LOCUS       NM_001414005             979 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens insulin like growth factor 1 (IGF1), transcript
            variant 5, mRNA.
ACCESSION   NM_001414005
VERSION     NM_001414005.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 979)
  AUTHORS   Li,X., Lin,S., Yang,X., Chen,C., Cao,S., Zhang,Q., Ma,J., Zhu,G.,
            Zhang,Q., Fang,Q., Zheng,C., Liang,W. and Wu,X.
  TITLE     When IGF-1 Meets Metabolic Inflammation and Polycystic Ovary
            Syndrome
  JOURNAL   Int Immunopharmacol 138, 112529 (2024)
   PUBMED   38941670
  REMARK    GeneRIF: When IGF-1 Meets Metabolic Inflammation and Polycystic
            Ovary Syndrome.
            Review article
REFERENCE   2  (bases 1 to 979)
  AUTHORS   Abudoureyimu,M., Tayier,T. and Zhang,L.
  TITLE     The role and mechanism of action of miR-483-3p in mediating the
            effects of IGF-1 on human renal tubular epithelial cells induced by
            high glucose
  JOURNAL   Sci Rep 14 (1), 15635 (2024)
   PUBMED   38972889
  REMARK    GeneRIF: The role and mechanism of action of miR-483-3p in
            mediating the effects of IGF-1 on human renal tubular epithelial
            cells induced by high glucose.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 979)
  AUTHORS   Smolarz,B., Szaflik,T., Romanowicz,H., Brys,M., Forma,E. and
            Szyllo,K.
  TITLE     Analysis of VEGF, IGF1/2 and the Long Noncoding RNA (lncRNA) H19
            Expression in Polish Women with Endometriosis
  JOURNAL   Int J Mol Sci 25 (10), 5271 (2024)
   PUBMED   38791310
  REMARK    GeneRIF: Analysis of VEGF, IGF1/2 and the Long Noncoding RNA
            (lncRNA) H19 Expression in Polish Women with Endometriosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 979)
  AUTHORS   Dreher,S.I., Grubba,P., von Toerne,C., Moruzzi,A., Maurer,J.,
            Goj,T., Birkenfeld,A.L., Peter,A., Loskill,P., Hauck,S.M. and
            Weigert,C.
  TITLE     IGF1 promotes human myotube differentiation toward a mature
            metabolic and contractile phenotype
  JOURNAL   Am J Physiol Cell Physiol 326 (5), C1462-C1481 (2024)
   PUBMED   38690930
  REMARK    GeneRIF: IGF1 promotes human myotube differentiation toward a
            mature metabolic and contractile phenotype.
REFERENCE   5  (bases 1 to 979)
  AUTHORS   Boussouf,F.Z., Medjdoub,A., Tahari,Z., Messatfa,M., Bouras,N.,
            Dahmani,C.A., Seddiki,S.A. and Sahraoui,T.
  TITLE     Characterisation of IGF-1 (rs7136446) and IL-6 (rs1800795)
            polymorphisms among breast cancer patients in western Algeria
  JOURNAL   Pol J Pathol 75 (3), 205-214 (2024)
   PUBMED   39451175
  REMARK    GeneRIF: Characterisation of IGF-1 (rs7136446) and IL-6 (rs1800795)
            polymorphisms among breast cancer patients in western Algeria.
REFERENCE   6  (bases 1 to 979)
  AUTHORS   Sato,A., Nishimura,S., Ohkubo,T., Kyogoku,Y., Koyama,S.,
            Kobayashi,M., Yasuda,T. and Kobayashi,Y.
  TITLE     1H-NMR assignment and secondary structure of human insulin-like
            growth factor-I (IGF-I) in solution
  JOURNAL   J Biochem 111 (4), 529-536 (1992)
   PUBMED   1319992
REFERENCE   7  (bases 1 to 979)
  AUTHORS   Ding,L., Becker,A.B., Suzuki,A. and Roth,R.A.
  TITLE     Comparison of the enzymatic and biochemical properties of human
            insulin-degrading enzyme and Escherichia coli protease III
  JOURNAL   J Biol Chem 267 (4), 2414-2420 (1992)
   PUBMED   1733942
REFERENCE   8  (bases 1 to 979)
  AUTHORS   Antoniades,H.N., Galanopoulos,T., Neville-Golden,J. and Maxwell,M.
  TITLE     Expression of insulin-like growth factors I and II and their
            receptor mRNAs in primary human astrocytomas and meningiomas; in
            vivo studies using in situ hybridization and immunocytochemistry
  JOURNAL   Int J Cancer 50 (2), 215-222 (1992)
   PUBMED   1370435
REFERENCE   9  (bases 1 to 979)
  AUTHORS   Sandberg-Nordqvist,A.C., Stahlbom,P.A., Lake,M. and Sara,V.R.
