LOCUS       NM_020800               3999 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens intraflagellar transport 80 (IFT80), transcript
            variant 1, mRNA.
ACCESSION   NM_020800
VERSION     NM_020800.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3999)
  AUTHORS   Bizaoui,V., Huber,C., Kohaut,E., Roume,J., Bonniere,M.,
            Attie-Bitach,T. and Cormier-Daire,V.
  TITLE     Mutations in IFT80 cause SRPS Type IV. Report of two families and
            review
  JOURNAL   Am J Med Genet A 179 (4), 639-644 (2019)
   PUBMED   30767363
  REMARK    GeneRIF: Mutations in IFT80 cause Short rib-polydactyly syndrome,
            Beemer type.
REFERENCE   2  (bases 1 to 3999)
  AUTHORS   Wang,R., Deng,X., Yuan,C., Xin,H., Liu,G., Zhu,Y., Jiang,X. and
            Wang,C.
  TITLE     IFT80 Improves Invasion Ability in Gastric Cancer Cell Line via
            ift80/p75NGFR/MMP9 Signaling
  JOURNAL   Int J Mol Sci 19 (11), 3616 (2018)
   PUBMED   30453504
  REMARK    GeneRIF: IFT80 plays an important role in invasion of gastric
            cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3999)
  AUTHORS   Katoh,Y., Terada,M., Nishijima,Y., Takei,R., Nozaki,S., Hamada,H.
            and Nakayama,K.
  TITLE     Overall Architecture of the Intraflagellar Transport (IFT)-B
            Complex Containing Cluap1/IFT38 as an Essential Component of the
            IFT-B Peripheral Subcomplex
  JOURNAL   J Biol Chem 291 (21), 10962-10975 (2016)
   PUBMED   26980730
REFERENCE   4  (bases 1 to 3999)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3999)
  AUTHORS   Cavalcanti,D.P., Huber,C., Sang,K.H., Baujat,G., Collins,F.,
            Delezoide,A.L., Dagoneau,N., Le Merrer,M., Martinovic,J.,
            Mello,M.F., Vekemans,M., Munnich,A. and Cormier-Daire,V.
  TITLE     Mutation in IFT80 in a fetus with the phenotype of Verma-Naumoff
            provides molecular evidence for Jeune-Verma-Naumoff dysplasia
            spectrum
  JOURNAL   J Med Genet 48 (2), 88-92 (2011)
   PUBMED   19648123
  REMARK    GeneRIF: Mutations in IFT80 can be responsible for a lethal form of
            short-rib polydactyly and provide the molecular basis for the
            Jeune-Verma-Naumoff dysplasia spectrum.
REFERENCE   6  (bases 1 to 3999)
  AUTHORS   Huang,W., Kane,J.K. and Li,M.D.
  TITLE     Identification and characterization of a long isoform of human
            IFT80, IFT80-L
  JOURNAL   Biochem Biophys Res Commun 373 (4), 653-658 (2008)
   PUBMED   18601909
  REMARK    GeneRIF: Identification and characterization of a human IFT80 long
            isoform (namely IFT80-L), the carboxyl terminus of which shares the
            protein sequence of IFT80, is reported.
REFERENCE   7  (bases 1 to 3999)
  AUTHORS   Beales,P.L., Bland,E., Tobin,J.L., Bacchelli,C., Tuysuz,B.,
            Hill,J., Rix,S., Pearson,C.G., Kai,M., Hartley,J., Johnson,C.,
            Irving,M., Elcioglu,N., Winey,M., Tada,M. and Scambler,P.J.
