LOCUS       NM_152275               5744 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens intraflagellar transport 70A (IFT70A), mRNA.
ACCESSION   NM_152275
VERSION     NM_152275.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5744)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5744)
  AUTHORS   Fan,Z.C., Behal,R.H., Geimer,S., Wang,Z., Williamson,S.M.,
            Zhang,H., Cole,D.G. and Qin,H.
  TITLE     Chlamydomonas IFT70/CrDYF-1 is a core component of IFT particle
            complex B and is required for flagellar assembly
  JOURNAL   Mol Biol Cell 21 (15), 2696-2706 (2010)
   PUBMED   20534810
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC042848.1, AC073834.6 and BM684657.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152275.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7346977.2296372.1,
                                        SRR1660807.145159.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355689.6/ ENSP00000347915.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1376              BC042848.1         229-1604
            1377-4314           AC073834.6         107525-110462       c
            4315-4445           BM684657.1         18-148              c
            4446-5744           AC073834.6         106095-107393       c
FEATURES             Location/Qualifiers
     source          1..5744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.2"
     gene            1..5744
                     /gene="IFT70A"
                     /gene_synonym="CFAP259; FAP259; TTC30A; TTC30B"
                     /note="intraflagellar transport 70A"
                     /db_xref="GeneID:92104"
                     /db_xref="HGNC:HGNC:25853"
                     /db_xref="MIM:620741"
     exon            1..5744
                     /gene="IFT70A"
                     /gene_synonym="CFAP259; FAP259; TTC30A; TTC30B"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..2039
                     /gene="IFT70A"
                     /gene_synonym="CFAP259; FAP259; TTC30A; TTC30B"
                     /note="tetratricopeptide repeat protein 30A; TPR repeat
                     protein 30A; Tetratricopeptide repeat protein 30B; TPR
                     repeat protein 30B; tetratricopeptide repeat domain 30A"
                     /codon_start=1
                     /product="intraflagellar transport protein 70A"
                     /protein_id="NP_689488.3"
                     /db_xref="CCDS:CCDS2276.1"
                     /db_xref="GeneID:92104"
                     /db_xref="HGNC:HGNC:25853"
                     /db_xref="MIM:620741"
                     /translation="MAGLSGAQIPDGEFTALVYRLIRDARYAEAVQLLGRELQRSPRS
                     RAGLSLLGYCYYRLQEFALAAECYEQLGQLHPELEQYRLYQAQALYKACLYPEATRVA
                     FLLLDNPAYHSRVLRLQAAIKYSEGDLPGSRSLVEQLLSGEGGEESGGDNETDGQVNL
                     GCLLYKEGQYEAACSKFSATLQASGYQPDLSYNLALAYYSSRQYASALKHIAEIIERG
                     IRQHPELGVGMTTEGFDVRSVGNTLVLHQTALVEAFNLKAAIEYQLRNYEVAQETLTD
                     MPPRAEEELDPVTLHNQALMNMDARPTEGFEKLQFLLQQNPFPPETFGNLLLLYCKYE
