LOCUS       NM_000618               7277 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens insulin like growth factor 1 (IGF1), transcript
            variant 4, mRNA.
ACCESSION   NM_000618
VERSION     NM_000618.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7277)
  AUTHORS   Li,X., Lin,S., Yang,X., Chen,C., Cao,S., Zhang,Q., Ma,J., Zhu,G.,
            Zhang,Q., Fang,Q., Zheng,C., Liang,W. and Wu,X.
  TITLE     When IGF-1 Meets Metabolic Inflammation and Polycystic Ovary
            Syndrome
  JOURNAL   Int Immunopharmacol 138, 112529 (2024)
   PUBMED   38941670
  REMARK    GeneRIF: When IGF-1 Meets Metabolic Inflammation and Polycystic
            Ovary Syndrome.
            Review article
REFERENCE   2  (bases 1 to 7277)
  AUTHORS   Abudoureyimu,M., Tayier,T. and Zhang,L.
  TITLE     The role and mechanism of action of miR-483-3p in mediating the
            effects of IGF-1 on human renal tubular epithelial cells induced by
            high glucose
  JOURNAL   Sci Rep 14 (1), 15635 (2024)
   PUBMED   38972889
  REMARK    GeneRIF: The role and mechanism of action of miR-483-3p in
            mediating the effects of IGF-1 on human renal tubular epithelial
            cells induced by high glucose.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7277)
  AUTHORS   Smolarz,B., Szaflik,T., Romanowicz,H., Brys,M., Forma,E. and
            Szyllo,K.
  TITLE     Analysis of VEGF, IGF1/2 and the Long Noncoding RNA (lncRNA) H19
            Expression in Polish Women with Endometriosis
  JOURNAL   Int J Mol Sci 25 (10), 5271 (2024)
   PUBMED   38791310
  REMARK    GeneRIF: Analysis of VEGF, IGF1/2 and the Long Noncoding RNA
            (lncRNA) H19 Expression in Polish Women with Endometriosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7277)
  AUTHORS   Dreher,S.I., Grubba,P., von Toerne,C., Moruzzi,A., Maurer,J.,
            Goj,T., Birkenfeld,A.L., Peter,A., Loskill,P., Hauck,S.M. and
            Weigert,C.
  TITLE     IGF1 promotes human myotube differentiation toward a mature
            metabolic and contractile phenotype
  JOURNAL   Am J Physiol Cell Physiol 326 (5), C1462-C1481 (2024)
   PUBMED   38690930
  REMARK    GeneRIF: IGF1 promotes human myotube differentiation toward a
            mature metabolic and contractile phenotype.
REFERENCE   5  (bases 1 to 7277)
  AUTHORS   Boussouf,F.Z., Medjdoub,A., Tahari,Z., Messatfa,M., Bouras,N.,
            Dahmani,C.A., Seddiki,S.A. and Sahraoui,T.
  TITLE     Characterisation of IGF-1 (rs7136446) and IL-6 (rs1800795)
            polymorphisms among breast cancer patients in western Algeria
  JOURNAL   Pol J Pathol 75 (3), 205-214 (2024)
   PUBMED   39451175
  REMARK    GeneRIF: Characterisation of IGF-1 (rs7136446) and IL-6 (rs1800795)
            polymorphisms among breast cancer patients in western Algeria.
REFERENCE   6  (bases 1 to 7277)
  AUTHORS   Sato,A., Nishimura,S., Ohkubo,T., Kyogoku,Y., Koyama,S.,
            Kobayashi,M., Yasuda,T. and Kobayashi,Y.
  TITLE     1H-NMR assignment and secondary structure of human insulin-like
            growth factor-I (IGF-I) in solution
  JOURNAL   J Biochem 111 (4), 529-536 (1992)
   PUBMED   1319992
REFERENCE   7  (bases 1 to 7277)
  AUTHORS   Ding,L., Becker,A.B., Suzuki,A. and Roth,R.A.
  TITLE     Comparison of the enzymatic and biochemical properties of human
            insulin-degrading enzyme and Escherichia coli protease III
  JOURNAL   J Biol Chem 267 (4), 2414-2420 (1992)
   PUBMED   1733942
REFERENCE   8  (bases 1 to 7277)
  AUTHORS   Antoniades,H.N., Galanopoulos,T., Neville-Golden,J. and Maxwell,M.
