttgcccg
     6061 cctcagcctc ccaaattgct gggattacag gcatgagcca ccacaccctg cccatgtgtt
     6121 ccctcttaat gtatgattac atggatctta aacatgatcc ttctctcctc attcttcaac
     6181 tatctttgat ggggtctttc aaggggaaaa aaatccaagc ttttttaaag taaaaaaaaa
     6241 aaaagagagg acacaaaacc aaatgttact gctcaactga aatatgagtt aagatggaga
     6301 cagagtttct cctaataacc ggagctgaat tacctttcac tttcaaaaac atgaccttcc
     6361 acaatcctta gaatctgcct ttttttatat tactgaggcc taaaagtaaa cattactcat
     6421 tttattttgc ccaaaatgca ctgatgtaaa gtaggaaaaa taaaaacaga gctctaaaat
     6481 ccctttcaag ccacccattg accccactca ccaactcata gcaaagtcac ttctgttaat
     6541 cccttaatct gattttgttt ggatatttat cttgtacccg ctgctaaaca cactgcagga
     6601 gggactctga aacctcaagc tgtctactta catcttttat ctgtgtctgt gtatcatgaa
     6661 aatgtctatt caaaatatca aaacctttca aatatcacgc agcttatatt cagtttacat
     6721 aaaggcccca aataccatgt cagatctttt tggtaaaaga gttaatgaac tatgagaatt
     6781 gggattacat catgtatttt gcctcatgta tttttatcac acttataggc caagtgtgat
     6841 aaataaactt acagacactg aattaatttc ccctgctact ttgaaaccag aaaataatga
     6901 ctggccattc gttacatctg tcttagttga aaagcatatt ttttattaaa ttaattctga
     6961 ttgtatttga aattattatt caattcactt atggcagagg aatatcaatc ctaatgactt
     7021 ctaaaaatgt aactaattga atcattatct tacatttact gtttaataag catattttga
     7081 aaatgtatgg ctagagtgtc ataataaaat ggtatatctt tctttagtaa ttacattaaa
     7141 attagtcatg tttgattaa
//