                     YFDLAADVLAENAHLTYKFLTPYLYDFLDALITCQTAPEEAFIKLDGLAGMLTEQLRR
                     LTKQVQEARHNRDDEAIKKAVNEYDETMEKYIPVLMAQAKIYWNLENYPMVEKVFRKS
                     VEFCNDHDVWKLNVAHVLFMQENKYKEAIGFYEPIVKKHYDNILNVSAIVLANLCVSY
                     IMTSQNEEAEELMRKIEKEEEQLSYDDPNRKMYHLCIVNLVIGTLYCAKGNYEFGISR
                     VIKSLEPYNKKLGTDTWYYAKRCFLSLLENMSKHMIVIHDSVIQECVQFLGHCELYGT
                     NIPAVIEQPLEEERMHVGKNTVTDESRQLKALIYEIIGWNK"
     regulatory      4421..4426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFT70A"
                     /gene_synonym="CFAP259; FAP259; TTC30A; TTC30B"
                     /note="hexamer: ATTAAA"
     polyA_site      4445
                     /gene="IFT70A"
                     /gene_synonym="CFAP259; FAP259; TTC30A; TTC30B"
                     /note="major polyA site"
     regulatory      4904..4909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFT70A"
                     /gene_synonym="CFAP259; FAP259; TTC30A; TTC30B"
                     /note="hexamer: AATAAA"
     polyA_site      4924
                     /gene="IFT70A"
                     /gene_synonym="CFAP259; FAP259; TTC30A; TTC30B"
     regulatory      5557..5562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFT70A"
                     /gene_synonym="CFAP259; FAP259; TTC30A; TTC30B"
                     /note="hexamer: ATTAAA"
     polyA_site      5583
                     /gene="IFT70A"
                     /gene_synonym="CFAP259; FAP259; TTC30A; TTC30B"
     regulatory      5716..5721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IFT70A"
                     /gene_synonym="CFAP259; FAP259; TTC30A; TTC30B"
                     /note="hexamer: AATAAT"
     polyA_site      5744
                     /gene="IFT70A"
                     /gene_synonym="CFAP259; FAP259; TTC30A; TTC30B"
ORIGIN      
        1 ctgttgccgt ggtaaccgca cgcataacag ccgtggtggt tatggctggt ctgagcggcg
       61 cgcagatccc cgacggggag tttaccgcgc tagtgtaccg gctcatccgc gatgcccgct
      121 acgccgaggc ggtgcagctg ctgggccgag aactgcagcg gagccccagg agccgtgccg
      181 gcctgtcgct gctaggctac tgctactacc gcctgcagga gttcgcgctg gcggccgagt
      241 gctatgagca gctgggccag ctgcacccgg aactggagca gtaccgcctg taccaggccc
      301 aggccctgta caaggcctgc ctttatccgg aggccactcg ggtcgccttc cttctcctgg
      361 ataaccccgc ctaccacagc cgggtcctcc gcctgcaagc tgccatcaag tatagcgagg
      421 gcgatctgcc agggtccagg agcctggtgg agcagctgct gagtggggaa gggggagaag
      481 aaagtggagg cgacaatgag accgatggcc aggtcaacct gggttgtttg ctctacaagg
      541 agggacagta tgaagctgca tgctccaagt tttctgccac actgcaggcc tcgggctacc
      601 agcctgacct ttcctacaac ctggctttgg cctattacag cagccgacag tatgcctcag
      661 cactgaagca tatcgctgag attattgagc gtggcatccg ccagcatcct gagctaggtg
      721 tgggcatgac caccgagggc tttgatgttc gcagtgttgg caacacctta gttctccatc
      781 agactgctct ggtggaagcc ttcaacctta aggcagccat agaataccaa ctgagaaact
      841 atgaggtagc tcaagaaacc ctcaccgaca tgccacccag ggcagaggaa gagttggacc