  TITLE     Expression of insulin-like growth factors I and II and their
            receptor mRNAs in primary human astrocytomas and meningiomas; in
            vivo studies using in situ hybridization and immunocytochemistry
  JOURNAL   Int J Cancer 50 (2), 215-222 (1992)
   PUBMED   1370435
REFERENCE   9  (bases 1 to 7277)
  AUTHORS   Sandberg-Nordqvist,A.C., Stahlbom,P.A., Lake,M. and Sara,V.R.
  TITLE     Characterization of two cDNAs encoding insulin-like growth factor 1
            (IGF-1) in the human fetal brain
  JOURNAL   Brain Res Mol Brain Res 12 (1-3), 275-277 (1992)
   PUBMED   1372070
REFERENCE   10 (bases 1 to 7277)
  AUTHORS   Rinderknecht,E. and Humbel,R.E.
  TITLE     The amino acid sequence of human insulin-like growth factor I and
            its structural homology with proinsulin
  JOURNAL   J Biol Chem 253 (8), 2769-2776 (1978)
   PUBMED   632300
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB209184.1 and AC010202.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_000618.4.
            
            Summary: The protein encoded by this gene is similar to insulin in
            function and structure and is a member of a family of proteins
            involved in mediating growth and development. The encoded protein
            is processed from a precursor, bound by a specific receptor, and
            secreted. Defects in this gene are a cause of insulin-like growth
            factor I deficiency. Alternative splicing results in multiple
            transcript variants encoding different isoforms that may undergo
            similar processing to generate mature protein. [provided by RefSeq,
            Sep 2015].
            
            Transcript Variant: This variant (4) lacks an alternate
            frame-shifting exon in the 3' coding region, compared to variant 1,
            resulting in a protein (isoform 4) with a novel C-terminus,
            compared to isoform 1. This isoform is also known as IA. Variants 4
            and 7 both encode the same isoform (4).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X57025.1, AB209184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153307, SAMEA2153932
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337514.11/ ENSP00000337612.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2413              AB209184.1         34-2446
            2414-7277           AC010202.6         163843-168706
FEATURES             Location/Qualifiers
     source          1..7277
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.2"
     gene            1..7277
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="insulin like growth factor 1"
                     /db_xref="GeneID:3479"
                     /db_xref="HGNC:HGNC:5464"
                     /db_xref="MIM:147440"
     exon            1..245
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..644
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="isoform 4 preproprotein is encoded by transcript
                     variant 4; insulin-like growth factor IB; somatomedin-C;
                     mechano growth factor; insulin-like growth factor 1
                     (somatomedin C)"
                     /codon_start=1
                     /product="insulin-like growth factor 1 isoform 4
                     preproprotein"
                     /protein_id="NP_000609.1"
                     /db_xref="CCDS:CCDS9091.1"
                     /db_xref="GeneID:3479"
                     /db_xref="HGNC:HGNC:5464"
