LOCUS       NM_001551               1682 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens immunoglobulin binding protein 1 (IGBP1), transcript
            variant 1, mRNA.
ACCESSION   NM_001551
VERSION     NM_001551.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1682)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1682)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1682)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1682)
  AUTHORS   Kwon,O.C., Lee,E.J., Oh,J.S., Hong,S., Lee,C.K., Yoo,B., Park,M.C.
            and Kim,Y.G.
  TITLE     Plasma immunoglobulin binding protein 1 as a predictor of
            development of lupus nephritis
  JOURNAL   Lupus 29 (6), 547-553 (2020)
   PUBMED   32183589
  REMARK    GeneRIF: Plasma immunoglobulin binding protein 1 as a predictor of
            development of lupus nephritis.
REFERENCE   5  (bases 1 to 1682)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1682)
  AUTHORS   Liu,J., Prickett,T.D., Elliott,E., Meroni,G. and Brautigan,D.L.
  TITLE     Phosphorylation and microtubule association of the Opitz syndrome
            protein mid-1 is regulated by protein phosphatase 2A via binding to
            the regulatory subunit alpha 4
  JOURNAL   Proc Natl Acad Sci U S A 98 (12), 6650-6655 (2001)
   PUBMED   11371618
REFERENCE   7  (bases 1 to 1682)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
REFERENCE   8  (bases 1 to 1682)
  AUTHORS   Chung,H., Nairn,A.C., Murata,K. and Brautigan,D.L.
  TITLE     Mutation of Tyr307 and Leu309 in the protein phosphatase 2A
            catalytic subunit favors association with the alpha 4 subunit which
            promotes dephosphorylation of elongation factor-2
  JOURNAL   Biochemistry 38 (32), 10371-10376 (1999)
   PUBMED   10441131
REFERENCE   9  (bases 1 to 1682)
  AUTHORS   Chen,J., Peterson,R.T. and Schreiber,S.L.
  TITLE     Alpha 4 associates with protein phosphatases 2A, 4, and 6
  JOURNAL   Biochem Biophys Res Commun 247 (3), 827-832 (1998)
   PUBMED   9647778
REFERENCE   10 (bases 1 to 1682)
  AUTHORS   Onda,M., Inui,S., Maeda,K., Suzuki,M., Takahashi,E. and
            Sakaguchi,N.
  TITLE     Expression and chromosomal localization of the human alpha 4/IGBP1
            gene, the structure of which is closely related to the yeast TAP42
            protein of the rapamycin-sensitive signal transduction pathway
  JOURNAL   Genomics 46 (3), 373-378 (1997)
   PUBMED   9441740
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158141.14 and BC004137.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001551.2.
            
            Summary: The proliferation and differentiation of B cells is
            dependent upon a B-cell antigen receptor (BCR) complex. Binding of
            antigens to specific B-cell receptors results in a tyrosine
            phosphorylation reaction through the BCR complex and leads to
            multiple signal transduction pathways. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004137.2, SRR5189655.103080.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356413.5/ ENSP00000348784.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AL158141.14        17308-17328         c
            22-1682             BC004137.2         1-1661
FEATURES             Location/Qualifiers
     source          1..1682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..1682
                     /gene="IGBP1"
                     /gene_synonym="ALPHA-4; alpha4; IBP1; MRXS28"
                     /note="immunoglobulin binding protein 1"
                     /db_xref="GeneID:3476"
                     /db_xref="HGNC:HGNC:5461"
                     /db_xref="MIM:300139"
     exon            1..94
                     /gene="IGBP1"
                     /gene_synonym="ALPHA-4; alpha4; IBP1; MRXS28"
                     /inference="alignment:Splign:2.1.0"
     exon            95..507
                     /gene="IGBP1"
                     /gene_synonym="ALPHA-4; alpha4; IBP1; MRXS28"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..1339
                     /gene="IGBP1"
                     /gene_synonym="ALPHA-4; alpha4; IBP1; MRXS28"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein phosphatase 2A, regulatory subunit alpha-4; B cell
                     signal transduction molecule alpha 4; bA351K23.1
                     (immunoglobulin binding protein 1 (CD79A)); protein
