LOCUS       NM_138787                866 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens intraflagellar transport associated protein (IFTAP),
            transcript variant 4, mRNA.
ACCESSION   NM_138787
VERSION     NM_138787.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 866)
  AUTHORS   Takahara,M., Kunii,M., Nakamura,K., Harada,A., Hirano,T., Katoh,Y.
            and Nakayama,K.
  TITLE     C11ORF74 interacts with the IFT-A complex and participates in
            ciliary BBSome localization
  JOURNAL   J Biochem 165 (3), 257-267 (2019)
   PUBMED   30476139
  REMARK    GeneRIF: The C11ORF74, interacts with the IFT-A complex via the
            IFT122 subunit and is accumulated at the distal tip in the absence
            of an IFT-A subunit IFT139, suggesting that at least a fraction of
            C11ORF74 molecules can be transported towards the ciliary tip by
            associating with the IFT-A complex, although its majority might be
            out of cilia at steady state.
REFERENCE   2  (bases 1 to 866)
  AUTHORS   Kasztura,M., Sniezewski,L., Laszkiewicz,A., Majkowski,M., Kobak,K.,
            Peczek,K., Janik,S., Kapusniak,V., Miazek,A., Cebrat,M. and
            Kisielow,P.
  TITLE     Search for the Function of NWC, Third Gene Within RAG Locus:
            Generation and Characterization of NWC-Deficient Mice
  JOURNAL   Arch Immunol Ther Exp (Warsz) 64 (4), 311-319 (2016)
   PUBMED   26703212
REFERENCE   3  (bases 1 to 866)
  AUTHORS   Huttlin,E.L., Ting,L., Bruckner,R.J., Gebreab,F., Gygi,M.P.,
            Szpyt,J., Tam,S., Zarraga,G., Colby,G., Baltier,K., Dong,R.,
            Guarani,V., Vaites,L.P., Ordureau,A., Rad,R., Erickson,B.K.,
            Wuhr,M., Chick,J., Zhai,B., Kolippakkam,D., Mintseris,J.,
            Obar,R.A., Harris,T., Artavanis-Tsakonas,S., Sowa,M.E., De
            Camilli,P., Paulo,J.A., Harper,J.W. and Gygi,S.P.
  TITLE     The BioPlex Network: A Systematic Exploration of the Human
            Interactome
  JOURNAL   Cell 162 (2), 425-440 (2015)
   PUBMED   26186194
REFERENCE   4  (bases 1 to 866)
  AUTHORS   Hong,M., Li,W., Wang,L., Jiang,L., Liu,L., Zhao,H. and Li,Q.
  TITLE     Identification of a novel transcriptional repressor (HEPIS) that
            interacts with nsp-10 of SARS coronavirus
  JOURNAL   Viral Immunol 21 (2), 153-162 (2008)
   PUBMED   18433331
REFERENCE   5  (bases 1 to 866)
  AUTHORS   Li,Q., Wang,L., Dong,C., Che,Y., Jiang,L., Liu,L., Zhao,H.,
            Liao,Y., Sheng,Y., Dong,S. and Ma,S.
  TITLE     The interaction of the SARS coronavirus non-structural protein 10
            with the cellular oxido-reductase system causes an extensive
            cytopathic effect
  JOURNAL   J Clin Virol 34 (2), 133-139 (2005)
   PUBMED   16157265
  REMARK    GeneRIF: identification of HEPIS as a protein that binds nsp10 of
            SARS-CoV
REFERENCE   6  (bases 1 to 866)
  AUTHORS   Cebrat,M., Miazek,A. and Kisielow,P.
  TITLE     Identification of a third evolutionarily conserved gene within the
            RAG locus and its RAG1-dependent and -independent regulation
  JOURNAL   Eur J Immunol 35 (7), 2230-2238 (2005)
   PUBMED   15971274
REFERENCE   7  (bases 1 to 866)
  AUTHORS   Tomarev,S.I., Wistow,G., Raymond,V., Dubois,S. and Malyukova,I.
  TITLE     Gene expression profile of the human trabecular meshwork: NEIBank
            sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 44 (6), 2588-2596 (2003)
   PUBMED   12766061
REFERENCE   8  (bases 1 to 866)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK290833.1, BC051031.1 and
            BM670168.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_138787.3.
            
            Summary: This gene encodes a protein that was identified as a
            cellular interacting partner of non-structural protein 10 of the
            severe acute respiratory syndrome coronavirus (SARS-CoV). The
            encoded protein may function as a negative regulator of
            transcription. There is a pseudogene for this gene on chromosome 1.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Mar 2013].