                     /db_xref="MIM:147440"
                     /translation="MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTS
                     SATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDL
                     RRLEMYCAPLKPAKSARSVRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM"
     exon            246..402
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /inference="alignment:Splign:2.1.0"
     exon            403..584
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /inference="alignment:Splign:2.1.0"
     exon            585..7277
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      782..787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="hexamer: AATACA"
     polyA_site      803
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="major polyA site"
     regulatory      7221..7226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="hexamer: AATAAA"
     regulatory      7253..7258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="hexamer: ATTAAA"
     polyA_site      7259
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
                     /note="major polyA site"
     polyA_site      7277
                     /gene="IGF1"
                     /gene_synonym="IGF; IGF-I; IGFI; MGF"
ORIGIN      
        1 cttctgtttg ctaaatctca ctgtcactgc taaattcaga gcagatagag cctgcgcaat
       61 ggaataaagt cctcaaaatt gaaatgtgac attgctctca acatctccca tctctctgga
      121 tttctttttg cttcattatt cctgctaacc aattcatttt cagactttgt acttcagaag
      181 caatgggaaa aatcagcagt cttccaaccc aattatttaa gtgctgcttt tgtgatttct
      241 tgaaggtgaa gatgcacacc atgtcctcct cgcatctctt ctacctggcg ctgtgcctgc
      301 tcaccttcac cagctctgcc acggctggac cggagacgct ctgcggggct gagctggtgg
      361 atgctcttca gttcgtgtgt ggagacaggg gcttttattt caacaagccc acagggtatg
      421 gctccagcag tcggagggcg cctcagacag gcatcgtgga tgagtgctgc ttccggagct
      481 gtgatctaag gaggctggag atgtattgcg cacccctcaa gcctgccaag tcagctcgct
      541 ctgtccgtgc ccagcgccac accgacatgc ccaagaccca gaaggaagta catttgaaga
      601 acgcaagtag agggagtgca ggaaacaaga actacaggat gtaggaagac cctcctgagg
      661 agtgaagagt gacatgccac cgcaggatcc tttgctctgc acgagttacc tgttaaactt
      721 tggaacacct accaaaaaat aagtttgata acatttaaaa gatgggcgtt tcccccaatg
      781 aaatacacaa gtaaacattc caacattgtc tttaggagtg atttgcacct tgcaaaaatg
      841 gtcctggagt tggtagattg ctgttgatct tttatcaata atgttctata gaaaagaaaa
      901 aaaaaatata tatatatata tatcttagtc cctgcctctc aagagccaca aatgcatggg
      961 tgttgtatag atccagttgc actaaattcc tctctgaatc ttggctgctg gagccattca
     1021 ttcagcaacc ttgtctaagt ggtttatgaa ttgtttcctt atttgcactt ctttctacac
     1081 aactcgggct gtttgtttta cagtgtctga taatcttgtt agtctatacc caccacctcc
     1141 cttcataacc tttatatttg ccgaatttgg cctcctcaaa agcagcagca agtcgtcaag
     1201 aagcacacca attctaaccc acaagattcc atctgtggca tttgtaccaa atataagttg
     1261 gatgcatttt attttagaca caaagcttta tttttccaca tcatgcttac aaaaaagaat
     1321 aatgcaaata gttgcaactt tgaggccaat catttttagg catatgtttt aaacatagaa
     1381 agtttcttca actcaaaaga gttccttcaa atgatgagtt aatgtgcaac ctaattagta
     1441 actttcctct ttttattttt tccatataga gcactatgta aatttagcat atcaattata
     1501 caggatatat caaacagtat gtaaaactct gttttttagt ataatggtgc tattttgtag
     1561 tttgttatat gaaagagtct ggccaaaacg gtaatacgtg aaagcaaaac aataggggaa
     1621 gcctggagcc aaagatgaca caaggggaag ggtactgaaa acaccatcca tttgggaaag
     1681 aaggcaaagt ccccccagtt atgccttcca agaggaactt cagacacaaa agtccactga