      901 ctgtgaccct gcacaaccag gcactaatga acatggatgc caggcctaca gaagggtttg
      961 aaaagctaca gtttttgctc caacagaatc cctttcctcc agagactttt ggcaacctgt
     1021 tgctgctcta ctgtaaatat gagtattttg acctggcagc agatgtcctg gcagaaaatg
     1081 cccatttgac gtataagttc ctcacaccct atctctatga cttcttagat gccctgatca
     1141 cttgccagac agctcctgaa gaggctttca ttaagcttga tgggctagca gggatgctga
     1201 ctgagcagct tcggagactc accaagcaag tacaggaagc aagacacaac agagatgatg
     1261 aagctatcaa aaaggcagtg aatgaatatg atgaaaccat ggagaaatac attcctgtgt
     1321 tgatggctca ggcaaaaatc tactggaatc ttgaaaatta tccaatggtg gaaaaggtct
     1381 tccgcaaatc tgtggaattc tgtaacgacc atgatgtgtg gaagttgaat gtggctcatg
     1441 ttctgttcat gcaggaaaac aaatacaaag aagccattgg tttctatgaa cccatagtca
     1501 agaagcatta tgataacatc ctgaatgtca gtgctattgt actggctaat ctctgtgttt
     1561 cctatattat gacaagtcaa aatgaagaag cagaggagtt gatgaggaag attgaaaagg
     1621 aggaagagca gctctcttat gatgacccaa atcggaaaat gtaccatctc tgcattgtga
     1681 atttggtgat aggaactctt tattgtgcca aaggaaacta tgagtttggt atttctcgag
     1741 ttatcaaaag cttggagcct tataataaaa agctgggaac agatacctgg tattatgcca
     1801 aaagatgctt cctgtccttg ttagaaaaca tgtcaaaaca catgatagtc attcatgaca
     1861 gtgttattca agaatgtgtc cagtttttag gacactgtga actttatggc acaaacatac
     1921 ctgctgttat tgaacaaccc ctcgaagaag aaagaatgca tgttgggaag aatacagtca
     1981 cagatgagtc cagacaattg aaagctttga tttatgagat tataggatgg aataagtagt
     2041 tatgactgat agtggctttt ttcaaaatgg ctttcttacg taccacactt ttttttatct
     2101 gtatttagcc ttggcatctt tatatttgtc ttattttgaa tcttatccac tttgtaagaa
     2161 caagtttatg tttgagcaac tttttcattt aatccagaag ggtagggact atgcagtgta
     2221 agctgcatca cttctgcttt cttcctacta gtgacaatca tctggtcttg ccctcaagca
     2281 acaattgcta gagtaacatc tttgtataag caagtaaccc cagatagagt tgacgtttca
     2341 gctttgggct gtcaaaaggg tatgtcatgg accaaagcac tgttagtacg ggtatgtttg
     2401 catttggtca ctgatatgta aatgactgct agcccacggc tggaccactt ctcaatcagc
     2461 aaataaagcc atgtctattt tgctatctca gcatagacta tgctgtctga taaatctaat
     2521 tcttaactct atttctccag ttttttagtc ctttaacttt ctggattgca acgaagtcta
     2581 gtttagacct ctaagccctt ttagaagtac aagtataatg ggaatttctt ttcttggttc
     2641 ttttcaggtt atgaggtttg gtcagtgaca aaattttttt tcataatttg gttgattggt
     2701 tgcttcttaa gttttataat aaacgttttt cttcatgttc tatttttgat tttacagaaa
     2761 tgattttgcc tccttgtgga tactgacata tattaagtgt ggaagcttat taatattttt
     2821 ggttttttaa aaactgaaat ttttaatttt tactttttaa ttttttagga aaaaataagc
     2881 actgaactga gaatgagaag aataaaagta tgagttccat accttctaat tttaggctgt
     2941 cagaaattcc tttattcttt gggatttcac aatcatttga actatcagaa gcctttacaa
     3001 ttacttttag ctgtaacatc cgattctgta taagccacat agaaaaaagt tgcctttctt
     3061 tttttatgac ctggatatat aagcaaatca gctaggaaat atataattgt attttatatt
     3121 aatgttttct aggattttgg cttacagtaa atgttaaccc ctatggtaag tgattgttat
     3181 tgttggatgt tatactgatt attaataaga aatttggatt tttgcctttt tacctggaat
     3241 ttttgcttac agccgtagct atgaatatat atagggtggt ccccagtctc tgttatggtt
     3301 gcgcataaat taataatttt ataagtattt agaaatggta taattctctt aacttcctct
