LOCUS       NM_020962               6363 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens immunoglobulin superfamily DCC subclass member 4
            (IGDCC4), mRNA.
ACCESSION   NM_020962
VERSION     NM_020962.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6363)
  AUTHORS   Kutting,F., Gebauer,F., Zweerink,S., Kramer,L., Schramm,C.,
            Quaas,A., Bruns,C., Goeser,T. and Nierhoff,D.
  TITLE     Expression of Neighbor of Punc E11 (NOPE) in early stage esophageal
            adenocarcinoma is associated with reduced survival
  JOURNAL   Sci Rep 12 (1), 3584 (2022)
   PUBMED   35246597
  REMARK    GeneRIF: Expression of Neighbor of Punc E11 (NOPE) in early stage
            esophageal adenocarcinoma is associated with reduced survival.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6363)
  AUTHORS   Zweerink,S., Mesghenna,S., Mueck,V., Schulte,S., Kuetting,F.,
            Quaas,A., Goeser,T. and Nierhoff,D.
  TITLE     First evaluation of Neighbor of Punc E11 (NOPE) as a novel marker
            in human hepatocellular carcinoma
  JOURNAL   Cancer Biomark 30 (1), 75-83 (2021)
   PUBMED   32986656
  REMARK    GeneRIF: First evaluation of Neighbor of Punc E11 (NOPE) as a novel
            marker in human hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 6363)
  AUTHORS   Marquardt,J.U., Quasdorff,M., Varnholt,H., Curth,H.M.,
            Mesghenna,S., Protzer,U., Goeser,T. and Nierhoff,D.
  TITLE     Neighbor of Punc E11, a novel oncofetal marker for hepatocellular
            carcinoma
  JOURNAL   Int J Cancer 128 (10), 2353-2363 (2011)
   PUBMED   20658536
  REMARK    GeneRIF: identified Nope as a novel oncofetal surface marker for
            murine and human HCC. Nope is specifically expressed by epithelial
            tumor cells but not in preneoplastic stages and is a promising
            marker
REFERENCE   4  (bases 1 to 6363)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   5  (bases 1 to 6363)
  AUTHORS   Salbaum,J.M. and Kappen,C.
  TITLE     Cloning and expression of nope, a new mouse gene of the
            immunoglobulin superfamily related to guidance receptors
  JOURNAL   Genomics 64 (1), 15-23 (2000)
   PUBMED   10708514
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB052622.1 and AC105129.4.
            
            On Nov 22, 2018 this sequence version replaced NM_020962.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB052622.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352385.3/ ENSP00000319623.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AB052622.1         126-239
            115-115             AC105129.4         62923-62923
            116-6360            AB052622.1         241-6485
            6361-6363           AC105129.4         104270-104272
FEATURES             Location/Qualifiers
     source          1..6363
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..6363
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /note="immunoglobulin superfamily DCC subclass member 4"
                     /db_xref="GeneID:57722"
                     /db_xref="HGNC:HGNC:13770"
                     /db_xref="MIM:616810"
     exon            1..155
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..3838
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /note="likely ortholog of mouse neighbor of Punc E11"
                     /codon_start=1
                     /product="immunoglobulin superfamily DCC subclass member 4
                     precursor"
                     /protein_id="NP_066013.1"
                     /db_xref="CCDS:CCDS10206.1"
                     /db_xref="GeneID:57722"
                     /db_xref="HGNC:HGNC:13770"
                     /db_xref="MIM:616810"