     1741 tgcaaattgg actggcgagt ccagagagga aactgtggaa tggaaaaagc agaaggctag
     1801 gaattttagc agtcctggtt tctttttctc atggaagaaa tgaacatctg ccagctgtgt
     1861 catggactca ccactgtgtg accttgggca agtcacttca cctctctgtg cctcagtttc
     1921 ctcatctgca aaatgggggc aatatgtcat ctacctacct caaaggggtg gtataaggtt
     1981 taaaaagata aagattcaga ttttttttac cctgggttgc tgtaagggtg caacatcagg
     2041 gcgcttgagt tgctgagatg caaggaattc tataaataac ccattcatag catagctaga
     2101 gattggtgaa ttgaatgctc ctgacatctc agttcttgtc agtgaagcta tccaaataac
     2161 tggccaacta gttgttaaaa gctaacagct caatctctta aaacactttt caaaatatgt
     2221 gggaagcatt tgattttcaa tttgattttg aattctgcat ttggttttat gaatacaaag
     2281 ataagtgaaa agagagaaag gaaaagaaaa aggagaaaaa caaagagatt tctaccagtg
     2341 aaaggggaat taattactct ttgttagcac tcactgactc ttctatgcag ttactacata
     2401 tctagtaaaa cctcgtttaa tactataaat aatattctat tcattttgaa aaacacaatg
     2461 attccttctt ttctaggcaa tataaggaaa gtgatccaaa atttgaaata ttaaaataat
     2521 atctaataaa aagtcacaaa gttatcttct ttaacaaact ttactcttat tcttagctgt
     2581 atatacattt ttttaaaagt ttgttaaaat atgcttgact agagtttcca gttgaaaggc
     2641 aaaaacttcc atcacaacaa gaaatttccc atgcctgctc agaagggtag cccctagctc
     2701 tctgtgaatg tgttttatcc attcaactga aaattggtat caagaaagtc cactggttag
     2761 tgtactagtc catcatagcc tagaaaatga tccctatctg cagatcaaga ttttctcatt
     2821 agaacaatga attatccagc attcagatct ttctagtcac cttagaactt tttggttaaa
     2881 agtacccagg cttgattatt tcatgcaaat tctatatttt acattcttgg aaagtctata
     2941 tgaaaaacaa aaataacatc ttcagttttt ctcccactgg gtcacctcaa ggatcagagg
     3001 ccaggaaaaa aaaaaaaaag actccctgga tctctgaata tatgcaaaaa gaaggcccca
     3061 tttagtggag ccagcaatcc tgttcagtca acaagtattt taactctcag tccaacatta
     3121 tttgaattga gcacctcaag catgcttagc aatgttctaa tcactatgga cagatgtaaa
     3181 agaaactata catcattttt gccctctgcc tgttttccag acatacaggt tctgtggaat
     3241 aagatactgg actcctcttc ccaagatggc acttcttttt atttcttgtc cccagtgtgt
     3301 accttttaaa attattccct ctcaacaaaa ctttataggc agtcttctgc agacttaacg
     3361 tgttttctgt catagttaga tgtgataatt ctaagagtgt ctatgactta tttccttcac
     3421 ttaattctat ccacagtcaa aaatccccca aggaggaaag ctgaaagatg cactgccata
     3481 ttatctttct taactttttc caacacataa tcctctccaa ctggattata aataaattga
     3541 aaataactca ttataccaat tcactatttt attttttaat gaattaaaac tagaaaacaa
     3601 attgatgcaa accctggaag tcagttgatt actatatact acagcagaat gactcagatt
     3661 tcatagaaag gagcaaccaa aatgtcacaa cccaaaactt tacaagcttt gcttcagaat
     3721 tagattgctt tataattctt gaatgaggca atttcaagat atttgtaaaa gaacagtaaa
     3781 cattggtaag aatgagcttt caactcatag gcttatttcc aatttaattg accatactgg
     3841 atacttaggt caaatttctg ttctctcttc cccaaataat attaaagtat tatttgaact
     3901 ttttaagatg aggcagttcc cctgaaaaag ttaatgcagc tctccatcag aatccactct
     3961 tctagggata tgaaaatctc ttaacaccca ccctacatac acagacacac acacacacac
     4021 acacacacac acacacacac acattcaccc taaggatcca atggaatact gaaaagaaat
     4081 cacttccttg aaaattttat taaaaaacaa acaaacaaac aaaaagcctg tccacccttg
     4141 agaatccttc ctctccttgg aacgtcaatg tttgtgtaga tgaaaccatc tcatgctctg
     4201 tggctccagg gtttctgtta ctattttatg cacttgggag aaggcttaga ataaaagatg
     4261 tagcacattt tgctttccca tttattgttt ggccagctat gccaatgtgg tgctattgtt
     4321 tctttaagaa agtacttgac taaaaaaaaa agaaaaaaag aaaaaaaaga aagcatagac
     4381 atattttttt aaagtataaa aacaacaatt ctatagatag atggcttaat aaaatagcat
     4441 taggtctatc tagccaccac cacctttcaa ctttttatca ctcacaagta gtgtactgtt