  TITLE     IFT80, which encodes a conserved intraflagellar transport protein,
            is mutated in Jeune asphyxiating thoracic dystrophy
  JOURNAL   Nat Genet 39 (6), 727-729 (2007)
   PUBMED   17468754
  REMARK    GeneRIF: Mutations in IFT80 is associated with Jeune asphyxiating
            thoracic dystrophy
REFERENCE   8  (bases 1 to 3999)
  AUTHORS   Muzny,D.M., Scherer,S.E., Kaul,R., Wang,J., Yu,J., Sudbrak,R.,
            Buhay,C.J., Chen,R., Cree,A., Ding,Y., Dugan-Rocha,S., Gill,R.,
            Gunaratne,P., Harris,R.A., Hawes,A.C., Hernandez,J., Hodgson,A.V.,
            Hume,J., Jackson,A., Khan,Z.M., Kovar-Smith,C., Lewis,L.R.,
            Lozado,R.J., Metzker,M.L., Milosavljevic,A., Miner,G.R.,
            Morgan,M.B., Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z.,
            Steffen,D., Wei,S., Wheeler,D.A., Wright,M.W., Worley,K.C.,
            Yuan,Y., Zhang,Z., Adams,C.Q., Ansari-Lari,M.A., Ayele,M.,
            Brown,M.J., Chen,G., Chen,Z., Clendenning,J.,
            Clerc-Blankenburg,K.P., Chen,R., Chen,Z., Davis,C., Delgado,O.,
            Dinh,H.H., Dong,W., Draper,H., Ernst,S., Fu,G.,
            Gonzalez-Garay,M.L., Garcia,D.K., Gillett,W., Gu,J., Hao,B.,
            Haugen,E., Havlak,P., He,X., Hennig,S., Hu,S., Huang,W.,
            Jackson,L.R., Jacob,L.S., Kelly,S.H., Kube,M., Levy,R., Li,Z.,
            Liu,B., Liu,J., Liu,W., Lu,J., Maheshwari,M., Nguyen,B.V.,
            Okwuonu,G.O., Palmeiri,A., Pasternak,S., Perez,L.M., Phelps,K.A.,
            Plopper,F.J., Qiang,B., Raymond,C., Rodriguez,R.,
            Saenphimmachak,C., Santibanez,J., Shen,H., Shen,Y., Subramanian,S.,
            Tabor,P.E., Verduzco,D., Waldron,L., Wang,J., Wang,J., Wang,Q.,
            Williams,G.A., Wong,G.K., Yao,Z., Zhang,J., Zhang,X., Zhao,G.,
            Zhou,J., Zhou,Y., Nelson,D., Lehrach,H., Reinhardt,R., Naylor,S.L.,
            Yang,H., Olson,M., Weinstock,G. and Gibbs,R.A.
  TITLE     The DNA sequence, annotation and analysis of human chromosome 3
  JOURNAL   Nature 440 (7088), 1194-1198 (2006)
   PUBMED   16641997
REFERENCE   9  (bases 1 to 3999)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   10 (bases 1 to 3999)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK125342.1, AB037795.1 and
            CA421514.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_020800.2.
            
            Summary: The protein encoded by this gene is part of the
            intraflagellar transport complex B and is necessary for the
            function of motile and sensory cilia. Defects in this gene are a
            cause of asphyxiating thoracic dystrophy 2 (ATD2). Three transcript
            variants encoding two different isoforms have been found for this
            gene.[provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.83383.1,
                                           SRR1803616.40152.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326448.12/ ENSP00000312778.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1235              AK125342.1         308-1542
            1236-3993           AB037795.1         1287-4044
            3994-3999           CA421514.1         17-22               c
FEATURES             Location/Qualifiers
     source          1..3999
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.33"
     gene            1..3999
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /note="intraflagellar transport 80"
                     /db_xref="GeneID:57560"
                     /db_xref="HGNC:HGNC:29262"
                     /db_xref="MIM:611177"
     exon            1..80
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            81..163
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2460
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /note="isoform a is encoded by transcript variant 1; WD
                     repeat domain 56; WD repeat-containing protein 56;
                     intraflagellar transport 80 homolog"
                     /codon_start=1
                     /product="intraflagellar transport protein 80 homolog
                     isoform a"