                     /translation="MARGDAGRGRGLLALTFCLLAARGELLLPQETTVELSCGVGPLQ
                     VILGPEQAAVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPN
                     GSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTA
                     RFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSA
                     RQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVS
                     WVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAA
                     PAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVI
                     TQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWE
                     RPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQ
                     LGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEY
                     GLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMH
                     NQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGG
                     RGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPA
                     PDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNASLV
                     TYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRL
                     SPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLE
                     SDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLSDSLDMHSVTGIIVGVCLGLLCLLA
                     CMCAGLRRSPHRESLPGLSSTATPGNPALYSRARLGPPSPPAAHELESLVHPHPQDWS
                     PPPSDVEDRAEVHSLMGGGVSEGRSHSKRKISWAQPSGLSWAGSWAGCELPQAGPRPA
                     LTRALLPPAGTGQTLLLQALVYDAIKGNGRKKSPPACRNQVEAEVIVHSDFSASNGNP
                     DLHLQDLEPEDPLPPEAPDLISGVGDPGQGAAWLDRELGGCELAAPGPDRLTCLPEAA
                     SASCSYPDLQPGEVLEETPGDSCQLKSPCPLGASPGLPRSPVSSSA"
     exon            156..506
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            507..648
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            649..785
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            786..926
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1082
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1496
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1661
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1799
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1970
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2207
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2309
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2493
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2621
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2792
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2930
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3036
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3265
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3427
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..6363
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6344..6349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /note="hexamer: AATAAA"
     polyA_site      6363
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /note="major polyA site"
ORIGIN      
        1 actgacgccc ggcgcgctct ccccccgcgg cggcggccga agcacgggga ggcggcggcg
       61 gcggcggcgg cccgagccca gccccatggc gcggggggac gccggccgcg gccgcgggct
      121 cctcgcgttg accttctgcc tgttggccgc gcgcggggag ctgctgttgc cccaggagac
      181 gactgtggag ctgagctgtg gagtggggcc actgcaagtg atcctgggcc cagagcaggc
      241 tgcagtgcta aactgtagcc tgggggctgc tgccgctgga ccccccacca gggtgacctg
      301 gagcaaggat ggggacaccc tgctggagca cgaccactta cacctgctgc ccaatggttc
      361 cctgtggctg tcccagccac tagcacccaa tggcagtgac gagtcagtcc ctgaggctgt
      421 gggggtcatt gaaggcaact attcgtgcct agcccacggc cccctcggag tgctggccag