                     alpha-4; CD79a-binding protein 1; immunoglobulin (CD79A)
                     binding protein 1; renal carcinoma antigen NY-REN-16;
                     protein phosphatase 2/4/6 regulatory subunit"
                     /codon_start=1
                     /product="immunoglobulin-binding protein 1 isoform 1"
                     /protein_id="NP_001542.1"
                     /db_xref="CCDS:CCDS14396.1"
                     /db_xref="GeneID:3476"
                     /db_xref="HGNC:HGNC:5461"
                     /db_xref="MIM:300139"
                     /translation="MAAEDELQLPRLPELFETGRQLLDEVEVATEPAGSRIVQEKVFK
                     GLDLLEKAAEMLSQLDLFSRNEDLEEIASTDLKYLLVPAFQGALTMKQVNPSKRLDHL
                     QRAREHFINYLTQCHCYHVAEFELPKTMNNSAENHTANSSMAYPSLVAMASQRQAKIQ
                     RYKQKKELEHRLSAMKSAVESGQADDERVREYYLLHLQRWIDISLEEIESIDQEIKIL
                     RERDSSREASTSNSSRQERPPVKPFILTRNMAQAKVFGAGYPSLPTMTVSDWYEQHRK
                     YGALPDQGIAKAAPEEFRKAAQQQEEQEEKEEEDDEQTLHRAREWDDWKDTHPRGYGN
                     RQNMG"
     exon            508..801
                     /gene="IGBP1"
                     /gene_synonym="ALPHA-4; alpha4; IBP1; MRXS28"
                     /inference="alignment:Splign:2.1.0"
     exon            802..997
                     /gene="IGBP1"
                     /gene_synonym="ALPHA-4; alpha4; IBP1; MRXS28"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1077
                     /gene="IGBP1"
                     /gene_synonym="ALPHA-4; alpha4; IBP1; MRXS28"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1190
                     /gene="IGBP1"
                     /gene_synonym="ALPHA-4; alpha4; IBP1; MRXS28"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1682
                     /gene="IGBP1"
                     /gene_synonym="ALPHA-4; alpha4; IBP1; MRXS28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1661..1666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IGBP1"
                     /gene_synonym="ALPHA-4; alpha4; IBP1; MRXS28"
                     /note="hexamer: ATTATA"
     polyA_site      1682
                     /gene="IGBP1"
                     /gene_synonym="ALPHA-4; alpha4; IBP1; MRXS28"
                     /note="major polyA site"
ORIGIN      
        1 gcacttcgcg ctcaagcgac cggatcttca aaccgtggga gtggtgcggc ggctagagtc
       61 cctggactcc tcaacctagg gagctactcg cgagatgcct acgacttgta acgggctgcc
      121 tggtaaaatg agtctatgga aacggttgcc agggccggct aacagcggct cccggaagtc
      181 ctttgatgct ttgttaacag tgaagctact ggaccaatga ggtgcttctt ccggttttgt
      241 ccgcgctcgc ctaattcttc tttatcaagg ttgcctttga ccccggaaaa gagatcttcc
      301 gggttcctct ctccccaaga tggctgctga ggacgagtta cagctgccgc ggctccccga
      361 gctgttcgaa actggtagac agttactgga cgaagtagaa gtggcgactg aacccgccgg
      421 ttcccggata gtccaggaga aggtgttcaa gggcttggac ctccttgaga aggctgccga
      481 aatgttatcg cagctcgact tgttcagccg aaatgaagat ttggaagaga ttgcttccac
      541 cgacctgaag taccttttgg tgccagcgtt tcaaggagcc ctcaccatga aacaagtcaa
      601 ccccagcaag cgtctagatc atttgcagcg ggctcgagaa cactttataa actacttaac
      661 tcagtgccat tgctatcatg tggcagagtt tgagctgccc aaaaccatga acaactctgc
      721 tgaaaatcac actgccaatt cctccatggc ttatcctagt ctcgttgcta tggcatctca
      781 aagacaggct aaaatacaga gatacaagca gaagaaggag ttggagcata ggttgtctgc
      841 aatgaaatct gctgtggaaa gtggtcaagc agatgatgag cgtgttcgtg aatattatct
      901 tcttcacctt cagaggtgga ttgatatcag cttagaagag attgagagca ttgaccagga
      961 aataaagatc ctgagagaaa gagactcttc aagagaggca tcaacttcta actcatctcg
     1021 ccaggagagg cctccagtga aacccttcat tctcactcgg aacatggctc aagccaaagt
     1081 atttggagct ggttatccaa gtctgccaac tatgacggtg agtgactggt atgagcaaca
     1141 tcggaaatat ggagcattac cggatcaggg aatagccaag gcagcaccag aggaattcag
     1201 aaaagcagct cagcaacagg aagaacaaga agaaaaggag gaagaggatg atgaacaaac
     1261 actccacaga gcccgggagt gggatgactg gaaggacacc catcctaggg gctatgggaa
     1321 ccgacagaac atgggctgat cttcccacaa caccacagga ctgcagggtg cacaactccc
     1381 ctgccaagga aaaccatgca gtcctcccct ccctggtctc ctgcttcagc tctgtacaac
     1441 gagggcaaag atgctaaatc ttgctttgca ttcagtaaag tgtcaagtga ttaagtgtgt
     1501 atttgtaccc tagatgatat gaaccagcag tcttgttttg gcatcatcct catcatgttg
     1561 tattccagct tcttaagtgg aaggaaaaga gtgctgagaa atggctctgt ataatctatg
     1621 gctatccgaa ttctctgaaa aaataataaa agtcccctct attatatgag cctgtacaga
     1681 aa
//