     4501 caccaaattg tgaatttggg ggtgcagggg caggagttgg aaatttttta aagttagaag
     4561 gctccattgt tttgttggct ctcaaactta gcaaaattag caatatatta tccaatcttc
     4621 tgaacttgat caagagcatg gagaataaac gcgggaaaaa agatcttata ggcaaataga
     4681 agaatttaaa agataagtaa gttccttatt gatttttgtg cactctgctc taaaacagat
     4741 attcagcaag tggagaaaat aagaacaaag agaaaaaata catagattta cctgcaaaaa
     4801 atagcttctg ccaaatcccc cttgggtatt ctttggcatt tactggttta tagaagacat
     4861 tctcccttca cccagacatc tcaaagagca gtagctctca tgaaaagcaa tcactgatct
     4921 catttgggaa atgttggaaa gtatttcctt atgagatggg ggttatctac tgataaagaa
     4981 agaatttatg agaaattgtt gaaagagatg gctaacaatc tgtgaagatt ttttgtttct
     5041 tgtttttgtt tttttttttt ttttacttta tacagtcttt atgaatttct taatgttcaa
     5101 aatgacttgg ttcttttctt ctttttttat atcagaatga ggaataataa gttaaaccca
     5161 catagactct ttaaaactat aggctagata gaaatgtatg tttgacttgt tgaagctata
     5221 atcagactat ttaaaatgtt ttgctatttt taatcttaaa agattgtgct aatttattag
     5281 agcagaacct gtttggctct cctcagaaga aagaatcttt ccattcaaat cacatggctt
     5341 tccaccaata ttttcaaaag ataaatctga tttatgcaat ggcatcattt attttaaaac
     5401 agaagaattg tgaaagttta tgcccctccc ttgcaaagac cataaagtcc agatctggta
     5461 ggggggcaac aacaaaagga aaatgttgtt gattcttggt tttggatttt gttttgtttt
     5521 caatgctagt gtttaatcct gtagtacata tttgcttatt gctattttaa tattttataa
     5581 gaccttcctg ttaggtatta gaaagtgata catagatatc ttttttgtgt aatttctatt
     5641 taaaaaagag agaagactgt cagaagcttt aagtgcatat ggtacaggat aaagatatca
     5701 atttaaataa ccaattccta tctggaacaa tgcttttgtt ttttaaagaa acctctcaca
     5761 gataagacag aggcccaggg gatttttgaa gctgtcttta ttctgccccc atcccaaccc
     5821 agcccttatt attttagtat ctgcctcaga attttataga gggctgacca agctgaaact
     5881 ctagaattaa aggaacctca ctgaaaacat atatttcacg tgttccctct tttttttttt
     5941 cctttttgtg agatggggtc tcgcactgtc ccccaggctg gagtgcagtg gcatgatctc
     6001 ggctcactgc aacctccacc tcctgggttt aagcgattct cctgcctcag cctcctgagt
     6061 agctgggatt acaggcaccc accactatgc ccggctaatt ttttggattt ttaatagaga
     6121 cggggtttta ccatgttggc caggttggtc tcaaactcct gaccttgtga tttgcccgcc
     6181 tcagcctccc aaattgctgg gattacaggc atgagccacc acaccctgcc catgtgttcc
     6241 ctcttaatgt atgattacat ggatcttaaa catgatcctt ctctcctcat tcttcaacta
     6301 tctttgatgg ggtctttcaa ggggaaaaaa atccaagctt ttttaaagta aaaaaaaaaa
     6361 aagagaggac acaaaaccaa atgttactgc tcaactgaaa tatgagttaa gatggagaca
     6421 gagtttctcc taataaccgg agctgaatta cctttcactt tcaaaaacat gaccttccac
     6481 aatccttaga atctgccttt ttttatatta ctgaggccta aaagtaaaca ttactcattt
     6541 tattttgccc aaaatgcact gatgtaaagt aggaaaaata aaaacagagc tctaaaatcc
     6601 ctttcaagcc acccattgac cccactcacc aactcatagc aaagtcactt ctgttaatcc
     6661 cttaatctga ttttgtttgg atatttatct tgtacccgct gctaaacaca ctgcaggagg
     6721 gactctgaaa cctcaagctg tctacttaca tcttttatct gtgtctgtgt atcatgaaaa
     6781 tgtctattca aaatatcaaa acctttcaaa tatcacgcag cttatattca gtttacataa
     6841 aggccccaaa taccatgtca gatctttttg gtaaaagagt taatgaacta tgagaattgg
     6901 gattacatca tgtattttgc ctcatgtatt tttatcacac ttataggcca agtgtgataa
     6961 ataaacttac agacactgaa ttaatttccc ctgctacttt gaaaccagaa aataatgact
     7021 ggccattcgt tacatctgtc ttagttgaaa agcatatttt ttattaaatt aattctgatt
     7081 gtatttgaaa ttattattca attcacttat ggcagaggaa tatcaatcct aatgacttct
     7141 aaaaatgtaa ctaattgaat cattatctta catttactgt ttaataagca tattttgaaa
     7201 atgtatggct agagtgtcat aataaaatgg tatatctttc tttagtaatt acattaaaat
     7261 tagtcatgtt tgattaa
//