                     /protein_id="NP_065851.1"
                     /db_xref="CCDS:CCDS3188.1"
                     /db_xref="GeneID:57560"
                     /db_xref="HGNC:HGNC:29262"
                     /db_xref="MIM:611177"
                     /translation="MRLKISLLKEPKHQELVSCVGWTTAEELYSCSDDHQIVKWNLLT
                     SETTQIVKLPDDIYPIDFHWFPKSLGVKKQTQAESFVLTSSDGKFHLISKLGRVEKSV
                     EAHCGAVLAGRWNYEGTALVTVGEDGQIKIWSKTGMLRSTLAQQGTPVYSVAWGPDSE
                     KVLYTAGKQLIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSY
                     GRPLYNSQPHEHPITSVAWAPDGELFAVGSFHTLRLCDKTGWSYALEKPNTGSIFNIA
                     WSIDGTQIAGACGNGHVVFAHVVEQHWEWKNFQVTLTKRRAMQVRNVLNDAVDLLEFR
                     DRVIKASLNYAHLVVSTSLQCYVFSTKNWNTPIIFDLKEGTVSLILQAERHFLLVDGS
                     SIYLYSYEGRFISSPKFPGMRTDILNAQTVSLSNDTIAIRDKADEKIIFLFEASTGKP
                     LGDGKFLSHKNEILEIALDQKGLTNDRKIAFIDKNRDLCITSVKRFGKEEQIIKLGTM
                     VHTLAWNDTCNILCGLQDTRFIVWYYPNTVYVDRDILPKTLYERDASEFSKNPHIVSF
                     VGNQVTIRRADGSLVHISITPYPAILHEYVSSSKWEDAVRLCRFVKEQTMWACLAAMA
                     VANRDMTTAEIAYAAIGEIDKVQYINSIKNLPSKESKMAHILLFSGNIQEAEIVLLQA
                     GLVYQAIQININLYNWERALELAVKYKTHVDTVLAYRQKFLETFGKQETNKRYLHYAE
                     GLQIDWEKIKAKIEMEITKEREQSSSSQSSKSIGLKP"
     exon            164..385
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            386..496
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            497..565
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            566..675
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            676..765
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            766..903
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1083
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1202
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1277
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1441
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1506
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1642
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1790
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1962
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2052
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2225
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2349
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..3999
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2782..2787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /note="hexamer: AATAAA"
     polyA_site      2805
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /note="major polyA site"
     regulatory      3962..3967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /note="hexamer: AATAAA"
     regulatory      3975..3980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /note="hexamer: AATAAA"
     polyA_site      3982
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /note="major polyA site"
     polyA_site      3999
                     /gene="IFT80"
                     /gene_synonym="ATD2; CFAP167; FAP167; SRTD2; WDR56"
                     /note="major polyA site"
ORIGIN      
        1 gtaactctta gaagtcacta tggtgacggg gaggtaccag gtatttgaga gcaatcgcca
       61 ccgctttcct ggaacttgag taaatacaat caagtggcat cttaaatttt tgctggaagt
      121 ggagtcatga gactaaagat atctctttta aaagaaccaa agcatcaaga attagtaagc
      181 tgtgtgggct ggactactgc tgaagagctg tattcatgta gtgatgatca ccagatagtg
      241 aagtggaact tgttaaccag tgaaacaact caaatagtaa agcttcctga tgatatttac
      301 cctattgatt ttcactggtt tccaaaaagt ttgggtgtaa agaaacaaac ccaggcagaa
      361 agctttgtcc tcacaagttc tgatggtaaa tttcatctga tttccaagtt aggaagagtg
      421 gaaaaaagtg tagaagctca ctgtggagca gtacttgcag gaagatggaa ttatgaagga
      481 acagcattag ttacagttgg agaagatgga caaataaaaa tttggtcaaa gactgggatg
      541 cttagatcaa ctttagctca gcaaggaaca ccagtgtatt cagtagcgtg gggccctgat
      601 tcagaaaagg ttctttatac agcaggcaag cagctaatca ttaaacctct tcaaccaaat
      661 gctaaagttt tgcagtggaa agctcatgat ggcattattt taaaagtaga ttggaactcg
