LOCUS       NM_025103               5325 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens intraflagellar transport 74 (IFT74), transcript
            variant 1, mRNA.
ACCESSION   NM_025103
VERSION     NM_025103.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5325)
  AUTHORS   Fassad,M.R., Rumman,N., Junger,K., Patel,M.P., Thompson,J.,
            Goggin,P., Ueffing,M., Beyer,T., Boldt,K., Lucas,J.S. and
            Mitchison,H.M.
  TITLE     Defective airway intraflagellar transport underlies a combined
            motile and primary ciliopathy syndrome caused by IFT74 mutations
  JOURNAL   Hum Mol Genet 32 (21), 3090-3104 (2023)
   PUBMED   37555648
  REMARK    GeneRIF: Defective airway intraflagellar transport underlies a
            combined motile and primary ciliopathy syndrome caused by IFT74
            mutations.
REFERENCE   2  (bases 1 to 5325)
  AUTHORS   Bakey,Z., Cabrera,O.A., Hoefele,J., Antony,D., Wu,K., Stuck,M.W.,
            Micha,D., Eguether,T., Smith,A.O., van der Wel,N.N., Wagner,M.,
            Strittmatter,L., Beales,P.L., Jonassen,J.A., Thiffault,I.,
            Cadieux-Dion,M., Boyes,L., Sharif,S., Tuysuz,B., Dunstheimer,D.,
            Niessen,H.W.M., Devine,W., Lo,C.W., Mitchison,H.M., Schmidts,M. and
            Pazour,G.J.
  TITLE     IFT74 variants cause skeletal ciliopathy and motile cilia defects
            in mice and humans
  JOURNAL   PLoS Genet 19 (6), e1010796 (2023)
   PUBMED   37315079
  REMARK    GeneRIF: IFT74 variants cause skeletal ciliopathy and motile cilia
            defects in mice and humans.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5325)
  AUTHORS   Zhou,Z., Qiu,H., Castro-Araya,R.F., Takei,R., Nakayama,K. and
            Katoh,Y.
  TITLE     Impaired cooperation between IFT74/BBS22-IFT81 and
            IFT25-IFT27/BBS19 causes Bardet-Biedl syndrome
  JOURNAL   Hum Mol Genet 31 (10), 1681-1693 (2022)
   PUBMED   34888642
  REMARK    GeneRIF: Impaired cooperation between IFT74/BBS22-IFT81 and
            IFT25-IFT27/BBS19 causes Bardet-Biedl syndrome.
REFERENCE   4  (bases 1 to 5325)
  AUTHORS   Mardy,A.H., Hodoglugil,U., Yip,T. and Slavotinek,A.M.
  TITLE     Third case of Bardet-Biedl syndrome caused by a biallelic variant
            predicted to affect splicing of IFT74
  JOURNAL   Clin Genet 100 (1), 93-99 (2021)
   PUBMED   33748949
  REMARK    GeneRIF: Third case of Bardet-Biedl syndrome caused by a biallelic
            variant predicted to affect splicing of IFT74.
REFERENCE   5  (bases 1 to 5325)
  AUTHORS   Bhogaraju,S., Weber,K., Engel,B.D., Lechtreck,K.F. and Lorentzen,E.
  TITLE     Getting tubulin to the tip of the cilium: one IFT train, many
            different tubulin cargo-binding sites?
  JOURNAL   Bioessays 36 (5), 463-467 (2014)
   PUBMED   24616010
REFERENCE   6  (bases 1 to 5325)
  AUTHORS   Momeni,P., Schymick,J., Jain,S., Cookson,M.R., Cairns,N.J.,
            Greggio,E., Greenway,M.J., Berger,S., Pickering-Brown,S., Chio,A.,
            Fung,H.C., Holtzman,D.M., Huey,E.D., Wassermann,E.M., Adamson,J.,
            Hutton,M.L., Rogaeva,E., St George-Hyslop,P., Rothstein,J.D.,
            Hardiman,O., Grafman,J., Singleton,A., Hardy,J. and Traynor,B.J.
  TITLE     Analysis of IFT74 as a candidate gene for chromosome 9p-linked
            ALS-FTD
  JOURNAL   BMC Neurol 6, 44 (2006)
   PUBMED   17166276
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5325)
  AUTHORS   Iomini,C., Tejada,K., Mo,W., Vaananen,H. and Piperno,G.
  TITLE     Primary cilia of human endothelial cells disassemble under laminar
            shear stress
  JOURNAL   J Cell Biol 164 (6), 811-817 (2004)
   PUBMED   15024030
REFERENCE   8  (bases 1 to 5325)
  AUTHORS   Bell,S.E., Mavila,A., Salazar,R., Bayless,K.J., Kanagala,S.,
            Maxwell,S.A. and Davis,G.E.