            
            Transcript Variant: This variant (4) uses an alternate splice site
            in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4
            encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290833.1, BC051031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334307.10/ ENSP00000334848.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AK290833.1         3-63
            62-861              BC051031.1         21-820
            862-866             BM670168.1         37-41               c
FEATURES             Location/Qualifiers
     source          1..866
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p12"
     gene            1..866
                     /gene="IFTAP"
                     /gene_synonym="C11orf74; HEPIS; NWC"
                     /note="intraflagellar transport associated protein"
                     /db_xref="GeneID:119710"
                     /db_xref="HGNC:HGNC:25142"
                     /db_xref="MIM:619270"
     exon            1..91
                     /gene="IFTAP"
                     /gene_synonym="C11orf74; HEPIS; NWC"
                     /inference="alignment:Splign:2.1.0"
     exon            92..250
                     /gene="IFTAP"
                     /gene_synonym="C11orf74; HEPIS; NWC"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..780
                     /gene="IFTAP"
                     /gene_synonym="C11orf74; HEPIS; NWC"
                     /note="isoform a is encoded by transcript variant 4;
                     uncharacterized protein C11orf74"
                     /codon_start=1
                     /product="intraflagellar transport-associated protein
                     isoform a"
                     /protein_id="NP_620142.2"
                     /db_xref="CCDS:CCDS7904.1"
                     /db_xref="GeneID:119710"
                     /db_xref="HGNC:HGNC:25142"
                     /db_xref="MIM:619270"
                     /translation="MSAHMSGLEIMDEDQLIKDVLDKFLNCHEQTYDEEFLNTFTHLS
                     QEDHVSKRGVFGTDSSENIFTSAKVTHKNEADDYHLRNKTIFLRTSSQCLEEQVDNFL
                     DLEDLDMDEEIKPQMSEDLLLLPGEVEQDVSTSIPSCIPFVAQPPTCEVKPKPSVKRM
                     DKQTEEILGDEVQLFSLDEEFDYDNVMLTSKFSPAEIENIKELCKQQKRKDTSPDLEK
                     SCD"
     exon            251..405
                     /gene="IFTAP"
                     /gene_synonym="C11orf74; HEPIS; NWC"
                     /inference="alignment:Splign:2.1.0"
     exon            406..472
                     /gene="IFTAP"
                     /gene_synonym="C11orf74; HEPIS; NWC"
                     /inference="alignment:Splign:2.1.0"
     exon            473..612
                     /gene="IFTAP"
                     /gene_synonym="C11orf74; HEPIS; NWC"
                     /inference="alignment:Splign:2.1.0"
     exon            613..866
                     /gene="IFTAP"
                     /gene_synonym="C11orf74; HEPIS; NWC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      844..849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFTAP"
                     /gene_synonym="C11orf74; HEPIS; NWC"
                     /note="hexamer: AATAAA"
     polyA_site      866
                     /gene="IFTAP"
                     /gene_synonym="C11orf74; HEPIS; NWC"
                     /note="major polyA site"
ORIGIN      
        1 ctctctggga tgtgtagctt tggaaatctg tctttgttgc tctgggagag gggactcctg
       61 gaatgtgtct gtgaataaag actagccgaa gatactgtgg cctcatgaat aggaatgtct
      121 gcccatatgt caggattgga aataatggat gaagatcaat taatcaaaga cgtcttggat
      181 aaattcctta attgtcatga gcaaacatat gatgaagaat ttctgaacac ttttactcat
      241 ctttcacaag aggatcatgt gtccaaaagg ggagtgtttg gaactgattc ttcagaaaac
      301 atttttacct cagcaaaagt tactcataaa aatgaagcag atgactacca tcttagaaat
      361 aaaaccatct ttcttcgtac ttcatcacaa tgtttggaag aacaggtaga taatttccta
      421 gatttagaag atttggacat ggatgaagag attaaacccc aaatgagtga ggatttgctg
      481 ctgcttccag gagaagtgga gcaggatgta agcaccagca ttccttcctg tatccctttt
      541 gtggcccagc ctcctacctg tgaagtgaag ccaaagccca gtgttaaaag aatggacaaa
      601 cagacggaag agatacttgg agatgaagtt caactttttt cacttgatga agaatttgat
      661 tatgacaatg tgatgctaac ctccaagttt agtcctgcag agatagagaa catcaaagag
      721 ctatgcaagc agcagaagag aaaggacacc agcccagact tagagaaatc ctgtgactga
      781 ttcacagagg cattttgtgt gtgtgtgctt attttaattt tgttcttatt ctagcaacat
      841 tagaataaaa gataaaccta ctataa
//