      481 ccagactgct gtcgtcaagc ttgccacact cgcagacttc tctctgcacc cggagtctca
      541 gacggtggag gagaacggga cagctcgctt tgagtgccac attgaagggc tgccagctcc
      601 catcattact tgggagaagg accaggtgac attgcctgag gagcctcggc tcatcgtgct
      661 tcccaacggc gtccttcaga tcctggatgt tcaggagagt gatgcaggcc cctaccgctg
      721 cgtggccacc aactcagctc gccagcactt cagccaggag gccctactca gtgtggccca
      781 cagagggtcc ctggcgtcca ccagggggca ggacgtggtc attgtggcag ccccagagaa
      841 caccacagtg gtgtctggcc agagtgtggt gatggaatgt gtggcctcag ctgaccccac
      901 cccttttgtg tcctgggtcc gacaagacgg gaagcccatc tccacagatg tcatcgtcct
      961 gggccgcacc aacctactaa ttgccaacgc gcagccctgg cactccggcg tctatgtctg
     1021 ccgcgccaac aagccccgca cgcgcgactt cgccactgca gccgctgagc tccgtgtgct
     1081 ggcggctccc gccatcactc aggcgcccga ggcgctgtcg cggacgcggg cgagcacagc
     1141 gcgcttcgtg tgccgcgcgt cgggggagcc gcggccagcg ctgcgctggc tgcacaacgg
     1201 ggcgccgctg cggcccaacg ggcgcgtcaa ggtccagggc ggcggtggca gcctggtcat
     1261 cacacagatc ggcctgcagg acgccggcta ctaccagtgc gtggctgaga acagcgcggg
     1321 aatggcgtgc gctgccgcgt cgctggccgt ggtggtgcgc gaggggctgc ccagcgcccc
     1381 cacgcgggtc actgctacgc cactgagcag ctccgctgtg ttggtggcct gggagcggcc
     1441 cgagatgcac agcgagcaga tcatcggctt ctctctccac taccagaagg cacggggcat
     1501 ggacaatgtg gaataccagt ttgcagtgaa caacgacacc acagaactac aggttcggga
     1561 cctggaaccc aacacagatt atgagttcta cgtggtggcc tactcccagc tgggagccag
     1621 ccgcacctcc accccagcac tggtgcacac actggatgat gtccccagtg cagcacccca
     1681 gctctccctg tccagcccca acccttcgga catcagggtg gcgtggctgc ccctgccccc
     1741 cagcctgagc aatgggcagg tggtgaagta caagatagaa tacggtttgg gaaaggaaga
     1801 tcagattttc tctactgagg tgcgaggaaa tgagacacag cttatgctga actcgcttca
     1861 gccaaacaag gtgtatcgag tacggatttc ggctggtaca gcagccggct tcggggcccc
     1921 ctcccagtgg atgcatcaca ggacgcccag tatgcacaac cagagccatg tcccttttgc
     1981 ccctgcagag ttgaaggtgc aggcaaagat ggagtccctg gtcgtgtcat ggcagccacc
     2041 ccctcacccc acccagatct ctggctacaa actatattgg cgggaggtgg gggctgagga
     2101 ggaggccaat ggcgatcgcc tgccaggggg ccgtggagac caggcttggg atgtggggcc
     2161 tgtccggctc aagaagaaag tgaagcagta tgagctgacc cagctagtcc ctggccggct
     2221 gtacgaggtg aagctcgtgg ctttcaacaa acatgaggat ggctatgcag cagtgtggaa
     2281 gggcaagacg gagaaggcgc cggcaccaga catgcctatc cagaggggac cacccctgcc
     2341 tccagcccac gtccatgcgg aatcaaacag ctccacatcc atctggcttc ggtggaaaaa
     2401 gccagatttc accacagtca agattgtcaa ctacactgtg cgcttcagcc cctgggggct
     2461 caggaatgcc tccctggtca cctattacac cagttctgga gaagacatcc tcattggcgg
     2521 cttgaagcca ttcaccaaat acgagtttgc agtgcagtct cacggcgtgg acatggatgg
     2581 gcctttcggc tctgtggtgg agcgctccac cctgcctgac cggccctcca cacccccatc
     2641 cgacctgcga ctgagccccc tgacaccgtc cacggttcgg ctgcactggt gcccccccac
     2701 agagcccaac ggggagatcg tggagtatct gatcctgtac agcagcaacc acacgcagcc
     2761 tgagcaccag tggaccttgc tcaccacgca gggaaacatc ttcagtgctg aggtccatgg
     2821 cctggagagc gacactcggt acttcttcaa gatgggggcg cgcacagagg tgggacctgg
     2881 gcctttctcc cgcctgcagg atgtgatcac gctccaggag aagctgtcag actcgctgga
     2941 catgcactca gtcacgggca tcatcgtggg tgtctgcctg ggcctcctct gcctcctggc
     3001 ctgcatgtgt gctggcctgc gccgcagccc ccacagggaa tccctcccag gcctgtcctc
     3061 caccgccacc cccgggaatc ccgcgctgta ctccagagct cggcttggcc cccccagccc
     3121 cccagctgcc catgaattgg agtcccttgt gcacccccat ccccaggact ggtccccgcc
     3181 accctcagac gtggaggaca gggctgaagt gcacagcctt atgggtggcg gtgtttctga
     3241 aggccggagt cactccaaaa gaaagatctc ctgggctcaa ccaagcgggc tgagctgggc
     3301 tggttcctgg gcaggctgtg agctgcccca ggcaggcccc cggccggctc tgacccgggc
     3361 cctgctgccc cctgctggaa ctgggcagac gctgttgctg caggctctgg tgtacgacgc