  TITLE     Characterization of two cDNAs encoding insulin-like growth factor 1
            (IGF-1) in the human fetal brain
  JOURNAL   Brain Res Mol Brain Res 12 (1-3), 275-277 (1992)
   PUBMED   1372070
REFERENCE   10 (bases 1 to 979)
  AUTHORS   Rinderknecht,E. and Humbel,R.E.
  TITLE     The amino acid sequence of human insulin-like growth factor I and
            its structural homology with proinsulin
  JOURNAL   J Biol Chem 253 (8), 2769-2776 (1978)
   PUBMED   632300
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010202.6.
            
            Summary: The protein encoded by this gene is similar to insulin in
            function and structure and is a member of a family of proteins
            involved in mediating growth and development. The encoded protein
            is processed from a precursor, bound by a specific receptor, and
            secreted. Defects in this gene are a cause of insulin-like growth
            factor I deficiency. Alternative splicing results in multiple
            transcript variants encoding different isoforms that may undergo
            similar processing to generate mature protein. [provided by RefSeq,
            Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138515.525503.1,
                                           DRR138522.1320176.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC010202.6         82833-82877
            46-127              AC010202.6         84180-84261
            128-284             AC010202.6         88781-88937
            285-466             AC010202.6         144890-145071
            467-979             AC010202.6         146577-147089
FEATURES             Location/Qualifiers
     source          1..979
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.2"
     gene            1..979
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="insulin like growth factor 1"
                     /db_xref="GeneID:3479"
                     /db_xref="HGNC:HGNC:5464"
                     /db_xref="MIM:147440"
     exon            1..45
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /inference="alignment:Splign:2.1.0"
     exon            46..127
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..652
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="isoform 3 preproprotein is encoded by transcript
                     variant 5; insulin-like growth factor IB; somatomedin-C;
                     mechano growth factor; insulin-like growth factor 1
                     (somatomedin C)"
                     /codon_start=1
                     /product="insulin-like growth factor 1 isoform 3
                     preproprotein"
                     /protein_id="NP_001400934.1"
                     /db_xref="GeneID:3479"
                     /db_xref="HGNC:HGNC:5464"
                     /db_xref="MIM:147440"
                     /translation="MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTS
                     SATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDL
                     RRLEMYCAPLKPAKSARSVRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGWPKTHPGGE
                     QKEGTEASLQIRGKKKEQRREIGSRNAECRGKKGK"
     exon            128..284
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /inference="alignment:Splign:2.1.0"
     exon            285..466
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /inference="alignment:Splign:2.1.0"
     exon            467..979
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      958..963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="hexamer: AATAAA"
     polyA_site      979
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="major polyA site"
ORIGIN      
        1 accactcctg ggaaaccagg cctggagagc tctctaggga aagagacttt gtacttcaga
       61 agcaatggga aaaatcagca gtcttccaac ccaattattt aagtgctgct tttgtgattt
      121 cttgaaggtg aagatgcaca ccatgtcctc ctcgcatctc ttctacctgg cgctgtgcct
      181 gctcaccttc accagctctg ccacggctgg accggagacg ctctgcgggg ctgagctggt
      241 ggatgctctt cagttcgtgt gtggagacag gggcttttat ttcaacaagc ccacagggta
      301 tggctccagc agtcggaggg cgcctcagac aggcatcgtg gatgagtgct gcttccggag
      361 ctgtgatcta aggaggctgg agatgtattg cgcacccctc aagcctgcca agtcagctcg
      421 ctctgtccgt gcccagcgcc acaccgacat gcccaagacc cagaagtatc agcccccatc
      481 taccaacaag aacacgaagt ctcagagaag gaaaggttgg ccaaagacac atccaggagg
      541 ggaacagaag gaggggacag aagcaagtct gcagatcaga ggaaagaaga aagagcagag
      601 gagggagatt ggaagtagaa atgctgaatg cagaggcaaa aaaggaaaat gaaggacagg
      661 aggattaaac agacagaggc aaggatgatg agagaggagc agacagcaag aatgaaaagc
      721 agaaaataca atagaggaaa tgaagaaaag taggcctgct ggagctagat gatgatgtga
      781 tggaaataga agtaaccttt tagagaatct cgctaagaaa catggagaaa acggaaaaga
      841 aaaatgtaat gccctagaaa gcgcaaagaa agacagtggc aaaaatgaaa aaaaaaaata
      901 aaaattataa aagaggcaaa aaaagacaca ctattctctg cctctaaaac acaattaaat
      961 aaaagaattt aaataaaaa
//