  TITLE     Differential gene expression during capillary morphogenesis in 3D
            collagen matrices: regulated expression of genes involved in
            basement membrane matrix assembly, cell cycle progression, cellular
            differentiation and G-protein signaling
  JOURNAL   J Cell Sci 114 (Pt 15), 2755-2773 (2001)
   PUBMED   11683410
REFERENCE   9  (bases 1 to 5325)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   10 (bases 1 to 5325)
  AUTHORS   Forsyth,R. and Gunay-Aygun,M.
  TITLE     Bardet-Biedl Syndrome Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301537
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA617917.1, AY040325.1,
            AI919195.1, AL355432.7 and AI699118.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_025103.3.
            
            Summary: This gene encodes a core intraflagellar transport (IFT)
            protein which belongs to a multi-protein complex involved in the
            transport of ciliary proteins along axonemal microtubules. IFT
            proteins are found at the base of the cilium as well as inside the
            cilium, where they assemble into long arrays between the ciliary
            base and tip. This protein, together with intraflagellar transport
            protein 81, binds and transports tubulin within cilia and is
            required for ciliogenesis. Naturally occurring mutations in this
            gene are associated with amyotrophic lateral
            sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome.
            [provided by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1, 2, and 3 encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.44262.1,
                                           SRR1803614.196639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380062.10/ ENSP00000369402.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DA617917.1         40-71
            33-1990             AY040325.1         1-1958
            1991-2124           AI919195.1         13-146              c
            2125-5023           AL355432.7         71618-74516         c
            5024-5325           AI699118.1         8-309               c
FEATURES             Location/Qualifiers
     source          1..5325
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.2"
     gene            1..5325
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /note="intraflagellar transport 74"
                     /db_xref="GeneID:80173"
                     /db_xref="HGNC:HGNC:21424"
                     /db_xref="MIM:608040"
     exon            1..105
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            106..244
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1927
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /note="isoform a is encoded by transcript variant 1;
                     capillary morphogenesis protein 1; coiled-coil domain
                     containing 2; intraflagellar transport protein 74 homolog;
                     capillary morphogenesis gene 1 protein; coiled-coil
                     domain-containing protein 2; intraflagellar transport 74
                     homolog"
                     /codon_start=1
                     /product="intraflagellar transport protein 74 homolog
                     isoform a"
                     /protein_id="NP_079379.2"
                     /db_xref="CCDS:CCDS43793.1"
                     /db_xref="GeneID:80173"
                     /db_xref="HGNC:HGNC:21424"
                     /db_xref="MIM:608040"
                     /translation="MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPG
                     TARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLR
                     SKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKL
                     NTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDI
                     IKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVL
                     LHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKIN
                     QFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEAN
                     IVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQ
                     LDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMIL
                     STHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNNFAMKEFIATK
                     SQESDYQPIKKNVTKQIAEYNKTIVDALHSTSGN"
