LOCUS       NP_066013               1250 aa            linear   PRI 27-APR-2025
DEFINITION  immunoglobulin superfamily DCC subclass member 4 precursor [Homo
            sapiens].
ACCESSION   NP_066013
VERSION     NP_066013.1
DBSOURCE    REFSEQ: accession NM_020962.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1250)
  AUTHORS   Kutting,F., Gebauer,F., Zweerink,S., Kramer,L., Schramm,C.,
            Quaas,A., Bruns,C., Goeser,T. and Nierhoff,D.
  TITLE     Expression of Neighbor of Punc E11 (NOPE) in early stage esophageal
            adenocarcinoma is associated with reduced survival
  JOURNAL   Sci Rep 12 (1), 3584 (2022)
   PUBMED   35246597
  REMARK    GeneRIF: Expression of Neighbor of Punc E11 (NOPE) in early stage
            esophageal adenocarcinoma is associated with reduced survival.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1250)
  AUTHORS   Zweerink,S., Mesghenna,S., Mueck,V., Schulte,S., Kuetting,F.,
            Quaas,A., Goeser,T. and Nierhoff,D.
  TITLE     First evaluation of Neighbor of Punc E11 (NOPE) as a novel marker
            in human hepatocellular carcinoma
  JOURNAL   Cancer Biomark 30 (1), 75-83 (2021)
   PUBMED   32986656
  REMARK    GeneRIF: First evaluation of Neighbor of Punc E11 (NOPE) as a novel
            marker in human hepatocellular carcinoma.
REFERENCE   3  (residues 1 to 1250)
  AUTHORS   Marquardt,J.U., Quasdorff,M., Varnholt,H., Curth,H.M.,
            Mesghenna,S., Protzer,U., Goeser,T. and Nierhoff,D.
  TITLE     Neighbor of Punc E11, a novel oncofetal marker for hepatocellular
            carcinoma
  JOURNAL   Int J Cancer 128 (10), 2353-2363 (2011)
   PUBMED   20658536
  REMARK    GeneRIF: identified Nope as a novel oncofetal surface marker for
            murine and human HCC. Nope is specifically expressed by epithelial
            tumor cells but not in preneoplastic stages and is a promising
            marker
REFERENCE   4  (residues 1 to 1250)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   5  (residues 1 to 1250)
  AUTHORS   Salbaum,J.M. and Kappen,C.
  TITLE     Cloning and expression of nope, a new mouse gene of the
            immunoglobulin superfamily related to guidance receptors
  JOURNAL   Genomics 64 (1), 15-23 (2000)
   PUBMED   10708514
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB052622.1 and AC105129.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB052622.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352385.3/ ENSP00000319623.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1250
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     Protein         1..1250
                     /product="immunoglobulin superfamily DCC subclass member 4
                     precursor"
                     /note="likely ortholog of mouse neighbor of Punc E11"
                     /calculated_mol_wt=131782
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2447
     mat_peptide     25..1250
                     /product="Immunoglobulin superfamily DCC subclass member
                     4. /id=PRO_0000304622"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TDY8.1)"
                     /calculated_mol_wt=131782
     Region          53..135
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cd00096"
                     /db_xref="CDD:409353"
     Region          53..57
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          69..73
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Site            90
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8TDY8.1)"
     Region          91..95
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Site            102
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8TDY8.1)"
     Region          118..123
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          132..135
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          145..218
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Site            157
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8TDY8.1)"
     Region          160..164
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409544"
     Region          173..177
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409544"
     Region          195..199
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409544"
     Region          209..214
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409544"
     Region          250..331
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Site            252
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8TDY8.1)"
     Region          261..265
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409389"
     Region          274..279
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409389"
     Region          295..299
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409389"
     Region          309..314
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409389"
     Region          324..327
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409389"
     Region          350..422
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          352..356
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:143205"
     Region          365..369
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:143205"
     Region          388..392
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:143205"
     Region          402..407
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:143205"
     Region          415..418
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:143205"
     Site            order(429,495,510)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          430..515
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          <477..812
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(511..512,514..515)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            582
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8TDY8.1)"
     Region          850..942
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(931..932,934..935)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            958..978
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TDY8.1)"
     Region          <984..1250
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Site            995
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q8TDY8.1)"
     Region          1140..1175
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TDY8.1)"
     Region          1215..1250
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TDY8.1)"
     CDS             1..1250
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /coded_by="NM_020962.3:86..3838"
                     /db_xref="CCDS:CCDS10206.1"
                     /db_xref="GeneID:57722"
                     /db_xref="HGNC:HGNC:13770"
                     /db_xref="MIM:616810"
ORIGIN      
        1 margdagrgr gllaltfcll aargelllpq ettvelscgv gplqvilgpe qaavlncslg
       61 aaaagpptrv twskdgdtll ehdhlhllpn gslwlsqpla pngsdesvpe avgviegnys
      121 clahgplgvl asqtavvkla tladfslhpe sqtveengta rfechieglp apiitwekdq
      181 vtlpeeprli vlpngvlqil dvqesdagpy rcvatnsarq hfsqeallsv ahrgslastr
      241 gqdvvivaap enttvvsgqs vvmecvasad ptpfvswvrq dgkpistdvi vlgrtnllia
      301 naqpwhsgvy vcrankprtr dfataaaelr vlaapaitqa pealsrtras tarfvcrasg
      361 eprpalrwlh ngaplrpngr vkvqggggsl vitqiglqda gyyqcvaens agmacaaasl
      421 avvvreglps aptrvtatpl sssavlvawe rpemhseqii gfslhyqkar gmdnveyqfa
      481 vnndttelqv rdlepntdye fyvvaysqlg asrtstpalv htlddvpsaa pqlslsspnp
      541 sdirvawlpl ppslsngqvv kykieyglgk edqifstevr gnetqlmlns lqpnkvyrvr
      601 isagtaagfg apsqwmhhrt psmhnqshvp fapaelkvqa kmeslvvswq ppphptqisg
      661 yklywrevga eeeangdrlp ggrgdqawdv gpvrlkkkvk qyeltqlvpg rlyevklvaf
      721 nkhedgyaav wkgktekapa pdmpiqrgpp lppahvhaes nsstsiwlrw kkpdfttvki
      781 vnytvrfspw glrnaslvty ytssgedili gglkpftkye favqshgvdm dgpfgsvver
      841 stlpdrpstp psdlrlsplt pstvrlhwcp ptepngeive ylilyssnht qpehqwtllt
      901 tqgnifsaev hglesdtryf fkmgartevg pgpfsrlqdv itlqeklsds ldmhsvtgii
      961 vgvclgllcl lacmcaglrr sphreslpgl sstatpgnpa lysrarlgpp sppaaheles
     1021 lvhphpqdws pppsdvedra evhslmgggv segrshskrk iswaqpsgls wagswagcel
     1081 pqagprpalt rallppagtg qtlllqalvy daikgngrkk sppacrnqve aevivhsdfs
     1141 asngnpdlhl qdlepedplp peapdlisgv gdpgqgaawl drelggcela apgpdrltcl
     1201 peaasascsy pdlqpgevle etpgdscqlk spcplgaspg lprspvsssa
//