     3421 cataaagggc aatgggagga agaagtcacc cccagcctgc aggaaccagg tggaggctga
     3481 agtcattgtc cactctgact ttagtgcatc taacgggaac cctgacctcc atctccaaga
     3541 cctggagcct gaggaccccc tgcctccaga ggctcctgat ctcatctcgg gtgttgggga
     3601 tccagggcag ggggcagcct ggctggacag ggagttggga gggtgtgagc tggcagcccc
     3661 cgggccagac agacttacct gcttgccaga ggcagccagt gcttcctgct cctacccgga
     3721 cctccagcca ggcgaggtgc tagaggagac ccctggagat agctgccagc tcaaatcccc
     3781 ctgccctcta ggagccagcc caggcctgcc cagatccccg gtctcctcct ctgcctagct
     3841 cttcccagag gatgtggttt ggggcaggca ggtatggatc acataggatg cgatacctgt
     3901 ggccgtgtat gtccacatgt gtgcctgtag atacatcatc aagccctttg gagcttccta
     3961 agttgctttg gctgagggga gaggaaaaca tggattattc actcccccca tactctttgt
     4021 gatacacatg tgacatgtga aagacatacg agacatagct acatgtgatg tgcacatgtg
     4081 tgaagtgcat gtatgcgtac tggttgttga gctgggaaac cgtggcccag gcagtggtca
     4141 ctacagcctg attggtcctc caggtcagaa cggtgcccca cagtggtcag tccccagccc
     4201 tgtgggcccc cacctccatc gcccagcctt ttattacaca ctctgagagt gtctccaatg
     4261 cctgtctgac aaagacagtc ccagcccatt ctcctgtctg gctgggttgg gtgcaagcag
     4321 gctctgaatg cctggcattt cagctgcatc acctcccagc tccttattgc ccaaatagag
     4381 agggtggccc tggctcccct ccgagcaact ctgcatttaa ttttgtaatc tgggaagtgc
     4441 ctggttttga aaatccgctt tctctcactc ttcccctcct tccttgcccc tggctgctct
     4501 agtgttctgt ctcccagtca cctcgctctc ccagcaccag tgcccttctc ctgctcccag
     4561 atactctttc ctttcctctc tcctgttttc cttcctctgc tatctctcac acctctccca
     4621 gactatgtca tcttgttctc ctgcctgggt tcaaactctg catccttctc taacaacgtg
     4681 actacctcat gtctgcttca aggcccccgt gcccttcctg tatccgcggc tgccgcgcac
     4741 tcgcctgcca tcctcctgcc tcctcttcac tcagtgcttc tgcttgccct gccccaggca
     4801 gcccacccac gcccagtgcg ggtgtggaga agatcttctg gcttccctgc atcttgcctt
     4861 tgggattggg atccaagggt tctccatgga tggatccaag tcatagaggg gaatgtttga
     4921 gacagggaag ggggctgtga tccagaggct cagaataaaa agatgccctc ccttctatgc
     4981 aggggggcaa gtttactgga tggagatgat ttgggcctct cttccagaag aagctaaagg
     5041 aagagaaggg gagtgagagt tcagggaggc ccttcccacc ctgtgaggct tgacttgatc
     5101 tggattgggg atgacaggaa tctcaccctc tggggtgctg gcaaggaggt ctttgcacag
     5161 gaaaaggggt agctcatttc agtttgtttt ttctttaaat tgaatcctca agtcattttc
     5221 tgttcacctg ccgcacaggg acaagcttga cttctatttt ctgtgtagtg aaaacaatgt
     5281 catttatttg gtttttcacc tcagccctct cataggagca tagaatgtta gggtctttac
     5341 tccctaatga tgtctgattg gcacatcaag agttaactct gccttctggg ccaaattcga
     5401 aataaccagt ccatttttcc tttttttttt tttttttttt aaatggtgga atgtctctca
     5461 gcacagttgc ggcttcctca aaccctgaaa gcatctgtgt ttattatact cgggtgtcac
     5521 tcactgttga tgtctgcacc tacgtttcca cctcctcccc ctccttcagc cagcctatga
     5581 taacactaaa gattattaat gttggttttg tatctcgtta aagacagaat tgtcacttgt
     5641 agtatttctg tagcattcag cgctgctgtg gctaacacca ctgtgtatgt ttcatcattg
     5701 ctctgaaggt caaaagcctc attttatttt gctggtttga tttttttttt ttaaagaaga
     5761 aaaaaaaact gccctgaatt aaatggctgt tttaacagta ggctcttagc attataccac
     5821 atagtcattt ttcatgttct tgtttaacag gcactgaggt tctggtttaa attaaatagc
     5881 tgcaaatgag acaatttata acccattagg ttgggtggaa aattgtttct caaaagcaaa
     5941 taagtaataa atctggtatc tgcctataac tcacagttga taagaaagtg gccatttctc
     6001 actagcacta tatatgattt gggctctggg taatttggaa gtgttaggtt tgtgtctttg
     6061 tagcagtatt tttattagaa aagaatctat tggcctttta cagggtatta atccctttgt
     6121 cacctaccat tgatgcctta agttttctga gtctcaatta aaaatcttcc ttttcttgat
     6181 gcatgacaag tgtaatcagt acttgctcat ttatttgtct gtatttagtt tatgctgtac
     6241 tatttaatta tccttccagc gttttttttt tctccttaca aatatgatac tctttagtgt
     6301 taagctaagg cattgattca tgtatctgtc cttataatga attaataaac tattttccag
     6361 aaa
//