     exon            245..380
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            381..429
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            430..528
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            529..589
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            590..649
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            650..711
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            712..850
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            851..913
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1057
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1098
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1178
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1232
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1330
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1457
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1621
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1747
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1808
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..5325
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2098..2103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /note="hexamer: AATAAA"
     polyA_site      2121
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /note="major polyA site"
     regulatory      4130..4135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /note="hexamer: AATAAA"
     polyA_site      4150
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
     regulatory      5077..5082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /note="hexamer: AATAAA"
     polyA_site      5101
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
     regulatory      5305..5310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
                     /note="hexamer: ATTATA"
     polyA_site      5325
                     /gene="IFT74"
                     /gene_synonym="BBS22; CCDC2; CMG-1; CMG1; JBTS40; SPGF58"
ORIGIN      
        1 agttagtggg taggcctgag agccgaggaa aactgagcgt gggcctcaga aagaagttaa
       61 ggcacccgcg agccgggcaa ctgccctcct tccgcgccgg cggagcgatt aaagtgaaga
      121 aacaatggcc agcaatcaca aatcttcagc agctcgccct gtttcaagag gtggagttgg
      181 gttaacagga aggcctcctt ctgggatacg acccctatca ggaaatattc gagtggcaac
      241 tgcaatgcca cctgggacag caagaccagg ttctcgtggt tgtcccatag ggactggtgg
      301 agttctgtct tctcaaatca aagttgccca tcgccctgta acacaacaag gtttgactgg
      361 aatgaaaact gggacgaaag gtccccagag gcaaatttta gacaaatctt actatcttgg
      421 gcttcttaga agtaaaataa gtgaacttac aactgaagtt aataaacttc agaagggaat
      481 agaaatgtac aatcaagaga attcagtata tttgtcatat gaaaagaggg ctgagacttt
      541 agctgttgag ataaaagagc ttcaaggaca actagcagac tacaacatgt tggtagataa
      601 acttaatacc aacactgaaa tggaagaagt aatgaatgat tacaatatgc ttaaagctca
      661 aaatgatcga gaaacacaaa gtttggatgt catatttact gaaagacaag cgaaagaaaa
      721 acaaatcaga agtgtcgaag aagaaattga acaggaaaaa caagcaacag atgacattat
      781 caaaaatatg tcttttgaaa accaagtcaa gtacctagag atgaaaacca caaatgagaa
      841 actgttacag gaattagata cacttcaaca acaattggat tcacagaaca tgaaaaaaga
      901 gagcctggaa gcagaaatag ctcactccca ggtgaaacag gaggcggtat tgctgcatga
      961 aaaactttat gagttggagt cccatcgaga tcaaatgatt gcagaagaca aaagcatagg
     1021 atctccaatg gaagagagag agaaattact taagcagatt aaagatgata atcaggaaat
     1081 agccagcatg gaaagacagt taacagatac aaaagaaaag ataaatcagt ttattgaaga
     1141 aattagacaa cttgacatgg atttagagga acaccaaggt gaaatgaacc agaaatacaa
     1201 ggagctaaag aaaagggagg aacatatgga cacttttatt gagacttttg aggaaacaaa
     1261 gaatcaggaa ctgaaacgaa aggcacagat agaagccaac attgttgcac tcttggagca
     1321 ctgcagtcga aatataaatc gtatagaaca gatatcctct atcaccaatc aagagctaaa
     1381 gatgatgcag gatgacctca attttaaatc tactgaagtg cagaaatcac aaagtacagc
     1441 tcagaatttg acttcagaca ttcaacgtct gcagttggat ctgcagaaaa tggagcttct
     1501 agaaagtaag atgactgaag aacagcattc tctaaaaagc aaaattaagc aaatgacaac
     1561 tgatctggag atatataatg atttgccagc tttaaaatca tcaggtgaag aaaagataaa
     1621 gaaattacat caggagagaa tgatattatc aacccacaga aatgccttta agaaaataat
     1681 ggagaagcaa aacatagagt atgaggcact aaaaacacaa ttgcaagaaa atgagacaca
     1741 ttctcagctt acaaatttgg agagaaagtg gcaacacctt gagcaaaata attttgcgat
     1801 gaaagaattc atagcaacca agagtcaaga gagtgattac cagccaatta agaaaaatgt