      721 gtcaatgatc ttattttatc tgctggtgaa gactgtaaat ataaggtatg ggatagttac
      781 ggccgcccac tgtacaattc acaacctcat gagcatccca ttacttcagt tgcctgggct
      841 ccagatggag aattatttgc tgttggatcg tttcatactt tacgcttgtg tgataaaact
      901 gggtggtcat atgcattaga aaaacccaac actggcagca tatttaatat tgcatggtct
      961 atcgatggca ctcagattgc tggagcctgt ggaaatggac atgtcgtttt tgcacatgtg
     1021 gtggaacaac attgggagtg gaaaaatttt caagtaacat taacgaaaag aagagccatg
     1081 caggttcgta atgttcttaa tgatgcagtg gatttactgg aattccgtga tagagtcatt
     1141 aaagcatctt tgaactatgc acacttagtt gtttcaacgt ctcttcaatg ttacgtgttc
     1201 tccacgaaga actggaacac accaattata tttgatctca aagaaggaac tgttagtttg
     1261 attctgcagg cagaaagaca ttttcttctt gtagatggta gtagtatcta tttatattca
     1321 tatgaagggc gctttatttc atctccaaaa tttcctggaa tgagaacaga tattctgaat
     1381 gcacagactg tgtctttgag taatgatacc atagcaataa gagacaaagc tgatgaaaaa
     1441 ataatcttcc tctttgaggc atcaaccgga aagccgttag gtgatggaaa gtttctttct
     1501 cataagaatg aaatcttgga aattgctctg gatcaaaaag gacttaccaa tgatagaaaa
     1561 attgctttca ttgataaaaa tagagatctc tgtatcactt ctgtgaaacg atttgggaag
     1621 gaagaacaaa ttatcaagct tggaacaatg gtgcatactt tggcatggaa cgatacatgc
     1681 aatatccttt gtggacttca agatactcga tttatagtgt ggtattaccc caatacagtt
     1741 tatgtggaca gagacatttt gcctaaaaca ttatatgaaa gggatgcaag tgaatttagt
     1801 aaaaatcccc atattgtgag ttttgttgga aatcaagtaa ctattagaag agctgatggc
     1861 tccctggttc acatcagcat aacaccatat cctgctattc tccatgaata tgtaagcagt
     1921 tcaaaatggg aagatgctgt gagactttgt cgctttgtta aggagcaaac catgtgggct
     1981 tgtctagctg ctatggcagt tgctaatcga gatatgacta ctgcagaaat agcctatgca
     2041 gcaattggtg aaattgataa ggttcagtac atcaattcta taaaaaatct tccatctaaa
     2101 gaatcaaaaa tggcccacat actactgttt agtgggaaca tacaggaggc tgaaatagta
     2161 cttcttcagg ctggccttgt ttatcaagca atccagatca atattaatct ctacaactgg
     2221 gaaagggcac tggaattggc tgtaaaatac aaaacacatg ttgatacagt tcttgcttac
     2281 cgtcaaaagt ttttggagac atttggtaaa caggaaacta ataaacgata cttgcattat
     2341 gcagaaggtc tccaaataga ttgggagaaa atcaaagcca aaattgagat ggaaattaca
     2401 aaagaaagag agcaatcatc aagcagccaa tccagcaaga gtataggttt aaagccctaa
     2461 atgccatgcg tatctttaag aaattttatc ttttgaaaca cgttctgatt aaccaagggt
     2521 aagcatgttt tggttgctaa agaaaaaagc ataatcttta accgagtata agtacttgct
     2581 gtgtatttag tgtaaaagta catgcagaaa gatgaaacac aaagtaattg atgtatttct
     2641 atcttttata ttttttagtc caataattag caaaatatta ctatgtactt aagagatacc
     2701 tgtgtagtgt cgattatatg tcagtttttt gcccattact tcatccctaa atcttcagca
     2761 tgaacaaata ttaatgtcga taataaaaca ttggactctt tgaaatgtat gttaccatta
     2821 atttctattt gacctctaaa ttgtaaaatg cctccaaaag tttatttata gaacaaaaat
     2881 acatgaggat ggatttgtac aaatgtataa aatgccacta tttatacacc aagttcatag
     2941 cagcattact ggaatagcaa aagatggaaa cagctcaagt gtctatcatg aatggataaa
     3001 caaatgtgct ataatacata caatggaata ttatttagct ttaaaaagga atgaaattct
     3061 gataaatact acctcaggat aaaccttgaa aacactatgc taagtgaaat aagccagaca
     3121 caaaaggcca aatatgatgc cacttttatg aggtaccagc ataggcaagt tcacagaaac
     3181 agaaaggaga atagtggttg ccagggactg cagggaggag gaaatggggg gtggggttat
     3241 tgtttaacga gtacatagtt tctgtttggg atgaacaaat tctggaaatg gatagcgatg
     3301 atggttgctc aacattttga atgttaatgc cactaaattg tacccataaa aatggttaaa
     3361 atggtaaatt ttgttatgta tattttatca taatttaaaa aatatatcta gaatgggcaa
     3421 gaaggattct cctcattcct ctcttgactt gagaatgatc agtcaatagg ccctgaagtc
     3481 tgaatttgtg aaaatttcct tgggtgacaa acttgtttga ttactctatt tagtgtatcc
     3541 caaagttatt accacataat cttttaaaca ataaaacaaa taccccttag aaagtcttct
     3601 gcaaacccat ttctgaaaat ggtacattat agggtgggta tagatgcata gatatgggat
     3661 tatgtatgat atatatatat atacacacac acacaaaggg atagagagat tacctctctt
     3721 aacccccatt ttaattacta tgtctaggtt ttttaaataa aaatcttttc tttttaacat
     3781 gtttcttttc ttttccggaa tattggaata ttctgttctt gatccagatg aaatctgatt
     3841 gagcagtgta cttacaagtt gtactgtgta tgtgtttcct atattgttat atttcaataa
     3901 gaagcttaaa atgtttaaaa ataaatggtt aaaaggtttt atgttatgta tattttacca
     3961 caataaatgc aaaaaataaa aagtctgtgt tctaaacaa
//