     3361 ttcagttttt gtactaatgt ttgtttttgt tcgggaagag gagatttgct tttaatcctt
     3421 ccaaaaaatg atgaaccacc gttccattca gtagtttgac aagctgttat aatgtgtatt
     3481 ttttcctcaa ttattcttga aatatttaga gcctctcctg cttctaacat gaaggccttt
     3541 agatgccagt ctgccagaaa tctggaaaca gaggaaccgg tgaagtgaag atgtaatgga
     3601 gatttagcta atgatgtact tcacaatcca ccttggatct cctgcatgtc caaatctcag
     3661 tagttaatca agtgtctgct gccattaaca gaacagaagt aatggataac agaatggaaa
     3721 taagagatgc cagaactact tccataacta actcaccaaa tcaaatcatc agtcctcata
     3781 ttcttgtttt atttaataca aggagaagag gccatgcact ttccaaaagg tcaaagccac
     3841 atagaatagg aaggcaatct ctagtttaaa gctttctctt ggagtgtttt ctccccctgt
     3901 cttcaaaggg tctacttgag agatagtggt gtttactgct gcagcatgta tcacaagata
     3961 agaaatgaaa aatcaatctt tcttaccacc ctgttctctt tccctttttt atcttttccc
     4021 ttttgtcaat tatagaatta tagggacatt tttctctgat agctggaagt tgaacctcaa
     4081 ccaggtataa aagatgcata acaacctttt agcagtaagt gtcaagtgag tgagcactat
     4141 gattatcaag gtgactttgg aaacctttta aaaatgcatt tttgcaaaac aagataacat
     4201 atattgataa aaagtgactc tcagattggt aatgccagaa aaaattttaa gaggactcac
     4261 caaaagtact agatctatgt aagttgtaga atagagtgaa gtttttttat atatttgtgg
     4321 tagcctccat cttttaaact ttttgaactc agtagaaaaa cagactgaaa ttttaaagac
     4381 atgcagtatt tgtatcattt taaattctgt aacactggga attaaatata ctcaacttta
     4441 gaggacactt gccttactgt aatctataat cattttatat tgaaaaatag ggccagacat
     4501 tagccaaacg gtaattaatt tactagccat aggtatagtg tttaatattc tcttggggag
     4561 tgagtcttta ctaagtgatt actctatact tgataccact attaattgag gttcttttgg
     4621 ttgtttaatt aaatcagctc ctttggattt gggccaagat tgatccacca catactgaaa
     4681 tccgttctac aacatcataa tgtgtattta ctagaaaagg acttgcttca taaggaaaaa
     4741 ttattagaat atagagactt ataagtacat ttctagtgtg aaaaataagc atttgttagt
     4801 ttaagtgaga cctgccaata acttgattgc aaatattaat atcatgtgaa catataaaat
     4861 gggcccaaat ccttgttcaa aagtgaaatt tgcacgtttg tgaaataaaa cacatcaata
     4921 tcaatgactg aataccttaa ttcaaaacag caaatggcta aaattatact atgcaagcag
     4981 gaccctagta agttatgtgg gaaagcattt attgctgcta atattttatt ttcaattatt
     5041 tcattaggag agtcaaatgc ttaagataga ggacacatga ctaaaagttt caccagcact
     5101 catggcatct gctataaaac atgtgtccac agagtaccca caaactctca agatcttaag
     5161 tctcaacagt aaattactgg ttagtttttc taatcagagt ctcaacgtct tagtcccaat
     5221 tcttccaaat tttccaaaac catacactat agtgtatatg gaaaggagaa tatgtacttt
     5281 tgtgaatata aagtgtctgt tccattttta gtcatgaagt accataggaa gagatggtca
     5341 caccctaaca ttgtaaagca aaagaaagct tcaggaatca gaccataaca gcaacacttt
     5401 gctgaaaaat atttaattag aaggcaatac cacatactca catatgctaa ggagtgcaat
     5461 tattttgtat gtttactgga aaaggcaaaa aatttttctg tagttaaaac aatatttttg
     5521 tttctagaac ttttgttctt gtactgattc attaccatta aactgttttc acaaaatgcc
     5581 aaagaacaga ggagagctat acatgatttg accaagacgc tgcaagtagt ttcagaaact
     5641 gaggagacta tttttctgac aatgtatata agatctataa tgaaatgatt ggtaaaatta
     5701 taaaatggtt ctggaaataa tcatgtaaaa tataaaatgg gaaa
//