     1861 gaccaagcag attgcagagt acaataaaac catcgtggat gctttacata gcaccagcgg
     1921 aaactgagtt taagtccact gaaagtctct aaggaagtat cctcttgctg ctaaacttgg
     1981 tacaagttga ctaccaaaaa aaaaaaaagc ttacttttgg agtttaccta aaatttctga
     2041 atgttataat ttttgtggcc tcttttaaga atgatatttt aaaatagtaa atagttcaat
     2101 aaatggtttg catattaaaa agtaccatct tcttttcttt ttatgctact tgtatttgaa
     2161 ccaagagata aagaaactaa aagtgaccgt tgaaatttat ttagctggta taatccatct
     2221 atggcaacaa atgagataag cttttcttgt atcaactcta ggacggatgc atggagtatg
     2281 attctgattt agcacttaga tcaaccttgt caatttttac ttctagaaaa aattagtaag
     2341 attagaaggg agatttttag ctttgaatgt tacttctcaa ataggttata tttgatgtgt
     2401 attagaccat ataatgtcac aggtaaatat ataacatata ttctttatat agcagttata
     2461 cctaaagatt tggaattaga aacttttaat ctttgcaatt cttaaaatat tttttcacat
     2521 atatatacct ggaagaacat taggtaaaag actacattta tagtgggctg ttttggacta
     2581 tggctactgc tgttcattgc caccctgcag tatgcattta ctctcttgta ctattaggag
     2641 aacttaagta gattaattta taaacattag ccagaatatt tggggaaaaa agctagaaga
     2701 ggtaggattg ggagagaggc atagagtctg gaagacatta tattaactgt agatgtatct
     2761 tctcttatcg tgcaggaatg agtcaccttg gccagcataa aatattactt aaaactatcc
     2821 tgtttttgct ctgatatcat gttcactaag taactctact tttcagtatt tctgaaacaa
     2881 cacattgatt tcttaaacca aaatagcttt attgagatat tatttacata ctttaaaatt
     2941 tactcatata tgttgatttt taaaaataaa tatttataat ggtaaattat tcaaattcag
     3001 tctatataca tttaaataaa ggagtgagca ttgttgagtt tgctgaactc tggattacta
     3061 atatggctga agatcctgga cattcattaa ggtagcattc ataaaatgtg ttccataaat
     3121 cctgagcatc ttgagttatt aatagtgtta tgcctccaaa ggattcatgg tcaaagaagt
     3181 ttgggaaacg ttgtctgaaa caaaggtgaa ttattttatt ttttcttgac tgctcataac
     3241 ccttaatatg ctaatgtata ataagctcaa gaagaatata tactgtaaag catttcccag
     3301 agatagttgt ccacaaaacc ctaactttca cagagcctag gtcacatgag atgtgtcatt
     3361 ccaagaaata gactttgtac accaaataga cttcatacac taaaataatt tcatctactc
     3421 aagtcctctg ggtggctcta tggccttttt cagatgactc ctgagtatgt ctctttttag
     3481 ccaccctcag ctgttttatg ctgtgattgt atggggtttt ctattggaaa ttggtagcag
     3541 aaagtgctta taaaatttca caagggaaaa aaactctttt agcagttaaa gagaatgaaa
     3601 tctgaaattc agtagataaa acaggtaata gattttgatg acagtttgca gcccttcgtt
     3661 cattcataaa gtattactgt aatttggtga ttaggagcct ttatggatat acccgactgc
     3721 tgaaaaacat tcatctttta tacagtaaca aacagaggta tgattgagca tagagtttag
     3781 gcaagagaac tgactactat ggtctcttaa tcacattgat tctatttcgt ggatacttcc
     3841 aaggaggaag ggaatctgga aaacatgttt gtggataggt aatctttgtt ttcctcattt
     3901 gaaagcaaat ttaaatgcct ttactttttc cttaggtttt tttttatgat ttctacttaa
     3961 gtgttcttga cattttactg caccctttta aataaccaac ttagtaattt ttactattag
     4021 taataagggt ttttttctga gtggtgggat tatgggtgat tgtaatcttc cttgggcttt
     4081 ttggtatttt caaaattgtc tgtgatgtac atttaatact tagaaatgca ataaaattca
     4141 aataaagtac tatatgcagt tactacttta actgacagaa aggatgtagt aaaaactctt
     4201 aagtccttga ctctagaact gaaccaatct ttacgcagaa agaaagtagg aggaagattg
     4261 gcctgtccat taaatatatg tgtttgcatt ataacaatgg gaaatttggc aggaaaaaaa
     4321 tttcttgaca aaaagcaagg ctttcaattt ccatcctaat ttattcatat gtaatattgg
     4381 tggggggcaa ataattgagc aggatttctt taaattaaaa catgttttat ctgagggaaa
     4441 ttctcactaa tgtctctctt ccttcctctg agagcctttc cacaaatcca acaagaatat
     4501 tctctttact gggatagaac tggaggctaa tagctgcatg aactggctct tcctgagtca
     4561 gtcacattac tcagggggtt ccattcatgc taaaataaca ccttgtaagt cacatggaaa
     4621 gaagctgcag actgaacaaa catgctgagc agttttacta gtgaagatca acatgggaaa
     4681 gttagcaagt ctttgttttt cccatcctta tcttttatca gtaaataaac atgagttctt
     4741 gatattcttt ttcctgtgga gcccctcgtt tggacaatac tatagtctca ttttaaggta
     4801 caaaattcag tgcctgctta gaggattaca gcatggagta atcatattca caccagagat
     4861 gaaaggccag ttagtagtag ttccaggggt ttttgctgtt cccttgctca gtttctctag
     4921 acttctttcc ttttgctata caattgcagt gtaaacaacc ttagggaaat tataatgttt
     4981 agactcaaag taagaagaaa taaagatgga ccactagaga attgtagtaa tctattttta
     5041 aattgatatt gtgtctcatt tttgtataac ttttgaaata aaagtagatt atgtcttaaa
     5101 attgtaagtt tacagtttga taactgaaaa acatttttaa aaaggcaatt tttaatacaa
     5161 aggtagataa tttaggaaga cagataaata aaatgaagaa agtaagttac ttgtgatctc
     5221 accagtcttt ttagatacgc atctatattt atgtcacaca tatctgtttt atttatgtat
     5281 ttatgcacct ttaattaaat taaaattata ttgtttttaa tttta
//
